NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907202616|ref|XP_036017704|]
View 

plexin-B3 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
 37-462 0e+00

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


:

Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 764.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   37 FSVPNTSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRT 116
Cdd:cd11277      1 FSAPNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQARLTDNANKLLLVSERA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  117 QELVACGQVKQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVPLPGRDLLLVARGLAGKLSAGVPPLTVR 196
Cdd:cd11277     81 GELVACGQVRQGVCEKRRLGNVAQVLYQAEDPGDGQFVAANDPGVATVGLVVEAPGRDLLLVGRGLTGKLSAGIPPLTIR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  197 QLAGPQPFSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLRDVNLYSYVEMPLTCH-G 275
Cdd:cd11277    161 QLAGAQAFSSEGLGKLVVGDFSDYNNSYVGAFAHNGYVYFLFRRRGARAQAEYRTYVARVCLGDTNLYSYVEVPLVCQgG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  276 QGLIQAAFLTPD--TLLGAFSAG-----TSQAQAALCAFPLADLDRSMEQARRLCYTTGGQGPSGMEEATVEYGVTSRCV 348
Cdd:cd11277    241 YNLAQAAYLAPGqgTLFVVFAAGqgstpTPTDQTALCAYPLVELDSAMERARRLCYTAGGGGPNGKEEATIEYGVTSRCV 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  349 TLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQLGQSISAVAALQTDGHTIAFLGDTQGQLHKVFLNSSHGQVYHSQQV 428
Cdd:cd11277    321 NLPKDSPESYPCGDEHTPSPIASRQPLEAEPLLTLTPPLTAVAALQEDGHTIAFLGDTQGQLHKVFLNGSAGQVYSSQPV 400

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1907202616  429 GPPGSAISPDLLVDSNGDHLYVLTAQQVDRILVA 462
Cdd:cd11277    401 GPPGSAVNPDLLLDATGSHLYVLTARQVTKVPVA 434
Plexin_cytopl super family cl48013
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1317-1574 3.44e-132

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


The actual alignment was detected with superfamily member pfam08337:

Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 420.06  E-value: 3.44e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEG-LGEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVA 1395
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVpVTNDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1396 SLLSLALHSKLEYLTDIMRTLLGDLAAHYV-HKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQ 1474
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1475 VDKGPVDAVTGKAKRTLNDSHLLREDVEFQPLTLMALVGPEADRaagnsgvHRVPARVLDTDTITQVKEKVLDQIYKGTP 1554
Cdd:pfam08337  161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENS-------ESVPVKVLDCDTITQVKEKILDAIYKNTP 233

                          250       260
                   ....*....|....*....|
gi 1907202616 1555 FSQRPSVHSLDLGPRWSNSG 1574
Cdd:pfam08337  234 YSQRPSIDEVDLEWRHGRGG 253
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 824-915 3.60e-31

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238585  Cd Length: 94  Bit Score: 118.19  E-value: 3.60e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRNAVTVAGQPCNPDPSLYRISARIVCVTSPAPN-GTAGPVQVAIKSR 902
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNpVFNGPVEVTVGHG 80

                           90
                   ....*....|....
gi 1907202616  903 P-PGISTQNFTYQD 915
Cdd:cd01180     81 SfRTESSEGFSFVD 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 916-1001 4.20e-28

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238584  Cd Length: 85  Bit Score: 108.85  E-value: 4.20e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNISVFVGDQPCPIQePVCPEAIICHTMPQTEPGEAVVLIVFGHVERkLLT 995
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKIL-SVSSSQIVCLTPPSASPGEAPVKVLIDGARR-LAP 78


                   ....*.
gi 1907202616  996 TPFRYT 1001
Cdd:cd01179     79 LVFTYT 84
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 678-775 1.87e-26

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


:

Pssm-ID: 465619  Cd Length: 94  Bit Score: 104.67  E-value: 1.87e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  678 SPQLVPVGWESHVTLHIQNLHYFQGLPALYHCWLELPGKLQKLPASLEETSrdsgLIHCQAQQFYPSMSQWELPVPIYVT 757
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSD----SITCQEHQFSYSGSSGELPATFYVT 76

                           90
                   ....*....|....*...
gi 1907202616  758 RGEIQRLDNAGDLHVTLY 775
Cdd:pfam18020   77 WNGGHRLDNPANLQVVLY 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 522-608 5.95e-23

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


:

Pssm-ID: 465588  Cd Length: 89  Bit Score: 94.26  E-value: 5.95e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  522 PAQHPRQEQGQIILSVPRLPTLAmdEYFHCAFGGYN-SLAQVEEPHVVCTTPPQDQMPPNPPGSDHVTLPLALMF--EDV 598
Cdd:pfam17960    2 PDNISRTTATQLTLTVPNLPALS--EGYSCVFGDLTeSPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTGV 79

                           90
                   ....*....|
gi 1907202616  599 VLTATTFSFY 608
Cdd:pfam17960   80 DFASTNFTFY 89
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 464-515 3.21e-14

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 68.50  E-value: 3.21e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907202616  464 CPQFPNCTTCLQARDPLCGWCILQGRCTRRGECGrAAQPNHWLWSYEDNHCP 515
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACG-APEGNCEEWEQASSKCP 52
IPT super family cl15674
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1004-1135 1.80e-07

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


The actual alignment was detected with superfamily member cd01181:

Pssm-ID: 472823  Cd Length: 99  Bit Score: 50.88  E-value: 1.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1004 PQLVEAEPSVSFRGGGRVIRVRGTGLDVVWQPLLsvwledepKVKALGVQaqdanprrscgapaadpqacihlesgllqc 1083
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRI--------RVKYGGVE------------------------------ 42

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907202616 1084 STLCSVNSSSLLLCHSPAVPDGALP-----KRVFFALDNMQVDFASASGGQGFLYQP 1135
Cdd:cd01181     43 KTSCKVRNSTLMTCPAPSLALLNRSpepgeRPVEFGLDGDNVQSLLILNRTSFSYYP 99
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1165-1232 1.51e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 44.75  E-value: 1.51e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907202616 1165 GLNLGISKEEVQVHIGDGECLVKTLTLTHLYCEPPPQAPQPTNgsgtlpqFVVQMGNLRLALGPVQYE 1232
Cdd:pfam01833   23 GSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVN-------VSVTVGGGGISSSPLTFT 83
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
622-658 5.03e-03

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 36.37  E-value: 5.03e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907202616   622 CRACVSSLW-RCHWCPQSSHCIYGEHCPEGEKAVYSAQ 658
Cdd:smart00423    8 CSECLLARDpYCAWCSSQGRCTSGERCDSRRQNWLSGG 45
 
Name Accession Description Interval E-value
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
 37-462 0e+00

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 764.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   37 FSVPNTSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRT 116
Cdd:cd11277      1 FSAPNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQARLTDNANKLLLVSERA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  117 QELVACGQVKQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVPLPGRDLLLVARGLAGKLSAGVPPLTVR 196
Cdd:cd11277     81 GELVACGQVRQGVCEKRRLGNVAQVLYQAEDPGDGQFVAANDPGVATVGLVVEAPGRDLLLVGRGLTGKLSAGIPPLTIR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  197 QLAGPQPFSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLRDVNLYSYVEMPLTCH-G 275
Cdd:cd11277    161 QLAGAQAFSSEGLGKLVVGDFSDYNNSYVGAFAHNGYVYFLFRRRGARAQAEYRTYVARVCLGDTNLYSYVEVPLVCQgG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  276 QGLIQAAFLTPD--TLLGAFSAG-----TSQAQAALCAFPLADLDRSMEQARRLCYTTGGQGPSGMEEATVEYGVTSRCV 348
Cdd:cd11277    241 YNLAQAAYLAPGqgTLFVVFAAGqgstpTPTDQTALCAYPLVELDSAMERARRLCYTAGGGGPNGKEEATIEYGVTSRCV 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  349 TLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQLGQSISAVAALQTDGHTIAFLGDTQGQLHKVFLNSSHGQVYHSQQV 428
Cdd:cd11277    321 NLPKDSPESYPCGDEHTPSPIASRQPLEAEPLLTLTPPLTAVAALQEDGHTIAFLGDTQGQLHKVFLNGSAGQVYSSQPV 400

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1907202616  429 GPPGSAISPDLLVDSNGDHLYVLTAQQVDRILVA 462
Cdd:cd11277    401 GPPGSAVNPDLLLDATGSHLYVLTARQVTKVPVA 434
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1317-1574 3.44e-132

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 420.06  E-value: 3.44e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEG-LGEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVA 1395
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVpVTNDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1396 SLLSLALHSKLEYLTDIMRTLLGDLAAHYV-HKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQ 1474
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1475 VDKGPVDAVTGKAKRTLNDSHLLREDVEFQPLTLMALVGPEADRaagnsgvHRVPARVLDTDTITQVKEKVLDQIYKGTP 1554
Cdd:pfam08337  161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENS-------ESVPVKVLDCDTITQVKEKILDAIYKNTP 233

                          250       260
                   ....*....|....*....|
gi 1907202616 1555 FSQRPSVHSLDLGPRWSNSG 1574
Cdd:pfam08337  234 YSQRPSIDEVDLEWRHGRGG 253
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
 1317-1489 1.83e-120

