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Conserved domains on  [gi|528482221|ref|XP_002662470|]
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bromodomain testis-specific protein isoform X1 [Danio rerio]

Protein Classification

Bromo_Brdt_I_like and Bromo_Brdt_II_like domain-containing protein( domain architecture ID 10860762)

protein containing domains Bromo_Brdt_I_like, Bromo_Brdt_II_like, BET, and BRD4_CDT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 29-135 6.16e-69

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99929  Cd Length: 107  Bit Score: 225.38  E-value: 6.16e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   29 RLTNHLQYIEKVVIRALWKHHFSWPFRQPVDAVRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCY 108
Cdd:cd05497     1 RHTNQLQYLLKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCY 80

                          90       100
                  ....*....|....*....|....*..
gi 528482221  109 VYNRPGDDIVLMAQVLEKLFLEKVAEM 135
Cdd:cd05497    81 IYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 273-373 8.79e-60

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99930  Cd Length: 102  Bit Score: 199.43  E-value: 8.79e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  273 LKYCNAILKEMFSKKHSAYAWPFYKPVDAETLGLLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYN 352
Cdd:cd05498     2 LKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYN 81

                          90       100
                  ....*....|....*....|.
gi 528482221  353 PPGHEVVSMARKLQDVFEFRF 373
Cdd:cd05498    82 PPDHPVHAMARKLQDVFEDRW 102
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 514-576 4.99e-24

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


:

Pssm-ID: 435704  Cd Length: 64  Bit Score: 96.03  E-value: 4.99e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528482221   514 PMSYEEKRQLSLDINKLPGDKLGKVVNIIKAREPLLRdTDPEEIEIDFETLKPSTLRALECYV 576
Cdd:pfam17035    1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERNPELQ-SDDDEIELDIDALDDDTLRKLYNFV 62
BRD4_CDT pfam17105
C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal ...
 1051-1093 1.16e-10

C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II.


:

Pssm-ID: 465349  Cd Length: 44  Bit Score: 57.40  E-value: 1.16e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 528482221  1051 SVDREREMARKREQERRRREAMSGVIDMTMQRDIMATFEKNLE 1093
Cdd:pfam17105    2 SLDKERELARKREQERRRREAMAGTIDMNLQSDIMASFEENLD 44
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 743-904 2.70e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  743 PPQPSRPSGKAAALPRKIwTTPSPLSLPPDQALSPLYNASATSPC---KDHTIIPAKSSPESVTPDPPNSLPKDPLFPCS 819
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRL-TRPAVASLSESRESLPSPWDPADPPAavlAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  820 PLlPP---------PDMQVSQVGPPSSVAAKI---------------PPQKSEKEGIPPL-LSPLTSPSAAMPATGSQST 874
Cdd:PHA03247 2845 PP-PPslplggsvaPGGDVRRRPPSRSPAAKPaaparppvrrlarpaVSRSTESFALPPDqPERPPQPQAPPPPQPQPQP 2923

                         170       180       190
                  ....*....|....*....|....*....|.
gi 528482221  875 SSSQFEQCRLLSP-LHESPLASMRNEQDCPE 904
Cdd:PHA03247 2924 PPPPQPQPPPPPPpRPQPPLAPTTDPAGAGE 2954
 
Name Accession Description Interval E-value
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 29-135 6.16e-69

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 225.38  E-value: 6.16e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   29 RLTNHLQYIEKVVIRALWKHHFSWPFRQPVDAVRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCY 108
Cdd:cd05497     1 RHTNQLQYLLKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCY 80

                          90       100
                  ....*....|....*....|....*..
gi 528482221  109 VYNRPGDDIVLMAQVLEKLFLEKVAEM 135
Cdd:cd05497    81 IYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 273-373 8.79e-60

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 199.43  E-value: 8.79e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  273 LKYCNAILKEMFSKKHSAYAWPFYKPVDAETLGLLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYN 352
Cdd:cd05498     2 LKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYN 81

                          90       100
                  ....*....|....*....|.
gi 528482221  353 PPGHEVVSMARKLQDVFEFRF 373
Cdd:cd05498    82 PPDHPVHAMARKLQDVFEDRW 102
BROMO smart00297
bromo domain;
271-376 6.76e-37

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 134.33  E-value: 6.76e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221    271 ERLKYCNAILKEMFSKKHS-AYAWPFYKPVDAETLGllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCY 349
Cdd:smart00297    3 KLQKKLQELLKAVLDKLDShPLSWPFLKPVSRKEAP--DYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                            90       100
                    ....*....|....*....|....*..
gi 528482221    350 KYNPPGHEVVSMARKLQDVFEFRFSKI 376
Cdd:smart00297   81 TYNGPDSEVYKDAKKLEKFFEKKLREL 107
BROMO smart00297
bromo domain;
29-135 4.78e-34

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 126.24  E-value: 4.78e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221     29 RLTNHLQYIEKVVIRALWKHHFSWPFRQPVDAVRLnlPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCY 108
Cdd:smart00297    3 KLQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                            90       100
                    ....*....|....*....|....*..
gi 528482221    109 VYNRPGDDIVLMAQVLEKLFLEKVAEM 135
Cdd:smart00297   81 TYNGPDSEVYKDAKKLEKFFEKKLREL 107
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 514-576 4.99e-24

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


Pssm-ID: 435704  Cd Length: 64  Bit Score: 96.03  E-value: 4.99e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528482221   514 PMSYEEKRQLSLDINKLPGDKLGKVVNIIKAREPLLRdTDPEEIEIDFETLKPSTLRALECYV 576
Cdd:pfam17035    1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERNPELQ-SDDDEIELDIDALDDDTLRKLYNFV 62
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 276-364 1.13e-20

