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Iqgap1 IQ motif containing GTPase activating protein 1 [ Mus musculus (house mouse) ]

Gene ID: 29875, updated on 9-Dec-2024

Summary

Official Symbol
Iqgap1provided by MGI
Official Full Name
IQ motif containing GTPase activating protein 1provided by MGI
Primary source
MGI:MGI:1352757
See related
Ensembl:ENSMUSG00000030536 AllianceGenome:MGI:1352757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0051; D7Ertd237e; D7Ertd257e
Summary
Enables small GTPase binding activity. Involved in several processes, including caveola assembly; cell surface receptor protein tyrosine kinase signaling pathway; and cellular response to epidermal growth factor stimulus. Acts upstream of or within fibroblast migration; negative regulation of dephosphorylation; and regulation of cytokine production. Located in several cellular components, including basolateral plasma membrane; focal adhesion; and lateral plasma membrane. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Orthologous to human IQGAP1 (IQ motif containing GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in lung adult (RPKM 47.3), spleen adult (RPKM 27.7) and 27 other tissues See more
Orthologs
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Genomic context

See Iqgap1 in Genome Data Viewer
Location:
7 D3; 7 45.68 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80361331..80453288, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80711583..80815549, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87699700-87699906 Neighboring gene predicted gene, 42398 Neighboring gene STARR-seq mESC enhancer starr_19331 Neighboring gene CREB regulated transcription coactivator 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87792406-87792515 Neighboring gene predicted gene 15880 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87812125-87812234 Neighboring gene STARR-positive B cell enhancer ABC_E6567 Neighboring gene predicted gene, 18392 Neighboring gene STARR-seq mESC enhancer starr_19336 Neighboring gene VISTA enhancer mm170 Neighboring gene STARR-positive B cell enhancer ABC_E10447 Neighboring gene STARR-seq mESC enhancer starr_19340 Neighboring gene STARR-positive B cell enhancer ABC_E11358 Neighboring gene STARR-seq mESC enhancer starr_19343 Neighboring gene STARR-positive B cell enhancer ABC_E552 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:88009760-88009913 Neighboring gene zinc finger and SCAN domain containing 2 Neighboring gene predicted gene, 32112 Neighboring gene WD repeat domain 73

