|
Name |
Accession |
Description |
Interval |
E-value |
| TROVE |
pfam05731 |
TROVE domain; This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding ... |
230-685 |
2.09e-148 |
|
TROVE domain; This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding.
:
Pssm-ID: 461724 Cd Length: 361 Bit Score: 465.71 E-value: 2.09e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 230 TSGDSGFHPETTDQVLQEKKMALLTLLCS---ALASNVNVKDAS------DLTRASILEVCSAL-----ASLEPEFILKA 295
Cdd:pfam05731 1 VSNDSGGYPEPTDDVLQEKRFLLLGLLCGtyyTLASEVTMDNAQaikiieDGTGASILETLRELsaagrAPKEPEFILKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 296 SLYARQQLNLRDIANTVLAVAALLPACRphvrryysaivhLPSDWIQVAEFYQSLAEGDEKKLVSLPACLRAAMTD---- 371
Cdd:pfam05731 81 ALYARQQLNIRDVANHVLAIAAVLPVCR------------LPTDLFEVAEYCEELAEGDEKKLTGWGRCLRRAMTDwyts 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 372 KFAEFDEYQLAKYNPRKHRSKRRSRQPPRPQKterpFSERGKCFPKSLWPLKNEQITFEAAYNAMPEKNRLPRFTLKKLV 451
Cdd:pfam05731 149 KFAEFLAYQLTKYNTRKHWSHKDPFRLPHPPK----FSETSLELKGLFRYATKEQRKFEKAYGAVPEKKESKRLTLKKLV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 452 EYLHIHKPAQHVQALLGYRYPAtlelfsrshlpgpwessragqrmklrrpeTWERELSLRGNKASVWEELIDNgKLPFMA 531
Cdd:pfam05731 225 QRLHISEPAEHVQALIGKRYRL-----------------------------TWEREPSLRGNSAEVWEELIDS-KLPMMA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 532 MLRNLCNLLRTGISARHHE-LVLQRLQHEKSVVHSRQFPFRFLNAHdsidkleaqlrskaspfpsnttlmkrimirnskk 610
Cdd:pfam05731 275 MLRNLCNLLRVGVSARHHEdLVLQRLQNPKSVIHSRQHPFRFLNAH---------------------------------- 320
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6678285 611 nrrpasrkhlctltrrqlraamtipVMYEQLKREKLRlhkaRQWNCDVELleryRQALETAVNLSVKhNLSPMPG 685
Cdd:pfam05731 321 -------------------------VVYEQGKGEKGK----LQWKPDPEI----SQALEAAFYLAVK-NLPPTPG 361
|
|
| DUF5920 |
pfam19334 |
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component ... |
696-898 |
8.61e-135 |
|
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component 1 (TEP1) and it contains an homology region to the telomerase associated protein from Tetrahymena p80. TEP1 is a component of the telomerase ribonucleoprotein complex and is thought to be responsible for catalysing the addition of new telomeres to chromosomes. TEP1 is also a component of the vault particle, a cytoplasmic ribonucleoprotein complex, in which it is required for vault RNA stability and its association with the vault particle. This domain is localized between the TROVE (pfam05731) and DUF4062 (pfam13271) domains.
:
Pssm-ID: 466045 Cd Length: 203 Bit Score: 419.95 E-value: 8.61e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 696 NADRLCPKSHSQGPPLNYVLLLIGMMVARAEQVTVCLCGGGFVKTPVLTADEGILKTAIKLQAQVQELEGNDEWPLDTFG 775
Cdd:pfam19334 1 NADRLCPKSNPQGPPLNYVLLLIGMMIARAEQVDLLLCGRGTLKTAVLKAEEGILKTAIKLQAQVQELEENDEWPLTTFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 776 KYLLSLAVQRTPIDRVILFGQRMDTELLKVAKQIIWQHVNSKCLFVGVLLQKTQYISPNLNPNDVTLSGCTDGILKFIAE 855
Cdd:pfam19334 81 KYLLSLAVQRVPVDRVILFGQTMNERLINVAKQLFWQHVNSKCLFVGVLLRKTQYISPDLNPNDVTLSGCTDGILKFIAE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 6678285 856 HGASRLLEHVGQLDKLFKIPPPPGKTQAPSLRPLEENIPGPLG 898
Cdd:pfam19334 161 RGASRLLEHVGQMDKIFKIPPPPGKTGVLSLRPLEEDTPSPLA 203
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1856-2275 |
1.19e-63 |
|
WD40 repeat [General function prediction only];
:
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 223.63 E-value: 1.19e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1856 AFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWSGFLGRPRGCLgSLPLS 1935
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL-LGHTA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1936 PALSVALNPDGDQVAVGYREDGINIYKISSGSQGPQHQELNVAVSALVWlSP--SVLVSGAEDGSLHGW-MFKGDSLHSL 2012
Cdd:COG2319 80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF-SPdgKTLASGSADGTVRLWdLATGKLLRTL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2013 wllSRYQKPVLGLAASR--ELMAAASEDFTVRLWprqlltqphvHAVELPCCAELRGHEGPVCCCSFSPDGGILATAGRD 2090
Cdd:COG2319 159 ---TGHSGAVTSVAFSPdgKLLASGSDDGTVRLW----------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2091 RNLLCWDmkiAQAPLLIHTFSScHRDWITGCAWTKDN-ILVSCSSDGSVGLWNPEAGQQLGQFSGHQSAVSAVV--AVEE 2167
Cdd:COG2319 226 GTVRLWD---LATGKLLRTLTG-HSGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAfsPDGK 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2168 HIVSVSRDGTLKVWD-HQGVELTSIPAHSGPISQCAAAleprPGGQpgselLVVTVGLDGATKLWHPLLVCQIRTLQGHS 2246
Cdd:COG2319 302 LLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFS----PDGK-----TLASGSDDGTVRLWDLATGELLRTLTGHT 372
|
410 420 430
....*....|....*....|....*....|
gi 6678285 2247 GPVTAAAASEASGLLLT-SDDSSVQLWQIP 2275
Cdd:COG2319 373 GAVTSVAFSPDGRTLASgSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1683-2099 |
9.21e-54 |
|
WD40 repeat [General function prediction only];
:
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 195.13 E-value: 9.21e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1683 SSSPTAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISSFAFLSDTALFLTT-FDGHLELWDLQHGCWVFQ 1761
Cdd:COG2319 78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGsADGTVRLWDLATGKLLRT 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1762 TKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYT-HPKSLNCVAFHPEGQVVATGSWAGSITFFQADGLK 1840
Cdd:COG2319 158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1841 VTKELGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWSG 1920
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1921 FLGRPRGCLGSlPLSPALSVALNPDGDQVAVGyredginiykissgsqgpqhqelnvavsalvwlspsvlvsgaedgslh 2000
Cdd:COG2319 318 ATGKLLRTLTG-HTGAVRSVAFSPDGKTLASG------------------------------------------------ 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2001 gwmfkgdslhslwllsryqkpvlglaasrelmaaaSEDFTVRLWPRQLLTQPHVhavelpccaeLRGHEGPVCCCSFSPD 2080
Cdd:COG2319 349 -----------------------------------SDDGTVRLWDLATGELLRT----------LTGHTGAVTSVAFSPD 383
|
410
....*....|....*....
