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Conserved domains on  [gi|125811451|ref|XP_683398|]
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alpha-2,8-sialyltransferase 8F [Danio rerio]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 77-351 6.91e-173

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467699  Cd Length: 271  Bit Score: 481.37  E-value: 6.91e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  77 ANYKRFRLLLNEKCHAVSKAVVTQNNTPLGSNVVYDGERRKPLQVTQALYNILAKEQPFGNATWESCAVVGNGGVLANSS 156
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 157 CGEEINSAQFVIRCNLPPLDDRyeKDVGNKTNLVTANPSILHEKYSGLMERRRPFVESLHSYGQALLLLPAFSYGHNTPV 236
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLNDS--KDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 237 SLRAFYTLEDFGREgPLPIFLNPEYLRKLTKFWREQGLNSVRPSTGLIMASLALEICTNVHLYGFWPFGKHPnDSRPITN 316
Cdd:cd23971  159 SLRALYTLEDFGSP-QKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISH 236

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125811451 317 HYYDNRESKKNVHSMPSEFEQLLKLHKQGVVHIHL 351
Cdd:cd23971  237 HYYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 77-351 6.91e-173

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 481.37  E-value: 6.91e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  77 ANYKRFRLLLNEKCHAVSKAVVTQNNTPLGSNVVYDGERRKPLQVTQALYNILAKEQPFGNATWESCAVVGNGGVLANSS 156
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 157 CGEEINSAQFVIRCNLPPLDDRyeKDVGNKTNLVTANPSILHEKYSGLMERRRPFVESLHSYGQALLLLPAFSYGHNTPV 236
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLNDS--KDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 237 SLRAFYTLEDFGREgPLPIFLNPEYLRKLTKFWREQGLNSVRPSTGLIMASLALEICTNVHLYGFWPFGKHPnDSRPITN 316
Cdd:cd23971  159 SLRALYTLEDFGSP-QKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISH 236

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125811451 317 HYYDNRESKKNVHSMPSEFEQLLKLHKQGVVHIHL 351
Cdd:cd23971  237 HYYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 97-346 1.93e-105

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 309.92  E-value: 1.93e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451   97 VVTQNNTPLGSNVVYdGERRKPLQVTQALYNILAKEQPFGNATWESCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLd 176
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  177 DRYEKDVGNKTNLVTANP-SILHEKYSGLMER--RRPFVESLHSY--GQALLLLPAFSYGHNTPVSLRAFYTLEDFG--R 249
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKipV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  250 EGPLPIFLNPEYLRKLTKFW-REQGLNSVRPSTGLIMASLALEICTNVHLYGFWPFgkhpNDSRPITNHYYDNRESKKN- 327
Cdd:pfam00777 159 DPDKVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF----LDSRGNSHHYYDNVLMKKGg 234

                         250       260
                  ....*....|....*....|..
gi 125811451  328 ---VHSMPSEFEQLLKLHKQGV 346
Cdd:pfam00777 235 fygVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 77-351 6.91e-173

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 481.37  E-value: 6.91e-173
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  77 ANYKRFRLLLNEKCHAVSKAVVTQNNTPLGSNVVYDGERRKPLQVTQALYNILAKEQPFGNATWESCAVVGNGGVLANSS 156
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 157 CGEEINSAQFVIRCNLPPLDDRyeKDVGNKTNLVTANPSILHEKYSGLMERRRPFVESLHSYGQALLLLPAFSYGHNTPV 236
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLNDS--KDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 237 SLRAFYTLEDFGREgPLPIFLNPEYLRKLTKFWREQGLNSVRPSTGLIMASLALEICTNVHLYGFWPFGKHPnDSRPITN 316
Cdd:cd23971  159 SLRALYTLEDFGSP-QKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDL-DGNPISH 236

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125811451 317 HYYDNRESKKNVHSMPSEFEQLLKLHKQGVVHIHL 351
Cdd:cd23971  237 HYYDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 77-351 3.76e-120

