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Conserved domains on  [gi|45387525|ref|NP_991102|]
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leucine-rich repeat-containing protein 17 precursor [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11471162)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
72-129 2.84e-15

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 2.84e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 45387525    72 HHLLLARNRIQVLRDNTFSHFRNLKSLDLQQNEISRIDDGAFDGLSKLTTLLLQHNRL 129
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-372 5.68e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 5.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525  69 EDIHHLLLARNRIQVLrDNTFSHFRNLKSLDLQQNEISRIDDgAFDGLSKLTTLLLQHNRLQVASEGmLIPMPQLKYLRL 148
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDL 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 149 HDNpwrcdcQLDSLvrfiqvpsnrnignyarcaePREFSG-RQLKKLDAEmlcspeqekeaildpENQqlpapqkksdat 227
Cdd:COG4886 190 SNN------QITDL--------------------PEPLGNlTNLEELDLS---------------GNQ------------ 216

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 228 slchtymhpvprmdcrnrdLKTVPADIPL--DIVKLDLSRNTIKQLrqKEFVNVKELKLLNLSGNSLESIDTAAftGLLY 305
Cdd:COG4886 217 -------------------LTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA--NLTN 273

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45387525 306 LGELDLSNNSLRYFQYGVLEDLYFLKRLSLGDNPWICDYNIHYLIYWLKHHPDVSHTGLVCSEPEEF 372
Cdd:COG4886 274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
72-129 2.84e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 2.84e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 45387525    72 HHLLLARNRIQVLRDNTFSHFRNLKSLDLQQNEISRIDDGAFDGLSKLTTLLLQHNRL 129
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-372 5.68e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 5.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525  69 EDIHHLLLARNRIQVLrDNTFSHFRNLKSLDLQQNEISRIDDgAFDGLSKLTTLLLQHNRLQVASEGmLIPMPQLKYLRL 148
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDL 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 149 HDNpwrcdcQLDSLvrfiqvpsnrnignyarcaePREFSG-RQLKKLDAEmlcspeqekeaildpENQqlpapqkksdat 227
Cdd:COG4886 190 SNN------QITDL--------------------PEPLGNlTNLEELDLS---------------GNQ------------ 216

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 228 slchtymhpvprmdcrnrdLKTVPADIPL--DIVKLDLSRNTIKQLrqKEFVNVKELKLLNLSGNSLESIDTAAftGLLY 305
Cdd:COG4886 217 -------------------LTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA--NLTN 273

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45387525 306 LGELDLSNNSLRYFQYGVLEDLYFLKRLSLGDNPWICDYNIHYLIYWLKHHPDVSHTGLVCSEPEEF 372
Cdd:COG4886 274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
LRR_8 pfam13855
Leucine rich repeat;
260-316 1.48e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.48e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 45387525   260 KLDLSRNTIKQLRQKEFVNVKELKLLNLSGNSLESIDTAAFTGLLYLGELDLSNNSL 316
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-314 1.42e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 1.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525  71 IHHLLLARNRIQVLRDntFSHFRNLKSLDLQQNEISRIDDgaFDGLSKLTTLLLQHNRLQVAsEGmLIPMPQLKYLRLHD 150
Cdd:cd21340   4 ITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 151 NpwrcdcqldslvrFIQVpsnrnIGNYARCAEPREfsgrqlkkldaemlcspeqekeaiLDPENQQLPAPQK-------- 222
Cdd:cd21340  78 N-------------RISV-----VEGLENLTNLEE------------------------LHIENQRLPPGEKltfdprsl 115

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 223 KSDATSLCHtymhpvprmdcrnrdlktvpadipldivkLDLSRNTIKQLrqKEFVNVKELKLLNLSGNSLESID--TAAF 300
Cdd:cd21340 116 AALSNSLRV-----------------------------LNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLL 164

                       250
                ....*....|....
gi 45387525 301 TGLLYLGELDLSNN 314
Cdd:cd21340 165 SSWPSLRELDLTGN 178
LRRCT smart00082
Leucine rich repeat C-terminal domain;
151-201 2.66e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.04  E-value: 2.66e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 45387525    151 NPWRCDCQLDSLVRFIQVPSNRNIGNYARCAEPREFSGRQLKKLDAEMLCS 201
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
13-271 3.02e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.70  E-value: 3.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525   13 VVWAaEARKGGRARRVRSRDHTTKRFAaDCketLVNGEKYFDCQERHLTAVLLGWPEDIHHLLLARNRIQVLRDNTFShf 92
Cdd:PRK15370 148 LIWS-EWVKEAPAKEAANREEAVQRMR-DC---LKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQG-- 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525   93 rNLKSLDLQQNEISRIDDGAFDGL------------------SKLTTLLLQHNRLQVASEGmlipMPQ-LKYLRLHDNPW 153
Cdd:PRK15370 221 -NIKTLYANSNQLTSIPATLPDTIqemelsinritelperlpSALQSLDLFHNKISCLPEN----LPEeLRYLSVYDNSI 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525  154 RC-DCQLDSLVRFIQVPSNrnignyARCAEPREFSgRQLKKLDAE---MLCSPEQekeaiLDPENQQLPApqKKSDATSL 229
Cdd:PRK15370 296 RTlPAHLPSGITHLNVQSN------SLTALPETLP-PGLKTLEAGenaLTSLPAS-----LPPELQVLDV--SKNQITVL 361

