|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
859-1135 |
4.15e-120 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 375.76 E-value: 4.15e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 859 LEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTW 938
Cdd:cd02897 2 LQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGSTW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 939 LTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNS----HGSPLALTSFVLLTFFENEeyMPKYK 1014
Cdd:cd02897 82 LTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAmqggVDDEVALTAYVLIALLEAG--LPSER 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1015 HVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGDHKWWT----------GSDKCKSSEVE 1084
Cdd:cd02897 160 PVVEKALSCLEAALDSISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSrpppseegpsYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 17648001 1085 TTSYVLLALLEHNISD--EPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKY 1135
Cdd:cd02897 240 MTAYALLALLSAGGEDlaEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
117-1200 |
3.57e-42 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 169.49 E-value: 3.57e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 117 YIQSDKATYKPGDKIQFRVLFLDKNTRPAViDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTAT 196
Cdd:COG2373 372 FLFTDRGIYRPGETVHLKALLRDADGKAPA-GLPLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELY 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 197 VQDEGKV--TNVLVVDkYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGhvvATIEGS--------------- 259
Cdd:COG2373 451 VDPKPALgsKSFRVEE-FKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAG---LKVEGEvtlrpartafpgypg 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 260 ---------STEQSLPI-------DGEVNVEFPISATAKRLLKITAIVTEELTDIkhNG-----TAYVTVHQHRHKL--- 315
Cdd:COG2373 527 yrfgdpdeeFEPEELDLgegtldaDGKASLSLPLPDAPDAPGPLRATVEASVFES--GGrpvtrSATVPVHPADFYVgir 604
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 316 EDLFWPthYRPGVSSEFKTVVRNLDGSPVmdSSKMVNFNVLccQVSKNF--SASLQNSIATEHIMLPETCQSCLVTSTFD 393
Cdd:COG2373 605 LPLFDG--DPEGAPATFEVVAVDPDGKPV--AGKGLKVELY--REEWRYvwYKSDDGGWRYESQEKEEPVAEGTLTTGAD 678
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 394 TAENIE-------RY----------------IY-------KLNKPLMIAINTKKPQLRK--LLKINIISdtylPY--FIL 439
Cdd:COG2373 679 GPASLSltpvewgRYrlevkdpdgglatsvrFYaggnaswGAERPDRLELSLDKESYKPgeTAKLLIQS----PFagRAL 754
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 440 TVVARGNIVLSLFQEMKekKKSQEIEFEPTFALVPQATIFVHYIIDGVlmSDEKT----------VDIER-DFENTIEIL 508
Cdd:COG2373 755 VTVERDGVLETQWVDVK--GGGTTVEIPVTEDWAPNAYVSATLVRPGD--STANDmparaygvapLPVDPpARRLKVELT 830
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 509 TTNEALPRDEVSLKVKTNPH----SFVGLLGVDQSVLLL---RSGNDLN-----RDLilnNLATYST-DLVILTNANINI 575
Cdd:COG2373 831 APEKLRPGETLTVTVKVKGAagkaAEVTLAAVDEGILNLtgyKTPDPLDffygkRAL---GVETRDLyGRLIGAFGGAAG 907
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 576 YRSSGGcytnpgytnctgsligrtmfkneptknsgpvpiVGSTRAQASLPPVRKLFPETWLFSNITDVGANGEYIIKETV 655