gi 6678285 2081 GGILATAGRDRNLLCWDMK 2099
Cdd:COG2319 384 GRTLASGSADGTVRLWDLA 402
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
1171-1346 |
3.55e-29 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 115.87 E-value: 3.55e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1171 RLSLVTGQAGQGKTAFLASLVSALKVPDQPNEPPFVFFHFAAARPDQCLAlnllRRLCTHLRQKLGELSALPSTYRGLVW 1250
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNA----RSLADLLFSQWPEPAAPVSEVWAVIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1251 ELQQKLLlkfaqslqpaqtlvLIIDGADKLVDRNGQ---------LISDWIPKSLPRRVHLVLSVSSDSG--LGETLQQS 1319
Cdd:pfam05729 77 ELPERLL--------------LILDGLDELVSDLGQldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEP 142
|
170 180
....*....|....*....|....*..
gi 6678285 1320 QgayVVALGSLVPSSRAQLVREELALY 1346
Cdd:pfam05729 143 R---YLEVRGFSESDRKQYVRKYFSDE 166
|
|
| DUF4062 |
pfam13271 |
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. ... |
909-1017 |
4.01e-17 |
|
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.
:
Pssm-ID: 463823 Cd Length: 78 Bit Score: 78.02 E-value: 4.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 909 RLFISSTFRDMHGERDLLMRSVLPALQARVfphrislhaidlrwGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGY 988
Cdd:pfam13271 1 KVFISSTFYDLKEEREALIEALLELGHIPV--------------GMEEFPASDESPLDVCLREVDECDIYILILGGRYGS 66
|
90 100
....*....|....*....|....*....
gi 6678285 989 IPpsydlpdhphfhwtheyPSGRSVTEME 1017
Cdd:pfam13271 67 ID-----------------PDGISYTELE 78
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
1-29 |
8.92e-12 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
:
Pssm-ID: 428450 Cd Length: 29 Bit Score: 61.26 E-value: 8.92e-12
10 20
....*....|....*....|....*....
gi 6678285 1 MEKLCGHVPGHSDILSLKNRCLTMLPDLQ 29
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
31-59 |
1.32e-11 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
:
Pssm-ID: 428450 Cd Length: 29 Bit Score: 60.88 E-value: 1.32e-11
10 20
....*....|....*....|....*....
gi 6678285 31 LEKIHGHRSVHSDILSLENQCLTMLSDLQ 59
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
91-119 |
1.37e-11 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
:
Pssm-ID: 428450 Cd Length: 29 Bit Score: 60.88 E-value: 1.37e-11
10 20
....*....|....*....|....*....
gi 6678285 91 LEKLCGHMSSHPDVLSLENQCLATLPTVK 119
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
61-89 |
1.87e-11 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
:
Pssm-ID: 428450 Cd Length: 29 Bit Score: 60.49 E-value: 1.87e-11
10 20
....*....|....*....|....*....
gi 6678285 61 TERIDGHISVHPDILSLENRCLTMLPDLQ 89
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| NACHT super family |
cl26020 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
1031-1466 |
8.98e-04 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
The actual alignment was detected with superfamily member COG5635:
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 44.80 E-value: 8.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1031 SAQALIYFRDPDFLSSVPDAWKPDFISESEEAAHRVSELKRYLHEQKEVTCRSYSCEWGGVAAGRPYTGGLEEFGQLVLQ 1110
Cdd:COG5635 42 LALLALLDLLLADLGALLALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALLELAALLKAVLLSL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1111 DVWSMIQKQHLQPGAQLEQPTSISEDDLIQTSFQQLKTPTSPARPRLLQDTVQQLLLPHGRLsLVTGQAGQGKTAFLASL 1190
Cdd:COG5635 122 SGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELLEAKKKRL-LILGEPGSGKTTLLRYL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1191 VSALKVPDQPNEPPFVFF----HFAAARpdqclalNLLRRLCTHLRQKLGELSAlpstyrglvwelqqklllkFAQSLQP 1266
Cdd:COG5635 201 ALELAERYLDAEDPIPILielrDLAEEA-------SLEDLLAEALEKRGGEPED-------------------ALERLLR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1267 AQTLVLIIDGADKLVDRNGQL-ISDWIPKSLPR--RVHLVLSVSSDSGLGETLQQSQgayVVALGSLVPSSRAQLVR--- 1340
Cdd:COG5635 255 NGRLLLLLDGLDEVPDEADRDeVLNQLRRFLERypKARVIITSRPEGYDSSELEGFE---VLELAPLSDEQIEEFLKkwf 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1341 EELALYGKRLEESPFNNQMRLLLAKQgsslPLYLHLVTDYLRL--------FTLYEQVSERLRTLPATLPLLLQHILSTL 1412
Cdd:COG5635 332 EATERKAERLLEALEENPELRELARN----PLLLTLLALLLRErgelpdtrAELYEQFVELLLERWDEQRGLTIYRELSR 407
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 6678285 1413 EQEhgHDVLPQ-ALTALEVTRSGLTVDQLHAILSTWLILPKETKSWEEVLAASHS 1466
Cdd:COG5635 408 EEL--RELLSElALAMQENGRTEFAREELEEILREYLGRRKDAEALLDELLLRTG 460
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TROVE |
pfam05731 |
TROVE domain; This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding ... |
230-685 |
2.09e-148 |
|
TROVE domain; This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding.
Pssm-ID: 461724 Cd Length: 361 Bit Score: 465.71 E-value: 2.09e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 230 TSGDSGFHPETTDQVLQEKKMALLTLLCS---ALASNVNVKDAS------DLTRASILEVCSAL-----ASLEPEFILKA 295
Cdd:pfam05731 1 VSNDSGGYPEPTDDVLQEKRFLLLGLLCGtyyTLASEVTMDNAQaikiieDGTGASILETLRELsaagrAPKEPEFILKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 296 SLYARQQLNLRDIANTVLAVAALLPACRphvrryysaivhLPSDWIQVAEFYQSLAEGDEKKLVSLPACLRAAMTD---- 371
Cdd:pfam05731 81 ALYARQQLNIRDVANHVLAIAAVLPVCR------------LPTDLFEVAEYCEELAEGDEKKLTGWGRCLRRAMTDwyts 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 372 KFAEFDEYQLAKYNPRKHRSKRRSRQPPRPQKterpFSERGKCFPKSLWPLKNEQITFEAAYNAMPEKNRLPRFTLKKLV 451
Cdd:pfam05731 149 KFAEFLAYQLTKYNTRKHWSHKDPFRLPHPPK----FSETSLELKGLFRYATKEQRKFEKAYGAVPEKKESKRLTLKKLV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 452 EYLHIHKPAQHVQALLGYRYPAtlelfsrshlpgpwessragqrmklrrpeTWERELSLRGNKASVWEELIDNgKLPFMA 531
Cdd:pfam05731 225 QRLHISEPAEHVQALIGKRYRL-----------------------------TWEREPSLRGNSAEVWEELIDS-KLPMMA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 532 MLRNLCNLLRTGISARHHE-LVLQRLQHEKSVVHSRQFPFRFLNAHdsidkleaqlrskaspfpsnttlmkrimirnskk 610
Cdd:pfam05731 275 MLRNLCNLLRVGVSARHHEdLVLQRLQNPKSVIHSRQHPFRFLNAH---------------------------------- 320
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6678285 611 nrrpasrkhlctltrrqlraamtipVMYEQLKREKLRlhkaRQWNCDVELleryRQALETAVNLSVKhNLSPMPG 685
Cdd:pfam05731 321 -------------------------VVYEQGKGEKGK----LQWKPDPEI----SQALEAAFYLAVK-NLPPTPG 361
|
|
| DUF5920 |
pfam19334 |
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component ... |
696-898 |
8.61e-135 |
|
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component 1 (TEP1) and it contains an homology region to the telomerase associated protein from Tetrahymena p80. TEP1 is a component of the telomerase ribonucleoprotein complex and is thought to be responsible for catalysing the addition of new telomeres to chromosomes. TEP1 is also a component of the vault particle, a cytoplasmic ribonucleoprotein complex, in which it is required for vault RNA stability and its association with the vault particle. This domain is localized between the TROVE (pfam05731) and DUF4062 (pfam13271) domains.
