NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|47086745|ref|NP_997812|]
View 

vesicle-associated membrane protein-associated protein B/C [Danio rerio]

Protein Classification

motile sperm domain-containing protein( domain architecture ID 10457611)

motile sperm domain-containing protein may form filaments, similar to major motile sperm protein (MSP) and vesicle-associated membrane protein-associated proteins

CATH:  2.60.40.10
SCOP:  4007566

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Motile_Sperm pfam00635
MSP (Major sperm protein) domain; Major sperm proteins are involved in sperm motility. These ...
 8-111 7.91e-38

MSP (Major sperm protein) domain; Major sperm proteins are involved in sperm motility. These proteins oligomerise to form filaments. This family contains many other proteins.


:

Pssm-ID: 459882  Cd Length: 109  Bit Score: 128.25  E-value: 7.91e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086745     8 LLLEPQHELRFRGPFTDVVTTTLKLANPTDRNVCFKVKTTAPRRYCVRPNSGVIDAGTSINVSVMLQPFDYDPNEKSKHK 87
Cdd:pfam00635   2 LTIDPPDLIFFAAPGNKQGTSTLTLKNTSDKRVAFKVKTTNPKKYRVRPNYGIIKPGESVTITITRQPFDEEPGDAKKDK 81

                          90       100
                  ....*....|....*....|....*...
gi 47086745    88 FMVQSLLAPPDMTDTEGV----WKDAKP 111
Cdd:pfam00635  82 FVIQYAVAPGDEKDAKEAfkraWKTGAP 109
YhaN super family cl34808
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
164-243 9.19e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


The actual alignment was detected with superfamily member COG4717:

Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 37.05  E-value: 9.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086745 164 EVKKIMEECKRLQTEVQRLREENKQIRQEDDGLRMRKstvmsaPHSSLAVRVKEEGLSSRVIALIVLFFVVGVIVGKLAL 243
Cdd:COG4717 200 ELEELQQRLAELEEELEEAQEELEELEEELEQLENEL------EAAALEERLKEARLLLLIAAALLALLGLGGSLLSLIL 273
 
Name Accession Description Interval E-value
Motile_Sperm pfam00635
MSP (Major sperm protein) domain; Major sperm proteins are involved in sperm motility. These ...
 8-111 7.91e-38

MSP (Major sperm protein) domain; Major sperm proteins are involved in sperm motility. These proteins oligomerise to form filaments. This family contains many other proteins.


Pssm-ID: 459882  Cd Length: 109  Bit Score: 128.25  E-value: 7.91e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086745     8 LLLEPQHELRFRGPFTDVVTTTLKLANPTDRNVCFKVKTTAPRRYCVRPNSGVIDAGTSINVSVMLQPFDYDPNEKSKHK 87
Cdd:pfam00635   2 LTIDPPDLIFFAAPGNKQGTSTLTLKNTSDKRVAFKVKTTNPKKYRVRPNYGIIKPGESVTITITRQPFDEEPGDAKKDK 81

                          90       100
                  ....*....|....*....|....*...
gi 47086745    88 FMVQSLLAPPDMTDTEGV----WKDAKP 111
Cdd:pfam00635  82 FVIQYAVAPGDEKDAKEAfkraWKTGAP 109
SCS2 COG5066
VAMP-associated protein involved in inositol metabolism [Intracellular trafficking and ...
 15-134 4.37e-30

VAMP-associated protein involved in inositol metabolism [Intracellular trafficking and secretion];


Pssm-ID: 227398 [Multi-domain]  Cd Length: 242  Bit Score: 112.36  E-value: 4.37e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086745  15 ELRFRGPFTDVVTTTLKLANPTDRNVCFKVKTTAPRRYCVRPNSGVIDAGTSINVSVMLQPFDYD--PNEKSKHKFMVQS 92
Cdd:COG5066   8 QTTFYVPLTNKSKEMFSVQNNSPEPVGFKVKTTAPKDYCVRPNMGLIEPMSTVEVEVILQGLTEEpaPDFKCRDKFLIQS 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 47086745  93 LLAPPDMT--DTEGVWKDAKPEDLMDSKLRCVFDmpaENEKTHE 134
Cdd:COG5066  88 YRFDWRLSgsDFADHWTSSSKKPIWTRKIRCVYS---EEEISKN 128
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
164-243 9.19e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 37.05  E-value: 9.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086745 164 EVKKIMEECKRLQTEVQRLREENKQIRQEDDGLRMRKstvmsaPHSSLAVRVKEEGLSSRVIALIVLFFVVGVIVGKLAL 243
Cdd:COG4717 200 ELEELQQRLAELEEELEEAQEELEELEEELEQLENEL------EAAALEERLKEARLLLLIAAALLALLGLGGSLLSLIL 273
 
Name Accession Description Interval E-value
Motile_Sperm pfam00635
MSP (Major sperm protein) domain; Major sperm proteins are involved in sperm motility. These ...
 8-111 7.91e-38

MSP (Major sperm protein) domain; Major sperm proteins are involved in sperm motility. These proteins oligomerise to form filaments. This family contains many other proteins.


Pssm-ID: 459882  Cd Length: 109  Bit Score: 128.25  E-value: 7.91e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086745     8 LLLEPQHELRFRGPFTDVVTTTLKLANPTDRNVCFKVKTTAPRRYCVRPNSGVIDAGTSINVSVMLQPFDYDPNEKSKHK 87
Cdd:pfam00635   2 LTIDPPDLIFFAAPGNKQGTSTLTLKNTSDKRVAFKVKTTNPKKYRVRPNYGIIKPGESVTITITRQPFDEEPGDAKKDK 81

                          90       100
                  ....*....|....*....|....*...
gi 47086745    88 FMVQSLLAPPDMTDTEGV----WKDAKP 111
Cdd:pfam00635  82 FVIQYAVAPGDEKDAKEAfkraWKTGAP 109
SCS2 COG5066
VAMP-associated protein involved in inositol metabolism [Intracellular trafficking and ...
 15-134 4.37e-30

VAMP-associated protein involved in inositol metabolism [Intracellular trafficking and secretion];


Pssm-ID: 227398 [Multi-domain]  Cd Length: 242  Bit Score: 112.36  E-value: 4.37e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086745  15 ELRFRGPFTDVVTTTLKLANPTDRNVCFKVKTTAPRRYCVRPNSGVIDAGTSINVSVMLQPFDYD--PNEKSKHKFMVQS 92
Cdd:COG5066   8 QTTFYVPLTNKSKEMFSVQNNSPEPVGFKVKTTAPKDYCVRPNMGLIEPMSTVEVEVILQGLTEEpaPDFKCRDKFLIQS 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 47086745  93 LLAPPDMT--DTEGVWKDAKPEDLMDSKLRCVFDmpaENEKTHE 134
Cdd:COG5066  88 YRFDWRLSgsDFADHWTSSSKKPIWTRKIRCVYS---EEEISKN 128
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
164-243 9.19e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 37.05  E-value: 9.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47086745 164 EVKKIMEECKRLQTEVQRLREENKQIRQEDDGLRMRKstvmsaPHSSLAVRVKEEGLSSRVIALIVLFFVVGVIVGKLAL 243
Cdd:COG4717 200 ELEELQQRLAELEEELEEAQEELEELEEELEQLENEL------EAAALEERLKEARLLLLIAAALLALLGLGGSLLSLIL 273
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH