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    anxa11a annexin A11a [ Danio rerio (zebrafish) ]

    Gene ID: 368215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    anxa11aprovided by ZNC
    Official Full Name
    annexin A11aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030707-4
    See related
    Ensembl:ENSDARG00000077383 AllianceGenome:ZFIN:ZDB-GENE-030707-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    anx11a; ANX-XIa; fc09a11; sb:cb401; wu:fc09a11
    Summary
    Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Predicted to be involved in cytokinetic process and phagocytosis. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in several structures, including cardiovascular system; ectoderm; integument; mesoderm; and musculature system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 23 and inclusion body myopathy and brain white matter abnormalities. Orthologous to human ANXA11 (annexin A11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See anxa11a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (16279890..16326599)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (16148885..16195607)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene zgc:110045 Neighboring gene molybdenum cofactor sulfurase Neighboring gene discs, large homolog 5a (Drosophila) Neighboring gene potassium large conductance calcium-activated channel, subfamily M, alpha member 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish annexin gene family. Farber SA, et al. Genome Res, 2003 Jun. PMID 12799347, Free PMC Article
    2. Role of annexin gene and its regulation during zebrafish caudal fin regeneration. Saxena S, et al. Wound Repair Regen, 2016 May. PMID 26972483
    3. In vivo imaging of molecular interactions at damaged sarcolemma. Roostalu U, et al. Dev Cell, 2012 Mar 13. PMID 22421042
    4. Phylogenetic and developmental analyses indicate complex functions of calcium-activated potassium channels in zebrafish embryonic development. Silic MR, et al. Dev Dyn, 2021 Oct. PMID 33728688, Free PMC Article
    5. Coherent but overlapping expression of microRNAs and their targets during vertebrate development. Shkumatava A, et al. Genes Dev, 2009 Feb 15. PMID 19240133, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC64024

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokinetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    annexin A11a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181765.2 → NP_861430.2  annexin A11a isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX323467
      UniProtKB/TrEMBL
      A0A8N7UZU9, B8A4V2
      Related
      ENSDARP00000092551.3, ENSDART00000101775.5
      Conserved Domains (2) summary
      pfam02084
      Location:8 → 89
      Bindin; Bindin
      pfam00191
      Location:456 → 521
      Annexin; Annexin

    2. NM_183410.2 → NP_899670.1  annexin A11a isoform 2

      See identical proteins and their annotated locations for NP_899670.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BX323467
      UniProtKB/TrEMBL
      A0A8M1PCE3, Q7T391
      Related
      ENSDARP00000057947.3, ENSDART00000057948.4
      Conserved Domains (2) summary
      pfam02084
      Location:8 → 89
      Bindin; Bindin
      pfam00191
      Location:413 → 478
      Annexin; Annexin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      16279890..16326599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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