Pssm-ID: 466045 Cd Length: 203 Bit Score: 419.95 E-value: 8.61e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 696 NADRLCPKSHSQGPPLNYVLLLIGMMVARAEQVTVCLCGGGFVKTPVLTADEGILKTAIKLQAQVQELEGNDEWPLDTFG 775
Cdd:pfam19334 1 NADRLCPKSNPQGPPLNYVLLLIGMMIARAEQVDLLLCGRGTLKTAVLKAEEGILKTAIKLQAQVQELEENDEWPLTTFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 776 KYLLSLAVQRTPIDRVILFGQRMDTELLKVAKQIIWQHVNSKCLFVGVLLQKTQYISPNLNPNDVTLSGCTDGILKFIAE 855
Cdd:pfam19334 81 KYLLSLAVQRVPVDRVILFGQTMNERLINVAKQLFWQHVNSKCLFVGVLLRKTQYISPDLNPNDVTLSGCTDGILKFIAE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 6678285 856 HGASRLLEHVGQLDKLFKIPPPPGKTQAPSLRPLEENIPGPLG 898
Cdd:pfam19334 161 RGASRLLEHVGQMDKIFKIPPPPGKTGVLSLRPLEEDTPSPLA 203
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1856-2275 |
1.19e-63 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 223.63 E-value: 1.19e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1856 AFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWSGFLGRPRGCLgSLPLS 1935
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL-LGHTA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1936 PALSVALNPDGDQVAVGYREDGINIYKISSGSQGPQHQELNVAVSALVWlSP--SVLVSGAEDGSLHGW-MFKGDSLHSL 2012
Cdd:COG2319 80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF-SPdgKTLASGSADGTVRLWdLATGKLLRTL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2013 wllSRYQKPVLGLAASR--ELMAAASEDFTVRLWprqlltqphvHAVELPCCAELRGHEGPVCCCSFSPDGGILATAGRD 2090
Cdd:COG2319 159 ---TGHSGAVTSVAFSPdgKLLASGSDDGTVRLW----------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2091 RNLLCWDmkiAQAPLLIHTFSScHRDWITGCAWTKDN-ILVSCSSDGSVGLWNPEAGQQLGQFSGHQSAVSAVV--AVEE 2167
Cdd:COG2319 226 GTVRLWD---LATGKLLRTLTG-HSGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAfsPDGK 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2168 HIVSVSRDGTLKVWD-HQGVELTSIPAHSGPISQCAAAleprPGGQpgselLVVTVGLDGATKLWHPLLVCQIRTLQGHS 2246
Cdd:COG2319 302 LLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFS----PDGK-----TLASGSDDGTVRLWDLATGELLRTLTGHT 372
|
410 420 430
....*....|....*....|....*....|
gi 6678285 2247 GPVTAAAASEASGLLLT-SDDSSVQLWQIP 2275
Cdd:COG2319 373 GAVTSVAFSPDGRTLASgSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1683-2099 |
9.21e-54 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 195.13 E-value: 9.21e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1683 SSSPTAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISSFAFLSDTALFLTT-FDGHLELWDLQHGCWVFQ 1761
Cdd:COG2319 78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGsADGTVRLWDLATGKLLRT 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1762 TKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYT-HPKSLNCVAFHPEGQVVATGSWAGSITFFQADGLK 1840
Cdd:COG2319 158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1841 VTKELGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWSG 1920
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1921 FLGRPRGCLGSlPLSPALSVALNPDGDQVAVGyredginiykissgsqgpqhqelnvavsalvwlspsvlvsgaedgslh 2000
Cdd:COG2319 318 ATGKLLRTLTG-HTGAVRSVAFSPDGKTLASG------------------------------------------------ 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2001 gwmfkgdslhslwllsryqkpvlglaasrelmaaaSEDFTVRLWPRQLLTQPHVhavelpccaeLRGHEGPVCCCSFSPD 2080
Cdd:COG2319 349 -----------------------------------SDDGTVRLWDLATGELLRT----------LTGHTGAVTSVAFSPD 383
|
410
....*....|....*....
gi 6678285 2081 GGILATAGRDRNLLCWDMK 2099
Cdd:COG2319 384 GRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1979-2273 |
2.48e-51 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 184.08 E-value: 2.48e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1979 VSALVWLSPS-VLVSGAEDGSLHGW-MFKGDSLHSLWLLSryqKPVLGLAAS--RELMAAASEDFTVRLWPRQLLtqphv 2054
Cdd:cd00200 12 VTCVAFSPDGkLLATGSGDGTIKVWdLETGELLRTLKGHT---GPVRDVAASadGTYLASGSSDKTIRLWDLETG----- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2055 havelPCCAELRGHEGPVCCCSFSPDGGILATAGRDRNLLCWDMKIAQaplLIHTFsSCHRDWITGCAWTKDNILVSCSS 2134
Cdd:cd00200 84 -----ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK---CLTTL-RGHTDWVNSVAFSPDGTFVASSS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2135 -DGSVGLWNPEAGQQLGQFSGHQSAVSAVVAV--EEHIVSVSRDGTLKVWDHQ-GVELTSIPAHSGPISQCAAAleprpg 2210
Cdd:cd00200 155 qDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFS------ 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6678285 2211 gqpGSELLVVTVGLDGATKLWHPLLVCQIRTLQGHSGPVTAAAASEASGLLLT-SDDSSVQLWQ 2273
Cdd:cd00200 229 ---PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASgSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1687-1962 |
1.01e-33 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 132.84 E-value: 1.01e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1687 TAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISSFAFLSDTALFLTT-FDGHLELWDLQHGCWVFQTKAH 1765
Cdd:cd00200 13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGsSDKTIRLWDLETGECVRTLTGH 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1766 QYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYT-HPKSLNCVAFHPEGQVVATGSWAGSITFFQADGLKVTKE 1844
Cdd:cd00200 93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1845 LGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWSGFLGR 1924
Cdd:cd00200 173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252
|
250 260 270
....*....|....*....|....*....|....*....