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 347.90  E-value: 3.76e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  77 ANYKRFRLLLNEKCHAVSKAVVTQNNTPLGSNVVYDGERRKPLQVTQALYNILAKEQPFGNATWESCAVVGNGGVLANSS 156
Cdd:cd23991    1 EEHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 157 CGEEINSAQFVIRCNLPPLDDRYEKDVGNKTNLVTANPSILHEKYSGLMERRRPFVESLHSYGQALLLLPAFSYGHNTPV 236
Cdd:cd23991   81 CGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 237 SLRAFYTLEDFGREGPlPIFLNPEYLRKLTKFWREQGLNSVRPSTGLIMASLALEICTNVHLYGFWPFGKHpNDSRPITN 316
Cdd:cd23991  161 SFKVYYTLEDFKAKQK-VIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKN-TEGKPISH 238

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 125811451 317 HYYDNRESKKNVHSMPSEFEQLLKLHKQGVVHIHL 351
Cdd:cd23991  239 HYYDNQLPKPGFHSMPKEFYQLLQLHSKGILKLQF 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 97-346 1.93e-105

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 309.92  E-value: 1.93e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451   97 VVTQNNTPLGSNVVYdGERRKPLQVTQALYNILAKEQPFGNATWESCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLd 176
Cdd:pfam00777   1 FLTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  177 DRYEKDVGNKTNLVTANP-SILHEKYSGLMER--RRPFVESLHSY--GQALLLLPAFSYGHNTPVSLRAFYTLEDFG--R 249
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKipV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  250 EGPLPIFLNPEYLRKLTKFW-REQGLNSVRPSTGLIMASLALEICTNVHLYGFWPFgkhpNDSRPITNHYYDNRESKKN- 327
Cdd:pfam00777 159 DPDKVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF----LDSRGNSHHYYDNVLMKKGg 234

                         250       260
                  ....*....|....*....|..
gi 125811451  328 ---VHSMPSEFEQLLKLHKQGV 346
Cdd:pfam00777 235 fygVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 80-351 1.68e-99

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 295.32  E-value: 1.68e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  80 KRFRLLLNEKCHAvSKAVVTQNNTPLGSNVVYDGERRKPLQVTQALYNILAKEQPFGNATWESCAVVGNGGVLANSSCGE 159
Cdd:cd23963    4 DKFRKELERLLNT-RKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 160 EINSAQFVIRCNLPPLdDRYEKDVGNKTNLVTANPSILHEKYSGLMERRRP--FVESLHSYGQALLLLPAFSYGHNTPVS 237
Cdd:cd23963   83 EIDSHDFVIRCNLPPI-KGFEKDVGRKTNLTTLNPSILKRRYNSLKKNRDRdkFLNRLKEYNGSILWYPKFSFKSSTNLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 238 LRAFYTLEDFGREgPLPIFLNPEYLRKLTKFWREQGLNSvRPSTGLIMASLALEICTNVHLYGFWPFGKHPNDsRPITNH 317
Cdd:cd23963  162 LKAARALKKNGLN-LTVVYSNPEHFLAVQKFWKRRGLEK-RPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNG-RPVPYH 238

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 125811451 318 YYDNR--ESKKNVHSMPSEFEQLLKLHKQGVVHIHL 351
Cdd:cd23963  239 YYDDLspSTKNKVHNMPEEFKLLRELHKKGVLKLHT 274
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 82-351 2.23e-97

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 290.19  E-value: 2.23e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  82 FRLLLNEKCHAVSKAVVTQNNTPLGSNVVYDGERRKPLQVTQALYNILAKEQPFgNATWESCAVVGNGGVLANSSCGEEI 161
Cdd:cd23989    6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPL-QLPLKKCSVVGNGGILKNSGCGQQI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 162 NSAQFVIRCNLPPLDDRYEKDVGNKTNLVTANPSILHEKYSGLMERRRPFVESLHSYGQALLLLPAFSYGHNTPVSLRAF 241
Cdd:cd23989   85 DRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVY 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 242 YTLEDFGREGPLpIFLNPEYLRKLTKFWREQGLNSVRPSTGLIMASLALEICTNVHLYGFWPFGKHPnDSRPITNHYYDN 321
Cdd:cd23989  165 YTLADVGANQTV-LFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDL-DERTISHHYYDN 242

                        250       260       270
                 ....*....|....*....|....*....|
gi 125811451 322 RESKKNVHSMPSEFEQLLKLHKQGVVHIHL 351
Cdd:cd23989  243 VLPDSGFHAMPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 80-350 2.35e-90

