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    Shfl shiftless antiviral inhibitor of ribosomal frameshifting [ Mus musculus (house mouse) ]

    Gene ID: 319278, updated on 9-Dec-2024

    Summary

    Official Symbol
    Shflprovided by MGI
    Official Full Name
    shiftless antiviral inhibitor of ribosomal frameshiftingprovided by MGI
    Primary source
    MGI:MGI:2441788
    See related
    Ensembl:ENSMUSG00000038884 AllianceGenome:MGI:2441788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RyDEN; A230050P20Rik
    Summary
    Predicted to enable identical protein binding activity; ribosome binding activity; and sequence-specific mRNA binding activity. Predicted to be involved in several processes, including defense response to symbiont; regulation of translation; and viral translational frameshifting. Predicted to be located in P-body; cytosol; and nucleoplasm. Is expressed in midbrain. Orthologous to human SHFL (shiftless antiviral inhibitor of ribosomal frameshifting). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 29.2), cortex adult (RPKM 29.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Shfl in Genome Data Viewer
    Location:
    9 A3; 9 7.65 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20779914..20785603)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20868635..20874307)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 8 Neighboring gene predicted gene, 39300 Neighboring gene angiopoietin-like 6 Neighboring gene STARR-positive B cell enhancer ABC_E6717 Neighboring gene predicted gene, 24067 Neighboring gene predicted gene, 23008 Neighboring gene peter pan homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA binding  
    enables identical protein binding  
    enables ribosome binding  
    enables ribosome binding  
    enables ribosome binding  
    enables sequence-specific mRNA binding  
    enables sequence-specific mRNA binding  
    enables sequence-specific mRNA binding  
    Process Evidence Code Pubs
    involved_in defense response to virus  
    involved_in defense response to virus  
    involved_in innate immune response  
    involved_in negative regulation of translational frameshifting  
    involved_in negative regulation of translational frameshifting  
    involved_in negative regulation of viral genome replication  
    involved_in negative regulation of viral genome replication  
    involved_in regulation of translational termination  
    involved_in regulation of translational termination  
    involved_in response to interferon-beta  
    involved_in response to interferon-beta  
    involved_in response to type I interferon  
    involved_in response to type I interferon  
    involved_in response to type II interferon  
    involved_in response to type II interferon  
    involved_in response to type III interferon  
    involved_in response to type III interferon  
    involved_in viral translational frameshifting  
    involved_in viral translational frameshifting  
    involved_in viral translational frameshifting  
    Component Evidence Code Pubs
    located_in P-body  
    located_in P-body  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    shiftless antiviral inhibitor of ribosomal frameshifting protein homolog
    Names
    UPF0515 protein C19orf66 homolog
    repressor of yield of DENV protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175687.2NP_783618.1  shiftless antiviral inhibitor of ribosomal frameshifting protein homolog

      See identical proteins and their annotated locations for NP_783618.1

      Status: VALIDATED

      Source sequence(s)
      AC170598, AK034516, AK149161, BY625900
      Consensus CDS
      CCDS22885.1
      UniProtKB/Swiss-Prot
      Q05BY8, Q8CAK3
      Related
      ENSMUSP00000045384.8, ENSMUST00000043911.8
      Conserved Domains (1) summary
      pfam15135
      Location:16272
      UPF0515; Uncharacterized protein UPF0515

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20779914..20785603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510405.5XP_006510468.1  shiftless antiviral inhibitor of ribosomal frameshifting protein homolog isoform X1

      See identical proteins and their annotated locations for XP_006510468.1

      UniProtKB/TrEMBL
      Q3U076
      Related
      ENSMUST00000175820.8
      Conserved Domains (1) summary
      pfam15135
      Location:1202
      UPF0515; Uncharacterized protein UPF0515
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