Cdd:COG2373 908 ALRSGG---------------------------------DGALGRGGNPKPPRKRFKPVALFSGPVKTDADGKATVSFDL 954
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 656 PDTLTSWVITGFSLSPQS-GLAVtrnpSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLG--MDVKAKVlmdNSDGQ 732
Cdd:COG2373 955 PDFNGTLRVMAVAWSDDRfGSAE----ATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGkaGTVTVTL---EASGG 1027
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 733 YEFIETTNKNVSqylrgvrrkktlwIPANTGRGISFMIRPKKVGLTTLKITAISKYAGDRLHQILKVEADGVQkyvnkav 812
Cdd:COG2373 1028 LTLEGEATQTVT-------------LAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDAREVELPVRPANPL------- 1087
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 813 linVQRLNRRSLAPPE-KTIIIEKADNVIEGSETVEFEVcGTSQAPQLE-HLDDLVHLPCGCGEQNMFNFVPSILALSYL 890
Cdd:COG2373 1088 ---VTRATSGVLAPGEsWTLPLDLPGGLRPGTGSLTLSL-SSSPPLDLAgLLRYLLRYPYGCTEQTTSRALPLLYLSDLA 1163
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 891 KAKNRQDQEIENKAKRyVETGYQIELNYKRNDGSFSAW-GQHDAlgSTWLTAYVIRSFHQAAKY-IDIDKNVLVAGLDFL 968
Cdd:COG2373 1164 EALGLKGDKDAELRAR-IQAAIARLLSMQNSDGGFGLWpGGSES--DPWLTAYATDFLLEAREAgYAVPDDALDRALDYL 1240
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 969 VSRQSTDGkfkelgmVIHNSHGSPLALTSFVLLTFFENEE----YMPKYKhviDRAVEFvvtevhQSNEPYDLAIAALAL 1044
Cdd:COG2373 1241 RNYLRNPW-------EIEYDDAYRLAVRAYALYVLARAGKadlgDLRYLY---DRRKDA------LSPLAKAQLAAALAL 1304
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1045 SLARNRnAYKVLDKLDKLATRRGDHKWWTGSDkckSSEVETTSYVLLALLEHNISDE-PKPIVDWLISKRNSnGGFVSSQ 1123
Cdd:COG2373 1305 LGDKAR-AEELLAAALARLRETGARDYWYGDY---GSPLRDQALALALLAELGPDAPlAPKLARWLAKALKS-GRWLSTQ 1379
|
1130 1140 1150 1160 1170 1180 1190
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17648001 1124 DTVVGIMALTKYeLQSHASTEAIDIEFWhlnEDKKHVRVTKENEFKVQTHQLPE-NTNEVKLLAKGQGRAQVQLTYRY 1200
Cdd:COG2373 1380 ETAWALLALAAY-ARAAGASPDFTATLT---LDGKTLPLTGRGPLARVTLPAAElLAGPLTITNTGDGPLYYTLTLSG 1453
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1243-1336 |
3.61e-27 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 106.50 E-value: 3.61e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1243 KTTNMALMQVQLPSGYVCDIEPFADIEAISDVKRVETkNEDTEVHIYFEKLSpGDRKCLTLEAIYTHAVANLKPSWVRLY 1322
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVET-VDDGKVILYLDKLS-GEPLCFSFRAEQTFPVANLKPAPVKVY 78
|
90
....*....|....
gi 17648001 1323 DYYATERSATEFYH 1336
Cdd:pfam07677 79 DYYEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
859-1135 |
4.15e-120 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 375.76 E-value: 4.15e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 859 LEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTW 938
Cdd:cd02897 2 LQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGSTW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 939 LTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNS----HGSPLALTSFVLLTFFENEeyMPKYK 1014
Cdd:cd02897 82 LTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAmqggVDDEVALTAYVLIALLEAG--LPSER 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1015 HVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGDHKWWT----------GSDKCKSSEVE 1084