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 87.37  E-value: 1.13e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   276 CNAILKEMfsKKHSAYAWpFYKPVDAETLGllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPG 355
Cdd:pfam00439    1 CLEILDKL--MEHPIAAP-FLEPVDPDEYP--DYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPG 75


                   ....*....
gi 528482221   356 HEVVSMARK 364
Cdd:pfam00439   76 SVIYKAAEK 84
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 41-122 2.37e-20

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 86.21  E-value: 2.37e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221    41 VIRALWKHHFSWPFRQPVDAVrlNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLM 120
Cdd:pfam00439    4 ILDKLMEHPIAAPFLEPVDPD--EYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKA 81


                   ..
gi 528482221   121 AQ 122
Cdd:pfam00439   82 AE 83
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 4-138 2.12e-19

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 91.41  E-value: 2.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221    4 VKPPQHFTMNGNPPPPEFKNPKKP--GRLTNHLQYIEKVVIRALWKHHFSWPFRQPVDAVRLNLPDYYTIIKNPMDLTTI 81
Cdd:COG5076   115 ESGLGSLLMAHLKTSVKKRKTPKIedELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTI 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 528482221   82 RKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLEKVAEMPEE 138
Cdd:COG5076   195 QKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLKLIEEIPEE 251
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 243-379 2.99e-18

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 87.94  E-value: 2.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  243 SGRPIKPPCKDLPESPPQHQVGRRTKLSERL---KYCNAILKEM---FSKKHSAYAWPFYKPVDAETLGllDYHEIIHQP 316
Cdd:COG5076   111 SVTPESGLGSLLMAHLKTSVKKRKTPKIEDEllyADNKAIAKFKkqlFLRDGRFLSSIFLGLPSKREYP--DYYEIIKSP 188

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528482221  317 MDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKLQDVFEFRFSKIPDE 379
Cdd:COG5076   189 MDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLKLIEEIPEE 251
BRD4_CDT pfam17105
C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal ...
 1051-1093 1.16e-10

C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II.


Pssm-ID: 465349  Cd Length: 44  Bit Score: 57.40  E-value: 1.16e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 528482221  1051 SVDREREMARKREQERRRREAMSGVIDMTMQRDIMATFEKNLE 1093
Cdd:pfam17105    2 SLDKERELARKREQERRRREAMAGTIDMNLQSDIMASFEENLD 44
PHA03247 PHA03247
large tegument protein UL36; Provisional
 743-904 2.70e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  743 PPQPSRPSGKAAALPRKIwTTPSPLSLPPDQALSPLYNASATSPC---KDHTIIPAKSSPESVTPDPPNSLPKDPLFPCS 819
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRL-TRPAVASLSESRESLPSPWDPADPPAavlAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  820 PLlPP---------PDMQVSQVGPPSSVAAKI---------------PPQKSEKEGIPPL-LSPLTSPSAAMPATGSQST 874
Cdd:PHA03247 2845 PP-PPslplggsvaPGGDVRRRPPSRSPAAKPaaparppvrrlarpaVSRSTESFALPPDqPERPPQPQAPPPPQPQPQP 2923

                         170       180       190
                  ....*....|....*....|....*....|.
gi 528482221  875 SSSQFEQCRLLSP-LHESPLASMRNEQDCPE 904
Cdd:PHA03247 2924 PPPPQPQPPPPPPpRPQPPLAPTTDPAGAGE 2954
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 737-911 1.18e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   737 ALHSRLPPQPSRPSGKAAALPRKIWTTPSPLSLPPDQA---LSPLYNASATSPCKDHTiIPAKSSPESVTPDPPNSLPKD 813
Cdd:pfam03154  270 SLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSqvpPGPSPAAPGQSQQRIHT-PPSQSQLQSQQPPREQPLPPA 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   814 PLfPCSPLLPPPDMQVSQVGPPSS------VAAKIPPQKSEKEGIPPLLSPLTSPSAAMPATGsqstsssqfeqcrllsp 887
Cdd:pfam03154  349 PL-SMPHIKPPPTTPIPQLPNPQShkhpphLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSA----------------- 410

                          170       180
                   ....*....|....*....|....
gi 528482221   888 lHESPLASMRNEQDCPETPEESSV 911
Cdd:pfam03154  411 -HPPPLQLMPQSQQLPPPPAQPPV 433
 
Name Accession Description Interval E-value
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 29-135 6.16e-69

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 225.38  E-value: 6.16e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   29 RLTNHLQYIEKVVIRALWKHHFSWPFRQPVDAVRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCY 108
Cdd:cd05497     1 RHTNQLQYLLKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCY 80

                          90       100
                  ....*....|....*....|....*..
gi 528482221  109 VYNRPGDDIVLMAQVLEKLFLEKVAEM 135
Cdd:cd05497    81 IYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 273-373 8.79e-60

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 199.43  E-value: 8.79e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  273 LKYCNAILKEMFSKKHSAYAWPFYKPVDAETLGLLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYN 352
Cdd:cd05498     2 LKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYN 81

                          90       100
                  ....*....|....*....|.
gi 528482221  353 PPGHEVVSMARKLQDVFEFRF 373
Cdd:cd05498    82 PPDHPVHAMARKLQDVFEDRW 102
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 273-371 5.97e-39