gi 6678285 1925 PRGCLgSLPLSPALSVALNPDGDQVAVGYrEDG-INIYK 1962
Cdd:cd00200 253 CVQTL-SGHTNSVTSLAWSPDGKRLASGS-ADGtIRIWD 289
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
1171-1346 |
3.55e-29 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 115.87 E-value: 3.55e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1171 RLSLVTGQAGQGKTAFLASLVSALKVPDQPNEPPFVFFHFAAARPDQCLAlnllRRLCTHLRQKLGELSALPSTYRGLVW 1250
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNA----RSLADLLFSQWPEPAAPVSEVWAVIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1251 ELQQKLLlkfaqslqpaqtlvLIIDGADKLVDRNGQ---------LISDWIPKSLPRRVHLVLSVSSDSG--LGETLQQS 1319
Cdd:pfam05729 77 ELPERLL--------------LILDGLDELVSDLGQldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEP 142
|
170 180
....*....|....*....|....*..
gi 6678285 1320 QgayVVALGSLVPSSRAQLVREELALY 1346
Cdd:pfam05729 143 R---YLEVRGFSESDRKQYVRKYFSDE 166
|
|
| DUF4062 |
pfam13271 |
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. ... |
909-1017 |
4.01e-17 |
|
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.
Pssm-ID: 463823 Cd Length: 78 Bit Score: 78.02 E-value: 4.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 909 RLFISSTFRDMHGERDLLMRSVLPALQARVfphrislhaidlrwGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGY 988
Cdd:pfam13271 1 KVFISSTFYDLKEEREALIEALLELGHIPV--------------GMEEFPASDESPLDVCLREVDECDIYILILGGRYGS 66
|
90 100
....*....|....*....|....*....
gi 6678285 989 IPpsydlpdhphfhwtheyPSGRSVTEME 1017
Cdd:pfam13271 67 ID-----------------PDGISYTELE 78
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
1-29 |
8.92e-12 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 61.26 E-value: 8.92e-12
10 20
....*....|....*....|....*....
gi 6678285 1 MEKLCGHVPGHSDILSLKNRCLTMLPDLQ 29
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
31-59 |
1.32e-11 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 60.88 E-value: 1.32e-11
10 20
....*....|....*....|....*....
gi 6678285 31 LEKIHGHRSVHSDILSLENQCLTMLSDLQ 59
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
91-119 |
1.37e-11 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 60.88 E-value: 1.37e-11
10 20
....*....|....*....|....*....
gi 6678285 91 LEKLCGHMSSHPDVLSLENQCLATLPTVK 119
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
61-89 |
1.87e-11 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 60.49 E-value: 1.87e-11
10 20
....*....|....*....|....*....
gi 6678285 61 TERIDGHISVHPDILSLENRCLTMLPDLQ 89
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
2061-2097 |
1.30e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 55.40 E-value: 1.30e-09
10 20 30
....*....|....*....|....*....|....*..
gi 6678285 2061 CCAELRGHEGPVCCCSFSPDGGILATAGRDRNLLCWD 2097
Cdd:smart00320 4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
2035-2207 |
2.61e-09 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 62.22 E-value: 2.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2035 ASEDFTVRLW--PRQLLTQ----PHVHavelpccaeLRGHEGPVCCCSFSPDG-GILATAGRDRNLLCWDMKIAQAPLLI 2107
Cdd:PTZ00421 94 ASEDGTIMGWgiPEEGLTQnisdPIVH---------LQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVI 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2108 htfsSCHRDWITGCAWTKD-NILVSCSSDGSVGLWNPEAGQQLGQFSGHQSAVS--AVVAVEEHIV-----SVSRDGTLK 2179
Cdd:PTZ00421 165 ----KCHSDQITSLEWNLDgSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIitlgcSKSQQRQIM 240
|
170 180
....*....|....*....|....*...
gi 6678285 2180 VWDHQGVEltsIPAHSGPISQCAAALEP 2207
Cdd:PTZ00421 241 LWDTRKMA---SPYSTVDLDQSSALFIP 265
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
2061-2097 |
6.90e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 50.42 E-value: 6.90e-08
10 20 30
....*....|....*....|....*....|....*..
gi 6678285 2061 CCAELRGHEGPVCCCSFSPDGGILATAGRDRNLLCWD 2097
Cdd:pfam00400 3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1763-1794 |
4.18e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.99 E-value: 4.18e-04
10 20 30
....*....|....*....|....*....|..
gi 6678285 1763 KAHQYQITGCCLSPDRRLLATVCLGGYLKLWD 1794
Cdd:smart00320 9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
1031-1466 |
8.98e-04 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 44.80 E-value: 8.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1031 SAQALIYFRDPDFLSSVPDAWKPDFISESEEAAHRVSELKRYLHEQKEVTCRSYSCEWGGVAAGRPYTGGLEEFGQLVLQ 1110
Cdd:COG5635 42 LALLALLDLLLADLGALLALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALLELAALLKAVLLSL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1111 DVWSMIQKQHLQPGAQLEQPTSISEDDLIQTSFQQLKTPTSPARPRLLQDTVQQLLLPHGRLsLVTGQAGQGKTAFLASL 1190
Cdd:COG5635 122 SGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELLEAKKKRL-LILGEPGSGKTTLLRYL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1191 VSALKVPDQPNEPPFVFF----HFAAARpdqclalNLLRRLCTHLRQKLGELSAlpstyrglvwelqqklllkFAQSLQP 1266
Cdd:COG5635 201 ALELAERYLDAEDPIPILielrDLAEEA-------SLEDLLAEALEKRGGEPED-------------------ALERLLR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1267 AQTLVLIIDGADKLVDRNGQL-ISDWIPKSLPR--RVHLVLSVSSDSGLGETLQQSQgayVVALGSLVPSSRAQLVR--- 1340
Cdd:COG5635 255 NGRLLLLLDGLDEVPDEADRDeVLNQLRRFLERypKARVIITSRPEGYDSSELEGFE---VLELAPLSDEQIEEFLKkwf 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1341 EELALYGKRLEESPFNNQMRLLLAKQgsslPLYLHLVTDYLRL--------FTLYEQVSERLRTLPATLPLLLQHILSTL 1412
Cdd:COG5635 332 EATERKAERLLEALEENPELRELARN----PLLLTLLALLLRErgelpdtrAELYEQFVELLLERWDEQRGLTIYRELSR 407
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 6678285 1413 EQEhgHDVLPQ-ALTALEVTRSGLTVDQLHAILSTWLILPKETKSWEEVLAASHS 1466
Cdd:COG5635 408 EEL--RELLSElALAMQENGRTEFAREELEEILREYLGRRKDAEALLDELLLRTG 460
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1763-1794 |
8.44e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.17 E-value: 8.44e-03
10 20 30
....*....|....*....|....*....|..
gi 6678285 1763 KAHQYQITGCCLSPDRRLLATVCLGGYLKLWD 1794
Cdd:pfam00400 8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TROVE |
pfam05731 |
TROVE domain; This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding ... |
230-685 |
2.09e-148 |
|
TROVE domain; This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding.
