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    xpnpep1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble [ Danio rerio (zebrafish) ]

    Gene ID: 406253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    xpnpep1provided by ZNC
    Official Full Name
    X-prolyl aminopeptidase (aminopeptidase P) 1, solubleprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-999
    See related
    Ensembl:ENSDARG00000029011 AllianceGenome:ZFIN:ZDB-GENE-040426-999
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa02e02; zgc:56366; zgc:77772; wu:fa02e02
    Summary
    Predicted to enable metalloaminopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm. Is expressed in intestine and liver. Orthologous to human XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See xpnpep1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (27092469..27115219, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (27230017..27252767, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) Neighboring gene rho-associated protein kinase 2-like Neighboring gene si:dkey-246e1.3 Neighboring gene Copper-only SOD repeat protein Neighboring gene uncharacterized LOC137488949 Neighboring gene si:dkey-208m12.2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of a plant isoflavonoid that causes biliary atresia. Lorent K, et al. Sci Transl Med, 2015 May 6. PMID 25947162, Free PMC Article
    2. Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. Tang V, et al. J Pediatr Gastroenterol Nutr, 2016 Nov. PMID 27526058, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC56366

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    xaa-Pro aminopeptidase 1
    NP_998145.1
    XP_021324983.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212980.1 → NP_998145.1  xaa-Pro aminopeptidase 1

      See identical proteins and their annotated locations for NP_998145.1

      Status: PROVISIONAL

      Source sequence(s)
      BC064889
      UniProtKB/TrEMBL
      A0A8M1PEE0, Q6P1S3
      Related
      ENSDARP00000022971.7, ENSDART00000019442.9
      Conserved Domains (5) summary
      COG0006
      Location:149 → 566
      PepP; Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
      cd01085
      Location:329 → 550
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:557 → 619
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:164 → 326
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:10 → 154
      Creatinase_N; Creatinase/Prolidase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      27092469..27115219 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469308.1 → XP_021324983.1  xaa-Pro aminopeptidase 1 isoform X1

      UniProtKB/TrEMBL
      A0A286Y8E9, A0A8M9PDT8
      Related
      ENSDARP00000143421.1, ENSDART00000178855.2
      Conserved Domains (4) summary
      cd01085
      Location:334 → 555
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:562 → 624
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:162 → 331
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:15 → 159
      Creatinase_N; Creatinase/Prolidase N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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