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 140.11  E-value: 5.97e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  273 LKYCNAILKEMFSKKHSAYAWPFYKPVDAETLGLLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYN 352
Cdd:cd05499     2 LKFCEEVLKELMKPKHSAYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFN 81

                          90
                  ....*....|....*....
gi 528482221  353 PPGHEVVSMARKLQDVFEF 371
Cdd:cd05499    82 PEGTDVYMMGHQLEEVFND 100
BROMO smart00297
bromo domain;
271-376 6.76e-37

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 134.33  E-value: 6.76e-37
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221    271 ERLKYCNAILKEMFSKKHS-AYAWPFYKPVDAETLGllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCY 349
Cdd:smart00297    3 KLQKKLQELLKAVLDKLDShPLSWPFLKPVSRKEAP--DYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                            90       100
                    ....*....|....*....|....*..
gi 528482221    350 KYNPPGHEVVSMARKLQDVFEFRFSKI 376
Cdd:smart00297   81 TYNGPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 273-373 2.36e-35

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 129.76  E-value: 2.36e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  273 LKYCNAILKEMFSKKHSayaWPFYKPVDAETLGLLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYN 352
Cdd:cd05506     2 MKQCGTLLRKLMKHKWG---WVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYN 78

                          90       100
                  ....*....|....*....|.
gi 528482221  353 PPGHEVVSMARKLQDVFEFRF 373
Cdd:cd05506    79 PPGNDVHTMAKELLKIFETRW 99
BROMO smart00297
bromo domain;
29-135 4.78e-34

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 126.24  E-value: 4.78e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221     29 RLTNHLQYIEKVVIRALWKHHFSWPFRQPVDAVRLnlPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCY 108
Cdd:smart00297    3 KLQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                            90       100
                    ....*....|....*....|....*..
gi 528482221    109 VYNRPGDDIVLMAQVLEKLFLEKVAEM 135
Cdd:smart00297   81 TYNGPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 277-369 6.74e-32

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 120.22  E-value: 6.74e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  277 NAILKEMFSKKHsayAWPFYKPVDAETLGLLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGH 356
Cdd:cd05497    11 KVVLKALWKHKF---AWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGD 87

                          90
                  ....*....|...
gi 528482221  357 EVVSMARKLQDVF 369
Cdd:cd05497    88 DVVLMAQTLEKLF 100
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 272-373 1.64e-31

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 118.63  E-value: 1.64e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  272 RLKYCNAILKEMFSKKHSaYAWPFYKPVDAETLGllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKY 351
Cdd:cd04369     1 LKKKLRSLLDALKKLKRD-LSEPFLEPVDPKEAP--DYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTY 77

                          90       100
                  ....*....|....*....|..
gi 528482221  352 NPPGHEVVSMARKLQDVFEFRF 373
Cdd:cd04369    78 NGPGSPIYKDAKKLEKLFEKLL 99
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 33-131 2.69e-31

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 118.15  E-value: 2.69e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   33 HLQYIEKVVIRALWKHH--FSWPFRQPVDAVRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVY 110
Cdd:cd05498     1 QLKFCSGILKELFSKKHkaYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90       100
                  ....*....|....*....|.
gi 528482221  111 NRPGDDIVLMAQVLEKLFLEK 131
Cdd:cd05498    81 NPPDHPVHAMARKLQDVFEDR 101
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 39-135 6.55e-31

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 116.89  E-value: 6.55e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   39 KVVIRALWKHHFSWPFRQPVDavRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIV 118
Cdd:cd05509     7 KKVLDSLKNHKSAWPFLEPVD--KEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDTEYY 84

                          90
                  ....*....|....*..
gi 528482221  119 LMAQVLEKLFLEKVAEM 135
Cdd:cd05509    85 KCANKLEKFFWKKLKEL 101
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 39-132 8.05e-31

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 116.70  E-value: 8.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   39 KVVIRALWKHH--FSWPFRQPVDavRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDD 116
Cdd:cd04369     6 RSLLDALKKLKrdLSEPFLEPVD--PKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSP 83

                          90
                  ....*....|....*.
gi 528482221  117 IVLMAQVLEKLFLEKV 132
Cdd:cd04369    84 IYKDAKKLEKLFEKLL 99
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 42-128 1.85e-29

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 112.81  E-value: 1.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   42 IRALWKHHFSWPFRQPVDAVRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMA 121
Cdd:cd05506     9 LRKLMKHKWGWVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPGNDVHTMA 88


                  ....*..
gi 528482221  122 QVLEKLF 128
Cdd:cd05506    89 KELLKIF 95
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 279-376 9.54e-28

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 108.03  E-value: 9.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  279 ILKEMfsKKHSaYAWPFYKPVDAETLGllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEV 358
Cdd:cd05509     9 VLDSL--KNHK-SAWPFLEPVDKEEAP--DYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDTEY 83

                          90
                  ....*....|....*...
gi 528482221  359 VSMARKLQDVFEFRFSKI 376
Cdd:cd05509    84 YKCANKLEKFFWKKLKEL 101
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 47-128 2.20e-27

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 106.99  E-value: 2.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   47 KHH-FSWPFRQPVDAVRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLE 125
Cdd:cd05499    16 KHSaYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPEGTDVYMMGHQLE 95


                  ...
gi 528482221  126 KLF 128
Cdd:cd05499    96 EVF 98
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 42-128 1.72e-25

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 101.62  E-value: 1.72e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   42 IRALWKHHFSWPFRQPVDAVRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMA 121
Cdd:cd05500    13 IRSLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHPVSQMG 92


                  ....*..
gi 528482221  122 QVLEKLF 128
Cdd:cd05500    93 KRLQAAF 99
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 274-370 2.88e-24

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 98.15  E-value: 2.88e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  274 KYCNAILKEMFSKKHSAyawPFYKPVDAETLGLLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNP 353
Cdd:cd05500     7 KFLLSSIRSLKRLKDAR---PFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNG 83

                          90
                  ....*....|....*..
gi 528482221  354 PGHEVVSMARKLQDVFE 370
Cdd:cd05500    84 PEHPVSQMGKRLQAAFE 100
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 514-576 4.99e-24

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


Pssm-ID: 435704  Cd Length: 64  Bit Score: 96.03  E-value: 4.99e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528482221   514 PMSYEEKRQLSLDINKLPGDKLGKVVNIIKAREPLLRdTDPEEIEIDFETLKPSTLRALECYV 576
Cdd:pfam17035    1 PMTYEEKRELSERINKLPGEKLGRVIEIIKERNPELQ-SDDDEIELDIDALDDDTLRKLYNFV 62
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 287-370 1.13e-22

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 93.66  E-value: 1.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  287 KHSAYAWPFYKPVDAETLGLLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKLQ 366
Cdd:cd05495    17 KQDPESLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSRVYKYCTKLA 96


                  ....
gi 528482221  367 DVFE 370
Cdd:cd05495    97 EVFE 100
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 273-378 4.28e-22

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 92.35  E-value: 4.28e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  273 LKYCNAILKEMFSKKHSAyawPFYKPVDAETLgllDYHEIIHQPMDMSTIKKKMEARE---YTDALQFAADMRLMFSNCY 349
Cdd:cd05502     6 QRKCERLLLELYCHELSL---PFHEPVSPSVP---NYYKIIKTPMDLSLIRKKLQPKSpqhYSSPEEFVADVRLMFKNCY 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 528482221  350 KYNPPGHEVVSMARKLQDVFEFRFSKI-PD 378
Cdd:cd05502    80 KFNEEDSEVAQAGKELELFFEEQLKEIlPD 109
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 51-132 3.89e-21

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 89.42  E-value: 3.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   51 SWPFRQPVDAVRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLE 130
Cdd:cd05495    22 SLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSRVYKYCTKLAEVFEQ 101


                  ..
gi 528482221  131 KV 132
Cdd:cd05495   102 EI 103
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 276-364 1.13e-20

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 87.37  E-value: 1.13e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   276 CNAILKEMfsKKHSAYAWpFYKPVDAETLGllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPG 355
Cdd:pfam00439    1 CLEILDKL--MEHPIAAP-FLEPVDPDEYP--DYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPG 75


                   ....*....
gi 528482221   356 HEVVSMARK 364
Cdd:pfam00439   76 SVIYKAAEK 84
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 41-122 2.37e-20

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 86.21  E-value: 2.37e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221    41 VIRALWKHHFSWPFRQPVDAVrlNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLM 120
Cdd:pfam00439    4 ILDKLMEHPIAAPFLEPVDPD--EYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKA 81


                   ..
gi 528482221   121 AQ 122
Cdd:pfam00439   82 AE 83
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 265-376 8.82e-20

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 85.91  E-value: 8.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  265 RRTKLSERLKYCNAILKEMFS--KKHSAyAWPFYKPVDAETLGllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMR 342
Cdd:cd05504     2 RRSEGRHHGPLNLSALEQLLVeiVKHKD-SWPFLRPVSKIEVP--DYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQ 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 528482221  343 LMFSNCYKYNPPGHEVVSMARKLQDVFEFRFSKI 376
Cdd:cd05504    79 LVFSNCFLYNPEHTSVYKAGTRLQRFFIKRCRKL 112
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 4-138 2.12e-19

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 91.41  E-value: 2.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221    4 VKPPQHFTMNGNPPPPEFKNPKKP--GRLTNHLQYIEKVVIRALWKHHFSWPFRQPVDAVRLNLPDYYTIIKNPMDLTTI 81
Cdd:COG5076   115 ESGLGSLLMAHLKTSVKKRKTPKIedELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTI 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 528482221   82 RKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLEKVAEMPEE 138
Cdd:COG5076   195 QKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLKLIEEIPEE 251
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 274-383 1.94e-18

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 82.12  E-value: 1.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  274 KYCNAILKEMFSKKHSAyawPFYKPVDaeTLGLLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNP 353
Cdd:cd05496     8 KQCKELVNLMWDCEDSE---PFRQPVD--LLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYTP 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 528482221  354 -PGHEVVSMARKLQDVFEFRFSKIPDEPKNA 383
Cdd:cd05496    83 nKRSRIYSMTLRLSALFEEHIKKIISDWKSA 113
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 243-379 2.99e-18

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 87.94  E-value: 2.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  243 SGRPIKPPCKDLPESPPQHQVGRRTKLSERL---KYCNAILKEM---FSKKHSAYAWPFYKPVDAETLGllDYHEIIHQP 316
Cdd:COG5076   111 SVTPESGLGSLLMAHLKTSVKKRKTPKIEDEllyADNKAIAKFKkqlFLRDGRFLSSIFLGLPSKREYP--DYYEIIKSP 188

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528482221  317 MDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKLQDVFEFRFSKIPDE 379
Cdd:COG5076   189 MDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLKLIEEIPEE 251
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 47-135 4.64e-18

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 80.90  E-value: 4.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   47 KHHFSWPFRQPVDavRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEK 126
Cdd:cd05504    26 KHKDSWPFLRPVS--KIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTSVYKAGTRLQR 103