Pssm-ID: 461724 Cd Length: 361 Bit Score: 465.71 E-value: 2.09e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 230 TSGDSGFHPETTDQVLQEKKMALLTLLCS---ALASNVNVKDAS------DLTRASILEVCSAL-----ASLEPEFILKA 295
Cdd:pfam05731 1 VSNDSGGYPEPTDDVLQEKRFLLLGLLCGtyyTLASEVTMDNAQaikiieDGTGASILETLRELsaagrAPKEPEFILKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 296 SLYARQQLNLRDIANTVLAVAALLPACRphvrryysaivhLPSDWIQVAEFYQSLAEGDEKKLVSLPACLRAAMTD---- 371
Cdd:pfam05731 81 ALYARQQLNIRDVANHVLAIAAVLPVCR------------LPTDLFEVAEYCEELAEGDEKKLTGWGRCLRRAMTDwyts 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 372 KFAEFDEYQLAKYNPRKHRSKRRSRQPPRPQKterpFSERGKCFPKSLWPLKNEQITFEAAYNAMPEKNRLPRFTLKKLV 451
Cdd:pfam05731 149 KFAEFLAYQLTKYNTRKHWSHKDPFRLPHPPK----FSETSLELKGLFRYATKEQRKFEKAYGAVPEKKESKRLTLKKLV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 452 EYLHIHKPAQHVQALLGYRYPAtlelfsrshlpgpwessragqrmklrrpeTWERELSLRGNKASVWEELIDNgKLPFMA 531
Cdd:pfam05731 225 QRLHISEPAEHVQALIGKRYRL-----------------------------TWEREPSLRGNSAEVWEELIDS-KLPMMA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 532 MLRNLCNLLRTGISARHHE-LVLQRLQHEKSVVHSRQFPFRFLNAHdsidkleaqlrskaspfpsnttlmkrimirnskk 610
Cdd:pfam05731 275 MLRNLCNLLRVGVSARHHEdLVLQRLQNPKSVIHSRQHPFRFLNAH---------------------------------- 320
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6678285 611 nrrpasrkhlctltrrqlraamtipVMYEQLKREKLRlhkaRQWNCDVELleryRQALETAVNLSVKhNLSPMPG 685
Cdd:pfam05731 321 -------------------------VVYEQGKGEKGK----LQWKPDPEI----SQALEAAFYLAVK-NLPPTPG 361
|
|
| DUF5920 |
pfam19334 |
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component ... |
696-898 |
8.61e-135 |
|
Domain of unknown function (DUF5920); This domain is found in the Telomerase protein component 1 (TEP1) and it contains an homology region to the telomerase associated protein from Tetrahymena p80. TEP1 is a component of the telomerase ribonucleoprotein complex and is thought to be responsible for catalysing the addition of new telomeres to chromosomes. TEP1 is also a component of the vault particle, a cytoplasmic ribonucleoprotein complex, in which it is required for vault RNA stability and its association with the vault particle. This domain is localized between the TROVE (pfam05731) and DUF4062 (pfam13271) domains.
Pssm-ID: 466045 Cd Length: 203 Bit Score: 419.95 E-value: 8.61e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 696 NADRLCPKSHSQGPPLNYVLLLIGMMVARAEQVTVCLCGGGFVKTPVLTADEGILKTAIKLQAQVQELEGNDEWPLDTFG 775
Cdd:pfam19334 1 NADRLCPKSNPQGPPLNYVLLLIGMMIARAEQVDLLLCGRGTLKTAVLKAEEGILKTAIKLQAQVQELEENDEWPLTTFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 776 KYLLSLAVQRTPIDRVILFGQRMDTELLKVAKQIIWQHVNSKCLFVGVLLQKTQYISPNLNPNDVTLSGCTDGILKFIAE 855
Cdd:pfam19334 81 KYLLSLAVQRVPVDRVILFGQTMNERLINVAKQLFWQHVNSKCLFVGVLLRKTQYISPDLNPNDVTLSGCTDGILKFIAE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 6678285 856 HGASRLLEHVGQLDKLFKIPPPPGKTQAPSLRPLEENIPGPLG 898
Cdd:pfam19334 161 RGASRLLEHVGQMDKIFKIPPPPGKTGVLSLRPLEEDTPSPLA 203
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1856-2275 |
1.19e-63 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 223.63 E-value: 1.19e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1856 AFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWSGFLGRPRGCLgSLPLS 1935
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL-LGHTA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1936 PALSVALNPDGDQVAVGYREDGINIYKISSGSQGPQHQELNVAVSALVWlSP--SVLVSGAEDGSLHGW-MFKGDSLHSL 2012
Cdd:COG2319 80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF-SPdgKTLASGSADGTVRLWdLATGKLLRTL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2013 wllSRYQKPVLGLAASR--ELMAAASEDFTVRLWprqlltqphvHAVELPCCAELRGHEGPVCCCSFSPDGGILATAGRD 2090
Cdd:COG2319 159 ---TGHSGAVTSVAFSPdgKLLASGSDDGTVRLW----------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2091 RNLLCWDmkiAQAPLLIHTFSScHRDWITGCAWTKDN-ILVSCSSDGSVGLWNPEAGQQLGQFSGHQSAVSAVV--AVEE 2167
Cdd:COG2319 226 GTVRLWD---LATGKLLRTLTG-HSGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAfsPDGK 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2168 HIVSVSRDGTLKVWD-HQGVELTSIPAHSGPISQCAAAleprPGGQpgselLVVTVGLDGATKLWHPLLVCQIRTLQGHS 2246
Cdd:COG2319 302 LLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFS----PDGK-----TLASGSDDGTVRLWDLATGELLRTLTGHT 372
|
410 420 430
....*....|....*....|....*....|
gi 6678285 2247 GPVTAAAASEASGLLLT-SDDSSVQLWQIP 2275
Cdd:COG2319 373 GAVTSVAFSPDGRTLASgSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1683-2099 |
9.21e-54 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 195.13 E-value: 9.21e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1683 SSSPTAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISSFAFLSDTALFLTT-FDGHLELWDLQHGCWVFQ 1761
Cdd:COG2319 78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGsADGTVRLWDLATGKLLRT 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1762 TKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYT-HPKSLNCVAFHPEGQVVATGSWAGSITFFQADGLK 1840
Cdd:COG2319 158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1841 VTKELGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWSG 1920
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1921 FLGRPRGCLGSlPLSPALSVALNPDGDQVAVGyredginiykissgsqgpqhqelnvavsalvwlspsvlvsgaedgslh 2000
Cdd:COG2319 318 ATGKLLRTLTG-HTGAVRSVAFSPDGKTLASG------------------------------------------------ 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2001 gwmfkgdslhslwllsryqkpvlglaasrelmaaaSEDFTVRLWPRQLLTQPHVhavelpccaeLRGHEGPVCCCSFSPD 2080
Cdd:COG2319 349 -----------------------------------SDDGTVRLWDLATGELLRT----------LTGHTGAVTSVAFSPD 383
|
410
....*....|....*....
