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    Tep1 Thioester-containing protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34937, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tep1provided by FlyBase
    Official Full Name
    Thioester-containing protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0041183
    Locus tag
    Dmel_CG18096
    See related
    AllianceGenome:FB:FBgn0041183
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00365.2; CG18096; Dmel\CG18096; dTEPI; Tep 1; Tep I; TEP I; Tep-1; tep1; TEP1; TEP1mel; TepI
    Summary
    Predicted to enable endopeptidase inhibitor activity. Involved in innate immune response. Predicted to be located in extracellular space. Is expressed in embryonic/larval fat body; embryonic/larval hemocyte; embryonic/larval lymph gland; and proventriculus. Orthologous to human CD109 (CD109 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tep1 in Genome Data Viewer
    Location:
    35D6-35D6; 2-51 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15888640..15893811, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15888640..15893811, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Independent effects on cellular and humoral immune responses underlie genotype-by-genotype interactions between Drosophila and parasitoids. Leitão AB, et al. PLoS Pathog, 2019 Oct. PMID 31589659, Free PMC Article
    2. Activation of immune defences against parasitoid wasps does not underlie the cost of infection. Leitão AB, et al. Front Immunol, 2023. PMID 38130722, Free PMC Article
    3. The Pupal Ectoparasitoid Pachycrepoideus vindemmiae Regulates Cellular and Humoral Immunity of Host Drosophila melanogaster. Yang L, et al. Front Physiol, 2019. PMID 31680999, Free PMC Article
    4. Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response. Shokal U, et al. Front Immunol, 2017. PMID 28706521, Free PMC Article
    5. Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization. Haller S, et al. EMBO Rep, 2018 May. PMID 29523648, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Thioester-containing protein 1
    Names
    CG18096-PA
    TEP
    Tep1-PA
    thioester containing protein I
    thiolester containing protein I

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15888640..15893811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078854.2 → NP_523578.1  Thioester-containing protein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523578.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NFV8, Q9VJN1
      Related
      FBpp0080369
      Conserved Domains (6) summary
      cd02897
      Location:859 → 1135
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:634 → 726
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:116 → 201
      A2M_N; MG2 domain
      pfam07677
      Location:1245 → 1335
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:910 → 1135
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:411 → 542
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NFV8 Q9NFV8

    Gene LinkOut

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