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Conserved domains on  [gi|528490449|ref|XP_005167872|]
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POU domain, class 2, transcription factor 1b isoform X4 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
POU2F1_C pfam19536
POU domain, class 2, transcription factor 1 C-terminal; This domain represents the C-terminal ...
406-699 1.33e-109

POU domain, class 2, transcription factor 1 C-terminal; This domain represents the C-terminal region of the POU domain, class 2 subfamily, transcription factor 1, which is localized adjacent to the homeobox domain. This transcription factor activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.


:

Pssm-ID: 437368  Cd Length: 284  Bit Score: 333.37  E-value: 1.33e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490449  406 STPIKAIFSPTTTLVPSTASLITSNTPTTMTVNPVLPLTSTSVSGISFTGTTLGSAiNNTASVISTAPAATTASSSPSLS 485
Cdd:pfam19536   1 STPIKAIFTPSSPLVASTASLVTSNTPTTLTVNPVMPLTSTSVSSLSFTGTTVGTA-TNTASVISTAPVVTTATSSPSLS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490449  486 PSPTAVQTSSSEQASAQETLTAVSQAPSSLASTLGTGQVMVAAPSLSAALQGAAQLPTSASIAAMAAAAGLNPGLMASSQ 565
Cdd:pfam19536  80 PSPTASQSSSSESKVSQENTTQVTQAPSSLASTLGTGQVMVAAPGLSAALQGAAQLPTSASFAAMAAAAGLNPGLMASSQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490449  566 FAPGGALLSLAPGGLGSALSPALMSNSTLATIQgvwsALASSGTLPITSLDGSGNLLFANTSAGSTPNLVTAPLFLNPQN 645
Cdd:pfam19536 160 FAPGGALLSLNPGGLGGALSPALMSNSTLATIQ----ALASSGTLPITSLDGSGNLLFANTSAGGTPNLVTAPLFLNPQN 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 528490449  646 LSLLASNPVSLVSAGGAAGAAGALNLHftadaHQSAVTTATMPASTITTASKAQ 699
Cdd:pfam19536 236 LSLLTSNPVSLVSAGAAGGLSGPVDSH-----HQASTATVSVQASTITTASKAQ 284
POU smart00352
Found in Pit-Oct-Unc transcription factors;
236-310 1.48e-46

Found in Pit-Oct-Unc transcription factors;


:

Pssm-ID: 197673  Cd Length: 75  Bit Score: 159.14  E-value: 1.48e-46
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528490449   236 EEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAE 310
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
338-395 2.36e-20

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 84.86  E-value: 2.36e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 528490449  338 RKKRTSIETNIRVALEKSFlEQNQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKR 395
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEF-QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
POU2F1_C pfam19536
POU domain, class 2, transcription factor 1 C-terminal; This domain represents the C-terminal ...
406-699 1.33e-109

POU domain, class 2, transcription factor 1 C-terminal; This domain represents the C-terminal region of the POU domain, class 2 subfamily, transcription factor 1, which is localized adjacent to the homeobox domain. This transcription factor activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.


Pssm-ID: 437368  Cd Length: 284  Bit Score: 333.37  E-value: 1.33e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490449  406 STPIKAIFSPTTTLVPSTASLITSNTPTTMTVNPVLPLTSTSVSGISFTGTTLGSAiNNTASVISTAPAATTASSSPSLS 485
Cdd:pfam19536   1 STPIKAIFTPSSPLVASTASLVTSNTPTTLTVNPVMPLTSTSVSSLSFTGTTVGTA-TNTASVISTAPVVTTATSSPSLS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490449  486 PSPTAVQTSSSEQASAQETLTAVSQAPSSLASTLGTGQVMVAAPSLSAALQGAAQLPTSASIAAMAAAAGLNPGLMASSQ 565
Cdd:pfam19536  80 PSPTASQSSSSESKVSQENTTQVTQAPSSLASTLGTGQVMVAAPGLSAALQGAAQLPTSASFAAMAAAAGLNPGLMASSQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490449  566 FAPGGALLSLAPGGLGSALSPALMSNSTLATIQgvwsALASSGTLPITSLDGSGNLLFANTSAGSTPNLVTAPLFLNPQN 645
Cdd:pfam19536 160 FAPGGALLSLNPGGLGGALSPALMSNSTLATIQ----ALASSGTLPITSLDGSGNLLFANTSAGGTPNLVTAPLFLNPQN 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 528490449  646 LSLLASNPVSLVSAGGAAGAAGALNLHftadaHQSAVTTATMPASTITTASKAQ 699
Cdd:pfam19536 236 LSLLTSNPVSLVSAGAAGGLSGPVDSH-----HQASTATVSVQASTITTASKAQ 284
POU smart00352
Found in Pit-Oct-Unc transcription factors;
236-310 1.48e-46