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 384.19  E-value: 1.83e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGLGEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12791      1 GIPFLDYRTYAERVFFPGHGGCPLQPSLEGDGEEGRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQVD 1476
Cdd:cd12791     81 LLSLALHGKLEYLTDIMKTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWMSICLYAFLREVAGEPLYMLFRAIKYQVD 160

                          170
                   ....*....|...
gi 1907202616 1477 KGPVDAVTGKAKR 1489
Cdd:cd12791    161 KGPVDAVTGKRER 173
Sema smart00630
semaphorin domain;
44-436 1.48e-77

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 262.69  E-value: 1.48e-77
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616    44 FNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAecpQAQLTDNANQL-LLVSSRTQELVAC 122
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSKG---KDPPTDCVNYIrLLLDYNEDRLLVC 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   123 GQ-VKQGVCEKRRLGDvtqvLYqaedpgdgqfvaantlgvttVGLVVPLPGRDlllvarglagklSAGVPPLTVRQLAGP 201
Cdd:smart00630   78 GTnAFQPVCRLRNLGE----LY--------------------VGTVADFSGSD------------PAIPRSLSVRRLKGT 121

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   202 QPFSSeglgRLVVGDFSDYNN-SYVGAFSDAHSAYFVFRRRGARAQTE---YRSYVARVCLRDV--------NLYSYVEM 269
Cdd:smart00630  122 SGVSL----RTVLYDSKWLNEpNFVYAFESGDFVYFFFRETAVEDDNCgkaVHSRVARVCKNDVggprsldkKWTSFLKA 197

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   270 PLTCHGQG-------LIQAAFLTP------DTLLGAFSAG-TSQAQAALCAFPLADLDRSMEQARRLCYTTGGQGpSGME 335
Cdd:smart00630  198 RLECSVPGedpfyfnELQAAFLLPpgsesdDVLYGVFSTSsNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQW-LPYS 276

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   336 EATVEYGVTSRCVTLPPDSpESYPC----GDEHTPSPIAGRQPLEAQPLL---QLGQSISAVAALQTD---GHTIAFLGD 405
Cdd:smart00630  277 RGKVPYPRPGTCPNKPPSS-KDLPDetlnFIKSHPLMDEVVQPLTGRPLFvktDSNYLLTSIAVDRVAtdgNYTVLFLGT 355

                           410       420       430
                    ....*....|....*....|....*....|....*
gi 1907202616   406 TQGQLHKVFL----NSSHGQVYHSQQVGPPGSAIS 436
Cdd:smart00630  356 SDGRILKVVLsessSSSESVVLEEISVFPDGSPIS 390
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 824-915 3.60e-31

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 118.19  E-value: 3.60e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRNAVTVAGQPCNPDPSLYRISARIVCVTSPAPN-GTAGPVQVAIKSR 902
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNpVFNGPVEVTVGHG 80

                           90
                   ....*....|....
gi 1907202616  903 P-PGISTQNFTYQD 915
Cdd:cd01180     81 SfRTESSEGFSFVD 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 916-1001 4.20e-28

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 108.85  E-value: 4.20e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNISVFVGDQPCPIQePVCPEAIICHTMPQTEPGEAVVLIVFGHVERkLLT 995
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKIL-SVSSSQIVCLTPPSASPGEAPVKVLIDGARR-LAP 78


                   ....*.
gi 1907202616  996 TPFRYT 1001
Cdd:cd01179     79 LVFTYT 84
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 678-775 1.87e-26

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 104.67  E-value: 1.87e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  678 SPQLVPVGWESHVTLHIQNLHYFQGLPALYHCWLELPGKLQKLPASLEETSrdsgLIHCQAQQFYPSMSQWELPVPIYVT 757
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSD----SITCQEHQFSYSGSSGELPATFYVT 76

                           90
                   ....*....|....*...
gi 1907202616  758 RGEIQRLDNAGDLHVTLY 775
Cdd:pfam18020   77 WNGGHRLDNPANLQVVLY 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 522-608 5.95e-23

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 94.26  E-value: 5.95e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  522 PAQHPRQEQGQIILSVPRLPTLAmdEYFHCAFGGYN-SLAQVEEPHVVCTTPPQDQMPPNPPGSDHVTLPLALMF--EDV 598
Cdd:pfam17960    2 PDNISRTTATQLTLTVPNLPALS--EGYSCVFGDLTeSPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTGV 79

                           90
                   ....*....|
gi 1907202616  599 VLTATTFSFY 608
Cdd:pfam17960   80 DFASTNFTFY 89
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 279-442 2.16e-15

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 75.77  E-value: 2.16e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  279 IQAAFLTP--------DTLLGAFSAGTSQA--QAALCAFPLADLDRSMEqaRRLCYTTGGQGPSGMEEATVEYGVTSRCV 348
Cdd:pfam01403    1 LQDVFVLKpgagdaldTVLYGVFTTQWSNSigGSAVCAFSLSDINAVFE--GPFKEQEKSDSKWLPYTGKVPYPRPGTCI 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  349 TLP--PDSPESYPCGDEHTPSPIAGRQPLEAQPLL-QLGQSISAVAALQTDG----HTIAFLGDTQGQLHKVFLNSSHGQ 421
Cdd:pfam01403   79 NDPlrLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLvRTGVRLTSIAVDRVQAldgnYTVLFLGTDDGRLHKVVLVGSEES 158

                          170       180
                   ....*....|....*....|..
gi 1907202616  422 VYHSQ-QVGPPGSAISPDLLVD 442
Cdd:pfam01403  159 HIIEEiQVFPEPQPVLNLLLSS 180
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 464-515 3.21e-14

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 68.50  E-value: 3.21e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907202616  464 CPQFPNCTTCLQARDPLCGWCILQGRCTRRGECGrAAQPNHWLWSYEDNHCP 515
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACG-APEGNCEEWEQASSKCP 52
IPT smart00429
ig-like, plexins, transcription factors;
915-1001 3.54e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 66.68  E-value: 3.54e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   915 DPVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNISVFVGD--QPCPIQePVCPEAIICHTMPQTEPGEAVVLIVFGHVERK 992
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVgeAPCTFS-PSSSTAIVCKTPPYHNIPGSVPVRTVGLRNGG 79


                    ....*....
gi 1907202616   993 LLTTPFRYT 1001
Cdd:smart00429   80 VPSSPQPFT 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 824-914 4.14e-13

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 66.32  E-value: 4.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRnaVTVAGQPCNPdpsLYRISARIVCVTspaPNGTAGPVQVAIKSRP 903
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLK--VTIGGTPCTV---ISVSSTTIVCTT---PPGTSGLVNVSVTVGG 72

                           90
                   ....*....|.
gi 1907202616  904 PGISTQNFTYQ 914
Cdd:pfam01833   73 GGISSSPLTFT 83
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
464-515 2.39e-11

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 59.87  E-value: 2.39e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1907202616   464 CPQFPNCTTCLQARDPLCGWCILQGRCTRRGECGRAAQpnhwlwSYEDNHCP 515
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQ------NWLSGGCP 47
IPT smart00429
ig-like, plexins, transcription factors;
824-913 3.33e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 60.90  E-value: 3.33e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   824 PSIDVIEPLTGPPEGGLAITILGSNLGqAFNDVRNAVTVAGQPCNPDPSLyriSARIVCVTSPAPNGTA-GPVQVAiKSR 902
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGsVPVRTV-GLR 76

                            90
                    ....*....|...
gi 1907202616   903 PPGIST--QNFTY 913
Cdd:smart00429   77 NGGVPSspQPFTY 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 916-1001 6.62e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 54.38  E-value: 6.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTG-GNISVFVGDQPCPIQEpVCPEAIIChTMPQTEPGeaVVLIVFGHVERKLL 994
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDsSDLKVTIGGTPCTVIS-VSSTTIVC-TTPPGTSG--LVNVSVTVGGGGIS 76


                   ....*..
gi 1907202616  995 TTPFRYT 1001
Cdd:pfam01833   77 SSPLTFT 83
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1004-1135 1.80e-07

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 50.88  E-value: 1.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1004 PQLVEAEPSVSFRGGGRVIRVRGTGLDVVWQPLLsvwledepKVKALGVQaqdanprrscgapaadpqacihlesgllqc 1083
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRI--------RVKYGGVE------------------------------ 42

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907202616 1084 STLCSVNSSSLLLCHSPAVPDGALP-----KRVFFALDNMQVDFASASGGQGFLYQP 1135
Cdd:cd01181     43 KTSCKVRNSTLMTCPAPSLALLNRSpepgeRPVEFGLDGDNVQSLLILNRTSFSYYP 99
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1165-1232 1.51e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 44.75  E-value: 1.51e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907202616 1165 GLNLGISKEEVQVHIGDGECLVKTLTLTHLYCEPPPQAPQPTNgsgtlpqFVVQMGNLRLALGPVQYE 1232
Cdd:pfam01833   23 GSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVN-------VSVTVGGGGISSSPLTFT 83
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
622-658 5.03e-03

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 36.37  E-value: 5.03e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907202616   622 CRACVSSLW-RCHWCPQSSHCIYGEHCPEGEKAVYSAQ 658
Cdd:smart00423    8 CSECLLARDpYCAWCSSQGRCTSGERCDSRRQNWLSGG 45
 
Name Accession Description Interval E-value
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
 37-462 0e+00

