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    Gli3 GLI-Kruppel family member GLI3 [ Mus musculus (house mouse) ]

    Gene ID: 14634, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gli3provided by MGI
    Official Full Name
    GLI-Kruppel family member GLI3provided by MGI
    Primary source
    MGI:MGI:95729
    See related
    Ensembl:ENSMUSG00000021318 AllianceGenome:MGI:95729
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xt; Bph; Pdn; add; GLI3FL; GLI3-190
    Summary
    Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative thymic T cell selection; regulation of alpha-beta T cell differentiation; and thymocyte apoptotic process. Acts upstream of or within several processes, including nervous system development; positive regulation of cell differentiation; and skeletal system morphogenesis. Located in axoneme and nuclear speck. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Greig cephalopolysyndactyly syndrome and Pallister-Hall syndrome. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 12.4), CNS E11.5 (RPKM 9.9) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Gli3 in Genome Data Viewer
    Location:
    13 A1; 13 5.43 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (15638308..15904611)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (15463723..15730026)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1862 Neighboring gene STARR-seq mESC enhancer starr_33721 Neighboring gene predicted gene 9512 Neighboring gene STARR-seq mESC enhancer starr_33722 Neighboring gene STARR-seq mESC enhancer starr_33723 Neighboring gene VISTA enhancers mm1179 and mm1887 Neighboring gene VISTA enhancer mm1893 Neighboring gene STARR-seq mESC enhancer starr_33728 Neighboring gene STARR-seq mESC enhancer starr_33729 Neighboring gene VISTA enhancer mm1896 Neighboring gene predicted gene, 20043 Neighboring gene STARR-seq mESC enhancer starr_33730 Neighboring gene STARR-seq mESC enhancer starr_33731 Neighboring gene STARR-seq mESC enhancer starr_33733 Neighboring gene predicted gene 6556 Neighboring gene VISTA enhancer mm1912 Neighboring gene VISTA enhancer mm652 Neighboring gene VISTA enhancer mm2028 Neighboring gene VISTA enhancer mm1935 Neighboring gene RIKEN cDNA 4933412O06 gene Neighboring gene predicted gene, 57607