Cdd:cd02897 160 PVVEKALSCLEAALDSISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSrpppseegpsYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 17648001 1085 TTSYVLLALLEHNISD--EPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKY 1135
Cdd:cd02897 240 MTAYALLALLSAGGEDlaEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
845-1135 |
2.56e-75 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 252.60 E-value: 2.56e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 845 TVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGS 924
Cdd:pfam07678 2 SVVGDIMGPAIQVVPENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 925 FSAWGQHDalGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNS-HGS---PLALTSFVL 1000
Cdd:pfam07678 82 YSAFGHSP--GSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAmKGGvdgEVSLTAYVT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1001 LTFFENEEYM---PKYKHVIDRAVEFVVTEVH-QSNEPYDLAIAALALSLARNR-NAYKVLDKLDKLATRRGDHKWWT-- 1073
Cdd:pfam07678 160 IALLEALDINgllQRVHPSIRKALTYLEQAQLaGLTSPYTLAILAYALALAGSPeTREELLKSLDAMAREEGNSRYWErd 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17648001 1074 ----------GSDKCKSSEVETTSYVLLALL---EHNISDepkPIVDWLISKRNSNGGFVSSQDTVVGIMALTKY 1135
Cdd:pfam07678 240 eksdpqgvpeYPPQAPSLEVETTAYALLAYLllgDLTYAD---PIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
117-1200 |
3.57e-42 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 169.49 E-value: 3.57e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 117 YIQSDKATYKPGDKIQFRVLFLDKNTRPAViDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTAT 196
Cdd:COG2373 372 FLFTDRGIYRPGETVHLKALLRDADGKAPA-GLPLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELY 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 197 VQDEGKV--TNVLVVDkYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGhvvATIEGS--------------- 259
Cdd:COG2373 451 VDPKPALgsKSFRVEE-FKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAG---LKVEGEvtlrpartafpgypg 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 260 ---------STEQSLPI-------DGEVNVEFPISATAKRLLKITAIVTEELTDIkhNG-----TAYVTVHQHRHKL--- 315
Cdd:COG2373 527 yrfgdpdeeFEPEELDLgegtldaDGKASLSLPLPDAPDAPGPLRATVEASVFES--GGrpvtrSATVPVHPADFYVgir 604
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 316 EDLFWPthYRPGVSSEFKTVVRNLDGSPVmdSSKMVNFNVLccQVSKNF--SASLQNSIATEHIMLPETCQSCLVTSTFD 393
Cdd:COG2373 605 LPLFDG--DPEGAPATFEVVAVDPDGKPV--AGKGLKVELY--REEWRYvwYKSDDGGWRYESQEKEEPVAEGTLTTGAD 678
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 394 TAENIE-------RY----------------IY-------KLNKPLMIAINTKKPQLRK--LLKINIISdtylPY--FIL 439
Cdd:COG2373 679 GPASLSltpvewgRYrlevkdpdgglatsvrFYaggnaswGAERPDRLELSLDKESYKPgeTAKLLIQS----PFagRAL 754
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 440 TVVARGNIVLSLFQEMKekKKSQEIEFEPTFALVPQATIFVHYIIDGVlmSDEKT----------VDIER-DFENTIEIL 508
Cdd:COG2373 755 VTVERDGVLETQWVDVK--GGGTTVEIPVTEDWAPNAYVSATLVRPGD--STANDmparaygvapLPVDPpARRLKVELT 830
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 509 TTNEALPRDEVSLKVKTNPH----SFVGLLGVDQSVLLL---RSGNDLN-----RDLilnNLATYST-DLVILTNANINI 575
