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    SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein [ Homo sapiens (human) ]

    Gene ID: 10492, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SYNCRIPprovided by HGNC
    Official Full Name
    synaptotagmin binding cytoplasmic RNA interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16918
    See related
    Ensembl:ENSG00000135316 MIM:616686; AllianceGenome:HGNC:16918
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP68; NSAP1; GRYRBP; HNRNPQ; HNRPQ1; GRY-RBP; hnRNP-Q
    Summary
    This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 21.7), appendix (RPKM 18.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SYNCRIP in Genome Data Viewer
    Location:
    6q14.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (85607784..85643870, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (86824588..86863388, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (86317502..86352604, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24787 Neighboring gene 5'-nucleotidase ecto Neighboring gene ReSE screen-validated silencer GRCh37_chr6:86210956-86211197 Neighboring gene sorting nexin 14 Neighboring gene Sharpr-MPRA regulatory region 13581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:86262889-86263390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:86263391-86263890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:86302067-86302652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:86302653-86303236 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:86303237-86303820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17368 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17369 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17370 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:86378928-86379449 Neighboring gene MPRA-validated peak5939 silencer Neighboring gene pyruvate kinase M1/2 pseudogene 3 Neighboring gene small nucleolar RNA, C/D box 50A Neighboring gene small nucleolar RNA host gene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Oculopharyngeal muscular dystrophy mutations link the RNA-binding protein HNRNPQ to autophagosome biogenesis. Ishtayeh H, et al. Aging Cell, 2023 Oct. PMID 37559347, Free PMC Article
    2. ATP binds nucleic-acid-binding domains beyond RRM fold. He Y, et al. Biochem Biophys Res Commun, 2020 Feb 19. PMID 31791586
    3. Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders. Gillentine MA, et al. Genome Med, 2021 Apr 19. PMID 33874999, Free PMC Article
    4. The GAIT system: a gatekeeper of inflammatory gene expression. Mukhopadhyay R, et al. Trends Biochem Sci, 2009 Jul. PMID 19535251, Free PMC Article
    5. SYNCRIP (synaptotagmin-binding, cytoplasmic RNA-interacting protein) is a host factor involved in hepatitis C virus RNA replication. Liu HM, et al. Virology, 2009 Apr 10. PMID 19232660, Free PMC Article

    See all (317) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oculopharyngeal muscular dystrophy mutations link the RNA-binding protein HNRNPQ to autophagosome biogenesis.
      Title: Oculopharyngeal muscular dystrophy mutations link the RNA-binding protein HNRNPQ to autophagosome biogenesis.
    2. Further evidence for de novo variants in SYNCRIP as the cause of a neurodevelopmental disorder.
      Title: Further evidence for de novo variants in SYNCRIP as the cause of a neurodevelopmental disorder.
    3. A novel antisense lncRNA NT5E promotes progression by modulating the expression of SYNCRIP and predicts a poor prognosis in pancreatic cancer.
      Title: A novel antisense lncRNA NT5E promotes progression by modulating the expression of SYNCRIP and predicts a poor prognosis in pancreatic cancer.
    4. ATP binds nucleic-acid-binding domains beyond RRM fold.
      Title: ATP binds nucleic-acid-binding domains beyond RRM fold.
    5. the terminal loop of pri-let-7a was shown to be the main contributor for its interaction with SYNCRIP. Functional studies demonstrated that the SYNCRIP RRM2-3 domain can promote the processing of pri-let-7a
      Title: SYNCRIP, a new player in pri-let-7a processing.
    6. Identification of the frequent presence of hnRNP R and hnRNP Q in frontotemporal lobar degeneration (FTLD)-FUS inclusions suggests a potential role for these hnRNPs in FTLD-FUS pathogenesis and supports the role of dysfunctional RNA metabolism in FTLD.
      Title: Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS.
    7. Results indentified two candidate haploinsufficient genes contiguous at 6q14 SYNCRIP (encoding hnRNP-Q) and SNHG5 (that hosts snoRNAs), both involved in regulating RNA maturation and translation inT-cell acute lymphoblastic leukemia (T-ALL).
      Title: Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation.
    8. The EGF/hnRNP Q1-induced translation of Aurora-A mRNA is mediated by the mTOR and ERK pathways.
      Title: The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes.
    9. A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets.
      Title: A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets.
    10. our data indicate that hnRNP Q1 is a novel trans-acting factor that binds to Aurora-A mRNA 5'-UTRs and regulates its translation, which increases cell proliferation and contributes to tumorigenesis in colorectal cancer
      Title: Translational upregulation of Aurora-A by hnRNP Q1 contributes to cell proliferation and tumorigenesis in colorectal cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2024-04-15)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2024-04-15)