                  ....*....
gi 528482221  127 LFLEKVAEM 135
Cdd:cd05504   104 FFIKRCRKL 112
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 38-134 7.53e-18

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 80.03  E-value: 7.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   38 EKVVIRaLWKHHFSWPFRQPVDAvrlNLPDYYTIIKNPMDLTTIRKRLE---NNYYWKAMECVEDFNTMFTNCYVYNRPG 114
Cdd:cd05502    10 ERLLLE-LYCHELSLPFHEPVSP---SVPNYYKIIKTPMDLSLIRKKLQpksPQHYSSPEEFVADVRLMFKNCYKFNEED 85

                          90       100
                  ....*....|....*....|
gi 528482221  115 DDIVLMAQVLEKLFLEKVAE 134
Cdd:cd05502    86 SEVAQAGKELELFFEEQLKE 105
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 62-134 1.92e-17

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 78.89  E-value: 1.92e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528482221   62 RLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLEKVAE 134
Cdd:cd05515    33 KSEYPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDALTLQKVLLETKRE 105
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 66-131 2.91e-17

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 78.15  E-value: 2.91e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 528482221   66 PDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLEK 131
Cdd:cd05519    37 PDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFKKK 102
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 279-365 5.04e-17

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 77.69  E-value: 5.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  279 ILKEMFSKKHSA-YAWPFYKPVDAETLglLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGH- 356
Cdd:cd05511     4 ILDEIVNELKNLpDSWPFHTPVNKKKV--PDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSv 81

                          90
                  ....*....|....*
gi 528482221  357 ------EVVSMARKL 365
Cdd:cd05511    82 ytkkakEMLELAEEL 96
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 276-378 7.46e-17

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 77.48  E-value: 7.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  276 CNAILKEMfsKKHSAYAWPFYKPV---DAEtlgllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYN 352
Cdd:cd05510    12 LDKVLNEL--KTYTEHSTPFLTKVskrEAP-----DYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYN 84

                          90       100
                  ....*....|....*....|....*..
gi 528482221  353 P-PGHEVVSMARKLQDVFEFRFSKIPD 378
Cdd:cd05510    85 SdPSHPLRRHANFMKKKAEHLLKLIPD 111
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 51-138 1.87e-16

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 76.15  E-value: 1.87e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   51 SWPFRQPVDAVRLnlPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLE 130
Cdd:cd05511    18 SWPFHTPVNKKKV--PDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYTKKAKEMLELAEE 95


                  ....*...
gi 528482221  131 KVAEMPEE 138
Cdd:cd05511    96 LLAEREEK 103
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 273-372 2.18e-16

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 75.49  E-value: 2.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  273 LKYCNAILKEMfsKKHSAyAWPFYKPVDAETLGllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYN 352
Cdd:cd05503     2 LALCETILDEM--EAHED-AWPFLEPVNTKLVP--GYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFN 76

                          90       100
                  ....*....|....*....|
gi 528482221  353 PPGHEVVSMARKLQDVFEFR 372
Cdd:cd05503    77 EDDSEVGRAGHNMRKFFEKR 96
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 45-131 7.73e-16

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 73.95  E-value: 7.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   45 LWKHHFSWPFRQPVDAvRLnLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVL 124
Cdd:cd05503    12 MEAHEDAWPFLEPVNT-KL-VPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDDSEVGRAGHNM 89


                  ....*..
gi 528482221  125 EKLFLEK 131
Cdd:cd05503    90 RKFFEKR 96
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 53-129 2.02e-15

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 73.91  E-value: 2.02e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528482221   53 PFRQPVDaVRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFL 129
Cdd:cd05529    47 YFEYPVD-LRAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAETFNEPNSEIAKKAKRLSDWLL 122
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 273-369 8.68e-15

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 71.03  E-value: 8.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  273 LKYCNAILKEMFSKKHSayaWPFYKPVDAETLGllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYN 352
Cdd:cd05505     2 LQKCEEILSKILKYRFS---WPFREPVTADEAE--DYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYY 76

                          90
                  ....*....|....*..
gi 528482221  353 PPGHEVVSMARKLQDVF 369
Cdd:cd05505    77 ENGSYVLSCMRKTEQCC 93
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 294-368 1.12e-14

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 71.23  E-value: 1.12e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528482221  294 PFYKPVDAETLGllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNP----PGHEVVSMARKLQDV 368
Cdd:cd05528    23 AFTKPVDEEEVP--DYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNPdrdpADKLIRSRACELRDE 99
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 41-118 3.32e-14

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 69.49  E-value: 3.32e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528482221   41 VIRALWKHHFSWPFRQPVDAVRLnlPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIV 118
Cdd:cd05505     8 ILSKILKYRFSWPFREPVTADEA--EDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENGSYVL 83
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 308-369 9.35e-14

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 68.10  E-value: 9.35e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528482221  308 DYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKLQDVF 369
Cdd:cd05515    38 DYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDALTLQKVL 99
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 66-132 1.26e-13

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 67.86  E-value: 1.26e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528482221   66 PDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLEKV 132
Cdd:cd05518    37 PDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYEDANILEKVLKEKR 103
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 37-126 1.86e-13

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 67.85  E-value: 1.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   37 IEKVV--IRALWKHhfSWPFRQPVDavRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNR-P 113
Cdd:cd05510    12 LDKVLneLKTYTEH--STPFLTKVS--KREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSdP 87

                          90
                  ....*....|...
gi 528482221  114 GDDIVLMAQVLEK 126
Cdd:cd05510    88 SHPLRRHANFMKK 100
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 278-367 7.64e-13

