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    pou2f1b POU class 2 homeobox 1b [ Danio rerio (zebrafish) ]

    Gene ID: 323702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pou2f1bprovided by ZNC
    Official Full Name
    POU class 2 homeobox 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2422
    See related
    Ensembl:ENSDARG00000007996 AllianceGenome:ZFIN:ZDB-GENE-030131-2422
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc07d06; wu:fc07d06; zgc:158360
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in telencephalon. Orthologous to human POU2F1 (POU class 2 homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See pou2f1b in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (34319333..34355548)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (34510148..34546363)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin-like domain containing receptor 2 Neighboring gene glycoprotein A33 (transmembrane), paralog b Neighboring gene uncharacterized LOC137496486 Neighboring gene CD247 antigen like Neighboring gene uncharacterized LOC101887113

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptors. Yoder JA, et al. Gene, 2007 Oct 15. PMID 17719728, Free PMC Article
    2. Evolutionary context can clarify gene names: Teleosts as a case study. Gasanov EV, et al. Bioessays, 2021 Jun. PMID 33829511
    3. YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. Lin J, et al. Natl Sci Rev, 2023 Dec. PMID 38152479, Free PMC Article
    4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    POU domain, class 2, transcription factor 1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089329.1 → NP_001082798.1  POU domain, class 2, transcription factor 1b

      See identical proteins and their annotated locations for NP_001082798.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134808
      UniProtKB/TrEMBL
      A4IFW4
      Related
      ENSDARP00000037034.6, ENSDART00000035522.8
      Conserved Domains (2) summary
      smart00352
      Location:214 → 287
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:321 → 375
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      34319333..34355548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167815.4 → XP_005167872.1  POU domain, class 2, transcription factor 1b isoform X4

      UniProtKB/TrEMBL
      A0A8M2BFW2
      Conserved Domains (3) summary
      smart00352
      Location:236 → 310
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:340 → 394
      Homeobox; Homeobox domain
      pfam03153
      Location:59 → 226
      TFIIA; Transcription factor IIA, alpha/beta subunit

    2. XM_009304814.3 → XP_009303089.1  POU domain, class 2, transcription factor 1b isoform X7

      UniProtKB/TrEMBL
      A0A8M3AW75
      Conserved Domains (3) summary
      smart00352
      Location:236 → 310
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:340 → 394
      Homeobox; Homeobox domain
      pfam03153
      Location:59 → 226
      TFIIA; Transcription factor IIA, alpha/beta subunit

    3. XM_005167816.4 → XP_005167873.1  POU domain, class 2, transcription factor 1b isoform X6

      UniProtKB/TrEMBL
      A0A8M2BF85
      Conserved Domains (3) summary
      smart00352
      Location:236 → 310
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:340 → 393
      Homeobox; Homeobox domain
      pfam03153
      Location:59 → 226
      TFIIA; Transcription factor IIA, alpha/beta subunit

    4. XM_017357651.3 → XP_017213140.1  POU domain, class 2, transcription factor 1b isoform X8

      UniProtKB/TrEMBL
      A0A8M6Z2I0

    5. XM_068223294.1 → XP_068079395.1  POU domain, class 2, transcription factor 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BFA0

    6. XM_068223297.1 → XP_068079398.1  POU domain, class 2, transcription factor 1b isoform X5

      UniProtKB/TrEMBL
      A0A8M3B2T2

    7. XM_068223296.1 → XP_068079397.1  POU domain, class 2, transcription factor 1b isoform X3

      UniProtKB/TrEMBL
      A0A8M2BFA3

    8. XM_068223299.1 → XP_068079400.1  POU domain, class 2, transcription factor 1b isoform X10

    9. XM_068223298.1 → XP_068079399.1  POU domain, class 2, transcription factor 1b isoform X9

      UniProtKB/TrEMBL
      A0A8M2BF93

    10. XM_068223295.1 → XP_068079396.1  POU domain, class 2, transcription factor 1b isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z0V0
    Nucleotide Protein Strain
    Heading Accession and Version

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