vapb VAMP (vesicle-associated membrane protein)-associated protein B and C [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vapbprovided by ZNC
Official Full Name: VAMP (vesicle-associated membrane protein)-associated protein B and Cprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2348
See related: Ensembl:ENSDARG00000070435 AllianceGenome:ZFIN:ZDB-GENE-030131-2348
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc05d09; zgc:66045; wu:fa96d05; wu:fc05d09
Summary: Predicted to enable protein-membrane adaptor activity. Acts upstream of or within regulation of heart contraction and swimming behavior. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Is expressed in atrium; cardiac ventricle; and heart. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to human VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (49583151..49638688)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (49584570..49653214)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ALS-Linked VapB P56S Mutation Alters Neuronal Mitochondrial Turnover at the Synapse.
Title: ALS-Linked VapB P56S Mutation Alters Neuronal Mitochondrial Turnover at the Synapse.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fc05d09.x1 (e-PCR)
- UniSTS:203706

fk55b03.x1 (e-PCR)
- UniSTS:201184

fa96d05 (e-PCR)
- UniSTS:188906

fb70h02 (e-PCR)
- UniSTS:187376

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum-plasma membrane tethering	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of heart contraction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to unfolded protein	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vesicle-associated membrane protein-associated protein B/C

Names: vesicle-associated membrane protein, associated protein B and C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212647.2 → NP_997812.1 vesicle-associated membrane protein-associated protein B/C

See identical proteins and their annotated locations for NP_997812.1

Status: VALIDATED

Source sequence(s)

BX323459, EH552051

UniProtKB/TrEMBL

A0A2R8QTI7, F6NWL2, Q6P2B0

Related

ENSDARP00000094134.4, ENSDART00000103357.5

Conserved Domains (1) summary

pfam00635
Location:8 → 111

Motile_Sperm; MSP (Major sperm protein) domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

49583151..49638688

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021476783.2 → XP_021332458.1 vesicle-associated membrane protein-associated protein B/C isoform X1

UniProtKB/TrEMBL

A0A8M9PZG9

Conserved Domains (1) summary

pfam00635
Location:8 → 111

Motile_Sperm; MSP (Major sperm protein) domain