gi 6678285 2081 GGILATAGRDRNLLCWDMK 2099
Cdd:COG2319 384 GRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1683-1965 |
6.51e-52 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 189.74 E-value: 6.51e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1683 SSSPTAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISSFAFLSDTALFLTT-FDGHLELWDLQHGCWVFQ 1761
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGsDDGTVRLWDLATGKLLRT 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1762 TKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYT-HPKSLNCVAFHPEGQVVATGSWAGSITFFQADGLK 1840
Cdd:COG2319 200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1841 VTKELGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWSG 1920
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 6678285 1921 flgRPRGCLGSLP--LSPALSVALNPDGDQVAVGYREDGINIYKISS 1965
Cdd:COG2319 360 ---ATGELLRTLTghTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1979-2273 |
2.48e-51 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 184.08 E-value: 2.48e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1979 VSALVWLSPS-VLVSGAEDGSLHGW-MFKGDSLHSLWLLSryqKPVLGLAAS--RELMAAASEDFTVRLWPRQLLtqphv 2054
Cdd:cd00200 12 VTCVAFSPDGkLLATGSGDGTIKVWdLETGELLRTLKGHT---GPVRDVAASadGTYLASGSSDKTIRLWDLETG----- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2055 havelPCCAELRGHEGPVCCCSFSPDGGILATAGRDRNLLCWDMKIAQaplLIHTFsSCHRDWITGCAWTKDNILVSCSS 2134
Cdd:cd00200 84 -----ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK---CLTTL-RGHTDWVNSVAFSPDGTFVASSS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2135 -DGSVGLWNPEAGQQLGQFSGHQSAVSAVVAV--EEHIVSVSRDGTLKVWDHQ-GVELTSIPAHSGPISQCAAAleprpg 2210
Cdd:cd00200 155 qDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFS------ 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6678285 2211 gqpGSELLVVTVGLDGATKLWHPLLVCQIRTLQGHSGPVTAAAASEASGLLLT-SDDSSVQLWQ 2273
Cdd:cd00200 229 ---PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASgSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1982-2393 |
1.02e-47 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 177.41 E-value: 1.02e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1982 LVWLSPSVLVSGAEDGSLHGWMFKGDSLHSLWLLSRYQKPVLGLAASRELMAAASEDFTVRLWPRQLLTQPHVhavelpc 2061
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2062 caeLRGHEGPVCCCSFSPDGGILATAGRDRNLLCWDmkiAQAPLLIHTFSScHRDWITGCAWTKD-NILVSCSSDGSVGL 2140
Cdd:COG2319 74 ---LLGHTAAVLSVAFSPDGRLLASASADGTVRLWD---LATGLLLRTLTG-HTGAVRSVAFSPDgKTLASGSADGTVRL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2141 WNPEAGQQLGQFSGHQSAVSAVV--AVEEHIVSVSRDGTLKVWD-HQGVELTSIPAHSGPISQCAAAleprPGGQpgsel 2217
Cdd:COG2319 147 WDLATGKLLRTLTGHSGAVTSVAfsPDGKLLASGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFS----PDGK----- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2218 LVVTVGLDGATKLWHPLLVCQIRTLQGHSGPVTAAAASEASGLLLT-SDDSSVQLWQIPKEADDSYKPRSSVAITAVAWA 2296
Cdd:COG2319 218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASgSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2297 PDGSMVVSGNEAGELTLW--QQAKAVATAQAPGRVSHLIWYSANSFFVLSANEN--VSEWQVGLRKgststssslhLKRV 2372
Cdd:COG2319 298 PDGKLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDgtVRLWDLATGE----------LLRT 367
|
410 420
....*....|....*....|.
gi 6678285 2373 LQEDWGVLTGLGLAPDGQSLI 2393
Cdd:COG2319 368 LTGHTGAVTSVAFSPDGRTLA 388
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1670-1919 |
7.80e-46 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 172.02 E-value: 7.80e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1670 QTLKGQqslsltmSSSPTAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISSFAFLSD-TALFLTTFDGHL 1748
Cdd:COG2319 156 RTLTGH-------SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgKLLASGSADGTV 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1749 ELWDLQHGCWVFQTKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYTHPKS-LNCVAFHPEGQVVATGSW 1827
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAFSPDGKLLASGSD 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1828 AGSITFFQADGLKVTKELGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFL 1907
Cdd:COG2319 309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388
|
250
....*....|..
gi 6678285 1908 TAGEDGKAQLWS 1919
Cdd:COG2319 389 SGSADGTVRLWD 400
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
2061-2315 |
1.14e-42 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 159.04 E-value: 1.14e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2061 CCAELRGHEGPVCCCSFSPDGGILATAGRDRNLLCWDMKIAQaplLIHTFSScHRDWITGCAWTKDNI-LVSCSSDGSVG 2139
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE---LLRTLKG-HTGPVRDVAASADGTyLASGSSDKTIR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2140 LWNPEAGQQLGQFSGHQSAVSAVVAVEEH--IVSVSRDGTLKVWD-HQGVELTSIPAHSGPISQCAAaleprpggqPGSE 2216
Cdd:cd00200 77 LWDLETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAF---------SPDG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2217 LLVVTVGLDGATKLWHP-LLVCqIRTLQGHSGPVTAAAASEASGLLLT-SDDSSVQLWQIpkEADDSYK--PRSSVAITA 2292
Cdd:cd00200 148 TFVASSSQDGTIKLWDLrTGKC-VATLTGHTGEVNSVAFSPDGEKLLSsSSDGTIKLWDL--STGKCLGtlRGHENGVNS 224
|
250 260
....*....|....*....|...
gi 6678285 2293 VAWAPDGSMVVSGNEAGELTLWQ 2315
Cdd:cd00200 225 VAFSPDGYLLASGSEDGTIRVWD 247
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1763-2182 |
6.95e-39 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 147.87 E-value: 6.95e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1763 KAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYT-HPKSLNCVAFHPEGQVVATGSWAGSITFFQADGLKV 1841
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1842 TKELGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAqcgcvsavlflHAGdrfltagedgkaqlwsgf 1921
Cdd:cd00200 86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG-----------HTD------------------ 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1922 lgrprgclgslplsPALSVALNPDGDQVAVGyredginiykissgsqgpqhqelnvavsalvwlspsvlvsgaedgslhg 2001
Cdd:cd00200 137 --------------WVNSVAFSPDGTFVASS------------------------------------------------- 153
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2002 wmfkgdslhslwllsryqkpvlglaasrelmaaaSEDFTVRLWprqlltqphvHAVELPCCAELRGHEGPVCCCSFSPDG 2081
Cdd:cd00200 154 ----------------------------------SQDGTIKLW----------DLRTGKCVATLTGHTGEVNSVAFSPDG 189
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2082 GILATAGRDRNLLCWDMKIAQaplLIHTFSScHRDWITGCAWTKDN-ILVSCSSDGSVGLWNPEAGQQLGQFSGHQSAVS 2160
Cdd:cd00200 190 EKLLSSSSDGTIKLWDLSTGK---CLGTLRG-HENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265
|
410 420
....*....|....*....|....