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 764.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   37 FSVPNTSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRT 116
Cdd:cd11277      1 FSAPNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQARLTDNANKLLLVSERA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  117 QELVACGQVKQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVPLPGRDLLLVARGLAGKLSAGVPPLTVR 196
Cdd:cd11277     81 GELVACGQVRQGVCEKRRLGNVAQVLYQAEDPGDGQFVAANDPGVATVGLVVEAPGRDLLLVGRGLTGKLSAGIPPLTIR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  197 QLAGPQPFSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLRDVNLYSYVEMPLTCH-G 275
Cdd:cd11277    161 QLAGAQAFSSEGLGKLVVGDFSDYNNSYVGAFAHNGYVYFLFRRRGARAQAEYRTYVARVCLGDTNLYSYVEVPLVCQgG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  276 QGLIQAAFLTPD--TLLGAFSAG-----TSQAQAALCAFPLADLDRSMEQARRLCYTTGGQGPSGMEEATVEYGVTSRCV 348
Cdd:cd11277    241 YNLAQAAYLAPGqgTLFVVFAAGqgstpTPTDQTALCAYPLVELDSAMERARRLCYTAGGGGPNGKEEATIEYGVTSRCV 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  349 TLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQLGQSISAVAALQTDGHTIAFLGDTQGQLHKVFLNSSHGQVYHSQQV 428
Cdd:cd11277    321 NLPKDSPESYPCGDEHTPSPIASRQPLEAEPLLTLTPPLTAVAALQEDGHTIAFLGDTQGQLHKVFLNGSAGQVYSSQPV 400

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1907202616  429 GPPGSAISPDLLVDSNGDHLYVLTAQQVDRILVA 462
Cdd:cd11277    401 GPPGSAVNPDLLLDATGSHLYVLTARQVTKVPVA 434
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
 44-462 7.33e-176

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 534.90  E-value: 7.33e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   44 FNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRTQELVACG 123
Cdd:cd11245      2 INHLAQDPQTGRLYLGAVNGLFQLSPNLQLESRADTGPKKDSPQCLPPITAAECPQAKETDNFNKLLLVNSANGTLVVCG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  124 QVKQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVP-LPGRDLLLVARGLAGKLSAGVPPLTVRQLAGPQ 202
Cdd:cd11245     82 SLFQGVCELRNLNSVNKPLYRPETPGDKQYVAANEPSVSTVGLISYfKDGLSLLFVGRGYTSSLSGGIPPITTRLLQEHG 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  203 P---FSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLRDVNLYSYVEMPLTCHGQ--- 276
Cdd:cd11245    162 EmdaFSNEVEAKLVVGSASRYHHDFVYAFADNGYIYFLFSRRPGTADSTKRTYISRLCENDHHYYSYVELPLNCTVNqen 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  277 --GLIQAAFLTP-------DTLLGAFSAG-----TSQAQAALCAFPLADLDRSMEQARRLCYTTGGQGPSGMEEATVEYG 342
Cdd:cd11245    242 tyNLVQAAYLAKpgkvlngKVLFGVFSADeastaAPDGRSALCMYPLSSVDARFERTRESCYTGEGLEDDKPETAYIEYN 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  343 VTSRCVTLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQLGQSISAVAALQTDGHTIAFLGDTQGQLHKVFLNSSHGQV 422
Cdd:cd11245    322 VKSICKTLPDKNVKAYPCGAEHTPSPLASRYPLAAKPILTRNDMLTAVAVAVENGHTIAFLGDSGGQLHKVYLDPNHTDF 401

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1907202616  423 YhSQQVGPPGSAISPDLLVDSNGDHLYVLTAQQVDRILVA 462
Cdd:cd11245    402 Y-STIPGDQDSAVNKDLLFDSTLNHLYVMTGKKISKVPVQ 440
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 37-462 2.31e-134

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 424.76  E-value: 2.31e-134
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   37 FSVPNTSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRT 116
Cdd:cd11275      1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  117 QELVACGQVKQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVV-PLPGRDLLLVARGLAGK-LSAGVPPLT 194
Cdd:cd11275     81 KELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAySKDGVPLLFVGRGYTSRgVGGGIPPIT 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  195 VRQLAGPQP--------FSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQT-EYRSYVARVCLRDVNLYS 265
Cdd:cd11275    161 TRNLRAHGDdatdshsiFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSrEYKTYISRICLDDSHYYS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  266 YVEMPLTCHGQ----GLIQAAFLTP--------------DTLLGAFSA-----GTSQAQAALCAFPLADLDRSMEQARRL 322
Cdd:cd11275    241 YVELPLLCQSKantySLLQAAYVTQpgerlaqgqldtdgEVLFAAFSAwqassGKLSEESALCAYPMDEVDRLTNWTRDV 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  323 CYTTGGQGPSGMEEATVEYGVTSRCVTLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQ-LGQSISAVAALQTDGHTIA 401
Cdd:cd11275    321 CYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEwTEIRLTAVAVNVEDGHTIA 400

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907202616  402 FLGDTQGQLHKVFLNS-SHGQVYHSQQVgPPGSAISPDLLVDSNGDHLYVLTAQQVDRILVA 462
Cdd:cd11275    401 FLGDSRGRLHKVYLGAgGDAHTYSSQSI-QQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1317-1574 3.44e-132

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 420.06  E-value: 3.44e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEG-LGEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVA 1395
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVpVTNDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1396 SLLSLALHSKLEYLTDIMRTLLGDLAAHYV-HKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQ 1474
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1475 VDKGPVDAVTGKAKRTLNDSHLLREDVEFQPLTLMALVGPEADRaagnsgvHRVPARVLDTDTITQVKEKVLDQIYKGTP 1554
Cdd:pfam08337  161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEGENS-------ESVPVKVLDCDTITQVKEKILDAIYKNTP 233

                          250       260
                   ....*....|....*....|
gi 1907202616 1555 FSQRPSVHSLDLGPRWSNSG 1574
Cdd:pfam08337  234 YSQRPSIDEVDLEWRHGRGG 253
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
 1317-1489 1.83e-120

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 384.19  E-value: 1.83e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGLGEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12791      1 GIPFLDYRTYAERVFFPGHGGCPLQPSLEGDGEEGRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQVD 1476
Cdd:cd12791     81 LLSLALHGKLEYLTDIMKTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWMSICLYAFLREVAGEPLYMLFRAIKYQVD 160

                          170
                   ....*....|...
gi 1907202616 1477 KGPVDAVTGKAKR 1489
Cdd:cd12791    161 KGPVDAVTGKRER 173
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
 1317-1498 1.09e-106

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 345.76  E-value: 1.09e-106
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGLGEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12787      1 GIPFLDYKTYAERVFFPGHKDGPLDVMIKLDIPEPRRPTVEQGLYQLSNLLNSKLFLINFIHTLENQREFSARDRVYVAS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQVD 1476
Cdd:cd12787     81 LLTVALHGKLEYYTDIMRTLLLDLLAQYVVKNPKLMLRRTETVVEKLLTNWMSICLYQFLRDSAGEPLYMLFRAIKHQVD 160

                          170       180
                   ....*....|....*....|..
gi 1907202616 1477 KGPVDAVTGKAKRTLNDSHLLR 1498
Cdd:cd12787    161 KGPVDAVTGKRAKAIPEIYLTR 182
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
 44-462 2.52e-84

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 282.68  E-value: 2.52e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   44 FNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRTQELVACG 123
Cdd:cd11236      2 FNHLAVDNSTGRVYVGAVNRLYQLDSSLLLEAEVSTGPVLDSPLCLPPGCCSCDHPRSPTDNYNKILLIDYSSGRLITCG 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  124 QVKQGVCEKRRLGDVTQVLYQAEDPgdgqfVAANTLGVTTVGLV--VPLPGRDLLLVARGLAGKLS-AGVPPLTVRQLAG 200
Cdd:cd11236     82 SLYQGVCQLRNLSNISVVVERSSTP-----VAANDPNASTVGFVgpGPYNNENVLYVGATYTNNGYrDYRPAVSSRSLPP 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  201 PQPFSSEGLG---RLVVGDFSDYNNS--YVGAFSDAHSAYFVFRRR-GARAQTEYRSYVARVCLRDVNLYSYVEMPLTCH 274
Cdd:cd11236    157 DDDFNAGSLTggsAISIDDEYRDRYSikYVYGFSSGGFSYFVTVQRkSVDDESPYISRLVRVCQSDSNYYSYTEVPLQCT 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  275 GQG-----LIQAAFLTP---------------DTLLGAFSAG-----TSQAQAALCAFPLADLDRSmeqARRLCyttggq 329
Cdd:cd11236    237 GGDgtnynLLQAAYVGKagsdlarslgistddDVLFGVFSKSkgpsaEPSSKSALCVFSMKDIEAA---FNDNC------ 307

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  330 gpsgmeeatveygvtsrcvtlppdspesypcgdehtpsPIAGRQPLEAQPLLQlGQSISAVAALQTDGHTIAFLGDTQGQ 409
Cdd:cd11236    308 --------------------------------------PLGGGVPITTSAVLS-DSLLTSVAVTTTRNHTVAFLGTSDGQ 348