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 159.14  E-value: 1.48e-46
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528490449   236 EEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAE 310
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
240-310 6.91e-42

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 146.27  E-value: 6.91e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528490449  240 DLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAE 310
Cdd:pfam00157   2 NLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
338-395 2.36e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 84.86  E-value: 2.36e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 528490449  338 RKKRTSIETNIRVALEKSFlEQNQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKR 395
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEF-QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
337-394 1.32e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 74.21  E-value: 1.32e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 528490449   337 RRKKRTSIETNIRVALEKSFlEQNQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEK 394
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEF-QKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
338-395 3.04e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 73.05  E-value: 3.04e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528490449 338 RKKRTSIETNIRVALEKSFlEQNQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKR 395
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEF-EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
336-397 4.97e-08

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 52.82  E-value: 4.97e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528490449 336 RRRKKRTSIETNIrvaLEKSFlEQNQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRIN 397
Cdd:COG5576   53 SKRRRTTDEQLMV---LEREF-EINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
 
Name Accession Description Interval E-value
POU2F1_C pfam19536
POU domain, class 2, transcription factor 1 C-terminal; This domain represents the C-terminal ...
406-699 1.33e-109

POU domain, class 2, transcription factor 1 C-terminal; This domain represents the C-terminal region of the POU domain, class 2 subfamily, transcription factor 1, which is localized adjacent to the homeobox domain. This transcription factor activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins.


Pssm-ID: 437368  Cd Length: 284  Bit Score: 333.37  E-value: 1.33e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490449  406 STPIKAIFSPTTTLVPSTASLITSNTPTTMTVNPVLPLTSTSVSGISFTGTTLGSAiNNTASVISTAPAATTASSSPSLS 485
Cdd:pfam19536   1 STPIKAIFTPSSPLVASTASLVTSNTPTTLTVNPVMPLTSTSVSSLSFTGTTVGTA-TNTASVISTAPVVTTATSSPSLS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490449  486 PSPTAVQTSSSEQASAQETLTAVSQAPSSLASTLGTGQVMVAAPSLSAALQGAAQLPTSASIAAMAAAAGLNPGLMASSQ 565
Cdd:pfam19536  80 PSPTASQSSSSESKVSQENTTQVTQAPSSLASTLGTGQVMVAAPGLSAALQGAAQLPTSASFAAMAAAAGLNPGLMASSQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528490449  566 FAPGGALLSLAPGGLGSALSPALMSNSTLATIQgvwsALASSGTLPITSLDGSGNLLFANTSAGSTPNLVTAPLFLNPQN 645
Cdd:pfam19536 160 FAPGGALLSLNPGGLGGALSPALMSNSTLATIQ----ALASSGTLPITSLDGSGNLLFANTSAGGTPNLVTAPLFLNPQN 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 528490449  646 LSLLASNPVSLVSAGGAAGAAGALNLHftadaHQSAVTTATMPASTITTASKAQ 699
Cdd:pfam19536 236 LSLLTSNPVSLVSAGAAGGLSGPVDSH-----HQASTATVSVQASTITTASKAQ 284
POU smart00352
Found in Pit-Oct-Unc transcription factors;
236-310 1.48e-46

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 159.14  E-value: 1.48e-46
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 528490449   236 EEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAE 310
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
240-310 6.91e-42

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 146.27  E-value: 6.91e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 528490449  240 DLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAE 310
Cdd:pfam00157   2 NLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
338-395 2.36e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 84.86  E-value: 2.36e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 528490449  338 RKKRTSIETNIRVALEKSFlEQNQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKR 395
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEF-QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
337-394 1.32e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 74.21  E-value: 1.32e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 528490449   337 RRKKRTSIETNIRVALEKSFlEQNQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEK 394
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEF-QKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
338-395 3.04e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 73.05  E-value: 3.04e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 528490449 338 RKKRTSIETNIRVALEKSFlEQNQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKR 395
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEF-EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
336-397 4.97e-08

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 52.82  E-value: 4.97e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 528490449 336 RRRKKRTSIETNIrvaLEKSFlEQNQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRIN 397
Cdd:COG5576   53 SKRRRTTDEQLMV---LEREF-EINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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