    ClinGen Genome Curation PagePubMed

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein Q (HNRNPQ; SYNCRIP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein Q (HNRNPQ; SYNCRIP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein Q (HNRNPQ; SYNCRIP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag hnRNP Q overexpression in HIV-1 infected HeLa cells increases levels of the HIV-1 Gag-p24 protein, while levels of viral Rev-dependent mRNAs are not affected PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein Q (HNRNPQ; SYNCRIP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev hnRNP Q overexpression increases levels of reporter proteins in a Rev-dependent manner PubMed
    rev HIV-1 Rev interacting protein, synaptotagmin binding, cytoplasmic RNA interacting protein, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SYNCRIP is increased by RRE PubMed
    rev HIV-1 Rev involves its amino acids 9-14 for specific binding to the heterogeneous nuclear ribonucleoproteins (hnRNP) Q PubMed
    capsid gag hnRNP Q overexpression in HIV-1 infected HeLa cells increases levels of the HIV-1 Gag-p24 protein, while levels of viral Rev-dependent mRNAs are not affected PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ31626

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables mRNA 5'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CRD-mediated mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CRD-mediated mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in RNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in RNA splicing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromosomal 5-methylcytosine DNA demethylation pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in osteoblast differentiation HDA PubMed 
    involved_in positive regulation of cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CRD-mediated mRNA stability complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CRD-mediated mRNA stability complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CRD-mediated mRNA stability complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of GAIT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone pre-mRNA 3'end processing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mCRD-mediated mRNA stability complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of mRNA editing complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein Q
    Names
    NS1-associated protein 1
    glycine- and tyrosine-rich RNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031848.1 RefSeqGene

      Range
      5440..34350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001159673.2 → NP_001153145.1  heterogeneous nuclear ribonucleoprotein Q isoform 2

      See identical proteins and their annotated locations for NP_001153145.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region and initiates translation at an alternate in-frame start codon, compared to variant 1. The resulting isoform (2) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AB209098, AF037448, AL136082, BF221524
      Consensus CDS
      CCDS75491.1
      UniProtKB/TrEMBL
      B7Z645, Q59GL1
      Related
      ENSP00000484577.1, ENST00000616122.5
      Conserved Domains (1) summary
      TIGR01648
      Location:5 → 459
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    2. NM_001159674.2 → NP_001153146.1  heterogeneous nuclear ribonucleoprotein Q isoform 3

      See identical proteins and their annotated locations for NP_001153146.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and coding region compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB209098, AF037448, AL136082, BC032643, BF221524
      UniProtKB/TrEMBL
      A0A7I2V4Z0
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 522
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    3. NM_001159675.1 → NP_001153147.1  heterogeneous nuclear ribonucleoprotein Q isoform 4

      See identical proteins and their annotated locations for NP_001153147.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (4) is shorter, compared to isoform 1.
      Source sequence(s)
      AL136082, AY034482, BC015575, DB160837
      Consensus CDS
      CCDS93967.1
      UniProtKB/TrEMBL
      B2R8Z8
      Related
      ENSP00000504120.1, ENST00000678930.1
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 580
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    4. NM_001159676.1 → NP_001153148.1  heterogeneous nuclear ribonucleoprotein Q isoform 5

      See identical proteins and their annotated locations for NP_001153148.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR, and coding region compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB209098, AL136082, AY034483, BC015575, BF221524
      Consensus CDS
      CCDS93966.1
      UniProtKB/TrEMBL
      A0A7I2V4Z0, A0A7I2YQN2
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 553
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    5. NM_001159677.2 → NP_001153149.1  heterogeneous nuclear ribonucleoprotein Q isoform 6

      See identical proteins and their annotated locations for NP_001153149.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 3' UTR and coding region compared to variant 1. The resulting isoform (6) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB209098, AF155568, AL136082, BF221524
      Consensus CDS
      CCDS55041.1
      UniProtKB/TrEMBL
      A0A7I2V4Z0
      Related
      ENSP00000347380.6, ENST00000355238.11
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 557
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    6. NM_001253771.2 → NP_001240700.1  heterogeneous nuclear ribonucleoprotein Q isoform 7

      See identical proteins and their annotated locations for NP_001240700.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 3' UTR, lacks an internal exon, uses an alternate splice site in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (7) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AA411631, AB209098, BC040844, BF221524, CV806885
      UniProtKB/Swiss-Prot
      O60506
      UniProtKB/TrEMBL
      Q59GL1
      Conserved Domains (1) summary
      TIGR01648
      Location:11 → 405
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    7. NM_001410938.1 → NP_001397867.1  heterogeneous nuclear ribonucleoprotein Q isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL136082
      Consensus CDS
      CCDS93965.1
      UniProtKB/TrEMBL
      A0A7I2V2F2, A0A7I2V309
      Related
      ENSP00000503183.1, ENST00000678899.1