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907202616  410 LHKVFLNSSH-GQVYHSQQVGpPGSAISPDLLVDSNGDHLYVLTAQQVDRILVA 462
Cdd:cd11236    349 LKKVVLESSSsATQYETLLVD-SGSPILPDMVFDPDGEHLYVMTPKKVTKVPVE 401
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 1317-1488 1.73e-83

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 279.99  E-value: 1.73e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGlgEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12793      1 GIPFLDYRMYAERIFFPGHRESPLRRDLDV--PECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVAS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQVD 1476
Cdd:cd12793     79 LLTVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVD 158

                          170
                   ....*....|..
gi 1907202616 1477 KGPVDAVTGKAK 1488
Cdd:cd12793    159 KGPVDAVTGKER 170
Sema smart00630
semaphorin domain;
44-436 1.48e-77

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 262.69  E-value: 1.48e-77
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616    44 FNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAecpQAQLTDNANQL-LLVSSRTQELVAC 122
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSKG---KDPPTDCVNYIrLLLDYNEDRLLVC 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   123 GQ-VKQGVCEKRRLGDvtqvLYqaedpgdgqfvaantlgvttVGLVVPLPGRDlllvarglagklSAGVPPLTVRQLAGP 201
Cdd:smart00630   78 GTnAFQPVCRLRNLGE----LY--------------------VGTVADFSGSD------------PAIPRSLSVRRLKGT 121

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   202 QPFSSeglgRLVVGDFSDYNN-SYVGAFSDAHSAYFVFRRRGARAQTE---YRSYVARVCLRDV--------NLYSYVEM 269
Cdd:smart00630  122 SGVSL----RTVLYDSKWLNEpNFVYAFESGDFVYFFFRETAVEDDNCgkaVHSRVARVCKNDVggprsldkKWTSFLKA 197

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   270 PLTCHGQG-------LIQAAFLTP------DTLLGAFSAG-TSQAQAALCAFPLADLDRSMEQARRLCYTTGGQGpSGME 335
Cdd:smart00630  198 RLECSVPGedpfyfnELQAAFLLPpgsesdDVLYGVFSTSsNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQW-LPYS 276

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   336 EATVEYGVTSRCVTLPPDSpESYPC----GDEHTPSPIAGRQPLEAQPLL---QLGQSISAVAALQTD---GHTIAFLGD 405
Cdd:smart00630  277 RGKVPYPRPGTCPNKPPSS-KDLPDetlnFIKSHPLMDEVVQPLTGRPLFvktDSNYLLTSIAVDRVAtdgNYTVLFLGT 355

                           410       420       430
                    ....*....|....*....|....*....|....*
gi 1907202616   406 TQGQLHKVFL----NSSHGQVYHSQQVGPPGSAIS 436
Cdd:smart00630  356 SDGRILKVVLsessSSSESVVLEEISVFPDGSPIS 390
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
 42-461 7.06e-76

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 260.09  E-value: 7.06e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   42 TSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRTQELVA 121
Cdd:cd11276      6 TELNHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTEAKMTDNYNKLLLLDSANKTLVV 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  122 CGQVKQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVPL-PGRD-LLLVARGLA----GKLsagvppLTV 195
Cdd:cd11276     86 CGSLFKGICSLRNLSNISEVIYYSDTSGEKSFVASNDEGVSTVGLISSLkPGNDrVFFVGKGNGsndnGKI------IST 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  196 RQLagpqpfsSEGLGRLVVGDFSD-----------YNNSYVGAFSDAHSAYFVFRRRgARAQTEYRSYVARVCLRDVNLY 264
Cdd:cd11276    160 RLL-------QNYDDREVFENYIDaatvksayvsrYTQQFRYAFEDNNYVYFLFNQQ-LGHPDKNRTLIARLCENDHHYY 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  265 SYVEMPLTC------HGQglIQAAFLTP---------------DT-LLGAFSA-GTSQAQAALCAFPLADLDRSMEQARR 321
Cdd:cd11276    232 SYTEMDLNCrdganaYNK--CQAAYVSTpgkelaqnygnsilsDKvLFAVFSRdEKDSGESALCMFPLKSINAKMEANRE 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  322 LCYTTGGQGPSGMEEAtVEYGVTSRCVTLPPDSPESYPCGDEHTPSPIAGRQPL-EAQPLLQL-GQSISAVAALQTDGHT 399
Cdd:cd11276    310 ACYTGTIDDRDVFYKP-FHSQKDIICGSHQQKNSKSFPCGSEHLPYPLGSRDELaLTAPVLQRgGLNLTAVTVAVENGHT 388

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907202616  400 IAFLGDTQGQLHKVFLnSSHGQVYHSQQVGPPGsAISPDLLVDSNGDHLYVLTAQQVDRILV 461
Cdd:cd11276    389 VAFLGTSDGRILKVHL-SPDPEEYNSILIEKNK-PVNKDLVLDKTLEHLYIMTEDKVFRLPV 448
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
 1317-1484 3.25e-70

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 240.97  E-value: 3.25e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1317 GIPFLDYRTYAERAFFPGHVGCPLQpgLEGLGEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12205      1 GIPFLDFREYIIRVLFPGVNDHPVL--LSKFVHGSRRPDLEDALSQFEQLLCNKQFLLTFIRTLESQPKFSSRDKCNVAS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYV-HKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQV 1475
Cdd:cd12205     79 LLMVALQGKMEYATEILFDLLTDLIEKSVsKKHPKLMLRRTESVVEKLLTNWLSLCLYDYLKETAGEPLFLLYKALKQQI 158


                   ....*....
gi 1907202616 1476 DKGPVDAVT 1484
Cdd:cd12205    159 EKGPVDAIK 167
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
 1317-1490 9.39e-68

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 234.90  E-value: 9.39e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1317 GIPFLDYRTYAERAFF-PGHVGCPlQPGLEGLGE--EGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCH 1393
Cdd:cd12792      1 RIPFLDYKTYTDRVFFlPSKDGAN-DVMITGKLDipEARRATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1394 VASLLSLALHSKLEYLTDIMRTLLGDLAAHYVH-KNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIK 1472
Cdd:cd12792     80 FASLLTVALHGKLEYYTDIMRTLLLELMEQYVHsKNPKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIK 159

                          170
                   ....*....|....*...
gi 1907202616 1473 YQVDKGPVDAVTGKAKRT 1490
Cdd:cd12792    160 HQVEKGPVDAVQKKKERT 177
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 1317-1483 1.70e-62

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 218.83  E-value: 1.70e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1317 GIPFLDYRTYAERAFFPGHVGCPLQPGLEGlgEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 1396
Cdd:cd12790      1 GIPFLDYRTYAMRVLFPGIEDHPVLRELEV--ERDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVAS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1397 LLSLALHSKLEYLTDIMRTLLGDLAAHYVHK--NPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQ 1474
Cdd:cd12790     79 LIMVVLQSKMEYATDILKQLLADLIEKNLESknHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQ 158


                   ....*....
gi 1907202616 1475 VDKGPVDAV 1483
Cdd:cd12790    159 MEKGPIDAI 167
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
 43-505 1.40e-55

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 202.85  E-value: 1.40e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   43 SFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQA-QLTDNANQLLLVSSRTQELVA 121
Cdd:cd11272     12 TFNHLTVHQSTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCSEVlTLTNNVNKLLIIDYSENRLLA 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  122 CGQVKQGVCEKRRLGDVTqVLYQAEDPGDGQFVAANTLGvTTVGLVVPLPGRD-LLLVARGLAGKLSAgVPPLTVRQLag 200
Cdd:cd11272     92 CGSLYQGVCKLLRLDDLF-ILVEPSHKKEHYLSSVNKTG-TMYGVIVRSEGEDgKLFIGTAVDGKQDY-FPTLSSRKL-- 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  201 PQ-PFSSEGLGRLVVGDF---------------SDYNNSYVGAFSDAHSAYFVfrrrgaRAQTE--------------YR 250
Cdd:cd11272    167 PRdPESSAMLDYELHSDFvsslikipsdtlalvSHFDIFYIYGFASGNFVYFL------TVQPEtpegvsinsagdlfYT 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  251 SYVARVCLRDVNLYSYVEMPLTCHGQG----LIQAAFLTP---------------DTLLGAFSAGTSQAQ-----AALCA 306
Cdd:cd11272    241 SRIVRLCKDDPKFHSYVSLPFGCVRGGveyrLLQAAYLSKpgevlarslnitaqeDVLFAIFSKGQKQYHhppddSALCA 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  307 FPLADLDRSMEQARRLCYttggQGPSGMEEATVeYGVTSRCVTLPPDSPESYpCGDEhTPSPIAGRQPLEAQPLLQLGQS 386
Cdd:cd11272    321 FPIRAINAQIKERLQSCY----QGEGNLELNWL-LGKDVQCTKAPVPIDDNF-CGLD-INQPLGGSTPVEGVTLYTSSRD 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  387 -ISAVAALQTDGHTIAFLGDTQGQLHKVFLNSS-HGQV-YHSQQVGPPGSAISPDLLVDSNGDHLYVLTAQQVDRILVAA 463
Cdd:cd11272    394 rLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPpHGGVqYEMVSVFKDGSPILRDMAFSIDHKYLYVMSERQVSRVPVES 473

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 1907202616  464 CPQFPNCTTCLQARDPLCGWCILQGRCTRRGECGRAAQPNHW 505
Cdd:cd11272    474 CEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEPFRF 515
RasGAP_plexin_D1 cd12788
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ...
 1317-1498 5.50e-54

Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213348 [Multi-domain]  Cd Length: 419  Bit Score: 195.21  E-value: 5.50e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1317 GIPFLDYRTYAERAFFPG----HVGCPLQPGLEGLGEEGRSV------------------TVRQGLTQLSNLLNSKLFLL 1374
Cdd:cd12788      2 GIPFLEYKHFVTRTFFPKcsslYEERYVLPSQENNSQGPRQVpethpllqewkipescrpNMEEGITLFSTLLNNKHFLV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1375 TLIHTLEEQPSFSQRDRCHVASLLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYT 1454
Cdd:cd12788     82 TFVHALEQQKDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDASASKNPKLMLRRTESVVEKMLTNWMSICMYS 161

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1907202616 1455 FLKEVAGEPLYMLFRAIKYQVDKGPVDAVtgkaKRTLNDSHLLR 1498
Cdd:cd12788    162 YLRETVGEPFFLLLCAIKQQINKGSIDAI----KKVLPEIYLTR 201
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
 1318-1488 1.85e-53

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 193.16  E-value: 1.85e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1318 IPFLDYRTYAERAFFPgHVGCPLQPGLEGLGEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVASL 1397
Cdd:cd12789      4 VPFLDYKHFALRTFFP-ESGGFTHIFTRDDPHDRDQTDKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLFASF 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1398 LSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQVDK 1477
Cdd:cd12789     83 LTIALQTKLVYLTEILEVLTKDLMDQSSNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINK 162

                          170
                   ....*....|.
gi 1907202616 1478 GPVDAVTGKAK 1488
Cdd:cd12789    163 GPVDVIKFKVK 173
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
 45-462 1.56e-44

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 169.64  E-value: 1.56e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   45 NHLVLAPDQGKLYVGAVNHLFQLSP-ELKMESVAVTGPVIDSPDC-VPFRDLAECP-QAQLTDNANQLLLVSSRTQELVA 121
Cdd:cd11247     12 NNFALDGGRGRLYLAAVNRLYQLSGlVLALEAEAAVGPVLDSPLChAPQLPQATCEhPRTLTDNYNKILQPDPEQGVLVV 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  122 CGQVKQGVCEKRRLGDVTQVLYQAEDPGDGQF-----VAANTLGVTTVGLVVPL---PGRDLLLVARGLAGKLSA----- 188
Cdd:cd11247     92 CGSIYQGLCQLRRLYNISAVAVRFPVDGDTVFpsmlnVAANHPNASTVGLVLWPrggGGGLRLLVGATYTGYGSGffprn 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  189 ---------GVPPLTVRQLAG----------PQPFSSEGLGRLVVGDFSDYNNSYVGAF---SDAHSAYFVFRR--RGAR 244
Cdd:cd11247    172 rsledhrfeNTPEIAIRALNTrgdlaklftfDINPSDDNIFKIKQGAKARHKLSFVRAFlqhFLQPYAYLAMNGeaNAAG 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  245 AQTEYRSYVARVCLRDVNL----------YSYVEMPLTCHG-QGLIQAAFLT--PDTLLGAFSAGTSQAQAALCAFPLAD 311
Cdd:cd11247    252 KESQPPSLLARICLPGRAPpppgeakkltESYIQLGLRCEGaYTRLVSVFPArvEEEQLFAVFERAGGAPAALCAFRFAE 331

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  312 LDRSMEQARRLCYTTGGQGPSGMEEATVEyGVTSRC-----VTLppdSPESYPCGDEHTPSPIAGRQPLEAQPLLQlGQS 386
Cdd:cd11247    332 VEEPIRAARTACFVSPAAGVVTVLDSVVQ-GTGPACerklnIQL---QPEQLDCGAAHLQHPLAILQPLKATPVFR-APG 406

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907202616  387 ISAVAALQTDGHTIAFLGDTQGQLHKVFLNSSHGQVYHSQQVGPPGSAISPDLLVD-SNGDHLYVLTAQQVDRILVA 462
Cdd:cd11247    407 LTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSVTVAYGEPVHHVMQFDpSDSTYLYLMTSHQMTRVKVA 483
Sema_plexin_A1 cd11271
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the ...
 37-461 5.53e-43

The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200532 [Multi-domain]  Cd Length: 474  Bit Score: 164.75  E-value: 5.53e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   37 FSVPNTSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQAQL-TDNANQLLLVSSR 115
Cdd:cd11271      7 FTASDWSLTHLVVHNKTGEVYVGAVNRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCPHGLGtTNNVNKLLLVDYA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  116 TQELVACGQVKQGVCEKRRLGDvtqvLYQAEDPGDGQ--FVAANTLGVTTVGLVVPLP-GRDLLLVARGLAGKlSAGVPP 192
Cdd:cd11271     87 ANRLIACGSASQGICQFLRLDD----LFKLGEPHHRKehYLSSVNESGTMSGVIIEVGnGQNKLFVGTPIDGK-SEYFPT 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  193 LTVRQLAGPQ------------PFSSEGLG--RLVVGDFSDYNNSYVGAFSDAHSAYFV-------FRRRGARAQTEYRS 251
Cdd:cd11271    162 LSSRKLMANEenaemfgfvyqdEFVSSQLKipSDTLSKFPTFDIYYVYSFSSEQFVYYLtlqldtqLTSPDSTGEQFFTS 241

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  252 YVARVCLRDVNLYSYVEMPLTCHGQG----LIQAAFLT---------------PDTLLGAFSAGTSQ-----AQAALCAF 307
Cdd:cd11271    242 KIVRLCVDDPKFYSYVEFPIGCEQDGveyrLIQDAYLSkpgkalakqlgiserEDILFTVFSQGQKNrvkppKESVLCLF 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  308 PLADLDRSMEQARRLCYTtgGQGPSGME-EATVEYGvtsrCVTLPPDSPESYpCGDEHTpSPIAGRQPLEAQPL-LQLGQ 385
Cdd:cd11271    322 TLKKIKDKIKERIQSCYR--GEGKLSLPwLLNKELG----CINSPLQIDDNF-CGQDFN-QPLGGTVTIEGTPLfVDKED 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  386 SISAVAALQTDGHTIAFLGDTQGQLHKVFLNSSHGQVYHSQQ----VGPPGSAISPDLLVDSNGDHLYVLTAQQVDRILV 461
Cdd:cd11271    394 GMTSVAAYDYRGRTVVFAGTRSGRIKKILVDLSAPSSRPALQyenvVAHEGSPILRDLVLSPDRQYIYAMTEKQVTRVPV 473
Sema_plexin_A cd11244
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of ...
 36-461 6.31e-43

The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of semaphorins and may be the ancestor of semaphorins. Members of the Plexin A subfamily are receptors for Sema1s, Sema3s, and Sema6s, and they mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a-Plexin A mediated axon repulsion. Sema3s do not interact directly with plexin A receptors, but instead bind Neuropilin-1 or Neuropilin-2 toactivate neuropilin-plexin A holoreceptor complexes. In contrast to Sema3s, Sema6s do not require neuropilins for plexin A binding. In the complex, plexin As serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200505 [Multi-domain]  Cd Length: 470  Bit Score: 164.23  E-value: 6.31e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   36 RFSVPNTSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQA-QLTDNANQLLLVSS 114
Cdd:cd11244      5 RGEPRDWSFNHLTVHRRTGEVYVGAINRVYKLSSNLTVLVTHETGPVEDNPKCYPPPIVQTCNEPlTTTNNVNKLLLIDY 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  115 RTQELVACGQVKQGVCEKRRLGDvtqvLYQAEDPGDGQ---FVAANTLGvTTVGLVVP-LPGRDLLLVARGLAGKlSAGV 190
Cdd:cd11244     85 SENRLIACGSLYQGVCKLLRLED----LFKLGEPHHKKehyLSGVNESG-TMFGVIVSySNGDDKLFIGTAVDGK-SEYF 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  191 PPLTVRQLagPQPFSSEGLGRLVVGD----------------FSDYNNSYVGAFSDAHSAYF-------VFRRRGARAQT 247
Cdd:cd11244    159 PTLSSRKL--TADEESDGMFAYVYHDefvssqikipsdtlsiIPDFDIYYVYGFSSGNFVYFltlqpetQLTPGDSTGEQ 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  248 EYRSYVARVCLRDVNLYSYVEMPLTCHGQG----LIQAAFLT---------------PDTLLGAFSAGTSQA-----QAA 303
Cdd:cd11244    237 FYTSKIVRLCKDDTKFYSYVEFPIGCTRDGveyrLLQAAYLSkpgkalaqalgisedEDVLFTIFSKGQKNRmkppdESA 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  304 LCAFPLADLDRSMEQARRLCYTtgGQGPSGMEEATV-EYGVTSRCVTLPPDSpesypCGDEHTpSPIAGRQPLEAQPLLQ 382
Cdd:cd11244    317 LCLFTLKQINLRIKERLQSCYR--GEGKLSLPWLLNkDLPCINAPLQIDDNF-----CGLDMN-QPLGGSDMVEGIPLFT 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  383 LGQS-ISAVAALQTDGHTIAFLGDTQGQLHKVFLNS-SHGQVYHSQQVGPPGSAISPDLLVDSNGDHLYVLTAQQVDRIL 460
Cdd:cd11244    389 DDRDrMTSVAAYVYKGHSVVFVGTKSGKLKKIRVDGpPHNALQYETVQVVEGSPILRDMAFSPDHQYLYIMSERQVTRVP 468