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 272.10  E-value: 2.35e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  80 KRFRLLLNEKCHAVSKAVVTQNNTPLGSNVVYDGERRKPLQVTQALYNILAKEQPFGNATWESCAVVGNGGVLANSSCGE 159
Cdd:cd23990    4 NAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 160 EINSAQFVIRCNLPPLDDRYEKDVGNKTNLVTANPSILHEKYSGLMERRRPFVESLHSYGQALLLLPAFSYGHNTPVSLR 239
Cdd:cd23990   84 EIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVSIR 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 240 AFYTLEDFgrEGPLPIF-LNPEYLRKLTKFWREQGLNSVRPSTGLIMASLALEICTNVHLYGFWPFGKHPNDSRpITNHY 318
Cdd:cd23990  164 VKYVLDDF--ESQQAVYyFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIF-ITHHY 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 125811451 319 YDNRESKKNVHSMPSEFEQLLKLHKQGVVHIH 350
Cdd:cd23990  241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVH 272
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 121-351 1.69e-71

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 224.19  E-value: 1.69e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 121 VTQALYNILAKEQPFGNATWESCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLdDRYEKDVGNKTNLVTANPSILHEK 200
Cdd:cd23970   49 ISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPT-EGFEKDVGRKTNLTTFNPSILEKY 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 201 YSGLM--ERRRPFVESLHSYGQALLLLPAFSYGHNTPVslraFYTLEDFGRE--GPLPIFLN-P-EYLRKLTKFWREQGL 274
Cdd:cd23970  128 YNNLLtiQDRNNFFLSLKKLDGAILWIPAFFFHTSATV----TRTLVDFFVEhrGQLKVQLAwPgNIMQHVNRYWKTKHL 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 275 NSVRPSTGLIMASLALEICTNVHLYGFWPFGKHPnDSRPITNHYYDNRESK-----KNVHSMPSEFEQLLKLHKQGVVHI 349
Cdd:cd23970  204 SPKRLSTGILMYTLASAICEEIHLYGFWPFGFDP-TGTPLPYHYYDKKGTKfttkwQESHQLPAEFVLLYKMHGAGVLKL 282


                 ..
gi 125811451 350 HL 351
Cdd:cd23970  283 TL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 98-350 8.68e-69

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 217.28  E-value: 8.68e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  98 VTQNNTPLGSNVVYDGERRKPLQVTQALYNILAKEQPFGNATWESCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDD 177
Cdd:cd23969   22 VLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 178 rYEKDVGNKTNLVTANPSILHEKYSGLMER--RRPFVESLHSYGQALLLLPAFSyghNTPVSLRAFYTLEDFGREGpLPI 255
Cdd:cd23969  102 -YEKDVGTKSNLTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAFV---SKGGEEHVQWTNEIILKHK-LNV 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 256 ---FLNPEYLRKLTKFWREQGLNSVRPSTGLIMASLALEICTNVHLYGFWPFGKHPNdSRPITNHYYDNRE--SKKNVHS 330
Cdd:cd23969  177 ktaYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGN-GRAVKYHYYDNRKylTTARPHK 255

                        250       260
                 ....*....|....*....|
gi 125811451 331 MPSEFEQLLKLHKQGVVHIH 350
Cdd:cd23969  256 MPEEFRALRSLHQRGALRLH 275
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 106-351 2.08e-54

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 180.14  E-value: 2.08e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 106 GSNVVYDGERRKPLQVTQALYNILAKEQPFGNATWESCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGN 185
Cdd:cd23987   30 GDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 186 KTNLVTANPSILHEKYSGLM--ERRRPFVESLHSYGQALLLLPAF-SYGHNTPVS-LRAFYTLEDFGREGPLPIFlnpEY 261
Cdd:cd23987  109 KTDLVTMNPSVVQRAFEDLVneTWKEKFLQRLQSLNGSILWIPAFmAKGGEERVEwVNDLILKHHINVRTAYPSL---RL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 262 LRKLTKFWREQGLNSVRPSTGLIMASLALEICTNVHLYGFWPFGKHPNDsRPITNHYYDNRE----SKKNVHSMPSEFEQ 337
Cdd:cd23987  186 LHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQ-NPVKYHYYDSLKygytSQASPHTMPLEFKA 264

                        250
                 ....*....|....
gi 125811451 338 LLKLHKQGVVHIHL 351
Cdd:cd23987  265 LKNLHQQGALKLTV 278
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 96-349 1.43e-51