gi 6678285 2161 AVVAVEE--HIVSVSRDGTLKVWD 2182
Cdd:cd00200 266 SLAWSPDgkRLASGSADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1726-2002 |
1.40e-35 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 138.24 E-value: 1.40e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1726 DGISSFAFLSDTALFLTTF-DGHLELWDLQHGCWVFQTKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQY 1804
Cdd:cd00200 10 GGVTCVAFSPDGKLLATGSgDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1805 T-HPKSLNCVAFHPEGQVVATGSWAGSITFFQADGLKVTKELGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGAR 1883
Cdd:cd00200 90 TgHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1884 LAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWSGFLGRprgCLGSLP--LSPALSVALNPDGDQVAVGYREDGINIY 1961
Cdd:cd00200 170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRghENGVNSVAFSPDGYLLASGSEDGTIRVW 246
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 6678285 1962 KISSGSQGPQHQELNVAVSALVWlSPS--VLVSGAEDGSLHGW 2002
Cdd:cd00200 247 DLRTGECVQTLSGHTNSVTSLAW-SPDgkRLASGSADGTIRIW 288
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1687-1962 |
1.01e-33 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 132.84 E-value: 1.01e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1687 TAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISSFAFLSDTALFLTT-FDGHLELWDLQHGCWVFQTKAH 1765
Cdd:cd00200 13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGsSDKTIRLWDLETGECVRTLTGH 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1766 QYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYT-HPKSLNCVAFHPEGQVVATGSWAGSITFFQADGLKVTKE 1844
Cdd:cd00200 93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1845 LGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWSGFLGR 1924
Cdd:cd00200 173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252
|
250 260 270
....*....|....*....|....*....|....*....
gi 6678285 1925 PRGCLgSLPLSPALSVALNPDGDQVAVGYrEDG-INIYK 1962
Cdd:cd00200 253 CVQTL-SGHTNSVTSLAWSPDGKRLASGS-ADGtIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
1683-1919 |
7.93e-30 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 121.67 E-value: 7.93e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1683 SSSPTAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISSFAFLSDTALFLTT-FDGHLELWDLQHGCWVFQ 1761
Cdd:cd00200 51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTT 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1762 TKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYT-HPKSLNCVAFHPEGQVVATGSWAGSITFFQADGLK 1840
Cdd:cd00200 131 LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6678285 1841 VTKELGAPGPSVCSLAFNKPGKIVAVGRIDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWS 1919
Cdd:cd00200 211 CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
1171-1346 |
3.55e-29 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 115.87 E-value: 3.55e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1171 RLSLVTGQAGQGKTAFLASLVSALKVPDQPNEPPFVFFHFAAARPDQCLAlnllRRLCTHLRQKLGELSALPSTYRGLVW 1250
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGFDFVFFLPCRELSRSGNA----RSLADLLFSQWPEPAAPVSEVWAVIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1251 ELQQKLLlkfaqslqpaqtlvLIIDGADKLVDRNGQ---------LISDWIPKSLPRRVHLVLSVSSDSG--LGETLQQS 1319
Cdd:pfam05729 77 ELPERLL--------------LILDGLDELVSDLGQldgpcpvltLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEP 142
|
170 180
....*....|....*....|....*..
gi 6678285 1320 QgayVVALGSLVPSSRAQLVREELALY 1346
Cdd:pfam05729 143 R---YLEVRGFSESDRKQYVRKYFSDE 166
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
1670-1838 |
1.65e-27 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 117.70 E-value: 1.65e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1670 QTLKGQqslsltmSSSPTAVAFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISSFAFLSDTALFLTT-FDGHL 1748
Cdd:COG2319 240 RTLTGH-------SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGsDDGTV 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1749 ELWDLQHGCWVFQTKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYT-HPKSLNCVAFHPEGQVVATGSW 1827
Cdd:COG2319 313 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFSPDGRTLASGSA 392
|
170
....*....|.
gi 6678285 1828 AGSITFFQADG 1838
Cdd:COG2319 393 DGTVRLWDLAT 403
|
|
| DUF4062 |
pfam13271 |
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. ... |
909-1017 |
4.01e-17 |
|
Domain of unknown function (DUF4062); This presumed domain is functionally uncharacterized. This domain family is found in bacteria, archaea and eukaryotes, and is approximately 80 amino acids in length. There is a conserved SST sequence motif.
Pssm-ID: 463823 Cd Length: 78 Bit Score: 78.02 E-value: 4.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 909 RLFISSTFRDMHGERDLLMRSVLPALQARVfphrislhaidlrwGITEEETRRNRQLEVCLGEVENSQLFVGILGSRYGY 988
Cdd:pfam13271 1 KVFISSTFYDLKEEREALIEALLELGHIPV--------------GMEEFPASDESPLDVCLREVDECDIYILILGGRYGS 66
|
90 100
....*....|....*....|....*....
gi 6678285 989 IPpsydlpdhphfhwtheyPSGRSVTEME 1017
Cdd:pfam13271 67 ID-----------------PDGISYTELE 78
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
1-29 |
8.92e-12 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 61.26 E-value: 8.92e-12
10 20
....*....|....*....|....*....
gi 6678285 1 MEKLCGHVPGHSDILSLKNRCLTMLPDLQ 29
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
31-59 |
1.32e-11 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 60.88 E-value: 1.32e-11
10 20
....*....|....*....|....*....
gi 6678285 31 LEKIHGHRSVHSDILSLENQCLTMLSDLQ 59
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
91-119 |
1.37e-11 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 60.88 E-value: 1.37e-11
10 20
....*....|....*....|....*....
gi 6678285 91 LEKLCGHMSSHPDVLSLENQCLATLPTVK 119
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| TEP1_N |
pfam05386 |
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus ... |
61-89 |
1.87e-11 |
|
TEP1 N-terminal domain; This short sequence region is found in four copies at the N-terminus of the TEP1 telomerase component. The functional significance of the region is uncertain. However the conservation of two histidines and a cysteine suggests it is a potential zinc binding domain.
Pssm-ID: 428450 Cd Length: 29 Bit Score: 60.49 E-value: 1.87e-11
10 20
....*....|....*....|....*....
gi 6678285 61 TERIDGHISVHPDILSLENRCLTMLPDLQ 89
Cdd:pfam05386 1 MEKPHGHVSAHPDILSLENRCLATLPDLK 29
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
2061-2097 |
1.30e-09 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 55.40 E-value: 1.30e-09
10 20 30
....*....|....*....|....*....|....*..
gi 6678285 2061 CCAELRGHEGPVCCCSFSPDGGILATAGRDRNLLCWD 2097
Cdd:smart00320 4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PTZ00421 |
PTZ00421 |
coronin; Provisional |
2035-2207 |
2.61e-09 |
|
coronin; Provisional
Pssm-ID: 173611 [Multi-domain] Cd Length: 493 Bit Score: 62.22 E-value: 2.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2035 ASEDFTVRLW--PRQLLTQ----PHVHavelpccaeLRGHEGPVCCCSFSPDG-GILATAGRDRNLLCWDMKIAQAPLLI 2107
Cdd:PTZ00421 94 ASEDGTIMGWgiPEEGLTQnisdPIVH---------LQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVI 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 2108 htfsSCHRDWITGCAWTKD-NILVSCSSDGSVGLWNPEAGQQLGQFSGHQSAVS--AVVAVEEHIV-----SVSRDGTLK 2179
Cdd:PTZ00421 165 ----KCHSDQITSLEWNLDgSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIitlgcSKSQQRQIM 240
|
170 180
....*....|....*....|....*...