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding  
    enables beta-catenin binding  
    enables beta-catenin binding  
    enables chromatin binding PubMed 
    enables histone acetyltransferase binding  
    enables histone acetyltransferase binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables mediator complex binding  
    enables mediator complex binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific double-stranded DNA binding  
    Items 1 - 25 of 134
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell differentiation in thymus PubMed 
    involved_in T cell differentiation in thymus PubMed 
    acts_upstream_of_or_within alpha-beta T cell differentiation PubMed 
    acts_upstream_of_or_within anatomical structure development PubMed 
    acts_upstream_of_or_within anatomical structure formation involved in morphogenesis PubMed 
    acts_upstream_of_or_within anterior semicircular canal development PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
    acts_upstream_of apoptotic process PubMed 
    acts_upstream_of_or_within artery development PubMed 
    acts_upstream_of_or_within axon guidance PubMed 
    acts_upstream_of_or_within brain development PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis PubMed 
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube PubMed 
    acts_upstream_of_or_within camera-type eye development PubMed 
    acts_upstream_of_or_within camera-type eye morphogenesis PubMed 
    acts_upstream_of_or_within cell differentiation involved in kidney development PubMed 
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of cell population proliferation PubMed 
    acts_upstream_of_or_within central nervous system development PubMed 
    acts_upstream_of_or_within central nervous system development PubMed 
    acts_upstream_of_or_within cerebral cortex radial glia-guided migration PubMed 
    acts_upstream_of chondrocyte differentiation PubMed 
    acts_upstream_of_or_within developmental growth PubMed 
    acts_upstream_of_or_within dorsal/ventral pattern formation PubMed 
    acts_upstream_of_or_within embryonic digestive tract development PubMed 
    acts_upstream_of_or_within embryonic digestive tract morphogenesis PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
    acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
    acts_upstream_of_or_within embryonic limb morphogenesis PubMed 
    acts_upstream_of_or_within embryonic limb morphogenesis PubMed 
    acts_upstream_of_or_within embryonic morphogenesis PubMed 
    acts_upstream_of_or_within embryonic neurocranium morphogenesis PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis PubMed 
    acts_upstream_of_or_within forebrain development PubMed 
    acts_upstream_of_or_within forebrain dorsal/ventral pattern formation PubMed 
    acts_upstream_of_or_within forebrain radial glial cell differentiation PubMed 
    acts_upstream_of_or_within frontal suture morphogenesis PubMed 
    acts_upstream_of_or_within gene expression PubMed 
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within hindgut morphogenesis PubMed 
    acts_upstream_of_or_within hippocampus development PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    acts_upstream_of_or_within inner ear development PubMed 
    acts_upstream_of_or_within kidney development PubMed 
    acts_upstream_of_or_within lambdoid suture morphogenesis PubMed 
    acts_upstream_of_or_within larynx morphogenesis PubMed 
    acts_upstream_of_or_within lateral ganglionic eminence cell proliferation PubMed 
    acts_upstream_of_or_within lateral semicircular canal development PubMed 
    acts_upstream_of_or_within layer formation in cerebral cortex PubMed 
    involved_in limb development PubMed 
    acts_upstream_of_or_within limb morphogenesis PubMed 
    involved_in limb morphogenesis  
    involved_in liver regeneration  
    acts_upstream_of_or_within lung development PubMed 
    acts_upstream_of_or_within lung development PubMed 
    acts_upstream_of_or_within mammary gland development PubMed 
    acts_upstream_of_or_within mammary gland specification PubMed 
    acts_upstream_of_or_within melanocyte differentiation PubMed 
    acts_upstream_of_or_within metanephros development PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of alpha-beta T cell differentiation PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within negative regulation of chondrocyte differentiation PubMed 
    acts_upstream_of_or_within negative regulation of neuron differentiation PubMed 
    involved_in negative regulation of smoothened signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of stem cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of stem cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative thymic T cell selection PubMed 
    acts_upstream_of_or_within neural tube development PubMed 
    acts_upstream_of neuroblast proliferation PubMed 
    acts_upstream_of_or_within neuroblast proliferation PubMed 
    acts_upstream_of neuron differentiation PubMed 
    acts_upstream_of_or_within neuron fate commitment PubMed 
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth PubMed 
    acts_upstream_of_or_within oligodendrocyte differentiation PubMed 
    acts_upstream_of_or_within optic nerve morphogenesis PubMed 
    acts_upstream_of osteoblast differentiation PubMed 
    acts_upstream_of osteoblast differentiation PubMed 
    acts_upstream_of_or_within pallium development PubMed 
    acts_upstream_of_or_within pattern specification process PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of alpha-beta T cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of chondrocyte differentiation PubMed 
    acts_upstream_of_or_within positive regulation of neuroblast proliferation PubMed 
    acts_upstream_of_or_within positive regulation of osteoblast differentiation PubMed 
    acts_upstream_of_or_within positive regulation of osteoblast differentiation PubMed 
    acts_upstream_of_or_within positive regulation of protein import into nucleus PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in prostate gland development  
    acts_upstream_of protein import into nucleus PubMed 
    acts_upstream_of_or_within protein processing PubMed 
    acts_upstream_of_or_within proximal/distal pattern formation PubMed 
    acts_upstream_of_or_within proximal/distal pattern formation PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of apoptotic process PubMed 
    acts_upstream_of_or_within regulation of bone development PubMed 
    acts_upstream_of_or_within regulation of cell differentiation PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    acts_upstream_of_or_within regulation of smoothened signaling pathway PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to estrogen  
    acts_upstream_of_or_within roof of mouth development PubMed 
    acts_upstream_of_or_within sagittal suture morphogenesis PubMed 
    involved_in smoothened signaling pathway  
    acts_upstream_of_or_within smoothened signaling pathway PubMed 
    involved_in smoothened signaling pathway PubMed 
    involved_in smoothened signaling pathway  
    acts_upstream_of_or_within smoothened signaling pathway involved in dorsal/ventral neural tube patterning PubMed 
    acts_upstream_of_or_within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification PubMed 
    acts_upstream_of_or_within smoothened signaling pathway involved in ventral spinal cord interneuron specification PubMed 
    acts_upstream_of_or_within spinal cord dorsal/ventral patterning PubMed 
    acts_upstream_of_or_within spinal cord motor neuron differentiation PubMed 
    acts_upstream_of stem cell proliferation PubMed 
    acts_upstream_of stem cell proliferation PubMed 
    acts_upstream_of_or_within subpallium development PubMed 
    acts_upstream_of_or_within telencephalon development PubMed 
    involved_in thymocyte apoptotic process PubMed 
    acts_upstream_of_or_within tongue development PubMed 
    acts_upstream_of_or_within tube development PubMed 
    acts_upstream_of_or_within vocalization behavior PubMed 
    Items 1 - 25 of 134
    Component Evidence Code Pubs
    part_of GLI-SUFU complex  
    located_in axoneme PubMed 
    is_active_in cilium PubMed 
    located_in cilium PubMed 
    located_in cilium PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in nuclear speck PubMed 
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    part_of transcription repressor complex PubMed 

    General protein information

    Preferred Names
    transcriptional activator GLI3
    Names
    GLI3 form of 190 kDa
    GLI3 full length protein
    anterior digit pattern deformity
    brachyphalangy
    extra toes
    polydactyly Nagoya
    zinc finger protein GLI3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008130.3NP_032156.2  transcriptional activator GLI3

      See identical proteins and their annotated locations for NP_032156.2

      Status: VALIDATED

      Source sequence(s)
      AC163610, AC173115, AC173210
      Consensus CDS
      CCDS36603.1
      UniProtKB/Swiss-Prot
      Q61602
      UniProtKB/TrEMBL
      B2RUG4, B7ZNV2
      Related
      ENSMUSP00000106137.4, ENSMUST00000110510.4
      Conserved Domains (2) summary
      sd00017
      Location:548570
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:562589
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      15638308..15904611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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