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    lrrc17 leucine rich repeat containing 17 [ Danio rerio (zebrafish) ]

    Gene ID: 321202, updated on 27-Dec-2024

    Summary

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    Official Symbol
    lrrc17provided by ZNC
    Official Full Name
    leucine rich repeat containing 17provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9774
    See related
    Ensembl:ENSDARG00000037960 AllianceGenome:ZFIN:ZDB-GENE-030131-9774
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb314; sb:cb314; zgc:77411; wu:fb08f12
    Summary
    Is expressed in several structures, including digestive system; epidermis; mesenchyme derived from head mesoderm; musculature system; and tail bud. Orthologous to human LRRC17 (leucine rich repeat containing 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lrrc17 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (20141191..20156120, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (20420216..20435248, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene si:dkey-159a18.1 Neighboring gene coiled-coil domain containing 146 Neighboring gene centrosomal protein 83 Neighboring gene siaz-interacting nuclear protein Neighboring gene fibrinogen-like 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function. Oh CK, et al. Anticancer Res, 2020 Oct. PMID 32988884
    2. A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis. Melvin VS, et al. Dev Dyn, 2013 Jul. PMID 23559552, Free PMC Article
    3. Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Martin S, et al. Mol Cell Proteomics, 2010 Dec. PMID 20802085, Free PMC Article
    4. The impact of gene expression regulation on evolution of extracellular signaling pathways. Charoensawan V, et al. Mol Cell Proteomics, 2010 Dec. PMID 20935258, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function.
      Title: LRRC17 Is Linked to Prognosis of Ovarian Cancer Through a p53-dependent Anti-apoptotic Function.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205539.1 → NP_991102.1  leucine-rich repeat-containing protein 17 precursor

      See identical proteins and their annotated locations for NP_991102.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065605
      UniProtKB/TrEMBL
      Q6P0I5
      Related
      ENSDARP00000055316.5, ENSDART00000055317.6
      Conserved Domains (5) summary
      smart00082
      Location:151 → 201
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:72 → 94
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:94 → 129
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:72 → 129
      LRR_8; Leucine rich repeat
      cl15307
      Location:338 → 389
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      20141191..20156120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009300345.4 → XP_009298620.1  leucine-rich repeat-containing protein 17 isoform X1

      UniProtKB/TrEMBL
      A0A8M3ARP9, F1R0N0
      Conserved Domains (5) summary
      smart00082
      Location:151 → 201
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:72 → 94
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:94 → 129
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:72 → 129
      LRR_8; Leucine rich repeat
      cl15307
      Location:338 → 389
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    Nucleotide Protein
    Heading Accession and Version

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