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    inf2 inverted formin 2 [ Danio rerio (zebrafish) ]

    Gene ID: 792715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    inf2provided by ZNC
    Official Full Name
    inverted formin 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-140711-5
    See related
    Ensembl:ENSDARG00000117069 AllianceGenome:ZFIN:ZDB-GENE-140711-5
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-193k8.5
    Summary
    Acts upstream of or within several processes, including glomerular filtration; podocyte development; and slit diaphragm assembly. Is expressed in several structures, including blood vessel; digestive system; eye; pronephros; and somite. Used to study glomerulosclerosis. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate E and focal segmental glomerulosclerosis 5. Orthologous to human INF2 (inverted formin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See inf2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (1193907..1267637)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (989912..1093842)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene cdc42 effector protein 3-like Neighboring gene GTP cyclohydrolase I feedback regulator Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 17 Neighboring gene adenylosuccinate synthase 1 Neighboring gene SIVA1, apoptosis-inducing factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutation of microphthalmia-associated transcription factor (mitf) in zebrafish sensitizes for glomerulopathy. Müller-Deile J, et al. Biol Open, 2019 Mar 4. PMID 30718228, Free PMC Article
    2. Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus. Sun H, et al. EBioMedicine, 2014 Dec. PMID 26086034, Free PMC Article
    3. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Schiffer M, et al. Nat Med, 2015 Jun. PMID 25962121, Free PMC Article
    4. Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Smith LC, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2016 Sep. PMID 27156127, Free PMC Article
    5. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within podocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of Rho protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of small GTPase mediated signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within slit diaphragm assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inverted formin 2; inverted formin-2
    Names
    inverted formin, FH2 and WH2 domain containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      1193907..1267637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467252.2 → XP_021322927.1  inverted formin-2

      UniProtKB/TrEMBL
      A0A8M9P0A2
      Related
      ENSDARP00000154373.1, ENSDART00000183177.1
      Conserved Domains (2) summary
      pfam06367
      Location:160 → 226
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:98 → 154
      Drf_GBD; Diaphanous GTPase-binding Domain
    Nucleotide Protein Strain
    Heading Accession and Version

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