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 45387525  230 CHTYMHPVPRMDCRNRDLKTVPADIPLDIVKLDLSRNTIKQL 271
Cdd:PRK15370 362 PETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL 403
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 310-379 2.35e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 40.45  E-value: 2.35e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45387525    310 DLSNNSLRYFQYGVLEDLYFLKRLSLGDNPWICDYNIHYLIYWLKH------HPDVShtglVCSEPEEFRGWPVEN 379
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEAA----LCAGPGALAGQPLLG 72
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 73-152 5.31e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 5.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525  73 HLLLARNRIQVLRDntFSHFRNLKSLDLQQNEISRIDDgafdglskLTTLLLQhnrlqvasegmlipMPQLKYLRLHDNP 152
Cdd:cd21340 124 VLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEE--------LLDLLSS--------------WPSLRELDLTGNP 179
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
72-129 2.84e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 2.84e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 45387525    72 HHLLLARNRIQVLRDNTFSHFRNLKSLDLQQNEISRIDDGAFDGLSKLTTLLLQHNRL 129
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
93-152 5.36e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 5.36e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525    93 RNLKSLDLQQNEISRIDDGAFDGLSKLTTLLLQHNRLQVASEGMLIPMPQLKYLRLHDNP 152
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-372 5.68e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 5.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525  69 EDIHHLLLARNRIQVLrDNTFSHFRNLKSLDLQQNEISRIDDgAFDGLSKLTTLLLQHNRLQVASEGmLIPMPQLKYLRL 148
Cdd:COG4886 113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDL 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 149 HDNpwrcdcQLDSLvrfiqvpsnrnignyarcaePREFSG-RQLKKLDAEmlcspeqekeaildpENQqlpapqkksdat 227
Cdd:COG4886 190 SNN------QITDL--------------------PEPLGNlTNLEELDLS---------------GNQ------------ 216

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 228 slchtymhpvprmdcrnrdLKTVPADIPL--DIVKLDLSRNTIKQLrqKEFVNVKELKLLNLSGNSLESIDTAAftGLLY 305
Cdd:COG4886 217 -------------------LTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA--NLTN 273

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45387525 306 LGELDLSNNSLRYFQYGVLEDLYFLKRLSLGDNPWICDYNIHYLIYWLKHHPDVSHTGLVCSEPEEF 372
Cdd:COG4886 274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-339 1.01e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 1.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525  87 NTFSHFRNLKSLDLQQNEISRIDDgAFDGLSKLTTLLLQHNRLQVASEGmLIPMPQLKYLRLHDNpwrcdcQLDSLvrfi 166
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN------QLTDL---- 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 167 qvpsnrnignyarcaePREFSgrQLKKLdaemlcspeqekeaildpenqqlpapqkksdaTSLchtymhpvprmDCRNRD 246
Cdd:COG4886 175 ----------------PEELG--NLTNL--------------------------------KEL-----------DLSNNQ 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 247 LKTVPADI--PLDIVKLDLSRNTIKQLrQKEFVNVKELKLLNLSGNSLESIdtAAFTGLLYLGELDLSNNSLRyfQYGVL 324
Cdd:COG4886 194 ITDLPEPLgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLT--DLPPL 268

                       250
                ....*....|....*
gi 45387525 325 EDLYFLKRLSLGDNP 339
Cdd:COG4886 269 ANLTNLKTLDLSNNQ 283
LRR_8 pfam13855
Leucine rich repeat;
260-316 1.48e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.48e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 45387525   260 KLDLSRNTIKQLRQKEFVNVKELKLLNLSGNSLESIDTAAFTGLLYLGELDLSNNSL 316
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-314 1.42e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 1.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525  71 IHHLLLARNRIQVLRDntFSHFRNLKSLDLQQNEISRIDDgaFDGLSKLTTLLLQHNRLQVAsEGmLIPMPQLKYLRLHD 150
Cdd:cd21340   4 ITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 151 NpwrcdcqldslvrFIQVpsnrnIGNYARCAEPREfsgrqlkkldaemlcspeqekeaiLDPENQQLPAPQK-------- 222
Cdd:cd21340  78 N-------------RISV-----VEGLENLTNLEE------------------------LHIENQRLPPGEKltfdprsl 115

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 223 KSDATSLCHtymhpvprmdcrnrdlktvpadipldivkLDLSRNTIKQLrqKEFVNVKELKLLNLSGNSLESID--TAAF 300
Cdd:cd21340 116 AALSNSLRV-----------------------------LNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLL 164

