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    Plxnb3 plexin B3 [ Mus musculus (house mouse) ]

    Gene ID: 140571, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plxnb3provided by MGI
    Official Full Name
    plexin B3provided by MGI
    Primary source
    MGI:MGI:2154240
    See related
    Ensembl:ENSMUSG00000031385 AllianceGenome:MGI:2154240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Plxn6
    Summary
    Enables Rho GDP-dissociation inhibitor binding activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of GTPase activity; and regulation of plasma membrane bounded cell projection organization. Predicted to be located in cell surface. Predicted to be part of semaphorin receptor complex. Predicted to be active in plasma membrane. Is expressed in brain. Orthologous to human PLXNB3 (plexin B3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 6.4), cortex adult (RPKM 3.8) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Plxnb3 in Genome Data Viewer
    Location:
    X A7.3; X 37.4 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72800564..72816116)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73756556..73772510)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene B cell receptor associated protein 31 Neighboring gene STARR-positive B cell enhancer ABC_E11048 Neighboring gene ATP-binding cassette, sub-family D member 1 Neighboring gene STARR-seq mESC enhancer starr_47353 Neighboring gene predicted gene, 25226 Neighboring gene serine/arginine-rich protein specific kinase 3 Neighboring gene isocitrate dehydrogenase 3 (NAD+), gamma

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Rho GDP-dissociation inhibitor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cell-cell adhesion mediator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cell-cell adhesion mediator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein domain specific binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables semaphorin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables semaphorin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables semaphorin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lamellipodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in semaphorin-plexin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in semaphorin-plexin signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of semaphorin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019587.2NP_062533.2  plexin-B3 precursor

      See identical proteins and their annotated locations for NP_062533.2

      Status: VALIDATED

      Source sequence(s)
      AK140240, AL672094, BX636029
      Consensus CDS
      CCDS41013.1
      UniProtKB/Swiss-Prot
      A2AFF9, Q80TH8, Q9QY40
      Related
      ENSMUSP00000002079.7, ENSMUST00000002079.7
      Conserved Domains (9) summary
      cd11277
      Location:37462
      Sema_plexin_B3; The Sema domain, a protein interacting module, of Plexin B3
      cd01179
      Location:9161001
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:824915
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:464515
      PSI; Plexin repeat
      pfam01833
      Location:11651232
      TIG; IPT/TIG domain
      pfam08337
      Location:13171868
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:522608
      TIG_plexin; TIG domain
      pfam18020
      Location:678775
      TIG_2; TIG domain found in plexin
      cl15674
      Location:10041135
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72800564..72816116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161810.1XP_036017703.1  plexin-B3 isoform X2

      Conserved Domains (10) summary
      cd11277
      Location:37462
      Sema_plexin_B3; The Sema domain, a protein interacting module, of Plexin B3
      smart00423
      Location:622658
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:9161001
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:824915
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:464515
      PSI; Plexin repeat
      pfam01833
      Location:11651232
      TIG; IPT/TIG domain
      pfam17960
      Location:522608
      TIG_plexin; TIG domain
      pfam18020
      Location:681775
      TIG_2; TIG domain found in plexin
      cl02569
      Location:13171566
      RasGAP; Ras GTPase Activating Domain
      cl15674
      Location:10041135
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    2. XM_036161811.1XP_036017704.1  plexin-B3 isoform X2

      Conserved Domains (10) summary
      cd11277
      Location:37462
      Sema_plexin_B3; The Sema domain, a protein interacting module, of Plexin B3
      smart00423
      Location:622658
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:9161001
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:824915
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:464515
      PSI; Plexin repeat
      pfam01833
      Location:11651232
      TIG; IPT/TIG domain
      pfam17960
      Location:522608
      TIG_plexin; TIG domain
      pfam18020
      Location:681775
      TIG_2; TIG domain found in plexin
      cl02569
      Location:13171566
      RasGAP; Ras GTPase Activating Domain
      cl15674
      Location:10041135
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    3. XM_036161808.1XP_036017701.1  plexin-B3 isoform X1

      Conserved Domains (10) summary
      cd11277
      Location:37462
      Sema_plexin_B3; The Sema domain, a protein interacting module, of Plexin B3
      smart00423
      Location:622658
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:9161001
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:824915
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:464515
      PSI; Plexin repeat
      pfam01833
      Location:11651232
      TIG; IPT/TIG domain
      pfam08337
      Location:13171749
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:522608
      TIG_plexin; TIG domain
      pfam18020
      Location:681775
      TIG_2; TIG domain found in plexin
      cl15674
      Location:10041135
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    4. XM_036161809.1XP_036017702.1  plexin-B3 isoform X1

      Conserved Domains (10) summary
      cd11277
      Location:37462
      Sema_plexin_B3; The Sema domain, a protein interacting module, of Plexin B3
      smart00423
      Location:622658
      PSI; domain found in Plexins, Semaphorins and Integrins
      cd01179
      Location:9161001
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:824915
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:464515
      PSI; Plexin repeat
      pfam01833
      Location:11651232
      TIG; IPT/TIG domain
      pfam08337
      Location:13171749
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:522608
      TIG_plexin; TIG domain
      pfam18020
      Location:681775
      TIG_2; TIG domain found in plexin
      cl15674
      Location:10041135
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...