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 65.85  E-value: 7.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  278 AILKeMFSKKHSA-YAWPFYKPV---DAETlglldYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNP 353
Cdd:cd05507     7 AILL-VYRTLASHrYASVFLKPVtedIAPG-----YHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNS 80

                          90
                  ....*....|....
gi 528482221  354 PGHEVVSMARKLQD 367
Cdd:cd05507    81 SDHDVYLMAVEMQR 94
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 295-352 1.09e-12

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 65.11  E-value: 1.09e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 528482221  295 FYKPVDAETLglLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYN 352
Cdd:cd05512    22 FSEPVDLSEV--PDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYN 77
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 54-112 1.22e-12

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 64.73  E-value: 1.22e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 528482221   54 FRQPVDAVRLnlPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNR 112
Cdd:cd05512    22 FSEPVDLSEV--PDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNA 78
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 39-132 6.50e-12

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 63.63  E-value: 6.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   39 KVVIRALWKHHFSWPFRQPVDAVRLnlPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYN-RPGDDI 117
Cdd:cd05496    11 KELVNLMWDCEDSEPFRQPVDLLKY--PDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYTpNKRSRI 88

                          90
                  ....*....|....*
gi 528482221  118 VLMAQVLEKLFLEKV 132
Cdd:cd05496    89 YSMTLRLSALFEEHI 103
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 308-368 1.36e-11

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 61.97  E-value: 1.36e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528482221  308 DYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKLQDV 368
Cdd:cd05520    38 DYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQKL 98
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 62-130 1.71e-11

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 62.06  E-value: 1.71e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528482221   62 RLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLE 130
Cdd:cd05516    34 RKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFKS 102
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 41-121 1.86e-11

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 61.61  E-value: 1.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   41 VIRALWKHHFSWPFRQPVDavRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLM 120
Cdd:cd05507    11 VYRTLASHRYASVFLKPVT--EDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLM 88


                  .
gi 528482221  121 A 121
Cdd:cd05507    89 A 89
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 308-370 8.35e-11

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 60.04  E-value: 8.35e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528482221  308 DYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKLQDVFE 370
Cdd:cd05524    40 EYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWELFL 102
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 62-133 9.56e-11

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 59.64  E-value: 9.56e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528482221   62 RLNLPDYYTIIKNPMDLTTIRKRLENnyYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLEKVA 133
Cdd:cd05521    34 RKDYPDYYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILEKYINDVII 103
BRD4_CDT pfam17105
C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal ...
 1051-1093 1.16e-10

C-terminal domain of bromodomain protein 4; BRD4_CDT is the short highly conserved C-terminal domain of certain bromodomain proteins, notably Brd4. The Brd4 CTD interacts with the cyclin T1 and Cdk9 subunits of positive transcription elongation factor b (pTEFb) complex. Brd4 displaces negative regulators, the HEXIM1 and 7SKsnRNA complex, from pTEFb, thereby transforming it into an active form that can phosphorylate RNA pol II.


Pssm-ID: 465349  Cd Length: 44  Bit Score: 57.40  E-value: 1.16e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 528482221  1051 SVDREREMARKREQERRRREAMSGVIDMTMQRDIMATFEKNLE 1093
Cdd:pfam17105    2 SLDKERELARKREQERRRREAMAGTIDMNLQSDIMASFEENLD 44
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 308-370 1.88e-10

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 58.89  E-value: 1.88e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528482221  308 DYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKLQDVFE 370
Cdd:cd05519    38 DYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFK 100
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 308-366 2.31e-10

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 58.41  E-value: 2.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 528482221  308 DYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKLQ 366
Cdd:cd05522    39 EYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVLLE 97
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 66-132 2.78e-10

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 58.50  E-value: 2.78e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528482221   66 PDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLEKV 132
Cdd:cd05520    37 PDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQKLMQAKK 103
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 50-114 3.81e-10

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 57.81  E-value: 3.81e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528482221   50 FSWPFrqpVDAVRlnlPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPG 114
Cdd:cd05513    22 FAFPV---TDFIA---PGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPD 80
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 66-128 6.86e-10

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 57.25  E-value: 6.86e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528482221   66 PDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLF 128
Cdd:cd05522    38 PEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVLLEKEA 100
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 295-365 7.18e-10

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 57.03  E-value: 7.18e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528482221  295 FYKPV-DAETLGlldYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKL 365
Cdd:cd05513    22 FAFPVtDFIAPG---YSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTIYYKAAKKL 90
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 255-369 7.81e-10

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 57.73  E-value: 7.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  255 PESPPQHQVGRRTKLSERLKYCNAILKEMF---SKKHSAYAWPFYKPVDaETLGLLDYHEIIHQPMDMSTIKKKMEAREY 331
Cdd:cd05529     5 LSSEWELFDPGWEQPHIRDEERERLISGLDkllLSLQLEIAEYFEYPVD-LRAWYPDYWNRVPVPMDLETIRSRLENRYY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 528482221  332 --TDALQFaaDMRLMFSNCYKYNPPGHEVVSMARKLQDVF 369
Cdd:cd05529    84 rsLEALRH--DVRLILSNAETFNEPNSEIAKKAKRLSDWL 121
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 282-368 8.81e-10

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 57.07  E-value: 8.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  282 EMFSKKHSAYAWPfykpvdaetlgllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSM 361
Cdd:cd05518    25 DLFMEKPSKKDYP-------------DYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYED 91