                       250
                ....*....|....
gi 45387525 301 TGLLYLGELDLSNN 314
Cdd:cd21340 165 SSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
281-339 3.04e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 3.04e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 45387525   281 ELKLLNLSGNSLESIDTAAFTGLLYLGELDLSNNSLRYFQYGVLEDLYFLKRLSLGDNP 339
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRRCT smart00082
Leucine rich repeat C-terminal domain;
151-201 2.66e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.04  E-value: 2.66e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 45387525    151 NPWRCDCQLDSLVRFIQVPSNRNIGNYARCAEPREFSGRQLKKLDAEMLCS 201
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
13-271 3.02e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.70  E-value: 3.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525   13 VVWAaEARKGGRARRVRSRDHTTKRFAaDCketLVNGEKYFDCQERHLTAVLLGWPEDIHHLLLARNRIQVLRDNTFShf 92
Cdd:PRK15370 148 LIWS-EWVKEAPAKEAANREEAVQRMR-DC---LKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPENLQG-- 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525   93 rNLKSLDLQQNEISRIDDGAFDGL------------------SKLTTLLLQHNRLQVASEGmlipMPQ-LKYLRLHDNPW 153
Cdd:PRK15370 221 -NIKTLYANSNQLTSIPATLPDTIqemelsinritelperlpSALQSLDLFHNKISCLPEN----LPEeLRYLSVYDNSI 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525  154 RC-DCQLDSLVRFIQVPSNrnignyARCAEPREFSgRQLKKLDAE---MLCSPEQekeaiLDPENQQLPApqKKSDATSL 229
Cdd:PRK15370 296 RTlPAHLPSGITHLNVQSN------SLTALPETLP-PGLKTLEAGenaLTSLPAS-----LPPELQVLDV--SKNQITVL 361

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 45387525  230 CHTYMHPVPRMDCRNRDLKTVPADIPLDIVKLDLSRNTIKQL 271
Cdd:PRK15370 362 PETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL 403
LRR_9 pfam14580
Leucine-rich repeat;
76-152 5.62e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 46.30  E-value: 5.62e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45387525    76 LARNRIQVLrDNtFSHFRNLKSLDLQQNEISRIDDGAFDGLSKLTTLLLQHNRLQVASEGM-LIPMPQLKYLRLHDNP 152
Cdd:pfam14580  49 FSDNEIRKL-DG-FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDpLASLKKLTFLSLLRNP 124
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-316 3.21e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 3.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525   80 RIQVLR--DNTFS--------HFRNLKSLDLQQNEIS-RIDDGAFDGlSKLTTLLLQHNRLQVASEGMLIPMPQLKYLRL 148
Cdd:PLN00113 333 RLQVLQlwSNKFSgeipknlgKHNNLTVLDLSTNNLTgEIPEGLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRVRL 411

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525  149 HDNPWRCDCQLD----SLVRFIQVPSNRNIGNYarcaEPREFSGRQLKKLD-------AEMLCSPEQEKEAILDPENQQL 217
Cdd:PLN00113 412 QDNSFSGELPSEftklPLVYFLDISNNNLQGRI----NSRKWDMPSLQMLSlarnkffGGLPDSFGSKRLENLDLSRNQF 487

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525  218 papqkkSDAtslchtymhpVPRmdcrnrDLKTVPadiplDIVKLDLSRNTIKQLRQKEFVNVKELKLLNLSGNSLESIDT 297
Cdd:PLN00113 488 ------SGA----------VPR------KLGSLS-----ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIP 540

                        250
                 ....*....|....*....
gi 45387525  298 AAFTGLLYLGELDLSNNSL 316
Cdd:PLN00113 541 ASFSEMPVLSQLDLSQNQL 559
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
258-338 3.93e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 3.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525 258 IVKLDLSRNtikqlrqKEFVNVKELKLLNLSGNSLESIDtAAFTGLLYLGELDLSNNSLRYFQyGVLEDLYFLKRLSLGD 337
Cdd:COG4886  98 LTELDLSGN-------EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSN 168


                .
gi 45387525 338 N 338
Cdd:COG4886 169 N 169
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 310-379 2.35e-03

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 40.45  E-value: 2.35e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45387525    310 DLSNNSLRYFQYGVLEDLYFLKRLSLGDNPWICDYNIHYLIYWLKH------HPDVShtglVCSEPEEFRGWPVEN 379
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvkvrQPEAA----LCAGPGALAGQPLLG 72
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 73-152 5.31e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 5.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387525  73 HLLLARNRIQVLRDntFSHFRNLKSLDLQQNEISRIDDgafdglskLTTLLLQhnrlqvasegmlipMPQLKYLRLHDNP 152
Cdd:cd21340 124 VLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEE--------LLDLLSS--------------WPSLRELDLTGNP 179
LRRCT smart00082
Leucine rich repeat C-terminal domain;
338-389 8.62e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 34.33  E-value: 8.62e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 45387525    338 NPWICDYNIHYLIYWL---KHHPDVSHtgLVCSEPEEFRGwPVENYVkTYNAECP 389
Cdd:smart00082   1 NPFICDCELRWLLRWLqanEHLQDPVD--LRCASPSSLRG-PLLELL-HSEFKCP 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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