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 172.83  E-value: 1.43e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451  96 AVVTQNNTPlGSNVVYDGERRKPLQVTQALYNILAKEQPFGNATWESCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPL 175
Cdd:cd23988   21 SVVKSSFKP-GDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 176 DDrYEKDVGNKTNLVTANPSILHEKYSGLMER--RRPFVESLHSYGQALLLLPAFSyghnTPVSLRAFYTLEDFGREGPL 253
Cdd:cd23988  100 VE-FAADVGTKSDFITMNPSVVQRAFGGFRNEsdREKFVHRLSMLNDSVLWIPAFM----VKGGEKHVEWVNALILKNKL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 254 PIFLNPEYLR---KLTKFWREQGLNSVRPSTGLIMASLALEICTNVHLYGFWPFGKHPNdSRPITNHYYDNRE----SKK 326
Cdd:cd23988  175 KVRTAYPSLRlihAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDAN-GNPVKYHYYDDLKyryfSNA 253

                        250       260
                 ....*....|....*....|...
gi 125811451 327 NVHSMPSEFEQLLKLHKQGVVHI 349
Cdd:cd23988  254 GPHRMPLEFKTLNVLHNRGALKL 276
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 143-341 5.07e-31

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 116.31  E-value: 5.07e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 143 CAVVGNGGVLANSSCGEEINSAQFVIRCNLPPlDDRYEKDVGNKTNLVTANPSILHEkysglMERRRPFVESLHSYGQAL 222
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAP-TKGFEKDVGSKTTFRVLNSKWAGF-----YLRGPRCGCHPLPLEEEV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 223 LLLpafsyghNTPVSLRAFYTLED-FGREGPLPIFLNP----------EYLRKLTKFWREQGlnsVRPSTGLIMASLALE 291
Cdd:cd19952   75 VLI-------LSRAAAADFKRLKRrKKRHDNAVLLLTDpapdllsyvrKRLEKLGLKSFFGG---NAPSSGLLAVLLALQ 144

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 125811451 292 ICTNVHLYGFWPF-GKHPNDSRpitnHYYDNRE--SKKNVHSMPSEFEQLLKL 341
Cdd:cd19952  145 LCDSVDLYGFGVDsGHAPKVPY----HYYDLVEaeEGTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 142-347 1.47e-24

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 101.57  E-value: 1.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 142 SCAVVGNGGVLANSSCGEEINSAQFVIRCNLPpLDDRYEKDVGNKT------------NLVTANPSILHEKYSGLMERRR 209
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHA-LTKGFEKDVGTKTsfytffpeslhnSLLKHVPQDKDTKYLFIPFKIR 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 210 PFVeslhsYGQALLL---LPAFSYGHNTPVSLRA-FYTLEDFGregplpiFLNPEYLRKLTKFWreqgLNSV---RPSTG 282
Cdd:cd23964  163 DYD-----YLDAVLSgkpVPDGCDKGKRPPPLFGpKLNATNVR-------LLHPDFIRYLFNRW----LNSStsyRPTTG 226

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 125811451 283 LIMASLALEICTNVHLYGfwpFGKHPNdsrpITNHYYDNRESKKNV----HSMPSEFEQLLKLHKQGVV 347
Cdd:cd23964  227 ALMLLTALHTCDQVSVYG---FGYDPR----FSLHYYDKTFVKFTVfyanHDFTNERKLWRKLHEEGII 288
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 143-341 4.64e-19

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 84.27  E-value: 4.64e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 143 CAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGNKTNLVTANPsilhekysglmerRRPFVESLHSYGQAL 222
Cdd:cd23967    5 CVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKG-YEKDVGSKTTFRMFYP-------------ESAFRDPEEYDSDWL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 223 LLLPAFSyghntPVSLRAFYTL---------EDFGREGPLPI--------FLNPEYLR----KLTKFWREQGLNSVRPST 281
Cdd:cd23967   71 LVLVPFK-----SMDLLWLQAVikgkkpngkGGFWKKIATSVpkppkkirILNPYILQeaafDLIGLPMNGKQGKNVPTT 145

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 125811451 282 GLIMASLALEICTNVHLYGfwpFGKHPNDSRpITNHYYDN---RESKKN-VHSMPSEFEQLLKL 341
Cdd:cd23967  146 GIIAIVMALHYCDEVDIAG---FGYDPSDPN-APLHYYDSltmKAIKRSwTHNVTKEKKYLKKL 205
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 143-321 2.16e-17

