Ttc8 tetratricopeptide repeat domain 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ttc8provided by RGD
Official Full Name: tetratricopeptide repeat domain 8provided by RGD
Primary source: RGD:1307769
See related: EnsemblRapid:ENSRNOG00000004542 AllianceGenome:RGD:1307769
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in establishment of anatomical structure orientation; fat cell differentiation; and non-motile cilium assembly. Predicted to act upstream of or within several processes, including morphogenesis of a polarized epithelium; negative regulation of GTPase activity; and nervous system development. Predicted to be located in several cellular components, including centrosome; ciliary membrane; and photoreceptor connecting cilium. Predicted to be part of BBSome. Predicted to be active in ciliary basal body and non-motile cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 71.2), Kidney (RPKM 47.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (123927657..124025354)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (118198186..118252422)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (122920308..122974525)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within camera-type eye photoreceptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in establishment of anatomical structure orientation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of planar polarity	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multi-ciliated epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within olfactory bulb development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal tubule development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of smell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BBSome	IBA Inferred from Biological aspect of Ancestor more info
part_of BBSome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in non-motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor connecting cilium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tetratricopeptide repeat protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106752.1 → NP_001100222.1 tetratricopeptide repeat protein 8 isoform 2

See identical proteins and their annotated locations for NP_001100222.1

Status: PROVISIONAL

Source sequence(s)

CH473982

UniProtKB/TrEMBL

A0A8I5ZJC8, A6JEF4, D3ZND5

Related

ENSRNOP00000060304.1, ENSRNOT00000068595.4

Conserved Domains (2) summary

sd00006
Location:202 → 225

TPR; TPR repeat [structural motif]

pfam13414
Location:231 → 294

TPR_11; TPR repeat
NM_001399497.1 → NP_001386426.1 tetratricopeptide repeat protein 8 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I5ZJC8, B1WBT5

Related

ENSRNOP00000077009.2, ENSRNOT00000118948.2

Conserved Domains (3) summary

COG0457
Location:231 → 488

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:350 → 378

TPR; TPR repeat [structural motif]

cd21341
Location:30 → 169

TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8
NM_001399499.1 → NP_001386428.1 tetratricopeptide repeat protein 8 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A1P8YVD0, A0A8I5ZJC8

Related

ENSRNOP00000068618.2, ENSRNOT00000082856.3

Conserved Domains (3) summary

COG0457
Location:241 → 498

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:360 → 388

TPR; TPR repeat [structural motif]

cd21341
Location:30 → 179

TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

123927657..124025354

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112066.2 → XP_038967994.1 tetratricopeptide repeat protein 8 isoform X4

UniProtKB/TrEMBL

A0A1P8YVD4

Conserved Domains (3) summary

smart00028
Location:220 → 246

TPR; Tetratricopeptide repeats

sd00006
Location:182 → 208

TPR; TPR repeat [structural motif]

cd21341
Location:30 → 169

TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8
XM_039112069.2 → XP_038967997.1 tetratricopeptide repeat protein 8 isoform X6

UniProtKB/TrEMBL

A0A1P8YVD8, A0A1P8YVF9

Conserved Domains (3) summary

smart00028
Location:220 → 246

TPR; Tetratricopeptide repeats

sd00006
Location:181 → 209

TPR; TPR repeat [structural motif]

cd21341
Location:30 → 169

TTC8_N; N-terminal domain of tetratricopeptide repeat domain 8
XM_063261761.1 → XP_063117831.1 tetratricopeptide repeat protein 8 isoform X3

UniProtKB/TrEMBL

A0A1P8YVG2

Related

ENSRNOP00000088851.1, ENSRNOT00000114433.2
XM_063261759.1 → XP_063117829.1 tetratricopeptide repeat protein 8 isoform X1

UniProtKB/TrEMBL

A0A8I6GM46
XM_063261760.1 → XP_063117830.1 tetratricopeptide repeat protein 8 isoform X2

UniProtKB/TrEMBL

A0A1P8YVH6
XM_039112067.2 → XP_038967995.1 tetratricopeptide repeat protein 8 isoform X5

UniProtKB/TrEMBL

A0A1P8YVE4

Related

ENSRNOP00000093561.1, ENSRNOT00000097062.2

Conserved Domains (2) summary

TIGR02917
Location:129 → 269

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:130 → 158

TPR; TPR repeat [structural motif]