Cdd:COG2373 831 APEKLRPGETLTVTVKVKGAagkaAEVTLAAVDEGILNLtgyKTPDPLDffygkRAL---GVETRDLyGRLIGAFGGAAG 907
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 576 YRSSGGcytnpgytnctgsligrtmfkneptknsgpvpiVGSTRAQASLPPVRKLFPETWLFSNITDVGANGEYIIKETV 655
Cdd:COG2373 908 ALRSGG---------------------------------DGALGRGGNPKPPRKRFKPVALFSGPVKTDADGKATVSFDL 954
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 656 PDTLTSWVITGFSLSPQS-GLAVtrnpSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLG--MDVKAKVlmdNSDGQ 732
Cdd:COG2373 955 PDFNGTLRVMAVAWSDDRfGSAE----ATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGkaGTVTVTL---EASGG 1027
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 733 YEFIETTNKNVSqylrgvrrkktlwIPANTGRGISFMIRPKKVGLTTLKITAISKYAGDRLHQILKVEADGVQkyvnkav 812
Cdd:COG2373 1028 LTLEGEATQTVT-------------LAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDAREVELPVRPANPL------- 1087
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 813 linVQRLNRRSLAPPE-KTIIIEKADNVIEGSETVEFEVcGTSQAPQLE-HLDDLVHLPCGCGEQNMFNFVPSILALSYL 890
Cdd:COG2373 1088 ---VTRATSGVLAPGEsWTLPLDLPGGLRPGTGSLTLSL-SSSPPLDLAgLLRYLLRYPYGCTEQTTSRALPLLYLSDLA 1163
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 891 KAKNRQDQEIENKAKRyVETGYQIELNYKRNDGSFSAW-GQHDAlgSTWLTAYVIRSFHQAAKY-IDIDKNVLVAGLDFL 968
Cdd:COG2373 1164 EALGLKGDKDAELRAR-IQAAIARLLSMQNSDGGFGLWpGGSES--DPWLTAYATDFLLEAREAgYAVPDDALDRALDYL 1240
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 969 VSRQSTDGkfkelgmVIHNSHGSPLALTSFVLLTFFENEE----YMPKYKhviDRAVEFvvtevhQSNEPYDLAIAALAL 1044
Cdd:COG2373 1241 RNYLRNPW-------EIEYDDAYRLAVRAYALYVLARAGKadlgDLRYLY---DRRKDA------LSPLAKAQLAAALAL 1304
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1045 SLARNRnAYKVLDKLDKLATRRGDHKWWTGSDkckSSEVETTSYVLLALLEHNISDE-PKPIVDWLISKRNSnGGFVSSQ 1123
Cdd:COG2373 1305 LGDKAR-AEELLAAALARLRETGARDYWYGDY---GSPLRDQALALALLAELGPDAPlAPKLARWLAKALKS-GRWLSTQ 1379
|
1130 1140 1150 1160 1170 1180 1190
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17648001 1124 DTVVGIMALTKYeLQSHASTEAIDIEFWhlnEDKKHVRVTKENEFKVQTHQLPE-NTNEVKLLAKGQGRAQVQLTYRY 1200
Cdd:COG2373 1380 ETAWALLALAAY-ARAAGASPDFTATLT---LDGKTLPLTGRGPLARVTLPAAElLAGPLTITNTGDGPLYYTLTLSG 1453
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
634-726 |
1.20e-34 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 127.70 E-value: 1.20e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 634 TWLFSNItDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRnPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVF 713
Cdd:pfam00207 1 TWLWDPV-LVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAE-PPELVVFKPFFVDLNLPYSVRRGEQFELKATVF 78
|
90
....*....|...
gi 17648001 714 NYLGMDVKAKVLM 726
Cdd:pfam00207 79 NYLDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1243-1336 |
3.61e-27 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 106.50 E-value: 3.61e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1243 KTTNMALMQVQLPSGYVCDIEPFADIEAISDVKRVETkNEDTEVHIYFEKLSpGDRKCLTLEAIYTHAVANLKPSWVRLY 1322
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVET-VDDGKVILYLDKLS-GEPLCFSFRAEQTFPVANLKPAPVKVY 78
|
90
....*....|....
