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Cadps Ca2+-dependent secretion activator [ Mus musculus (house mouse) ]

Gene ID: 27062, updated on 27-Nov-2024

Summary

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Official Symbol
Cadpsprovided by MGI
Official Full Name
Ca2+-dependent secretion activatorprovided by MGI
Primary source
MGI:MGI:1350922
See related
Ensembl:ENSMUSG00000054423 AllianceGenome:MGI:1350922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAPS; CAPS1; mKIAA1121
Summary
Enables protein kinase binding activity. Involved in presynaptic dense core vesicle exocytosis and synaptic vesicle priming. Acts upstream of or within catecholamine secretion; establishment of localization in cell; and vesicle organization. Located in cytoplasmic vesicle. Is active in glutamatergic synapse. Is expressed in several structures, including adrenal gland; heart; nervous system; olfactory epithelium; and retina. Orthologous to human CADPS (calcium dependent secretion activator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 23.4), cerebellum adult (RPKM 20.6) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Cadps in Genome Data Viewer
Location:
14 A1; 14 6.37 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (9646424..10097203)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (12372560..12823339, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35969 Neighboring gene predicted gene 5087 Neighboring gene STARR-seq mESC enhancer starr_35968 Neighboring gene STARR-seq mESC enhancer starr_35966 Neighboring gene STARR-seq mESC enhancer starr_35965 Neighboring gene STARR-seq mESC enhancer starr_35964 Neighboring gene STARR-seq mESC enhancer starr_35963 Neighboring gene STARR-seq mESC enhancer starr_35962 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_35960 Neighboring gene STARR-seq mESC enhancer starr_35958 Neighboring gene STARR-seq mESC enhancer starr_35957 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_35956 Neighboring gene predicted gene, 24578 Neighboring gene Fez family zinc finger 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis. Miyake K, et al. Cell Rep, 2016 Nov 15. PMID 27851964, Free PMC Article
  2. Interaction of Ca(2+)-dependent activator protein for secretion 1 (CAPS1) with septin family proteins in mouse brain. Hosono M, et al. Neurosci Lett, 2016 Mar 23. PMID 26917099
  3. RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission. Shumate KM, et al. J Neurochem, 2021 Jul. PMID 33894004, Free PMC Article
  4. CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons. Eckenstaler R, et al. J Cell Sci, 2016 Apr 1. PMID 26869227
  5. CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles. Liu Y, et al. J Neurosci, 2008 May 21. PMID 18495893, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress.
    Title: CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress.
  2. RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.
    Title: RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.
  3. CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning.
    Title: CAPS1 is involved in hippocampal synaptic plasticity and hippocampus-associated learning.
  4. The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex.
    Title: The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex.
  5. CAPS1 promotes colorectal cancer metastasis through PI3K/Akt/GSK3beta/Snail signal pathway-mediated epithelial mesenchymal transformation process
    Title: CAPS1 promotes colorectal cancer metastasis via Snail mediated epithelial mesenchymal transformation.
  6. Together, these data show that the CAPS-1 C-terminus regulates synaptic enrichment of CAPS-1. All CAPS-1 functional domains are required, and the C2 and PH domain together are not sufficient, for dense core vesicles exocytosis in mammalian central nervous system neurons.
    Title: CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons.
  7. findings suggest that CAPS1 stabilizes the state of readily releasable synaptic vesicles, thereby enhancing neurotransmitter release at hippocampal synapses.
    Title: CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampus.
  8. edited CAPS1 bound preferentially to the activated form of syntaxin-1A, a component of the exocytotic fusion complex.
    Title: CAPS1 RNA Editing Promotes Dense Core Vesicle Exocytosis.
  9. CAPS1 protein plays an important role during protein release from secretory granules in hippocampal neurons. The cytosolic protein CAPS1 regulates several stages of secretory granule processing.
    Title: CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons.
  10. identified a specific interaction of CAPS1 with septin family proteins; demonstrated that the C-terminal region of the CAPS1 protein binds to part of the deduced GTP-binding domain of septin proteins.
    Title: Interaction of Ca(2+)-dependent activator protein for secretion 1 (CAPS1) with septin family proteins in mouse brain.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90712

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within catecholamine secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT acts_upstream_of_or_within exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in presynaptic dense core vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic dense core vesicle exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle priming IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within synaptic vesicle priming IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in synaptic vesicle priming IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vesicle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dense core granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in extrinsic component of neuronal dense core vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal dense core vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcium-dependent secretion activator 1
Names
Ca2+-dependent activator protein for secretion
Ca<2+>dependent activator protein for secretion
calcium-dependent activator protein for secretion 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042617.1 → NP_001036082.1  calcium-dependent secretion activator 1 isoform 2

