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anxa11a annexin A11a [ Danio rerio (zebrafish) ]

Gene ID: 368215, updated on 9-Dec-2024

Summary

Official Symbol
anxa11aprovided by ZNC
Official Full Name
annexin A11aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030707-4
See related
Ensembl:ENSDARG00000077383 AllianceGenome:ZFIN:ZDB-GENE-030707-4
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
anx11a; ANX-XIa; fc09a11; sb:cb401; wu:fc09a11
Summary
Predicted to enable calcium-dependent phospholipid binding activity and phosphatidylserine binding activity. Predicted to be involved in cytokinetic process and phagocytosis. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Is expressed in several structures, including cardiovascular system; ectoderm; integument; mesoderm; and musculature system. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 23 and inclusion body myopathy and brain white matter abnormalities. Orthologous to human ANXA11 (annexin A11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See anxa11a in Genome Data Viewer
Location:
chromosome: 13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (16279890..16326599)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (16148885..16195607)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene zgc:110045 Neighboring gene molybdenum cofactor sulfurase Neighboring gene discs, large homolog 5a (Drosophila) Neighboring gene potassium large conductance calcium-activated channel, subfamily M, alpha member 1a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Clone Names

  • MGC64024

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding  
enables calcium-dependent phospholipid binding  
enables calcium-dependent phospholipid binding  
enables phosphatidylserine binding  
Process Evidence Code Pubs
involved_in cytokinetic process  
involved_in phagocytosis  
Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in nucleus  
is_active_in plasma membrane  
is_active_in vesicle membrane  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181765.2NP_861430.2  annexin A11a isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BX323467
    UniProtKB/TrEMBL
    A0A8N7UZU9, B8A4V2
    Related
    ENSDARP00000092551.3, ENSDART00000101775.5
    Conserved Domains (2) summary
    pfam02084
    Location:889
    Bindin; Bindin
    pfam00191
    Location:456521
    Annexin; Annexin
  2. NM_183410.2NP_899670.1  annexin A11a isoform 2

    See identical proteins and their annotated locations for NP_899670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BX323467
    UniProtKB/TrEMBL
    A0A8M1PCE3, Q7T391
    Related
    ENSDARP00000057947.3, ENSDART00000057948.4
    Conserved Domains (2) summary
    pfam02084
    Location:889
    Bindin; Bindin
    pfam00191
    Location:413478
    Annexin; Annexin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    16279890..16326599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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