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    Tep1 telomerase associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 21745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tep1provided by MGI
    Official Full Name
    telomerase associated protein 1provided by MGI
    Primary source
    MGI:MGI:109573
    See related
    Ensembl:ENSMUSG00000006281 AllianceGenome:MGI:109573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tp1
    Summary
    Enables telomerase RNA binding activity. Contributes to telomerase activity. Predicted to be involved in telomere maintenance via recombination. Part of telomerase holoenzyme complex. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and stomach cancer. Orthologous to human TEP1 (telomerase associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in large intestine adult (RPKM 17.7), colon adult (RPKM 17.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tep1 in Genome Data Viewer
    Location:
    14 C1; 14 26.26 cM
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51061513..51108036, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50824059..50870579, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E753 Neighboring gene ribonuclease P RNA component H1 Neighboring gene poly (ADP-ribose) polymerase family, member 2 Neighboring gene predicted gene, 52116 Neighboring gene STARR-positive B cell enhancer ABC_E8557 Neighboring gene predicted gene, 26782 Neighboring gene kelch-like 33 Neighboring gene Apex1 promoter region Neighboring gene O-sialoglycoprotein endopeptidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The cytosolic chaperonin subunit TRiC-P5 begins to be expressed at the two-cell stage in mouse embryos. Sévigny G, et al. Biochem Biophys Res Commun, 1995 Nov 2. PMID 7488101
    2. Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Liu Y, et al. Mol Cell Biol, 2000 Nov. PMID 11027287, Free PMC Article
    3. TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Nakayama J, et al. Cell, 1997 Mar 21. PMID 9118230
    4. Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis. Raval-Fernandes S, et al. Cancer Res, 2005 Oct 1. PMID 16204055
    5. A mammalian telomerase-associated protein. Harrington L, et al. Science, 1997 Feb 14. PMID 9020079

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91078

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomerase RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to telomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to telomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to telomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in telomere maintenance via recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance via recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance via recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within telomere maintenance via telomerase IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of telomerase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    telomerase protein component 1
    Names
    p240
    p80 homolog
    p80 telomerase homolog
    telomerase protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009351.2 → NP_033377.1  telomerase protein component 1

      See identical proteins and their annotated locations for NP_033377.1

      Status: VALIDATED

      Source sequence(s)
      BC082996, U86137
      Consensus CDS
      CCDS36907.1
      UniProtKB/Swiss-Prot
      P97499
      UniProtKB/TrEMBL
      Q5XKB2
      Related
      ENSMUSP00000006444.8, ENSMUST00000006444.9
      Conserved Domains (8) summary
      COG2319
      Location:1806 → 2198
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:1979 → 2273
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05386
      Location:1 → 29
      TEP1_N; TEP1 N-terminal domain
      pfam05729
      Location:1171 → 1346
      NACHT; NACHT domain
      pfam05731
      Location:230 → 685
      TROVE; TROVE domain
      pfam13271
      Location:917 → 1017
      DUF4062; Domain of unknown function (DUF4062)
      sd00039
      Location:1769 → 1804
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:2534 → 2602
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51061513..51108036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247719.2 → XP_030103579.1  telomerase protein component 1 isoform X1

      Conserved Domains (4) summary
      pfam05386
      Location:1 → 29
      TEP1_N; TEP1 N-terminal domain
      pfam05729
      Location:1171 → 1346
      NACHT; NACHT domain
      pfam05731
      Location:230 → 685
      TROVE; TROVE domain
      pfam13271
      Location:909 → 1017
      DUF4062; Domain of unknown function (DUF4062)

    RNA

    1. XR_004938374.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97499.1 GenPept UniProtKB/Swiss-Prot:P97499

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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