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Conserved domains on  [gi|24663292|ref|NP_524042|]
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eyegone, isoform A [Drosophila melanogaster]

Protein Classification

homeobox protein( domain architecture ID 11021495)

homeobox protein with a paired box domain similar to mammalian Pax6, a transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas, and Drosophila gooseberry-neuro, which is involved in defining the polarity of embryonic segments

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
120-217 1.45e-37

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member smart00351:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 125  Bit Score: 135.91  E-value: 1.45e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663292    120 HRLLEFSRfGGLRGYDIAQHMLTQQGAVSKLL------GSLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRE 193
Cdd:smart00351  24 QRIVELAQ-NGVRPCDISRQLCVSHGCVSKILgryyetGSIRP-GAIGGSKPKVATPKVVKKIADYKQENPGIFAWEIRD 101
                           90       100
                   ....*....|....*....|....
gi 24663292    194 RLISEGVCTNATAPSVSSINRILR 217
Cdd:smart00351 102 RLLSEGVCDKDNVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
349-405 7.18e-29

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 109.13  E-value: 7.18e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24663292   349 RRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARVQVWFSNRRAKWRR 405
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
120-217 1.45e-37

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 135.91  E-value: 1.45e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663292    120 HRLLEFSRfGGLRGYDIAQHMLTQQGAVSKLL------GSLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRE 193
Cdd:smart00351  24 QRIVELAQ-NGVRPCDISRQLCVSHGCVSKILgryyetGSIRP-GAIGGSKPKVATPKVVKKIADYKQENPGIFAWEIRD 101
                           90       100
                   ....*....|....*....|....
gi 24663292    194 RLISEGVCTNATAPSVSSINRILR 217
Cdd:smart00351 102 RLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
119-220 4.94e-37

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 134.47  E-value: 4.94e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663292 119 QHRLLEFSRfGGLRGYDIAQHMLTQQGAVSKLL------GSLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIR 192
Cdd:cd00131  23 RQRIVELAQ-SGIRPCDISRQLRVSHGCVSKILnryyetGSIRP-GAIGGSKPRVATPEVVKKIEIYKQENPGMFAWEIR 100
                        90       100
                ....*....|....*....|....*...
gi 24663292 193 ERLISEGVCTNATAPSVSSINRILRNRA 220
Cdd:cd00131 101 DRLLQEGVCDKSNVPSVSSINRILRNKA 128
PAX pfam00292
'Paired box' domain;
119-217 8.76e-34

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 125.37  E-value: 8.76e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663292   119 QHRLLEFSRfGGLRGYDIAQHMLTQQGAVSKLL------GSLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIR 192
Cdd:pfam00292  23 RQKIVELAH-SGVRPCDISRQLRVSHGCVSKILgryyetGSIRP-GVIGGSKPKVATPEVVTKIAEYKRENPSIFAWEIR 100
                          90       100
                  ....*....|....*....|....*
gi 24663292   193 ERLISEGVCTNATAPSVSSINRILR 217
Cdd:pfam00292 101 DRLLKEGVCDNDTVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
349-405 7.18e-29

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 109.13  E-value: 7.18e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24663292   349 RRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARVQVWFSNRRAKWRR 405
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
349-407 1.87e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 99.24  E-value: 1.87e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24663292 349 RRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARVQVWFSNRRAKWRRHQ 407
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
349-404 6.14e-25

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 97.71  E-value: 6.14e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24663292    349 RRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARVQVWFSNRRAKWR 404
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
310-408 2.37e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.45  E-value: 2.37e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663292 310 TPTNRAISPGSGSHDTlESADenrHIDSDYLDDDDEPKFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSE 389
Cdd:COG5576  17 MPQIRTIKTTKNKREV-EAAD---SEMKLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPP 92
                        90
                ....*....|....*....
gi 24663292 390 ARVQVWFSNRRAKWRRHQR 408
Cdd:COG5576  93 KSVQIWFQNKRAKEKKKRS 111
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
120-217 1.45e-37

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 135.91  E-value: 1.45e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663292    120 HRLLEFSRfGGLRGYDIAQHMLTQQGAVSKLL------GSLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRE 193
Cdd:smart00351  24 QRIVELAQ-NGVRPCDISRQLCVSHGCVSKILgryyetGSIRP-GAIGGSKPKVATPKVVKKIADYKQENPGIFAWEIRD 101
                           90       100
                   ....*....|....*....|....
gi 24663292    194 RLISEGVCTNATAPSVSSINRILR 217
Cdd:smart00351 102 RLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
119-220 4.94e-37

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 134.47  E-value: 4.94e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663292 119 QHRLLEFSRfGGLRGYDIAQHMLTQQGAVSKLL------GSLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIR 192
Cdd:cd00131  23 RQRIVELAQ-SGIRPCDISRQLRVSHGCVSKILnryyetGSIRP-GAIGGSKPRVATPEVVKKIEIYKQENPGMFAWEIR 100
                        90       100
                ....*....|....*....|....*...
gi 24663292 193 ERLISEGVCTNATAPSVSSINRILRNRA 220
Cdd:cd00131 101 DRLLQEGVCDKSNVPSVSSINRILRNKA 128
PAX pfam00292
'Paired box' domain;
119-217 8.76e-34

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 125.37  E-value: 8.76e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663292   119 QHRLLEFSRfGGLRGYDIAQHMLTQQGAVSKLL------GSLRPpGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIR 192
Cdd:pfam00292  23 RQKIVELAH-SGVRPCDISRQLRVSHGCVSKILgryyetGSIRP-GVIGGSKPKVATPEVVTKIAEYKRENPSIFAWEIR 100
                          90       100
                  ....*....|....*....|....*
gi 24663292   193 ERLISEGVCTNATAPSVSSINRILR 217
Cdd:pfam00292 101 DRLLKEGVCDNDTVPSVSSINRILR 125
Homeodomain pfam00046
Homeodomain;
349-405 7.18e-29

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 109.13  E-value: 7.18e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 24663292   349 RRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARVQVWFSNRRAKWRR 405
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
349-407 1.87e-25

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 99.24  E-value: 1.87e-25
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24663292 349 RRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARVQVWFSNRRAKWRRHQ 407
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
349-404 6.14e-25

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 97.71  E-value: 6.14e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24663292    349 RRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARVQVWFSNRRAKWR 404
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
310-408 2.37e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.45  E-value: 2.37e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663292 310 TPTNRAISPGSGSHDTlESADenrHIDSDYLDDDDEPKFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSE 389
Cdd:COG5576  17 MPQIRTIKTTKNKREV-EAAD---SEMKLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPP 92
                        90
                ....*....|....*....
gi 24663292 390 ARVQVWFSNRRAKWRRHQR 408
Cdd:COG5576  93 KSVQIWFQNKRAKEKKKRS 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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