gi 17648001 1323 DYYATERSATEFYH 1336
Cdd:pfam07677 79 DYYEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
859-1135 |
4.15e-120 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 375.76 E-value: 4.15e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 859 LEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDALGSTW 938
Cdd:cd02897 2 LQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGSTW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 939 LTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNS----HGSPLALTSFVLLTFFENEeyMPKYK 1014
Cdd:cd02897 82 LTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAmqggVDDEVALTAYVLIALLEAG--LPSER 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1015 HVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGDHKWWT----------GSDKCKSSEVE 1084
Cdd:cd02897 160 PVVEKALSCLEAALDSISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSrpppseegpsYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 17648001 1085 TTSYVLLALLEHNISD--EPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKY 1135
Cdd:cd02897 240 MTAYALLALLSAGGEDlaEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
859-1135 |
1.83e-85 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 280.43 E-value: 1.83e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 859 LEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDAlGSTW 938
Cdd:cd02891 2 LGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDS-GSTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 939 LTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNS----HGSPLALTSFVLLTFFENEEYMPkyk 1014
Cdd:cd02891 81 LTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREmkggVDDSVSLTAYVLIALAEAGKACD--- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1015 HVIDRAVEFVVTEVHQSNEPYDLAIA----ALALSLARNRNAYKVLDKLDKLATRRGDHKWWTGSDKCKSSEVETTSYVL 1090
Cdd:cd02891 158 ASIEKALAYLETQLDGLLDPYALAILayalALAGDSTRADEALKKLLEAAREKGGTAHWSLSWPGDYGSSLRVEATAYAL 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 17648001 1091 LALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKY 1135
Cdd:cd02891 238 LALLKLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
845-1135 |
2.56e-75 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 252.60 E-value: 2.56e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 845 TVEFEVCGTSQAPQLEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGS 924
Cdd:pfam07678 2 SVVGDIMGPAIQVVPENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 925 FSAWGQHDalGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNS-HGS---PLALTSFVL 1000
Cdd:pfam07678 82 YSAFGHSP--GSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAmKGGvdgEVSLTAYVT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1001 LTFFENEEYM---PKYKHVIDRAVEFVVTEVH-QSNEPYDLAIAALALSLARNR-NAYKVLDKLDKLATRRGDHKWWT-- 1073
Cdd:pfam07678 160 IALLEALDINgllQRVHPSIRKALTYLEQAQLaGLTSPYTLAILAYALALAGSPeTREELLKSLDAMAREEGNSRYWErd 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17648001 1074 ----------GSDKCKSSEVETTSYVLLALL---EHNISDepkPIVDWLISKRNSNGGFVSSQDTVVGIMALTKY 1135
Cdd:pfam07678 240 eksdpqgvpeYPPQAPSLEVETTAYALLAYLllgDLTYAD---PIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
859-1135 |
1.15e-69 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 236.02 E-value: 1.15e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 859 LEHLDDLVHLPCGCGEQNMFNFVPSILALSYLKAKN---RQDQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQHDalG 935
Cdd:cd02896 2 PEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNqweKLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRP--S 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 936 STWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNS-HG------SPLALTSFVLLTFFENEE 1008
Cdd:cd02896 80 STWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREmTGgvegseGDVSLTAFVLIALQEARS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1009 YMP----KYKHVIDRAVEFVVTEVHQSNEPYDLAIAALALSLARNRNAYKVLDKLDKLATRRGDHK--WWTGSDKCKSSE 1082