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 79.79  E-value: 2.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 143 CAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGNKTNLVTANP-SIlhekysglmerrrpFVESLHSYGQA 221
Cdd:cd23984    5 CVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIG-YENDVGKRTTFRLCYPeSI--------------FSDPSHYDPNT 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 222 LLLLPAFS----------YGHNtPVSLRAFYtledfgREGPLPI--------FLNPEYLRKL--------TKFWREQglN 275
Cdd:cd23984   70 TVVLIPFKphdlrwlldlLMGK-KVSAKGFW------KKPALNLiykpnqirILNPFILRIAayellhfpKRFPKEK--K 140

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 125811451 276 SVRPSTGLIMASLALEICTNVHLYGFwpfgKHPNDSRPITNHYYDN 321
Cdd:cd23984  141 PKHPTTGIIAITLALHICNEVHIAGF----KYDFSNLNSTLHYYGN 182
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 142-341 3.16e-17

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 78.94  E-value: 3.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 142 SCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGNKTNLvtanpsilhekysglmerRRPFVESLHSYGQA 221
Cdd:cd23982    4 RCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRG-FEKDVGSKTTI------------------RLFYPESAQFDPGI 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 222 ------LLLLPAFSyghntPVSLRAFYTL--------EDFGREGPLPIFLNPEYLRKLTKFWREQGLN-----------S 276
Cdd:cd23982   65 endpdtLLVLVPFK-----PLDFYWLYEIlsnekrvrKGFWKQPPRIWDANPKQIRILNPYYTYVAATkllqvpgqrkkK 139

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 125811451 277 VRPSTGLIMASLALEICTNVHLYGF-WPFGKHPNdsRPItnHYYDNRESKKNV---HSMPSEFEQLLKL 341
Cdd:cd23982  140 QKPTTGLLAITLALHLCDEVHIAGFgYPDNGNSN--QPI--HYYNQITLKSMAnsgHNLNAEAQAIQRL 204
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 142-350 1.49e-16

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 78.86  E-value: 1.49e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 142 SCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGNKTNLVTANPsilhEKYSGLmerrRPFVEslhsygqa 221
Cdd:cd23966   79 RCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKG-FEKDVGSKTTHHFMYP----ESAVDL----DPGVH-------- 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 222 LLLLP-----------AFSYGH--NTPVSLRAFYTLEdfgREGPLpiFLNPEYLRKLTKFWREqgLNSVRPSTGLIMASL 288
Cdd:cd23966  142 LVLVPfkvldlqwlisALTTGEitRTYTPVKRFIKAD---KDKVL--VINPAFIKYVHDNWTE--HHGRYPSTGFLALIF 214

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 125811451 289 ALEICTNVHLYGfwpFGKhpnDSRPITNHYYDNRESKKN-----VHSMPSEFEQLLKLHKQGVVHIH 350
Cdd:cd23966  215 ALHICDEVSVFG---FGA---DSKGNWHHYWEKNRSAGAfrktgVHDADFESDIIKKLAKEGKIRVY 275
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 143-351 1.91e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 79.03  E-value: 1.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 143 CAVVGNGGVLANSSCGEEINSAQFVIRCNlPPLDDRYEKDVGNKTNLVTANPSILHEK---YSGLMERRRPFVES----- 214
Cdd:cd23974   87 CAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTLMNSlraYAGVGFNGPPQSKEtryif 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 215 LHSYGQALLLLPAFSYghNTPV------SLR-AFYTLEDFGREgPLPIFlNPEYLRKL-TKFWREQGLNS-----VRPST 281
Cdd:cd23974  166 LPDHDRDYLLVKAALT--HTPIdrgrdkSKRpSKYFGKDVTAE-KFKIY-HPDFIRYLrNRFLWSPILNTkqrdiYRPST 241