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 28
Function Evidence Code Pubs
enables GTPase activator activity  
enables MAP-kinase scaffold activity  
enables MAP-kinase scaffold activity  
enables S100 protein binding  
enables S100 protein binding  
enables actin filament binding  
enables calcium ion binding  
enables calcium ion binding  
enables calmodulin binding  
enables calmodulin binding  
enables calmodulin binding  
enables mitogen-activated protein kinase binding  
enables mitogen-activated protein kinase binding  
enables molecular adaptor activity  
enables phosphatidylinositol-3,4,5-trisphosphate binding  
enables phosphatidylinositol-3,4,5-trisphosphate binding  
enables protein binding PubMed 
enables protein domain specific binding  
enables protein domain specific binding  
enables protein kinase binding  
enables protein phosphatase binding  
enables protein phosphatase binding  
enables protein serine/threonine kinase activator activity  
enables protein serine/threonine kinase activator activity  
enables protein-containing complex binding  
enables protein-containing complex binding  
enables small GTPase binding PubMed 
enables small GTPase binding  
Items 1 - 25 of 28
Items 1 - 25 of 39
Process Evidence Code Pubs
involved_in MAPK cascade  
involved_in caveola assembly PubMed 
involved_in cell migration  
involved_in cellular response to calcium ion  
involved_in cellular response to calcium ion  
involved_in cellular response to epidermal growth factor stimulus PubMed 
involved_in cellular response to epidermal growth factor stimulus  
involved_in cellular response to fibroblast growth factor stimulus PubMed 
involved_in cellular response to platelet-derived growth factor stimulus PubMed 
involved_in epidermal growth factor receptor signaling pathway  
involved_in epidermal growth factor receptor signaling pathway PubMed 
involved_in epidermal growth factor receptor signaling pathway  
involved_in fibroblast growth factor receptor signaling pathway PubMed 
involved_in fibroblast migration  
acts_upstream_of_or_within fibroblast migration PubMed 
involved_in mitotic actomyosin contractile ring assembly actin filament organization  
acts_upstream_of_or_within negative regulation of dephosphorylation PubMed 
involved_in neuron projection extension  
involved_in neuron projection extension  
involved_in platelet-derived growth factor receptor signaling pathway PubMed 
involved_in podocyte development  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of dendrite development  
involved_in positive regulation of dendrite development  
involved_in positive regulation of focal adhesion assembly  
involved_in positive regulation of focal adhesion assembly  
involved_in positive regulation of peptidyl-tyrosine autophosphorylation  
involved_in positive regulation of protein kinase activity PubMed 
involved_in positive regulation of protein kinase activity  
involved_in positive regulation of protein localization  
involved_in positive regulation of protein localization  
involved_in positive regulation of vascular associated smooth muscle cell migration  
involved_in positive regulation of vascular associated smooth muscle cell migration  
acts_upstream_of_or_within regulation of cytokine production PubMed 
involved_in regulation of mitotic cell cycle  
involved_in regulation of mitotic cell cycle  
involved_in regulation of postsynapse assembly  
involved_in response to angiotensin  
Items 1 - 25 of 39
Items 1 - 20 of 44
Component Evidence Code Pubs
located_in actin cytoskeleton  
colocalizes_with actin cytoskeleton  
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
located_in axon  
located_in axon  
located_in basolateral plasma membrane PubMed 
is_active_in cell cortex  
located_in cell leading edge PubMed 
located_in cell leading edge PubMed 
located_in cell-cell junction PubMed 
located_in cortical actin cytoskeleton PubMed 
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytoplasmic ribonucleoprotein granule  
located_in cytoplasmic ribonucleoprotein granule  
located_in cytoplasmic side of plasma membrane  
located_in cytoplasmic side of plasma membrane  
located_in focal adhesion PubMed 
located_in focal adhesion  
located_in growth cone  
located_in growth cone  
located_in lateral plasma membrane PubMed 
located_in microtubule  
located_in microtubule  
located_in microtubule cytoskeleton  
colocalizes_with microtubule cytoskeleton  
located_in midbody  
located_in midbody  
located_in neuron projection PubMed 
located_in neuron projection  
located_in neuron projection  
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus  
located_in plasma membrane  
located_in plasma membrane  
located_in postsynapse  
part_of protein-containing complex  
part_of ribonucleoprotein complex PubMed 
part_of ribonucleoprotein complex PubMed 
located_in ruffle  
located_in ruffle  
located_in slit diaphragm  
Items 1 - 20 of 44

General protein information

Preferred Names
ras GTPase-activating-like protein IQGAP1
Names
Cdc42-Rac1 effector protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016721.2NP_057930.2  ras GTPase-activating-like protein IQGAP1

    See identical proteins and their annotated locations for NP_057930.2

    Status: VALIDATED

    Source sequence(s)
    AK160892, AK164482, BQ174517, BY107028, CB519254, DV069947
    Consensus CDS
    CCDS40001.1
    UniProtKB/Swiss-Prot
    G3UW45, Q9JKF1
    UniProtKB/TrEMBL
    Q80UW7
    Related
    ENSMUSP00000128278.2, ENSMUST00000167377.3
    Conserved Domains (6) summary
    smart00015
    Location:774796
    IQ; Calmodulin-binding motif
    cd05133
    Location:10031382
    RasGAP_IQGAP1; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 1
    smart00323
    Location:9921344
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:45159
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00201
    Location:685712
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam03836
    Location:14521580
    RasGAP_C; RasGAP C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    80361331..80453288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001785567.3 RNA Sequence

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