eyg eyegone [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eygprovided by FlyBase
Official Full Name: eyegoneprovided by FlyBase
Primary source: FLYBASE:FBgn0000625
Locus tag: Dmel_CG10488
See related: AllianceGenome:FB:FBgn0000625
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Bk27; BK27; CG10488; Dmel\CG10488; Eyg; EYG; lun
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including antennal development; negative regulation of transcription by RNA polymerase II; and notum development. Located in nucleus. Is expressed in several structures, including antennal sense organ; embryonic imaginal tissue; epithelium; imaginal disc; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 69C2-69C2; 3-38 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12462537..12468021, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12455637..12461121, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eyg interacts with Aubergine (Aub), a component of the pi-RNA pathway during egg chamber development. This interaction could be essential for Eyg to be retained in the cytoplasm and fulfill its functions there.
Title: The Pax protein Eyegone (Eyg) interacts with the pi-RNA component Aubergine (Aub) and controls egg chamber development in Drosophila.
eyg has a dose-dependent effect on heterochromatin gene silencing and identifies a genetic interaction with HP1a in this process.
Title: Functional association between eyegone and HP1a mediates wingless transcriptional repression during development.
Eyg is required for the development of the lateral bristles in the head vertex.
Title: The role of eyg Pax gene in the development of the head vertex in Drosophila.
The function of eyg in eye development is required only at the second instar larval stage, while its function for head and antenna development can be provided at any time during embryo and larval development.
Title: Temporal switching of regulation and function of eye gone (eyg) in Drosophila eye development.
Eyg makes differential use of several domains when compared to Toe, and the number of repressor domains also differs between the two Pax6(5a) homologs.
Title: Differential requirements for the Pax6(5a) genes eyegone and twin of eyegone during eye development in Drosophila.
eyg is the first dedicated repressor Pax protein; acts exclusively as a transcriptional repressor
Title: Eyg and Ey Pax proteins act by distinct transcriptional mechanisms in Drosophila development.
Data show that eyegone and its related gene, twin of eyegone (toe), are expressed in part of the anterior compartment of the adult mesothorax (notum).
Title: The Pax-homeobox gene eyegone is involved in the subdivision of the thorax of Drosophila.
Data report the identification of a Drosophila Pax gene, eye gone (eyg), which is required for eye development and appears to act cooperatively with eyeless protein.
Title: Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development.
Notch signaling controls eye growth through Pax6 protein Eyegone (review)
Title: Growth and specification: fly Pax6 homologs eyegone and eyeless have distinct functions.
A major effector mediating the growth promotion function of Notch in the eye disc.
Title: Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in antennal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in notum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in salivary gland morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eyegone

Names: CG10488-PA; CG10488-PB; CG10488-PC; eye gone; eyeone; eyg-PA; eyg-PB; eyg-PC; eygone; lune

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

12462537..12468021 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300118.1 → NP_001287047.1 eyegone, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287047.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A4P2YUU9, Q8MTJ1, Q9VTX7

Conserved Domains (2) summary

pfam00046
Location:352 → 404

Homeobox; Homeobox domain

cl21459
Location:120 → 217

HTH; Helix-turn-helix domains
NM_001014582.2 → NP_001014582.1 eyegone, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014582.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A4P2YUU9, Q8MTJ1, Q9VTX7

Conserved Domains (2) summary

pfam00046
Location:352 → 404

Homeobox; Homeobox domain

cl21459
Location:120 → 217

HTH; Helix-turn-helix domains
NM_079318.3 → NP_524042.2 eyegone, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524042.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A4P2YUU9, Q8MTJ1, Q9VTX7

Related

FBpp0075711

Conserved Domains (2) summary

pfam00046
Location:352 → 404

Homeobox; Homeobox domain

cl21459
Location:120 → 217

HTH; Helix-turn-helix domains