gi 6678285 2180 VWDHQGVEltsIPAHSGPISQCAAALEP 2207
Cdd:PTZ00421 241 LWDTRKMA---SPYSTVDLDQSSALFIP 265
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
2061-2097 |
6.90e-08 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 50.42 E-value: 6.90e-08
10 20 30
....*....|....*....|....*....|....*..
gi 6678285 2061 CCAELRGHEGPVCCCSFSPDGGILATAGRDRNLLCWD 2097
Cdd:pfam00400 3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
2106-2142 |
2.26e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 43.46 E-value: 2.26e-05
10 20 30
....*....|....*....|....*....|....*...
gi 6678285 2106 LIHTFSsCHRDWITGCAWTKD-NILVSCSSDGSVGLWN 2142
Cdd:smart00320 4 LLKTLK-GHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
|
|
| AAA_16 |
pfam13191 |
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ... |
1156-1289 |
3.25e-04 |
|
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.
Pssm-ID: 433025 [Multi-domain] Cd Length: 167 Bit Score: 43.65 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1156 RLLQDTVQQLLLPHGRLSLVTGQAGQGKTAFLASLVSALKvpdqPNEPPFVFFHFAAARP-----DQCLALNLLRRLCTH 1230
Cdd:pfam13191 10 EQLLDALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALE----RDGGYFLRGKCDENLPyspllEALTREGLLRQLLDE 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6678285 1231 LR---------QKLGELSALPSTYRGLVWELQQKLLLKFAQSLQPAQTLVLIIDGADKLVDRNGQLIS 1289
Cdd:pfam13191 86 LEsslleawraALLEALAPVPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEASLQLLA 153
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
2146-2182 |
3.79e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.99 E-value: 3.79e-04
10 20 30
....*....|....*....|....*....|....*....
gi 6678285 2146 GQQLGQFSGHQSAVSAVV--AVEEHIVSVSRDGTLKVWD 2182
Cdd:smart00320 2 GELLKTLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1763-1794 |
4.18e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 39.99 E-value: 4.18e-04
10 20 30
....*....|....*....|....*....|..
gi 6678285 1763 KAHQYQITGCCLSPDRRLLATVCLGGYLKLWD 1794
Cdd:smart00320 9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
2146-2182 |
4.41e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 39.64 E-value: 4.41e-04
10 20 30
....*....|....*....|....*....|....*....
gi 6678285 2146 GQQLGQFSGHQSAVSAVV--AVEEHIVSVSRDGTLKVWD 2182
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAfsPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
2106-2142 |
4.63e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 39.64 E-value: 4.63e-04
10 20 30
....*....|....*....|....*....|....*...
gi 6678285 2106 LIHTFSsCHRDWITGCAWTKD-NILVSCSSDGSVGLWN 2142
Cdd:pfam00400 3 LLKTLE-GHTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
1031-1466 |
8.98e-04 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 44.80 E-value: 8.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1031 SAQALIYFRDPDFLSSVPDAWKPDFISESEEAAHRVSELKRYLHEQKEVTCRSYSCEWGGVAAGRPYTGGLEEFGQLVLQ 1110
Cdd:COG5635 42 LALLALLDLLLADLGALLALVSRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALLELAALLKAVLLSL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1111 DVWSMIQKQHLQPGAQLEQPTSISEDDLIQTSFQQLKTPTSPARPRLLQDTVQQLLLPHGRLsLVTGQAGQGKTAFLASL 1190
Cdd:COG5635 122 SGGSDLVLLLSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELLEAKKKRL-LILGEPGSGKTTLLRYL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1191 VSALKVPDQPNEPPFVFF----HFAAARpdqclalNLLRRLCTHLRQKLGELSAlpstyrglvwelqqklllkFAQSLQP 1266
Cdd:COG5635 201 ALELAERYLDAEDPIPILielrDLAEEA-------SLEDLLAEALEKRGGEPED-------------------ALERLLR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1267 AQTLVLIIDGADKLVDRNGQL-ISDWIPKSLPR--RVHLVLSVSSDSGLGETLQQSQgayVVALGSLVPSSRAQLVR--- 1340
Cdd:COG5635 255 NGRLLLLLDGLDEVPDEADRDeVLNQLRRFLERypKARVIITSRPEGYDSSELEGFE---VLELAPLSDEQIEEFLKkwf 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1341 EELALYGKRLEESPFNNQMRLLLAKQgsslPLYLHLVTDYLRL--------FTLYEQVSERLRTLPATLPLLLQHILSTL 1412
Cdd:COG5635 332 EATERKAERLLEALEENPELRELARN----PLLLTLLALLLRErgelpdtrAELYEQFVELLLERWDEQRGLTIYRELSR 407
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 6678285 1413 EQEhgHDVLPQ-ALTALEVTRSGLTVDQLHAILSTWLILPKETKSWEEVLAASHS 1466
Cdd:COG5635 408 EEL--RELLSElALAMQENGRTEFAREELEEILREYLGRRKDAEALLDELLLRTG 460
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
2238-2272 |
9.36e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.83 E-value: 9.36e-04
10 20 30
....*....|....*....|....*....|....*.
gi 6678285 2238 QIRTLQGHSGPVTAAAASEASGLLLT-SDDSSVQLW 2272
Cdd:smart00320 4 LLKTLKGHTGPVTSVAFSPDGKYLASgSDDGTIKLW 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
1806-1834 |
3.57e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.29 E-value: 3.57e-03
10 20
....*....|....*....|....*....
gi 6678285 1806 HPKSLNCVAFHPEGQVVATGSWAGSITFF 1834
Cdd:smart00320 11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
2238-2272 |
3.65e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.32 E-value: 3.65e-03
10 20 30
....*....|....*....|....*....|....*.
gi 6678285 2238 QIRTLQGHSGPVTAAAASEASGLLLT-SDDSSVQLW 2272
Cdd:pfam00400 3 LLKTLEGHTGSVTSLAFSPDGKLLASgSDDGTVKVW 38
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
1169-1280 |
4.03e-03 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 39.63 E-value: 4.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678285 1169 HGRLSLVTGQAGQGKTAFLASLVSALkvpdQPNEPPFVFFhfaaarpdQCLALNLLRRLCTHLRQKLGELSALPSTYRGL 1248
Cdd:pfam13401 4 GAGILVLTGESGTGKTTLLRRLLEQL----PEVRDSVVFV--------DLPSGTSPKDLLRALLRALGLPLSGRLSKEEL 71
|
90 100 110
....*....|....*....|....*....|..
gi 6678285 1249 VWELQQKLLLKFAqslqpaqTLVLIIDGADKL 1280
Cdd:pfam13401 72 LAALQQLLLALAV-------AVVLIIDEAQHL 96
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
1763-1794 |
8.44e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.17 E-value: 8.44e-03
10 20 30
....*....|....*....|....*....|..
gi 6678285 1763 KAHQYQITGCCLSPDRRLLATVCLGGYLKLWD 1794
Cdd:pfam00400 8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| |
