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    brdt bromodomain, testis-specific [ Danio rerio (zebrafish) ]

    Gene ID: 333996, updated on 9-Dec-2024

    Summary

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    Official Symbol
    brdtprovided by ZNC
    Official Full Name
    bromodomain, testis-specificprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5928
    See related
    Ensembl:ENSDARG00000102802 AllianceGenome:ZFIN:ZDB-GENE-030131-5928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fi25h02; wu:fi25h02; si:dkeyp-85h7.3
    Summary
    Predicted to enable lysine-acetylated histone binding activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in azoospermia; oligospermia; and spermatogenic failure 21. Orthologous to human BRDT (bromodomain testis associated). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See brdt in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (24364678..24392909, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (24264869..24293101, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490209 Neighboring gene epoxide hydrolase 4 Neighboring gene transforming growth factor, beta receptor III Neighboring gene uncharacterized LOC137495882 Neighboring gene myb-related transcription factor, partner of profilin-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Toxicity and non-harmful effects of the soya isoflavones, genistein and daidzein, in embryos of the zebrafish, Danio rerio. Sarasquete C, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2018 Sep. PMID 29870789
    2. Transcriptome analysis reveals positive selection on the divergent between topmouth culter and zebrafish. Ren L, et al. Gene, 2014 Dec 1. PMID 25267534
    3. Protein kinase C family evolution in jawed vertebrates. Garcia-Concejo A, et al. Dev Biol, 2021 Nov. PMID 34329618
    4. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain testis-specific protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305664.1 → NP_001292593.1  bromodomain testis-specific protein

      Status: VALIDATED

      Source sequence(s)
      BX927081
      UniProtKB/Swiss-Prot
      F1QW93
      UniProtKB/TrEMBL
      A0A0R4IJ54, A0A8M1P1D1
      Related
      ENSDARP00000134162.2, ENSDART00000171042.2
      Conserved Domains (4) summary
      cd05497
      Location:29 → 135
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:273 → 373
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:514 → 577
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:936 → 979
      BRD4_CDT; C-terminal domain of bromodomain protein 4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      24364678..24392909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002662424.7 → XP_002662470.2  bromodomain testis-specific protein isoform X1

      See identical proteins and their annotated locations for XP_002662470.2

      UniProtKB/Swiss-Prot
      F1QW93
      UniProtKB/TrEMBL
      A0A8M2BGL6, I3IS77
      Related
      ENSDARP00000139180.1, ENSDART00000168355.2
      Conserved Domains (4) summary
      cd05497
      Location:29 → 135
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:273 → 373
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:514 → 577
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:1050 → 1093
      BRD4_CDT; C-terminal domain of bromodomain protein 4

    2. XM_068221653.1 → XP_068077754.1  bromodomain testis-specific protein isoform X1

      UniProtKB/Swiss-Prot
      F1QW93
      UniProtKB/TrEMBL
      A0A8M2BGL6, I3IS77

    3. XM_005168751.5 → XP_005168808.1  bromodomain testis-specific protein isoform X1

      See identical proteins and their annotated locations for XP_005168808.1

      UniProtKB/Swiss-Prot
      F1QW93
      UniProtKB/TrEMBL
      A0A8M2BGL6, I3IS77
      Related
      ENSDARP00000130622.1, ENSDART00000163965.2
      Conserved Domains (4) summary
      cd05497
      Location:29 → 135
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:273 → 373
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:514 → 577
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:1050 → 1093
      BRD4_CDT; C-terminal domain of bromodomain protein 4

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394641.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      84041..112272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395254.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      86170..114117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1QW93.2 GenPept UniProtKB/Swiss-Prot:F1QW93

    Gene LinkOut

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