                   .
gi 1907202616  461 V 461
Cdd:cd11244    469 V 469
Sema_plexin_A3 cd11273
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ...
 33-461 3.19e-41

The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200534 [Multi-domain]  Cd Length: 469  Bit Score: 159.33  E-value: 3.19e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   33 RVHR-FSVPNTSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQA-QLTDNANQLL 110
Cdd:cd11273      1 RPFRaFVVTDTTLTHLAVHRVTGEVFVGAVNRVYKLSANLTELRAHVTGPVEDNARCYPPPSVRVCAHRlAPVDNVNKLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  111 LVSSRTQELVACGQVKQGVCEKRRLGDVTQV----------LYQAEDPgDGQfvaantlgvttVGLVVPLP-GRDLLLVA 179
Cdd:cd11273     81 LVDYAGNRLVACGSIWQGVCQFLRLEDLFKLgephhrkehyLSGAQEP-DSM-----------AGVIVEQGkGPSKLFVG 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  180 RGLAGKlSAGVPPLTVRQLAGPQpfSSEGLGRLVVGD----------------FSDYNNSYVGAFSDAHSAYFVFRRRGA 243
Cdd:cd11273    149 TAIDGK-SEYFPTLSSRKLISDE--DSADMFSLVYQDefvssqikipsdtlslYPAFDIYYVYGFVSASFVYFLTLQLDT 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  244 rAQTE--------YRSYVARVCLRDVNLYSYVEMPLTCHGQG----LIQAAFLT---------------PDTLLGAFSAG 296
Cdd:cd11273    226 -QQTLldtagekfFTSKIVRMCANDTEFYSYVEFPLGCSKDGveyrLVQAAHLAkpglllaqalgvpedEDVLFTIFSQG 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  297 -----TSQAQAALCAFPLADLDRSMEQARRLCYTTGGQgpsgmeeatveygvtsrcVTLPPDSPESYPCGDehTP----- 366
Cdd:cd11273    305 qknraSPPRETILCLFTLSNINAHIRERIQSCYRGEGT------------------LSLPWLLNKELPCIN--TPmqing 364

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  367 --------SPIAGRQPLEAQPLL-QLGQSISAVAALQTDGHTIAFLGDTQGQLHKVFLNSSH-GQVYHSQQVgPPGSAIS 436
Cdd:cd11273    365 nfcglvlnQPLGGLHVIEGLPLLaDSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQdAHLYETVPV-VDGSPIL 443

                          490       500
                   ....*....|....*....|....*
gi 1907202616  437 PDLLVDSNGDHLYVLTAQQVDRILV 461
Cdd:cd11273    444 RDMVFSPDHRYIYLLSEKQVSQLPV 468
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
 40-464 1.52e-39

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 154.34  E-value: 1.52e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   40 PNTSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAEC-PQAQLTDNANQLLLVSSRTQE 118
Cdd:cd11274      9 TEWTFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCnEPLTLTNNINKMLLIDYKENR 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  119 LVACGQVKQGVCEKRRLGDVTQV---LYQAEDPGDGQFVAANTLGVTTVGLVVPlpgrDLLLVARGLAGKlSAGVPPLTV 195
Cdd:cd11274     89 LIACGSLYQGICKLLRLDDLFKLgepFHKKEHYLSGVNESGSVFGVIVSYSNLD----DKLFIATAVDGK-PEYFPTISS 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  196 RQLAGPQP--------FSSEGLGRL---------VVGDFSDYnnsYVGAFSDAHSAYFVFRR--------RGARAQTeYR 250
Cdd:cd11274    164 RKLTKNSEadgmfayvFHDEFVASMikipsdtftIIPDFDIY---YIYGFSSGNFVYFLTLQpemisppgSTTKEQV-YT 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  251 SYVARVCLRDVNLYSYVEMPLTCHGQG----LIQAAFLTP---------------DTLLGAFSAG-----TSQAQAALCA 306
Cdd:cd11274    240 SKLVRLCKEDTAFNSYVEVPIGCEKNGveyrLLQAAYLSKagailarslgvgpddDILFTVFSKGqkrkmKSLDESALCI 319

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  307 FPLADLDRSMEQARRLCYTtgGQGPSGMEEATV-EYGVTSRCVTLPPDSpesypCGDEHTpSPIAGRQPLEAQPLL-QLG 384
Cdd:cd11274    320 FVLKEINDRIKDRLQSCYR--GEGTLDLAWLKVkDIPCSSALLTIDDNF-----CGLDMN-APLGVSEMVRGLPVFtEDR 391

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  385 QSISAVAALQTDGHTIAFLGDTQGQLHKVFLNSSHGQV--YHSQQVGPPGsAISPDLLVDSNGDHLYVLTAQQVDRILVA 462
Cdd:cd11274    392 DRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGTTKNAlqYETVQVVDTG-PILRDMAFSKDHEQLYIMSEKQLTRVPVE 470


                   ..
gi 1907202616  463 AC 464
Cdd:cd11274    471 SC 472
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 824-915 3.60e-31

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 118.19  E-value: 3.60e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRNAVTVAGQPCNPDPSLYRISARIVCVTSPAPN-GTAGPVQVAIKSR 902
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNpVFNGPVEVTVGHG 80

                           90
                   ....*....|....
gi 1907202616  903 P-PGISTQNFTYQD 915
Cdd:cd01180     81 SfRTESSEGFSFVD 94
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 916-1001 4.20e-28

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 108.85  E-value: 4.20e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNISVFVGDQPCPIQePVCPEAIICHTMPQTEPGEAVVLIVFGHVERkLLT 995
Cdd:cd01179      1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKIL-SVSSSQIVCLTPPSASPGEAPVKVLIDGARR-LAP 78


                   ....*.
gi 1907202616  996 TPFRYT 1001
Cdd:cd01179     79 LVFTYT 84
Plexin_RBD pfam20170
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ...
 1491-1566 3.14e-27

Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.


Pssm-ID: 466321  Cd Length: 113  Bit Score: 107.67  E-value: 3.14e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907202616 1491 LNDSHLLREDVEFQPLTLMALVgpeadraAGNSGVHRVPARVLDTDTITQVKEKVLDQIYKGTPFSQRPSVHSLDL 1566
Cdd:pfam20170    1 LSEDKLLREQIDYKTLTLNVIF-------EEGEVSESVPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDL 69
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 678-775 1.87e-26

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 104.67  E-value: 1.87e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  678 SPQLVPVGWESHVTLHIQNLHYFQGLPALYHCWLELPGKLQKLPASLEETSrdsgLIHCQAQQFYPSMSQWELPVPIYVT 757
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSD----SITCQEHQFSYSGSSGELPATFYVT 76

                           90
                   ....*....|....*...
gi 1907202616  758 RGEIQRLDNAGDLHVTLY 775
Cdd:pfam18020   77 WNGGHRLDNPANLQVVLY 94
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 522-608 5.95e-23

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 94.26  E-value: 5.95e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  522 PAQHPRQEQGQIILSVPRLPTLAmdEYFHCAFGGYN-SLAQVEEPHVVCTTPPQDQMPPNPPGSDHVTLPLALMF--EDV 598
Cdd:pfam17960    2 PDNISRTTATQLTLTVPNLPALS--EGYSCVFGDLTeSPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSseTGV 79

                           90
                   ....*....|
gi 1907202616  599 VLTATTFSFY 608
Cdd:pfam17960   80 DFASTNFTFY 89
Sema_MET_like cd11248
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This ...
 42-459 8.23e-20

The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This family includes MET and RON receptor tyrosine kinases. MET is encoded by the c-met protooncogene. MET is the receptor for hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET regulates multiple cellular events and are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a variety of effects including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. MET and RON receptors have been implicated in cancer development and migration. They are composed of alpha-beta heterodimers. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain is necessary for receptor dimerization and activation.