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 125811451 282 GLIMASLALEICTNVHLYGFWpfgkhPNDSRPITNHYYDNRESKKNV---HSMPSEFEQLLKLHKQGVVHIHL 351
Cdd:cd23974  242 GAVMLLAALHTCDQVSAYGFM-----TPDYGKYSDHYYDKTYHKVVFyanHDLRLEMQLWQKLHKAGLIKLYM 309
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 134-352 6.06e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 77.48  E-value: 6.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 134 PFGNATWESCAVVGNGGVLANSSCGEEINSAQFVIRCNlPPLDDRYEKDVGNKTNL-------VTANPSILHE------- 199
Cdd:cd23973   77 PPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVN-GAVIKGYEEDVGTRTSFyvhtahsITSSLMILQKrgfknip 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 200 -----KYSGLMERRRPFveslhSYGQALLL---LPAFSYGHNTPvslRAFYTlEDFGREGPLpiFLNPEYLRKL-TKFWR 270
Cdd:cd23973  156 qdkdiKYILFPEGPRDY-----QWLEALLKnktIPSGAYYGRRP---RSYFS-GDFTEDKYL--VLHPDFLRYVkNRFLR 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 271 EQGLNS-----VRPSTGLIMASLALEICTNVHLYGFWpfgkhPNDSRPITNHYYDnRESKKNV----HSMPSEFEQLLKL 341
Cdd:cd23973  225 SKTLKGkywaiYRPTTGAFLLLTALHLCDTVSAYGFI-----TEDYRKYPDHYYD-KKKTKLVfyinHDFRLEKKLWKRL 298

                        250
                 ....*....|.
gi 125811451 342 HKQGVVHIHLG 352
Cdd:cd23973  299 HDEKIIKLYQR 309
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 139-342 4.53e-15

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 74.23  E-value: 4.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 139 TWESCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLdDRYEKDVGNKTNLVTANPSIlhekysgLMERRRPFVESLHSY 218
Cdd:cd23968   44 RYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPT-KGFEKDVGSKTTLRLINSQI-------LSKPEFNFLTDPLYR 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 219 GQALLLLPAFSYGhntpVSLRAFYTLEDFG--------R----EGPLPIfLNPEYLRKLtkfWRE-QGLNSVR-----PS 280
Cdd:cd23968  116 NVTLLVWDPSSYN----VNLEKWYKKPDFDffpnyikyRrrhpEEPFYL-IDPRFLWRL---WDIlQEYTPEKikpnpPS 187

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 125811451 281 TGLIMASLALEICTNVHLYGFWPfgkhpndSRPITN--HYYDNRESKK----NVHSMpsEFEQLLKLH 342
Cdd:cd23968  188 SGFIGIVLMLHLCDWVDVYEYVP-------SVRQTDrcHYYDVEKDLActlgAWHPL--AAEKLLVRH 246
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 142-325 2.06e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 68.81  E-value: 2.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 142 SCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGNKTNL-VTANPSILHekysglMERRRPFVESLHSYGQ 220
Cdd:cd23965    3 TCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRG-YEKDVGRRTTIrVVSHSSLPR------LLRNAILLLAGTRAPT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 221 ALLLlpafsYGHNTPVSLRAFYT---LEDFGREGP--LPIFLNPEYLRKLTK-FWREQGLNSVRP----STGLIMASLAL 290
Cdd:cd23965   76 VVVF-----WGPETKMNKDGAGKynlLRSLSKKYPdvEFYSLTPEKMDYADElFEKETGKSRIKSgtwlSTGWFTMLLAL 150

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 125811451 291 EICTNVHLYGFWPFG---KHPNDSRPItnHYYDNRESK 325
Cdd:cd23965  151 DVCDEIKVYGMVPENycrEHPNSKVPY--HYYEPGGLK 186
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 131-303 1.16e-12

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 67.17  E-value: 1.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 131 KEQPFGNATWE-----------------SCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGNKTNLVTAN 193
Cdd:cd23986   23 KEAPFSALGWEkyvpkiplsklhlrgfrSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRG-YEKDVGNKTTIRIIN 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 194 PSILHEKYSGLMErrrpfvESLHSYGQALLLLPAFSYghntpVSLRAFYTLEDFGREGPL----------PIF-LNPEYL 262
Cdd:cd23986  102 SQILTNPNHHFID------SSLYKDVILVAWDPAPYS-----ANLHKWYKKPDYNLFTPYvqyrkrnpnqPFYiLHPKFI 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 125811451 263 RKLTKFWREQGLNSVR---PSTGLIMASLALEICTNVHLYGFWP 303
Cdd:cd23986  171 WQLWDIIQENTQEKIQpnpPSSGFIGILIMMSMCREVHVYEYIP 214
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 143-350 4.10e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 66.00  E-value: 4.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 143 CAVVGNGGVLANSSCGEEINSAQFVIRCNlPPLDDRYEKDVGNKTNLV-----TANPSILHEKYSGLMER------RRPF 211
Cdd:cd23972   85 CAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFYgftvnTMKNSLISYWNLGFTRTpqgqdlQYIF 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 212 VES-------LHSygqALLLLPAFSyGHNTPVSLRAFYTLEDFGREGPLpifLNPEYLRKLT-KFWREQGLNS-----VR 278
Cdd:cd23972  164 IPSdirdyvmLRS---AILGVPVPE-GLDKGDRPHKYFGPEASAKKFKL---LHPDFISYLTdRFLKSKLLNThyghlYM 236