                  ....*..
gi 528482221  362 ARKLQDV 368
Cdd:cd05518    92 ANILEKV 98
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 306-376 8.49e-09

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 54.36  E-value: 8.49e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528482221  306 LLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKLQDVFEFRFSKI 376
Cdd:cd05516    37 LPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFKSARQKI 107
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 66-128 3.37e-08

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 52.44  E-value: 3.37e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528482221   66 PDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLF 128
Cdd:cd05517    37 PDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDANAIKKIF 99
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 53-138 1.11e-07

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 51.20  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   53 PFRQPVDAVRLnlPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNrPGDD-----IVLMAQVLEKL 127
Cdd:cd05528    23 AFTKPVDEEEV--PDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYN-PDRDpadklIRSRACELRDE 99

                          90
                  ....*....|..
gi 528482221  128 FLEKV-AEMPEE 138
Cdd:cd05528   100 VHAMIeAELDPL 111
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 62-140 1.52e-07

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 50.79  E-value: 1.52e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 528482221   62 RLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLEKVAEMPEEEY 140
Cdd:cd05524    35 RRNEPEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWELFLSARNEVLSGGE 113
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 308-376 4.37e-07

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 49.35  E-value: 4.37e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528482221  308 DYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNC---YKYNppghEVVSMARKLQDVFEFRFSKI 376
Cdd:cd05501    32 DYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHklfYKDD----DFGQVGITLEKKFEKNFKEV 99
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 36-86 4.95e-07

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 49.36  E-value: 4.95e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 528482221   36 YIEKVVIRALWKHHFSWPFRQPVDAVRLNLPDYYTIIKNPMDLTTIRKRLE 86
Cdd:cd05494     6 ERVLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTKVNNIV 56
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 268-365 1.77e-06

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 47.38  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  268 KLSERLKYcnaILKEMFSKKHSayawPFYKPVDAETLglLDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSN 347
Cdd:cd05508     3 QLSKLLKF---ALERMKQPGAE----PFLKPVDLEQF--PDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHN 73

                          90
                  ....*....|....*...
gi 528482221  348 CYKYNPPGHEVVSMARKL 365
Cdd:cd05508    74 AIIYNGGDHKLTQAAKAI 91
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 62-129 8.15e-06

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 45.84  E-value: 8.15e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528482221   62 RLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFL 129
Cdd:cd05525    35 KKKNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYY 102
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 67-131 9.48e-06

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 45.50  E-value: 9.48e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528482221   67 DYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRpGDDIVLMAQVLEKLFlEK 131
Cdd:cd05501    32 DYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYK-DDDFGQVGITLEKKF-EK 94
PHA03247 PHA03247
large tegument protein UL36; Provisional
 743-904 2.70e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  743 PPQPSRPSGKAAALPRKIwTTPSPLSLPPDQALSPLYNASATSPC---KDHTIIPAKSSPESVTPDPPNSLPKDPLFPCS 819
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRL-TRPAVASLSESRESLPSPWDPADPPAavlAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  820 PLlPP---------PDMQVSQVGPPSSVAAKI---------------PPQKSEKEGIPPL-LSPLTSPSAAMPATGSQST 874
Cdd:PHA03247 2845 PP-PPslplggsvaPGGDVRRRPPSRSPAAKPaaparppvrrlarpaVSRSTESFALPPDqPERPPQPQAPPPPQPQPQP 2923

                         170       180       190
                  ....*....|....*....|....*....|.
gi 528482221  875 SSSQFEQCRLLSP-LHESPLASMRNEQDCPE 904
Cdd:PHA03247 2924 PPPPQPQPPPPPPpRPQPPLAPTTDPAGAGE 2954
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 52-132 1.15e-04

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 45.57  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   52 WPFRQPVDavRLNLPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKLFLEK 131
Cdd:COG5076   282 WPFLRPVS--DEEVPDYYKDIRDPMDLSTKELKLRNNYYRPEETFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDFVIKK 359


                  .
gi 528482221  132 V 132
Cdd:COG5076   360 T 360
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 307-370 1.28e-04

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 42.38  E-value: 1.28e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 528482221  307 LDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKLQDVFE 370
Cdd:cd05525    39 PDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYY 102
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 273-336 2.10e-04

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 42.05  E-value: 2.10e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 528482221  273 LKYCNAILKEMFSKKHSAYAWPFYKPVDAETLGLLDYHEIIHQPMDMSTIKK---KMEAREYTDALQ 336
Cdd:cd05494     2 YEALERVLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTKVNnivETGARDLEDLQI 68
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 279-372 2.46e-04

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 41.27  E-value: 2.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  279 ILKEMFSKKHSAYAWPfykpvdaetlgllDYHEIIHQPMDMSTIKKKMEAREYTDALQFAADMRLMFSNCYKYNPPGHEV 358
Cdd:cd05517    22 LISELFQKLPSKVLYP-------------DYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQV 88

                          90
                  ....*....|....
gi 528482221  359 VSMARKLQDVFEFR 372
Cdd:cd05517    89 YKDANAIKKIFTAK 102
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 53-127 4.40e-04

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 40.44  E-value: 4.40e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528482221   53 PFRQPVDAVRLnlPDYYTIIKNPMDLTTIRKRLENNYYWKAMECVEDFNTMFTNCYVYNRPGDDIVLMAQVLEKL 127
Cdd:cd05508    22 PFLKPVDLEQF--PDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDHKLTQAAKAIVKI 94
PRK10118 PRK10118
flagellar hook length control protein FliK;
663-862 8.80e-04

flagellar hook length control protein FliK;


