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    st8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 [ Danio rerio (zebrafish) ]

    Gene ID: 553212, updated on 9-Dec-2024

    Summary

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    Official Symbol
    st8sia6provided by ZNC
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060322-9
    See related
    Ensembl:ENSDARG00000021195 AllianceGenome:ZFIN:ZDB-GENE-060322-9
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa12f08; fb95c11; siat 8F; wu:fa12f08; wu:fb95c11
    Summary
    Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Acts upstream of or within olfactory nerve formation and olfactory placode morphogenesis. Predicted to be located in Golgi membrane. Is expressed in several structures, including cardiovascular system; central nervous system; myotome; pleuroperitoneal region; and unfertilized egg. Orthologous to human ST8SIA6 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See st8sia6 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (16265502..16282357)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (16115535..16135457)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, beta 1 subunit Neighboring gene ribosomal protein L19 Neighboring gene branched chain keto acid dehydrogenase E1 subunit beta, like Neighboring gene gap junction protein gamma 1 Neighboring gene elongation factor Tu GTP binding domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation of oligosialylation in zebrafish. Chang LY, et al. Glycoconj J, 2009 Apr. PMID 18704683
    2. Novel Zebrafish Mono-α2,8-sialyltransferase (ST8Sia VIII): An Evolutionary Perspective of α2,8-Sialylation. Chang LY, et al. Int J Mol Sci, 2019 Jan 31. PMID 30709055, Free PMC Article
    3. Molecular cloning and characterization of the expression pattern of the zebrafish alpha2, 8-sialyltransferases (ST8Sia) in the developing nervous system. Chang LY, et al. Glycoconj J, 2009 Apr. PMID 18642128
    4. Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome. Garaffo G, et al. Front Endocrinol (Lausanne), 2013. PMID 24427155, Free PMC Article
    5. Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Vanbeselaere J, et al. J Proteome Res, 2012 Apr 6. PMID 22352757

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within olfactory nerve formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within olfactory placode morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-2,8-sialyltransferase 8F
    Names
    alpha-2,8-sialyltransferase ST8Sia VI
    XP_021327056.1
    XP_683398.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      16265502..16282357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_678306.10 → XP_683398.2  alpha-2,8-sialyltransferase 8F

      UniProtKB/TrEMBL
      A0A8M9PXN4, F1R0F8
      Related
      ENSDARP00000104838.2, ENSDART00000122519.3
      Conserved Domains (1) summary
      pfam00777
      Location:95 → 351
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394525.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      22945..42705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471381.2 → XP_021327056.1  alpha-2,8-sialyltransferase 8F

      UniProtKB/TrEMBL
      A0A8M9PXN4, F1R0F8
      Conserved Domains (1) summary
      pfam00777
      Location:95 → 351
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version

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