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 125811451 279 PSTGLIMASLALEICTNVHLYGFWpfgkhPNDSRPITNHYYDnRESKKNV----HSMPSEFEQLLKLHKQGVVHIH 350
Cdd:cd23972  237 PSTGALMLLTALHTCDQVSAYGFI-----TSNYWKFSDHYYE-RKKKPLVfyanHDMLLEAALWRRLHKAGILQLY 306
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 120-350 1.32e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 61.43  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 120 QVTQALYNILAKEQPFGN---ATWESCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGNKT--------- 187
Cdd:cd23979   57 EVLSKLFQIIPGENPYRSwdpSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVG-FEADVGSRTthhfmypes 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 188 --NLvTANPSILHEKYSGLmerRRPFVESLHSYGQAllllpAFSYGhntPVslRAFYTLEdfgrEGPLPIFlNPEYLRKL 265
Cdd:cd23979  136 akNL-PANVSFVLVPFKTL---DLLWITSALSTGQI-----RFTYA---PV--KQFLRVD----KDKVQIY-NPAFFKYI 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 266 TKFWREQglNSVRPSTGLIMASLALEICTNVHLYGFwpfgkhPNDSRPITNHYYDNRE-----SKKNVHSMPSEFEQLLK 340
Cdd:cd23979  197 HDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYGF------GADSRGNWHHYWENNRyagefRKTGVHDADFEAHIIDM 268

                        250
                 ....*....|
gi 125811451 341 LHKQGVVHIH 350
Cdd:cd23979  269 LAKAGKIKVY 278
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 143-341 3.18e-10

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 59.37  E-value: 3.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 143 CAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGNKTNL----VTANPSILHEKYSGLMERRRPFVESLHSY 218
Cdd:cd23983    5 CVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQG-YSQDVGNKTTIrmtyPEGAPKSEQEYDPTSLFVAVLFKSVDFAW 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 219 GQALLllpafsygHNTPVSL--RAFytledFGREGPLPIFLNPEYLRKLT-KFWREQGLNSVR---------------PS 280
Cdd:cd23983   84 LKAMV--------KKEPLSFwsRLF-----FWKEVADSIPLKPSQFRILNpLIIKETALDILQypepqsrlwgwdknvPT 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 125811451 281 TGLIMASLALEICTNVHLYGFWPFGKHPndSRPItnHYYDNRE----SKKNVHSMPSEFEQLLKL 341
Cdd:cd23983  151 LGVTAVVLATHLCDEVSLAGFGYDLSQP--HAPL--HYYDSVCmaamNTQTMHNVTKETKFLKKL 211
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 128-319 3.51e-10

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 60.11  E-value: 3.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 128 ILAKEQPFGNATWES----------------CAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGNKTNLVT 191
Cdd:cd23985   17 LEGTDFPFNTSEWEGylpkkslreevgplgrCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAG-FQQDVGTKTTIRL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 192 ANpsilhekySGLM--ERRRPFVESLHSYGQALLLLPA-----FSYGHNTPvSLRAFYTLEDFGREGPLPIF--LNPEYL 262
Cdd:cd23985   96 IN--------SQLVttEKHKFLKDSLYNEGILIVWDPApyhsdIPEWYKNP-DYNFFENYKTYRRLNPNQPFyiLHPQMQ 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 125811451 263 RKLTKFWREQGLNSVR---PSTGLIMASLALEICTNVHLYGFWPfgkhpndSRPITN--HYY 319
Cdd:cd23985  167 WELWDIIQENSPEEIQpnpPSSGMLGIILMMTLCDQVDVYEFLP-------SKRKTDvcHYY 221
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 143-341 6.05e-10