Cdd:cd02896 160 ICPpevqNLDQSIRKAISYLENQLPNLQRPYALAITAYALALADSPLSHAANRKLLSLAKRDGNGWywWTIDSPYWPVPG 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 17648001 1083 -----VETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKY 1135
Cdd:cd02896 240 psaitVETTAYALLALLKLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
859-1135 |
2.60e-52 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 186.22 E-value: 2.60e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 859 LEHLDDLVHLPCG--------CGEQNMFNFVPSILALSYLKAknrqdQEIENKAKRYVETGYQIELNYKRNDGSFSAWGQ 930
Cdd:cd00688 2 EKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAA-----TGIRDKADENIEKGIQRLLSYQLSDGGFSGWGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 931 HDaLGSTWLTAYVIRSFHQAAKYIDIDKNVLVAGLDFLVSRQSTDGKFKELGMVIHNSHGSP--LALTSFVLLTFFENEE 1008
Cdd:cd00688 77 ND-YPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHRIGGDEsdVRLTAYALIALALLGK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1009 YMPkyKHVIDRAVEFVvtEVHQSNEPYDLAIAAL-------------ALSLARNRNAYKVLDKLDKLATRRGDHKWWT-- 1073
Cdd:cd00688 156 LDP--DPLIEKALDYL--LSCQNYDGGFGPGGEShgygtacaaaalaLLGDLDSPDAKKALRWLLSRQRPDGGWGEGRdr 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17648001 1074 GSDKCKSSEVETTSYVLLALLEHNISDEPKPIVDWLISKRNSNGGFVS-------SQDTVVGIMALTKY 1135
Cdd:cd00688 232 TNKLSDSCYTEWAAYALLALGKLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFALLALSLY 300
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
117-1200 |
3.57e-42 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 169.49 E-value: 3.57e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 117 YIQSDKATYKPGDKIQFRVLFLDKNTRPAViDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTAT 196
Cdd:COG2373 372 FLFTDRGIYRPGETVHLKALLRDADGKAPA-GLPLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELY 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 197 VQDEGKV--TNVLVVDkYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGhvvATIEGS--------------- 259
Cdd:COG2373 451 VDPKPALgsKSFRVEE-FKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAG---LKVEGEvtlrpartafpgypg 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 260 ---------STEQSLPI-------DGEVNVEFPISATAKRLLKITAIVTEELTDIkhNG-----TAYVTVHQHRHKL--- 315
Cdd:COG2373 527 yrfgdpdeeFEPEELDLgegtldaDGKASLSLPLPDAPDAPGPLRATVEASVFES--GGrpvtrSATVPVHPADFYVgir 604
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 316 EDLFWPthYRPGVSSEFKTVVRNLDGSPVmdSSKMVNFNVLccQVSKNF--SASLQNSIATEHIMLPETCQSCLVTSTFD 393
Cdd:COG2373 605 LPLFDG--DPEGAPATFEVVAVDPDGKPV--AGKGLKVELY--REEWRYvwYKSDDGGWRYESQEKEEPVAEGTLTTGAD 678
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 394 TAENIE-------RY----------------IY-------KLNKPLMIAINTKKPQLRK--LLKINIISdtylPY--FIL 439
Cdd:COG2373 679 GPASLSltpvewgRYrlevkdpdgglatsvrFYaggnaswGAERPDRLELSLDKESYKPgeTAKLLIQS----PFagRAL 754
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 440 TVVARGNIVLSLFQEMKekKKSQEIEFEPTFALVPQATIFVHYIIDGVlmSDEKT----------VDIER-DFENTIEIL 508
Cdd:COG2373 755 VTVERDGVLETQWVDVK--GGGTTVEIPVTEDWAPNAYVSATLVRPGD--STANDmparaygvapLPVDPpARRLKVELT 830
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 509 TTNEALPRDEVSLKVKTNPH----SFVGLLGVDQSVLLL---RSGNDLN-----RDLilnNLATYST-DLVILTNANINI 575
Cdd:COG2373 831 APEKLRPGETLTVTVKVKGAagkaAEVTLAAVDEGILNLtgyKTPDPLDffygkRAL---GVETRDLyGRLIGAFGGAAG 907
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 576 YRSSGGcytnpgytnctgsligrtmfkneptknsgpvpiVGSTRAQASLPPVRKLFPETWLFSNITDVGANGEYIIKETV 655
Cdd:COG2373 908 ALRSGG---------------------------------DGALGRGGNPKPPRKRFKPVALFSGPVKTDADGKATVSFDL 954
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 656 PDTLTSWVITGFSLSPQS-GLAVtrnpSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVFNYLG--MDVKAKVlmdNSDGQ 732
Cdd:COG2373 955 PDFNGTLRVMAVAWSDDRfGSAE----ATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGkaGTVTVTL---EASGG 1027
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 733 YEFIETTNKNVSqylrgvrrkktlwIPANTGRGISFMIRPKKVGLTTLKITAISKYAGDRLHQILKVEADGVQkyvnkav 812
Cdd:COG2373 1028 LTLEGEATQTVT-------------LAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDAREVELPVRPANPL------- 1087