    See identical proteins and their annotated locations for NP_001036082.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2 which is 6 aa shorter than isoform 1.
    Source sequence(s)
    AC116395, AK122453, BC079679
    Consensus CDS
    CCDS36807.1
    UniProtKB/Swiss-Prot
    E9QN90, Q3TSP2, Q61374, Q6AXB4, Q6PGF0, Q80TJ1
    Related
    ENSMUSP00000108277.2, ENSMUST00000112658.8
    Conserved Domains (4) summary
    smart00239
    Location:397 → 480
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:521 → 620
    PH; PH domain
    pfam06292
    Location:838 → 942
    DUF1041; Domain of Unknown Function (DUF1041)

  2. NM_001359919.1 → NP_001346848.1  calcium-dependent secretion activator 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC116395, AC154592, AC156025, AV298053, BE950560, BM899966, BM946816, CF534768, CF727759, CK780913, CO432703, CV559777, CX239615, CX566190
    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 938
    DUF1041; Domain of Unknown Function (DUF1041)

  3. NM_001359920.1 → NP_001346849.1  calcium-dependent secretion activator 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC116395, AC154592, AC156025, AV298053, BE950560, BM899966, BM946816, CF534768, CF727759, CK780913, CO432703, CV559777, CX239615, CX566190
    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834 → 932
    DUF1041; Domain of Unknown Function (DUF1041)

  4. NM_001359921.1 → NP_001346850.1  calcium-dependent secretion activator 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC116395, AC154592, AC156025, AV298053, BM899966, BM946816, CF534768, CF727759, CK780913, CO432703, CV559777, CX239615, CX566190
    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834 → 961
    DUF1041; Domain of Unknown Function (DUF1041)

  5. NM_012061.3 → NP_036191.2  calcium-dependent secretion activator 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AC116395, AC156025, AK133310, BQ715095, CB245630, CB527086, CF539197, CX238199
    Consensus CDS
    CCDS36806.1
    Related
    ENSMUSP00000064706.7, ENSMUST00000067491.14
    Conserved Domains (4) summary
    smart00239
    Location:397 → 480
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:521 → 620
    PH; PH domain
    pfam06292
    Location:834 → 948
    DUF1041; Domain of Unknown Function (DUF1041)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    9646424..10097203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158614.1 → XP_036014507.1  calcium-dependent secretion activator 1 isoform X1

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 1021
    DUF1041; Domain of Unknown Function (DUF1041)

  2. XM_036158620.1 → XP_036014513.1  calcium-dependent secretion activator 1 isoform X7

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 1021
    DUF1041; Domain of Unknown Function (DUF1041)

  3. XM_036158630.1 → XP_036014523.1  calcium-dependent secretion activator 1 isoform X16

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 1021
    DUF1041; Domain of Unknown Function (DUF1041)

  4. XM_036158618.1 → XP_036014511.1  calcium-dependent secretion activator 1 isoform X5

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 1014
    DUF1041; Domain of Unknown Function (DUF1041)

  5. XM_036158631.1 → XP_036014524.1  calcium-dependent secretion activator 1 isoform X18

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 1014
    DUF1041; Domain of Unknown Function (DUF1041)

  6. XM_036158615.1 → XP_036014508.1  calcium-dependent secretion activator 1 isoform X2

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 1018
    DUF1041; Domain of Unknown Function (DUF1041)

  7. XM_036158619.1 → XP_036014512.1  calcium-dependent secretion activator 1 isoform X6

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 1011
    DUF1041; Domain of Unknown Function (DUF1041)

  8. XM_036158632.1 → XP_036014525.1  calcium-dependent secretion activator 1 isoform X20

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 1011
    DUF1041; Domain of Unknown Function (DUF1041)

  9. XM_036158617.1 → XP_036014510.1  calcium-dependent secretion activator 1 isoform X4

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 1015
    DUF1041; Domain of Unknown Function (DUF1041)

  10. XM_036158621.1 → XP_036014514.1  calcium-dependent secretion activator 1 isoform X8

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 1005
    DUF1041; Domain of Unknown Function (DUF1041)

  11. XM_036158634.1 → XP_036014527.1  calcium-dependent secretion activator 1 isoform X23

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 1005
    DUF1041; Domain of Unknown Function (DUF1041)

  12. XM_036158622.1 → XP_036014515.1  calcium-dependent secretion activator 1 isoform X9

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 998
    DUF1041; Domain of Unknown Function (DUF1041)

  13. XM_036158626.1 → XP_036014519.1  calcium-dependent secretion activator 1 isoform X12

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 991
    DUF1041; Domain of Unknown Function (DUF1041)

  14. XM_036158624.1 → XP_036014517.1  calcium-dependent secretion activator 1 isoform X10

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 995
    DUF1041; Domain of Unknown Function (DUF1041)

  15. XM_036158627.1 → XP_036014520.1  calcium-dependent secretion activator 1 isoform X13

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 988
    DUF1041; Domain of Unknown Function (DUF1041)

  16. XM_036158625.1 → XP_036014518.1  calcium-dependent secretion activator 1 isoform X11

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 992
    DUF1041; Domain of Unknown Function (DUF1041)

  17. XM_036158629.1 → XP_036014522.1  calcium-dependent secretion activator 1 isoform X15

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 982
    DUF1041; Domain of Unknown Function (DUF1041)

  18. XM_036158638.1 → XP_036014531.1  calcium-dependent secretion activator 1 isoform X30

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:891 → 982
    DUF1041; Domain of Unknown Function (DUF1041)

  19. XM_006518024.5 → XP_006518087.1  calcium-dependent secretion activator 1 isoform X17

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 966
    DUF1041; Domain of Unknown Function (DUF1041)

  20. XM_006518029.5 → XP_006518092.1  calcium-dependent secretion activator 1 isoform X21

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 956
    DUF1041; Domain of Unknown Function (DUF1041)

  21. XM_017316035.3 → XP_017171524.1  calcium-dependent secretion activator 1 isoform X35

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 956
    DUF1041; Domain of Unknown Function (DUF1041)

  22. XM_006518031.5 → XP_006518094.1  calcium-dependent secretion activator 1 isoform X25

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 950
    DUF1041; Domain of Unknown Function (DUF1041)

  23. XM_017316037.3 → XP_017171526.1  calcium-dependent secretion activator 1 isoform X37

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 950
    DUF1041; Domain of Unknown Function (DUF1041)

  24. XM_006518032.5 → XP_006518095.1  calcium-dependent secretion activator 1 isoform X26

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 943
    DUF1041; Domain of Unknown Function (DUF1041)

  25. XM_036158641.1 → XP_036014534.1  calcium-dependent secretion activator 1 isoform X39

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 942
    DUF1041; Domain of Unknown Function (DUF1041)

  26. XM_036158637.1 → XP_036014530.1  calcium-dependent secretion activator 1 isoform X29

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 935
    DUF1041; Domain of Unknown Function (DUF1041)

  27. XM_006518036.5 → XP_006518099.1  calcium-dependent secretion activator 1 isoform X31

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 930
    DUF1041; Domain of Unknown Function (DUF1041)

  28. XM_030247840.2 → XP_030103700.1  calcium-dependent secretion activator 1 isoform X40

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 930
    DUF1041; Domain of Unknown Function (DUF1041)

  29. XM_030247838.2 → XP_030103698.1  calcium-dependent secretion activator 1 isoform X33

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 927
    DUF1041; Domain of Unknown Function (DUF1041)

  30. XM_006518043.5 → XP_006518106.1  calcium-dependent secretion activator 1 isoform X42

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:838 → 927
    DUF1041; Domain of Unknown Function (DUF1041)

  31. XM_036158616.1 → XP_036014509.1  calcium-dependent secretion activator 1 isoform X3

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:887 → 1017
    DUF1041; Domain of Unknown Function (DUF1041)

  32. XM_036158633.1 → XP_036014526.1  calcium-dependent secretion activator 1 isoform X22

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:887 → 1007
    DUF1041; Domain of Unknown Function (DUF1041)

  33. XM_036158628.1 → XP_036014521.1  calcium-dependent secretion activator 1 isoform X14

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:887 → 988
    DUF1041; Domain of Unknown Function (DUF1041)

  34. XM_006518048.4 → XP_006518111.1  calcium-dependent secretion activator 1 isoform X34

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:887 → 976
    DUF1041; Domain of Unknown Function (DUF1041)

  35. XM_006518026.5 → XP_006518089.1  calcium-dependent secretion activator 1 isoform X19

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834 → 962
    DUF1041; Domain of Unknown Function (DUF1041)

  36. XM_036158635.1 → XP_036014528.1  calcium-dependent secretion activator 1 isoform X24

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834 → 954
    DUF1041; Domain of Unknown Function (DUF1041)

  37. XM_036158640.1 → XP_036014533.1  calcium-dependent secretion activator 1 isoform X36

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834 → 954
    DUF1041; Domain of Unknown Function (DUF1041)

  38. XM_006518041.5 → XP_006518104.1  calcium-dependent secretion activator 1 isoform X38

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834 → 946
    DUF1041; Domain of Unknown Function (DUF1041)

  39. XM_036158636.1 → XP_036014529.1  calcium-dependent secretion activator 1 isoform X27

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834 → 941
    DUF1041; Domain of Unknown Function (DUF1041)

  40. XM_006518034.5 → XP_006518097.1  calcium-dependent secretion activator 1 isoform X28

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834 → 936
    DUF1041; Domain of Unknown Function (DUF1041)

  41. XM_036158639.1 → XP_036014532.1  calcium-dependent secretion activator 1 isoform X32

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834 → 931
    DUF1041; Domain of Unknown Function (DUF1041)

  42. XM_017316038.3 → XP_017171527.1  calcium-dependent secretion activator 1 isoform X41

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834 → 929
    DUF1041; Domain of Unknown Function (DUF1041)

  43. XM_006518044.5 → XP_006518107.1  calcium-dependent secretion activator 1 isoform X43

    Conserved Domains (2) summary
    cd01234
    Location:513 → 632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834 → 923
    DUF1041; Domain of Unknown Function (DUF1041)

RNA

  1. XR_004938408.1 RNA Sequence

  2. XR_004938409.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TJ1.3 GenPept UniProtKB/Swiss-Prot:Q80TJ1

Gene LinkOut

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