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    srrm2 serine/arginine repetitive matrix 2 [ Danio rerio (zebrafish) ]

    Gene ID: 553531, updated on 4-Jan-2025

    Summary

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    Official Symbol
    srrm2provided by ZNC
    Official Full Name
    serine/arginine repetitive matrix 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-399
    See related
    Ensembl:ENSDARG00000037965 AllianceGenome:ZFIN:ZDB-GENE-050522-399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110023
    Summary
    Predicted to act upstream of or within mRNA processing. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human SRRM2 (serine/arginine repetitive matrix 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See srrm2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (32631336..32650278)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (32499622..32518564)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene unc-119 lipid binding chaperone c Neighboring gene matrix metallopeptidase 25a Neighboring gene THO complex 6 Neighboring gene si:dkey-16l2.16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons. Torres-Méndez A, et al. Nat Ecol Evol, 2019 Apr. PMID 30833759
    2. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110023

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine repetitive matrix protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030075.2 → NP_001025246.2  serine/arginine repetitive matrix protein 2

      Status: VALIDATED

      Source sequence(s)
      BX571714, CU459155
      UniProtKB/TrEMBL
      A0A8M1N752, F1QLP6, F1QUP6
      Related
      ENSDARP00000110322.3, ENSDART00000129339.4
      Conserved Domains (1) summary
      pfam08312
      Location:61 → 103
      cwf21; cwf21 domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      32631336..32650278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470715.2 → XP_021326390.1  serine/arginine repetitive matrix protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PZ27
      Conserved Domains (4) summary
      pfam08312
      Location:61 → 103
      cwf21; cwf21 domain
      cl25887
      Location:482 → 584
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl28033
      Location:743 → 917
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
      cl28310
      Location:288 → 515
      Rho; Transcription termination factor Rho [Transcription]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394535.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      118898..137860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395227.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      380..12204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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