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 813 linVQRLNRRSLAPPE-KTIIIEKADNVIEGSETVEFEVcGTSQAPQLE-HLDDLVHLPCGCGEQNMFNFVPSILALSYL 890
Cdd:COG2373 1088 ---VTRATSGVLAPGEsWTLPLDLPGGLRPGTGSLTLSL-SSSPPLDLAgLLRYLLRYPYGCTEQTTSRALPLLYLSDLA 1163
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 891 KAKNRQDQEIENKAKRyVETGYQIELNYKRNDGSFSAW-GQHDAlgSTWLTAYVIRSFHQAAKY-IDIDKNVLVAGLDFL 968
Cdd:COG2373 1164 EALGLKGDKDAELRAR-IQAAIARLLSMQNSDGGFGLWpGGSES--DPWLTAYATDFLLEAREAgYAVPDDALDRALDYL 1240
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 969 VSRQSTDGkfkelgmVIHNSHGSPLALTSFVLLTFFENEE----YMPKYKhviDRAVEFvvtevhQSNEPYDLAIAALAL 1044
Cdd:COG2373 1241 RNYLRNPW-------EIEYDDAYRLAVRAYALYVLARAGKadlgDLRYLY---DRRKDA------LSPLAKAQLAAALAL 1304
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1045 SLARNRnAYKVLDKLDKLATRRGDHKWWTGSDkckSSEVETTSYVLLALLEHNISDE-PKPIVDWLISKRNSnGGFVSSQ 1123
Cdd:COG2373 1305 LGDKAR-AEELLAAALARLRETGARDYWYGDY---GSPLRDQALALALLAELGPDAPlAPKLARWLAKALKS-GRWLSTQ 1379
|
1130 1140 1150 1160 1170 1180 1190
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17648001 1124 DTVVGIMALTKYeLQSHASTEAIDIEFWhlnEDKKHVRVTKENEFKVQTHQLPE-NTNEVKLLAKGQGRAQVQLTYRY 1200
Cdd:COG2373 1380 ETAWALLALAAY-ARAAGASPDFTATLT---LDGKTLPLTGRGPLARVTLPAAElLAGPLTITNTGDGPLYYTLTLSG 1453
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
634-726 |
1.20e-34 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 127.70 E-value: 1.20e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 634 TWLFSNItDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRnPSRIRVFQPFFITTNLPYSVKRGEVIAIPVIVF 713
Cdd:pfam00207 1 TWLWDPV-LVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAE-PPELVVFKPFFVDLNLPYSVRRGEQFELKATVF 78
|
90
....*....|...
gi 17648001 714 NYLGMDVKAKVLM 726
Cdd:pfam00207 79 NYLDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1243-1336 |
3.61e-27 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 106.50 E-value: 3.61e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 1243 KTTNMALMQVQLPSGYVCDIEPFADIEAISDVKRVETkNEDTEVHIYFEKLSpGDRKCLTLEAIYTHAVANLKPSWVRLY 1322
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVET-VDDGKVILYLDKLS-GEPLCFSFRAEQTFPVANLKPAPVKVY 78
|
90
....*....|....
gi 17648001 1323 DYYATERSATEFYH 1336
Cdd:pfam07677 79 DYYEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
409-543 |
1.16e-19 |
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Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 86.63 E-value: 1.16e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 409 LMIAINTKKPQLRKLLKINIIS----DTYLPYFILTVVARGNIVLSlfqemKEKKKSQEIEFEPTFALVPQATIFVHYII 484
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSpfdgTVERDGFTYLVLSKGQIVVV-----GRGGVTTSFSLPVTAEMAPSARVVAYYVR 75
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17648001 485 ----DGVLMSDEKTVDIERDFENTIEI-LTTNEALPRDEVSLKVKTNPHSFVGLLGVDQSVLLL 543
Cdd:pfam07703 76 vdlsKPEVVADSVWVDVDDTCENKLKVtLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
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| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
116-204 |
1.46e-14 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 70.42 E-value: 1.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 116 LYIQSDKATYKPGDKIQFRVLFLDKNTRPAViDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSDRPVLGNWTVTA 195
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLA-GLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVL 80
|
....*....
gi 17648001 196 TVQDEGKVT 204
Cdd:pfam01835 81 RDGAGGSLG 89
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| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
211-284 |
1.53e-08 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 53.04 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17648001 211 KYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVKGHVVATI---------EGSSTEQSLPIDGEVNVEFPISATA 281
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLclkddskrkCFESFSKELDKDGCGSASLSTEEFQ 80
|
...
gi 17648001 282 KRL 284
Cdd:pfam17791 81 LTF 83
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