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 59.51  E-value: 6.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 143 CAVVGNGGVLANSSCGEEINSAQFVIRCNLPPlDDRYEKDVGNKTNLVTANPSILHEKYSGLMERRRPF-------VESL 215
Cdd:cd23980   84 CAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFktldlewVISA 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 216 HSYGQAllllpAFSYghnTPVSLRAFYTLEDFgregplpIFLNPEYLRKLTKFWReqgLNSVR-PSTGLIMASLALEICT 294
Cdd:cd23980  163 TTTGTI-----SHTY---VPVPRKIKVKKEKI-------LIYHPAFIKYVFDRWL---QGHGRyPSTGILSVIFSLHVCD 224

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 125811451 295 NVHLYGFWPfgkhpnDSRPITNHYYDNRES-----KKNVHSMPSEFEQLLKL 341
Cdd:cd23980  225 EVDLYGFGA------DSKGNWHHYWENNPSagafrKTGVHDGDFESNVTTIL 270
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 143-341 6.91e-10

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 58.40  E-value: 6.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 143 CAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGNKTNLVTANPSILHEKYSGlMERRRPFVESLHSYgQAL 222
Cdd:cd23981    5 CIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKG-FEKDVGSKTTLRITYPEGAIQKPEQ-YEKDSLFVLAGFKW-QDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 223 LLLPAFSYGHNTPVSLRAFYTLEDFGREGPLPI-FLNPEYLRKLTKFWREQGLNSVR------PSTGLIMASLALEICTN 295
Cdd:cd23981   82 KWLKYIVYKEKVSASDGFWKSVATRVPREPHEIrILNPYFIQEAAFSFIGLPFNNGLmgrgniPTLGSVAITMALHNCDE 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 125811451 296 VHLYGFWPFGKHPNdsRPItnHYYDN------RESKknVHSMPSEFEQLLKL 341
Cdd:cd23981  162 VAVAGFGYDMNTPN--APL--HYYETikmsaiKESW--THNIQREKEFLRKL 207
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 142-322 7.82e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 58.33  E-value: 7.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 142 SCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGNKTNL-VTANPSIlhekySGLMERRRPFVeslhSYGQ 220
Cdd:cd23978    3 QCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTG-YEKDVGNKTTLrVVAHSSV-----YRVLRRPQEFL----NRTP 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 221 ALLLL---PAFSYGHNTPVSLraFYTLEDFGREGP-LPIF-LNPEYLRKLTK-FWREQGLNSVRP----STGLIMASLAL 290
Cdd:cd23978   73 ETTLIfwgPPNKMQKDGKSNL--FRIIQRASMTFPnMSAFvVSPRRMRQFDDlFRGETGRDRKKShswlSTGWFTMVIAV 150

                        170       180       190
                 ....*....|....*....|....*....|....
gi 125811451 291 EICTNVHLYGFWP--FGKHPNDSRPITNHYYDNR 322
Cdd:cd23978  151 ELCDNVHVYGMVPpnYCSKRPTPKKMPYHYYEPK 184
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 141-320 4.60e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 53.33  E-value: 4.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 141 ESCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPlDDRYEKDVGNKTNLVTanpsILHEKYSGLMERRRPFVESlhSYGQ 220
Cdd:cd23976   16 KSCALVTSSGHLTGSNRGNEIDETECVIRMNDAP-TRGYGKDVGNKTSLRV----IAHSSIQRILRNRNELLNV--SQGT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125811451 221 ALLLLPAFSYGHNTPVSLrAFYTLEDFGREGP-LPIFL--NPEYLRKLTKFWREQGLNSVRP----STGLIMASLALEIC 293
Cdd:cd23976   89 VFIFWGPSNYMRRDGKGL-VYNNLQLMNQILPkLKVYTitRHKMLQFDELFKRETGKDRKISntwlSTGWFTMIIALELC 167

                        170       180
                 ....*....|....*....|....*....
gi 125811451 294 TNVHLYGFWP--FGKHPNdSRPITNHYYD 320
Cdd:cd23976  168 DRINVYGMVPpdFCRDPN-HPSVPYHYYE 195
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 142-189 7.60e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 43.70  E-value: 7.60e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 125811451 142 SCAVVGNGGVLANSSCGEEINSAQFVIRCNLPPLDDrYEKDVGNKTNL 189
Cdd:cd23977    3 RCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAG-YEADVGNRSSL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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