Pssm-ID: 200509 [Multi-domain]  Cd Length: 467  Bit Score: 94.79  E-value: 8.23e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   42 TSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIdSPDCVPFRD-LAECPQAQLTDNANQLLLVSS-RTQEL 119
Cdd:cd11248      8 TPIQNIVLNEGSTEVYVAAQNVIYALNPDLQKVWEYKTGPVG-SPDCQTCQDcSSGADPGVPKDTDNMVLVLETyYDDYL 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  120 VACGQVKQGVCEKRRLGDVTQV------LY--QAEDPGDGQFVAANTLG--VTTV--GLVVplpgrdLLLVARGLAGKLS 187
Cdd:cd11248     87 YSCGSTQNGVCYRHVLEDGADIqsevhcLFskKNNSPSYCPDCVASPLGtkVTNVesGRTI------YFFVANSVNSSLA 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  188 AGVPPLTV---RQLAGPQPFSSEGLGRLVVGDFSD-YNNSYVGAFSDAHSAYF--VFRRRGARAQTEYRSYVARVCLRDV 261
Cdd:cd11248    161 GSFPPHSIsvrRLKEDGFGFLSDQSYLDVLPSLRDsYPIKYVYSFHSGPFVYFltVQRESLTKPSSAFHTRLVRLCSSDS 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  262 NLYSYVEMPLTCHGQ--------------GLIQAAFLTP---------------DTLLGAFS-----AGTSQAQAALCAF 307
Cdd:cd11248    241 EIWRYREMPLECIFTpkrrrrsteedvvyNVLQAAHVSKvgadladelgasegdDILFGVFArskpdSGEPMPNSALCAF 320

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  308 PLADLDRSMEQARRLCYTtggqgpSGMEEATVEYGVTSRCVTLPPDSPEsypCGDEHTPSPIAGRQPLEAQPLL--QLGQ 385
Cdd:cd11248    321 PIKYVNDAIEKGVEKCCT------SGLEHFSGSLCHFQPCPTCPGESSS---CEATCKEYRTEVTKPYQRVDLFngQMSN 391

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907202616  386 S-ISAVAALQTDGHTIAFLGDTQGQLHKVFLNSShGQVYHS--QQVGPPgsaISPDLLVDSNGDHLYVLTAQQVDRI 459
Cdd:cd11248    392 VlLTSILVTTIGNHTVAHLGTSDGRVLQVVLSRS-GPIPHVnfSLDSQP---VSREVAVLSSNGSLLFVTGDKITKV 464
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 824-915 1.02e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.50  E-value: 1.02e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRnaVTVAGQPCNPDPSlyrISARIVCVTSPAPNGTAGPVQVAIKSRP 903
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVR--VTVGGVPCKVLNV---SSTEIVCRTPAAATPGEGPVEVTVDGAN 75

                           90
                   ....*....|....*
gi 1907202616  904 ---PGISTQNFTYQD 915
Cdd:cd00603     76 vsaRVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 916-1001 1.55e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 79.04  E-value: 1.55e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTG-GNISVFVGDQPCPIqEPVCPEAIICHTMPQTEPGEAVVLIVFGHVERKLL 994
Cdd:cd00603      1 PVITSISPSSGPLSGGTRLTITGSNLGSGsPRVRVTVGGVPCKV-LNVSSTEIVCRTPAAATPGEGPVEVTVDGANVSAR 79

                           90
                   ....*....|
gi 1907202616  995 TTP---FRYT 1001
Cdd:cd00603     80 VLSnttFTYV 89
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 279-442 2.16e-15

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 75.77  E-value: 2.16e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  279 IQAAFLTP--------DTLLGAFSAGTSQA--QAALCAFPLADLDRSMEqaRRLCYTTGGQGPSGMEEATVEYGVTSRCV 348
Cdd:pfam01403    1 LQDVFVLKpgagdaldTVLYGVFTTQWSNSigGSAVCAFSLSDINAVFE--GPFKEQEKSDSKWLPYTGKVPYPRPGTCI 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  349 TLP--PDSPESYPCGDEHTPSPIAGRQPLEAQPLL-QLGQSISAVAALQTDG----HTIAFLGDTQGQLHKVFLNSSHGQ 421
Cdd:pfam01403   79 NDPlrLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLvRTGVRLTSIAVDRVQAldgnYTVLFLGTDDGRLHKVVLVGSEES 158

                          170       180
                   ....*....|....*....|..
gi 1907202616  422 VYHSQ-QVGPPGSAISPDLLVD 442
Cdd:pfam01403  159 HIIEEiQVFPEPQPVLNLLLSS 180
Sema_MET cd11278
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor ...
 53-309 7.21e-15

The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); MET is encoded by the c-met protooncogene. MET is a receptor tyrosine kinase that binds its ligand, hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. It also plays a major role in the abnormal migration of cancer cells as a result of overexpression or MET mutations. MET is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The cytoplasmic C-terminal region acts as a docking site for multiple protein substrates, including Grb2, Gab1, STAT3, Shc, SHIP-1 and Src. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. The Sema domain of Met is necessary for receptor dimerization and activation.


Pssm-ID: 200539 [Multi-domain]  Cd Length: 492  Bit Score: 79.52  E-value: 7.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   53 QGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAE---CPQAQLTDNANQLLLVSS-RTQELVACGQVKQG 128
Cdd:cd11278     35 KHHIYVGAVNKIYVLNEDLQKVSEYKTGPVLEHPDCFPCQDCSDkanLSNGVWKDNVNMALFVETyYDDQLISCGSVNRG 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  129 VCEKRRL-----GDV---TQVLYQAEDPGDGQfvAANTLGVTTVGLVVPLPGRDLLL---VARGLAGklsAGVPP----- 192
Cdd:cd11278    115 TCQRHVFphdhpADIqseVHCIYSPQIEEEPD--QCPDCVVSTLGSKVLVTVKDRFVnffVGNTINS---SYFPDhplhs 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  193 LTVRQLAGPQpfssEGLGRL-------VVGDFSD-YNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLRDVNLY 264
Cdd:cd11278    190 ISVRRLKETQ----DGFEFLtdqsyidVLPEFRDsYPIKYVHAFESNNFVYFLTVQRESLDSQTFHTRIIRFCSIDSELR 265

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907202616  265 SYVEMPLTC-------------HGQGLIQAAFLTP---------------DTLLGAFSAGTSQAQ-----AALCAFPL 309
Cdd:cd11278    266 SYMEMPLECiftekrrkrstkkEVFNILQAAYVSKpgaqlaremgaslndDILFGVFAQSKPDSAepmnrSAVCAVSI 343
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 916-1001 7.28e-15

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 71.34  E-value: 7.28e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNISV-FVGDQPCPIqEPVCPEAIICHTMPQTEPGEAVVLIVFGH--VERK 992
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVtFGGGVPCSV-LSVSSTAIVCTTPPYANPGPGPVEVTVDRgnGGIT 79


                   ....*....
gi 1907202616  993 LLTTPFRYT 1001
Cdd:cd00102     80 SSPLTFTYV 88
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 824-915 9.65e-15

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 70.95  E-value: 9.65e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNdVRnaVTV-AGQPCNPDPSlyrISARIVCVTSPAPNGTAGPVQVAIKSR 902
Cdd:cd00102      1 PVITSISPSSGPVSGGTEVTITGSNFGSGSN-LR--VTFgGGVPCSVLSV---SSTAIVCTTPPYANPGPGPVEVTVDRG 74

                           90
                   ....*....|....*
gi 1907202616  903 PPGI--STQNFTYQD 915
Cdd:cd00102     75 NGGItsSPLTFTYVP 89
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 464-515 3.21e-14

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 68.50  E-value: 3.21e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907202616  464 CPQFPNCTTCLQARDPLCGWCILQGRCTRRGECGrAAQPNHWLWSYEDNHCP 515
Cdd:pfam01437    2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACG-APEGNCEEWEQASSKCP 52
IPT smart00429
ig-like, plexins, transcription factors;
915-1001 3.54e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 66.68  E-value: 3.54e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   915 DPVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNISVFVGD--QPCPIQePVCPEAIICHTMPQTEPGEAVVLIVFGHVERK 992
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVgeAPCTFS-PSSSTAIVCKTPPYHNIPGSVPVRTVGLRNGG 79


                    ....*....
gi 1907202616   993 LLTTPFRYT 1001
Cdd:smart00429   80 VPSSPQPFT 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 824-914 4.14e-13

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 66.32  E-value: 4.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  824 PSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRnaVTVAGQPCNPdpsLYRISARIVCVTspaPNGTAGPVQVAIKSRP 903
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLK--VTIGGTPCTV---ISVSSTTIVCTT---PPGTSGLVNVSVTVGG 72

                           90
                   ....*....|.
gi 1907202616  904 PGISTQNFTYQ 914
Cdd:pfam01833   73 GGISSSPLTFT 83
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
464-515 2.39e-11

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 59.87  E-value: 2.39e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1907202616   464 CPQFPNCTTCLQARDPLCGWCILQGRCTRRGECGRAAQpnhwlwSYEDNHCP 515
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQ------NWLSGGCP 47
IPT smart00429
ig-like, plexins, transcription factors;
824-913 3.33e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 60.90  E-value: 3.33e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   824 PSIDVIEPLTGPPEGGLAITILGSNLGqAFNDVRNAVTVAGQPCNPDPSLyriSARIVCVTSPAPNGTA-GPVQVAiKSR 902
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLK-SISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGsVPVRTV-GLR 76

                            90
                    ....*....|...
gi 1907202616   903 PPGIST--QNFTY 913
Cdd:smart00429   77 NGGVPSspQPFTY 89
Sema_RON cd11279
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ...
 47-459 1.04e-10

The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.