    8. NM_006372.5 → NP_006363.4  heterogeneous nuclear ribonucleoprotein Q isoform 1

      See identical proteins and their annotated locations for NP_006363.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF037448, AL136082, DA117533, DB160837
      Consensus CDS
      CCDS5005.1
      UniProtKB/Swiss-Prot
      E1P501, E1P502, O60506, Q53H05, Q5TCG2, Q5TCG3, Q8IW78, Q8N599, Q96LC1, Q96LC2, Q9Y583
      UniProtKB/TrEMBL
      B2R8Z8
      Related
      ENSP00000358635.3, ENST00000369622.8
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 615
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      85607784..85643870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010179.2 → XP_016865668.1  heterogeneous nuclear ribonucleoprotein Q isoform X5

      UniProtKB/TrEMBL
      A0A7I2V4Z0, A0A7I2YQN2
      Related
      ENSP00000504816.1, ENST00000677771.1
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 553
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    2. XM_017010178.3 → XP_016865667.1  heterogeneous nuclear ribonucleoprotein Q isoform X4

      UniProtKB/TrEMBL
      A0A7I2V4Z0
      Related
      ENSP00000503246.1, ENST00000678528.1
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 557
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    3. XM_047418082.1 → XP_047274038.1  heterogeneous nuclear ribonucleoprotein Q isoform X3

      UniProtKB/TrEMBL
      B2R8Z8

    4. XM_047418081.1 → XP_047274037.1  heterogeneous nuclear ribonucleoprotein Q isoform X2

      UniProtKB/TrEMBL
      B2R8Z8

    5. XM_047418083.1 → XP_047274039.1  heterogeneous nuclear ribonucleoprotein Q isoform X6

      UniProtKB/TrEMBL
      A0A7I2V2F2

    6. XM_005248635.5 → XP_005248692.1  heterogeneous nuclear ribonucleoprotein Q isoform X5

      See identical proteins and their annotated locations for XP_005248692.1

      UniProtKB/TrEMBL
      A0A7I2V4Z0, A0A7I2YQN2
      Related
      ENSP00000504086.1, ENST00000678878.1
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 553
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    7. XM_017010177.2 → XP_016865666.1  heterogeneous nuclear ribonucleoprotein Q isoform X3

      UniProtKB/TrEMBL
      B2R8Z8
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 592
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    8. XM_017010176.2 → XP_016865665.1  heterogeneous nuclear ribonucleoprotein Q isoform X2

      UniProtKB/TrEMBL
      B2R8Z8
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 592
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    9. XM_005248637.3 → XP_005248694.1  heterogeneous nuclear ribonucleoprotein Q isoform X1

      See identical proteins and their annotated locations for XP_005248694.1

      UniProtKB/Swiss-Prot
      E1P501, E1P502, O60506, Q53H05, Q5TCG2, Q5TCG3, Q8IW78, Q8N599, Q96LC1, Q96LC2, Q9Y583
      UniProtKB/TrEMBL
      B2R8Z8
      Related
      ENSP00000504706.1, ENST00000676688.1
      Conserved Domains (2) summary
      TIGR01648
      Location:103 → 615
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd21066
      Location:23 → 107
      NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      86824588..86863388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354042.1 → XP_054210017.1  heterogeneous nuclear ribonucleoprotein Q isoform X5

      UniProtKB/TrEMBL
      A0A7I2V4Z0, A0A7I2YQN2

    2. XM_054354040.1 → XP_054210015.1  heterogeneous nuclear ribonucleoprotein Q isoform X4

      UniProtKB/TrEMBL
      A0A7I2V4Z0

    3. XM_054354039.1 → XP_054210014.1  heterogeneous nuclear ribonucleoprotein Q isoform X3

      UniProtKB/TrEMBL
      B2R8Z8

    4. XM_054354037.1 → XP_054210012.1  heterogeneous nuclear ribonucleoprotein Q isoform X2

      UniProtKB/TrEMBL
      B2R8Z8

    5. XM_054354043.1 → XP_054210018.1  heterogeneous nuclear ribonucleoprotein Q isoform X6

      UniProtKB/TrEMBL
      A0A7I2V2F2

    6. XM_054354041.1 → XP_054210016.1  heterogeneous nuclear ribonucleoprotein Q isoform X5

      UniProtKB/TrEMBL
      A0A7I2V4Z0, A0A7I2YQN2

    7. XM_054354038.1 → XP_054210013.1  heterogeneous nuclear ribonucleoprotein Q isoform X3

      UniProtKB/TrEMBL
      B2R8Z8

    8. XM_054354036.1 → XP_054210011.1  heterogeneous nuclear ribonucleoprotein Q isoform X2

      UniProtKB/TrEMBL
      B2R8Z8

    9. XM_054354035.1 → XP_054210010.1  heterogeneous nuclear ribonucleoprotein Q isoform X1

      UniProtKB/Swiss-Prot
      E1P501, E1P502, O60506, Q53H05, Q5TCG2, Q5TCG3, Q8IW78, Q8N599, Q96LC1, Q96LC2, Q9Y583
      UniProtKB/TrEMBL
      B2R8Z8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60506.2 GenPept UniProtKB/Swiss-Prot:O60506

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