Pssm-ID: 236652 [Multi-domain]  Cd Length: 408  Bit Score: 42.93  E-value: 8.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  663 EQKTKRKQSKG-------PGHANKIKKKALRQANAEVK-DSSSASGVMCQSRPSSLV-SETGSKDLFASQHAKHPV---- 729
Cdd:PRK10118   55 LQAAGGKLSKGllttkgePLVSDKLADLLAQQANLLIPvDETLPVITDEQSLSSPLTpALKTSALAALSKNAQKDEkadd 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  730 ---EDITAITALHSRLPPQPsrPSGKAAALPRKIWTTPSPLSLPPDQAlSPLYNASATSPCKDHTIIPAKSSPESVTPDP 806
Cdd:PRK10118  135 lsdEDLASLSALFAMLPGQD--NTTPVADAPSTVLPAEKPTLLTKDMP-SAPQDETHTLSSDEHEKGLTSAQLTTAQPDD 211

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528482221  807 PNSlpkDPLFPCSPLLPPPDMQVSQVGPPSSVAAKIPPQKSEKEGIP------PLLS-PLTSP 862
Cdd:PRK10118  212 APG---TPAQPLTPLAAEAQAKAEVISTPSPVTAAASPTITPHQTQPlptaaaPVLSaPLGSH 271
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 737-911 1.18e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   737 ALHSRLPPQPSRPSGKAAALPRKIWTTPSPLSLPPDQA---LSPLYNASATSPCKDHTiIPAKSSPESVTPDPPNSLPKD 813
Cdd:pfam03154  270 SLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSqvpPGPSPAAPGQSQQRIHT-PPSQSQLQSQQPPREQPLPPA 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   814 PLfPCSPLLPPPDMQVSQVGPPSS------VAAKIPPQKSEKEGIPPLLSPLTSPSAAMPATGsqstsssqfeqcrllsp 887
Cdd:pfam03154  349 PL-SMPHIKPPPTTPIPQLPNPQShkhpphLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSA----------------- 410

                          170       180
                   ....*....|....*....|....
gi 528482221   888 lHESPLASMRNEQDCPETPEESSV 911
Cdd:pfam03154  411 -HPPPLQLMPQSQQLPPPPAQPPV 433
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 763-910 1.21e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 1.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221   763 TPSPLSLPPDQALSPLYNASATSPCKDHTIIPAKSSP-------ESVTPDPPNSLPKDPLFPCSPLLP---PPDMQVSQV 832
Cdd:pfam03154  176 AQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPatsqppnQTQSTAAPHTLIQQTPTLHPQRLPsphPPLQPMTQP 255

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 528482221   833 GPPSSVAAKIPPQKSEKEGIPPLLSPLTSPSAAMPATGSQSTSSSQFEQCRLLSPLHESPLASMRNEQDCPETPEESS 910
Cdd:pfam03154  256 PPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQ 333
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 308-367 2.22e-03

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 38.84  E-value: 2.22e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  308 DYHEIIHQPMDMSTIKKKMeaREYTDALQFAADMRLMFSNCYKYNPPGHEVVSMARKLQD 367
Cdd:cd05521    39 DYYKIIKNPLSLNTVKKRL--PHYTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILEK 96
PHA03247 PHA03247
large tegument protein UL36; Provisional
 688-868 3.65e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  688 ANAEVKDSSSASGVMCQSRPSSLVSETGSKDLFASQHAKHPVEDITAITA-------LHSRLPPQPSRPSGKAAALPR-- 758
Cdd:PHA03247 2805 ADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvapggdVRRRPPSRSPAAKPAAPARPPvr 2884

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  759 -----KIWTTPSPLSLPPDQALSPLYNASATSPckdhtiIPAKSSPESVTPDPPnslPKDPLFPCSPLLPPPDMQVSQVG 833
Cdd:PHA03247 2885 rlarpAVSRSTESFALPPDQPERPPQPQAPPPP------QPQPQPPPPPQPQPP---PPPPPRPQPPLAPTTDPAGAGEP 2955

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 528482221  834 PPSSVAAKIPPQKSEKEGIPPLLSPLTSPSAAMPA 868
Cdd:PHA03247 2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPA 2990
PHA03247 PHA03247
large tegument protein UL36; Provisional
 707-861 7.92e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 7.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  707 PSSLVSETGSKDLFASQHAKHPVEDITAITALHSRLPPQPSRPsgKAAALPRKIWTTPSPLSLPPDQALSPLYNASATSp 786
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARP--RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS- 2632

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528482221  787 ckdhtiiPAKSSPESVTPDPPNSLPKDPLFPCSPLLPPPDMQVSQVGPPSSVAakiPPQKSEKEGIPPLLSPLTS 861
Cdd:PHA03247 2633 -------PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS---PPQRPRRRAARPTVGSLTS 2697
PHA03247 PHA03247
large tegument protein UL36; Provisional
 743-863 8.84e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528482221  743 PPQPSRPSGKAAALPRKIwTTPSPLSLPPDqalsPLYNASATSPckdhtiipaKSSPESVTPDPPNSLPKDPLFPCSPLL 822
Cdd:PHA03247 2551 PPPPLPPAAPPAAPDRSV-PPPRPAPRPSE----PAVTSRARRP---------DAPPQSARPRAPVDDRGDPRGPAPPSP 2616

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 528482221  823 PPPDMQVSQVGPPSSVAAKIPPQKSEKEGIPPLLSPLTSPS 863
Cdd:PHA03247 2617 LPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPA 2657
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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