Pssm-ID: 200540 [Multi-domain]  Cd Length: 493  Bit Score: 65.96  E-value: 1.04e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   47 LVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPvIDSPDCvpfRDLAECPQA----QLTDNANQLLLVSSRTQELVAC 122
Cdd:cd11279     32 IVSYEDASAVFVATRNHLHVLNPELKLLQNLVTGP-TGSPGC---QICALCPPGppgpSPEDTDNKVLVLDPEEPWLYSC 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  123 GQVKQGVC-----EKR----RLGDvTQVLYQAE--DPGDGQFVAANTLGvTTVgLVVPLPGRDLLLVARGLAGKLSAGVP 191
Cdd:cd11279    108 GSSLHGRCflhelESRgsavHIAS-TACLFSANanKPSDCPDCVASPLG-TRV-TVVEQSHTSYFYVASTLNSSVAASYS 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  192 P--LTVRQLAGPQPFSSEGLGRL-VVGDFSD-YNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLRDVNLYSYV 267
Cdd:cd11279    185 PrsVSIRRLKSDQDGFAPGFHSLtVLPKYLDsYPIHYVHSFTSGDFVYFLTVQPESPDSSAYHTRLVRLSAKEPELRDYR 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  268 EMPLTCH------------GQG----LIQAAFLTP---------------DTLLGAFS---AGTSQAQ--AALCAFPLAD 311
Cdd:cd11279    265 ELVLDCRfepkrrrrrrpaEREvpynVLQAAHAAPvgsklavelgisegqEVLFGVFAesqPGSPVPQknSAVCAFPISL 344

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  312 LDRSMEQARRLCYTTGGQgpSGMEEATVEYGVTSRCvtlpPDSPEsypcGDEHTPSPIAGRQPLEAQPLL--------QL 383
Cdd:cd11279    345 LNEAIDEGMEKCCSSSNS--DRLFRGLDFFQPQSYC----PHPPN----LSAAVSNTSCWNFPTLVSTSSfrvdlfngHL 414

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907202616  384 GQS-ISAVAALQTDGHTIAFLGDTQGQLHKVFLNSSHG-QVYHSQQVGPPGSAISPDllVDSNGDHLYVLTAQQVDRI 459
Cdd:cd11279    415 SGVlLTSIYVTVLDNVTVAHLGTSDGRILQVVLQRSLNyLLYVSNFSLGDGQPVQRD--VSRLGDSLLFASGNQVFKV 490
Sema_5B cd11264
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed ...
 37-355 1.73e-10

The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed in regions of the basal telencephalon in rat. Sema5B is an inhibitory cue for corticofugal axons and acts as a source of repulsion for the appropriate guidance of cortical axons away from structures such as the ventricular zone as they navigate toward and within subcortical regions. In addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, the sema domain of Sema5B can be cleaved of the whole protein and exerts its function in regulation of synapse morphology. Sema5B belongs to the class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200525 [Multi-domain]  Cd Length: 437  Bit Score: 65.00  E-value: 1.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   37 FSVPNT-SFNHLVLAPDQGKLYVGAVNHLFQLSpelkMESVAVTGPVIDSPDCVPFRDLAECPQAQL-TDNANQLLLVSS 114
Cdd:cd11264      1 FTYPGVrDFSQLALDLNRNQLIVGARNYLFRLS----LHNVSLIQATEWGSDEDTRRSCQSKGKTEEeCQNYVRVLIVYG 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  115 RtqELVACG-QVKQGVCEKRRLGDVTQVLYQAE-------DPGDGQFVAANTLGVTTVGLVVPLPGRDlLLVARGLagkl 186
Cdd:cd11264     77 K--KVFTCGtNAFSPVCTSRQVGNLSKVIERINgvarcpyDPRHNSTAVITSRGELYAATVIDFSGRD-PAIYRSL---- 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  187 sAGVPPLTVRQlagpqpFSSEGLGRlvvgdfsdynNSYVGAFSDAHSAYFVFRRRGAR---AQTEYrSYVARVCLRDV-- 261
Cdd:cd11264    150 -GSVPPLRTAQ------YNSKWLNE----------PNFIAAYDIGLFTYFFFRENAVEhdcGKTVY-SRVARVCKNDIgg 211

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  262 ------NLYSYVEMPLTCHGQGLI-------QAAFLTP--DTLLGAFSAG-TSQAQAALCAFPLADLD-------RSMEQ 318
Cdd:cd11264    212 rflledTWTTFMKARLNCSRPGEIpfyynelQSTFYLPeqDLIYGVFTTNvNSIAASAVCAFNLSAITqafngpfRYQEN 291

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 1907202616  319 ARRLCYTTGGQGPSgmeeatveygvtSRCVTLPPDSP 355
Cdd:cd11264    292 PRSAWLPTANPIPN------------FQCGTLSDDSP 316
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 916-1001 6.62e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 54.38  E-value: 6.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTG-GNISVFVGDQPCPIQEpVCPEAIIChTMPQTEPGeaVVLIVFGHVERKLL 994
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDsSDLKVTIGGTPCTVIS-VSSTTIVC-TTPPGTSG--LVNVSVTVGGGGIS 76


                   ....*..
gi 1907202616  995 TTPFRYT 1001
Cdd:pfam01833   77 SSPLTFT 83
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1004-1135 1.80e-07

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 50.88  E-value: 1.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616 1004 PQLVEAEPSVSFRGGGRVIRVRGTGLDVVWQPLLsvwledepKVKALGVQaqdanprrscgapaadpqacihlesgllqc 1083
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRI--------RVKYGGVE------------------------------ 42

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907202616 1084 STLCSVNSSSLLLCHSPAVPDGALP-----KRVFFALDNMQVDFASASGGQGFLYQP 1135
Cdd:cd01181     43 KTSCKVRNSTLMTCPAPSLALLNRSpepgeRPVEFGLDGDNVQSLLILNRTSFSYYP 99
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1165-1232 1.51e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 44.75  E-value: 1.51e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907202616 1165 GLNLGISKEEVQVHIGDGECLVKTLTLTHLYCEPPPQAPQPTNgsgtlpqFVVQMGNLRLALGPVQYE 1232
Cdd:pfam01833   23 GSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVN-------VSVTVGGGGISSSPLTFT 83
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
 42-459 2.57e-05

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 48.56  E-value: 2.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616   42 TSFNHLVLAPDQGKLYVGAVNHLF-----QLSPELKMESVAvtgpvidSPDcvpfrDLAECPQA--QLTDNANQLLLVSS 114
Cdd:cd11235      1 LKYHTKLLHEDRSTLYVGARDRVYlvdldSLYTEQKVAWPS-------SPD-----DVDTCYLKgkSKDDCRNFIKVLEK 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  115 RTQE-LVACG-QVKQGVCEKRRLGDVTQVlyqaEDPGDGQFVAANTLGVTTVGLVVplpgrdlllvarglAGKLSAGVP- 191
Cdd:cd11235     69 NSDDsLLVCGtNAFNPSCRNYNVETFELV----GKEESGRGKCPYDPDHNSTALFA--------------DGELYSGTSa 130

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  192 ------PLTVRQLAGPQPFSSEGLGRLVVGDfsdynNSYVGAFSDAHSAYFVFRRRGARAQTEYR---SYVARVCLRDV- 261
Cdd:cd11235    131 dflgtdPVIYRTLGHNPPLRTEYHDSKWLNE-----PQFVGAFDIGDYVYFFFREIAVEYINCGKavySRVARVCKNDQg 205

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  262 -------NLYSYVEMPLTCHGQGL-------IQAAFLTPDT------LLGAFSAGTSQ-AQAALCAFPLADLDRSMeQAR 320
Cdd:cd11235    206 gsrslekKWTTFLKARLNCSVPGEfpfyfneLQDVFDLPSPsnkekiFYAVFTTPYNSiPGSAVCAYSLSDIEAVF-NGP 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  321 RLCYTTGGQGPSGMEEATVEYGVTSRCVT----LPPDS---PESYPCGDEHTPsPIAGRqPLEAQPLLQLGQSISAVAAL 393
Cdd:cd11235    285 FKEQHSSNSAWLPVPDERVPEPRPGTCVDdsspLPDDTlnfIKSHPLMDEAVT-PILNR-PLFIKTDVNYRFTKIAVDRV 362

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907202616  394 QTDG---HTIAFLGDTQGQLHKVFLNSSHGQ----VYHSQQVGPPGSAISpDLLVDSNGDHLYVLTAQQVDRI 459
Cdd:cd11235    363 QAKLgqtYDVLFVGTDRGIILKVVSLPEQGLqasnILEEMPVGPPPEPIQ-TMQLSRKRRSLYVGSETGVLQV 434
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 916-1000 9.57e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 39.99  E-value: 9.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQ---TGGNISVFVGDQPCpiqEPVCPEA-----IICHTMPQTEPGE--AVVLIV 985
Cdd:cd01180      1 PVITEFFPLSGPLEGGTRLTICGSNLGlrkNDVRHGVRVGGVPC---NPEPPEYsssekIVCTTGPAGNPVFngPVEVTV 77

                           90
                   ....*....|....*
gi 1907202616  986 FGHVERKLLTTPFRY 1000
Cdd:cd01180     78 GHGSFRTESSEGFSF 92
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 916-1000 4.19e-03

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 38.17  E-value: 4.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907202616  916 PVLLSLNPQWGPQAGGTQLTIHGQYLQTGGN--ISVFVGDQ---PCPI---QEPVCPEAIICHTMPQTEPGEAVVLIVF- 986
Cdd:cd01181      1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEprIRVKYGGVektSCKVrnsTLMTCPAPSLALLNRSPEPGERPVEFGLd 80

                           90
                   ....*....|....*..
gi 1907202616  987 GHVERKLLT---TPFRY 1000
Cdd:cd01181     81 GDNVQSLLIlnrTSFSY 97
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
622-658 5.03e-03

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 36.37  E-value: 5.03e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1907202616   622 CRACVSSLW-RCHWCPQSSHCIYGEHCPEGEKAVYSAQ 658
Cdd:smart00423    8 CSECLLARDpYCAWCSSQGRCTSGERCDSRRQNWLSGG 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH