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    Iqgap1 IQ motif containing GTPase activating protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 29875, updated on 9-Dec-2024

    Summary

    Official Symbol
    Iqgap1provided by MGI
    Official Full Name
    IQ motif containing GTPase activating protein 1provided by MGI
    Primary source
    MGI:MGI:1352757
    See related
    Ensembl:ENSMUSG00000030536 AllianceGenome:MGI:1352757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0051; D7Ertd237e; D7Ertd257e
    Summary
    Enables small GTPase binding activity. Involved in several processes, including caveola assembly; cell surface receptor protein tyrosine kinase signaling pathway; and cellular response to epidermal growth factor stimulus. Acts upstream of or within fibroblast migration; negative regulation of dephosphorylation; and regulation of cytokine production. Located in several cellular components, including basolateral plasma membrane; focal adhesion; and lateral plasma membrane. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 47.3), spleen adult (RPKM 27.7) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Iqgap1 in Genome Data Viewer
    Location:
    7 D3; 7 45.68 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80361331..80453288, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80711583..80815549, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87699700-87699906 Neighboring gene predicted gene, 42398 Neighboring gene STARR-seq mESC enhancer starr_19331 Neighboring gene CREB regulated transcription coactivator 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87792406-87792515 Neighboring gene predicted gene 15880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87812125-87812234 Neighboring gene STARR-positive B cell enhancer ABC_E6567 Neighboring gene predicted gene, 18392 Neighboring gene STARR-seq mESC enhancer starr_19336 Neighboring gene VISTA enhancer mm170 Neighboring gene STARR-positive B cell enhancer ABC_E10447 Neighboring gene STARR-seq mESC enhancer starr_19340 Neighboring gene STARR-positive B cell enhancer ABC_E11358 Neighboring gene STARR-seq mESC enhancer starr_19343 Neighboring gene STARR-positive B cell enhancer ABC_E552 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:88009760-88009913 Neighboring gene zinc finger and SCAN domain containing 2 Neighboring gene predicted gene, 32112 Neighboring gene WD repeat domain 73

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 28
    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables MAP-kinase scaffold activity  
    enables MAP-kinase scaffold activity  
    enables S100 protein binding  
    enables S100 protein binding  
    enables actin filament binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calmodulin binding  
    enables calmodulin binding  
    enables calmodulin binding  
    enables mitogen-activated protein kinase binding  
    enables mitogen-activated protein kinase binding  
    enables molecular adaptor activity  
    enables phosphatidylinositol-3,4,5-trisphosphate binding  
    enables phosphatidylinositol-3,4,5-trisphosphate binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein kinase binding  
    enables protein phosphatase binding  
    enables protein phosphatase binding  
    enables protein serine/threonine kinase activator activity  
    enables protein serine/threonine kinase activator activity  
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    enables small GTPase binding PubMed 
    enables small GTPase binding  
    Items 1 - 25 of 28
    Items 1 - 25 of 39
    Process Evidence Code Pubs
    involved_in MAPK cascade  
    involved_in caveola assembly PubMed 
    involved_in cell migration  
    involved_in cellular response to calcium ion  
    involved_in cellular response to calcium ion  
    involved_in cellular response to epidermal growth factor stimulus PubMed 
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to fibroblast growth factor stimulus PubMed 
    involved_in cellular response to platelet-derived growth factor stimulus PubMed 
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway PubMed 
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway PubMed 
    involved_in fibroblast migration  
    acts_upstream_of_or_within fibroblast migration PubMed 
    involved_in mitotic actomyosin contractile ring assembly actin filament organization  
    acts_upstream_of_or_within negative regulation of dephosphorylation PubMed 
    involved_in neuron projection extension  
    involved_in neuron projection extension  
    involved_in platelet-derived growth factor receptor signaling pathway PubMed 
    involved_in podocyte development  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of dendrite development  
    involved_in positive regulation of dendrite development  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of peptidyl-tyrosine autophosphorylation  
    involved_in positive regulation of protein kinase activity PubMed 
    involved_in positive regulation of protein kinase activity  
    involved_in positive regulation of protein localization  
    involved_in positive regulation of protein localization  
    involved_in positive regulation of vascular associated smooth muscle cell migration  
    involved_in positive regulation of vascular associated smooth muscle cell migration  
    acts_upstream_of_or_within regulation of cytokine production PubMed 
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of postsynapse assembly  
    involved_in response to angiotensin  
    Items 1 - 25 of 39
    Items 1 - 20 of 44
    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    colocalizes_with actin cytoskeleton  
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in axon  
    located_in axon  
    located_in basolateral plasma membrane PubMed 
    is_active_in cell cortex  
    located_in cell leading edge PubMed 
    located_in cell leading edge PubMed 
    located_in cell-cell junction PubMed 
    located_in cortical actin cytoskeleton PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in cytoplasmic side of plasma membrane  
    located_in cytoplasmic side of plasma membrane  
    located_in focal adhesion PubMed 
    located_in focal adhesion  
    located_in growth cone  
    located_in growth cone  
    located_in lateral plasma membrane PubMed 
    located_in microtubule  
    located_in microtubule  
    located_in microtubule cytoskeleton  
    colocalizes_with microtubule cytoskeleton  
    located_in midbody  
    located_in midbody  
    located_in neuron projection PubMed 
    located_in neuron projection  
    located_in neuron projection  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynapse  
    part_of protein-containing complex  
    part_of ribonucleoprotein complex PubMed 
    part_of ribonucleoprotein complex PubMed 
    located_in ruffle  
    located_in ruffle  
    located_in slit diaphragm  
    Items 1 - 20 of 44

    General protein information

    Preferred Names
    ras GTPase-activating-like protein IQGAP1
    Names
    Cdc42-Rac1 effector protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016721.2NP_057930.2  ras GTPase-activating-like protein IQGAP1

      See identical proteins and their annotated locations for NP_057930.2

      Status: VALIDATED

      Source sequence(s)
      AK160892, AK164482, BQ174517, BY107028, CB519254, DV069947
      Consensus CDS
      CCDS40001.1
      UniProtKB/Swiss-Prot
      G3UW45, Q9JKF1
      UniProtKB/TrEMBL
      Q80UW7
      Related
      ENSMUSP00000128278.2, ENSMUST00000167377.3
      Conserved Domains (6) summary
      smart00015
      Location:774796
      IQ; Calmodulin-binding motif
      cd05133
      Location:10031382
      RasGAP_IQGAP1; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 1
      smart00323
      Location:9921344
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd00014
      Location:45159
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00201
      Location:685712
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam03836
      Location:14521580
      RasGAP_C; RasGAP C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      80361331..80453288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001785567.3 RNA Sequence

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