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Conserved domains on  [gi|47085707|ref|NP_998145|]
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xaa-Pro aminopeptidase 1 [Danio rerio]

Protein Classification

aminopeptidase P family protein( domain architecture ID 11047996)

aminopeptidase P family protein (metallopeptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
329-550 8.11e-141

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


:

Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 408.10  E-value: 8.11e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 329 GMKMAHIKDAVALCELFAWLEKEIPKG-TVTEISAADKAEELRSQQKEFVGLSFPTISSVGPNGAIIHYRPLPETNRTLS 407
Cdd:cd01085   1 GMRAAHIRDGVALVEFLAWLEQEVPKGeTITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESNRKIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 408 LNEVYLIDSGAQYTDGTTDVTRTVHFGTPSEYEKECFTYVLKGHIAVSAAVFPNGTKGHLLDSFARAALWDSGLDYLHGT 487
Cdd:cd01085  81 PDGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGT 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47085707 488 GHGVGCFLNVHEGPCGIsYKTFADEPLEAGMIVSDEPGYYEDGSFGIRLENVVLVVPATTKYN 550
Cdd:cd01085 161 GHGVGSFLNVHEGPQSI-SPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEF 222
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
157-326 2.41e-66

Creatinase/Prolidase N-terminal domain;


:

Pssm-ID: 465053  Cd Length: 159  Bit Score: 213.89  E-value: 2.41e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707   157 DRPSRPSTKLTALALKYTGFTWQDKITTLRGKMSERKISWFVVTALDEIAWLFNLRGSDIEYNPVFFAYAIIGMNSIRLF 236
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKGADALVLSALDEIAWLLNLRGSDVPYNPVFLSYALVTDDEATLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707   237 VDSKRLSDpAIREHLELDspskpdlSVQCFPYESVYTELqavcAALEPKDKMWI-CDKASCALTQAIPKSHRSAIPYTPL 315
Cdd:pfam16189  81 VDPEKLSD-EVRAHLEEN-------GVEIRPYDDIYEDL----AALAAGKKVLLdPSRTSYALYSALPAGAKVVEAPSPI 148
                         170
                  ....*....|.
gi 47085707   316 CLAKAVKNATE 326
Cdd:pfam16189 149 TLMKAVKNETE 159
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
557-619 5.70e-28

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


:

Pssm-ID: 465052  Cd Length: 63  Bit Score: 106.34  E-value: 5.70e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47085707   557 LTFEPLTLVPIQLKMINTDLLTQKERDWVNDYHRKCRETIGAELERQGrkEARDWLIRETQPI 619
Cdd:pfam16188   3 LGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEE--DALEWLKRATRPI 63
Creatinase_N super family cl46291
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
10-154 6.21e-09

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


The actual alignment was detected with superfamily member pfam01321:

Pssm-ID: 480631  Cd Length: 128  Bit Score: 54.62  E-value: 6.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707    10 LRQLRQAMKNSKyitepIQAYIVPSGDahqseyiapcdcRREFICGFNGSAGTAI-VTEQHAALWTD-GRYFLQASQQmd 87
Cdd:pfam01321   2 LEKLRKLMEEKG-----LDAALVTSPE------------NLRYLTGFTGSRGLLLlVTADGALLLVDaLEYERAAAES-- 62
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47085707    88 nnWTLMKM-GLKETPSQEDWLISVLPENSKVGVDPWIIAADQWKNMSKALSGAghSLVAVqDNLIDAI 154
Cdd:pfam01321  63 --APDFDVvPYRDYEALADLLKELGAGGKRVGFEADALTVAFYEALKEALPGA--ELVDV-SGLIERL 125
 
Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
329-550 8.11e-141

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 408.10  E-value: 8.11e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 329 GMKMAHIKDAVALCELFAWLEKEIPKG-TVTEISAADKAEELRSQQKEFVGLSFPTISSVGPNGAIIHYRPLPETNRTLS 407
Cdd:cd01085   1 GMRAAHIRDGVALVEFLAWLEQEVPKGeTITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESNRKIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 408 LNEVYLIDSGAQYTDGTTDVTRTVHFGTPSEYEKECFTYVLKGHIAVSAAVFPNGTKGHLLDSFARAALWDSGLDYLHGT 487
Cdd:cd01085  81 PDGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGT 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47085707 488 GHGVGCFLNVHEGPCGIsYKTFADEPLEAGMIVSDEPGYYEDGSFGIRLENVVLVVPATTKYN 550
Cdd:cd01085 161 GHGVGSFLNVHEGPQSI-SPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEF 222
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
185-569 7.22e-71

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 230.86  E-value: 7.22e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 185 LRGKMSERKISWFVVTALDEIAWLFNLRGSdieynPVFFAYAII-GMNSIRLFVDSkrlsdpaiREhleldspskpdlsv 263
Cdd:COG0006   3 LRALMAEAGLDALLLTDPSNFAYLTGFRGS-----PERLAALLVtADGEPVLFVDE--------LE-------------- 55
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 264 qcfpYESVYTELQAVCAALepkdkmwicdkascaltqaipkshrsaipytplclaKAVKNATEIQGMKMAHIKDAVALCE 343
Cdd:COG0006  56 ----AERELVDASDLLEEL------------------------------------RAIKSPEEIELMRKAARIADAAHEA 95
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 344 LFAWLEKEipkgtVTEISAADKAEELRSQQkEFVGLSFPTISSVGPNGAIIHYRPlpeTNRTLSLNEVYLIDSGAQYTDG 423
Cdd:COG0006  96 ALAALRPG-----VTEREVAAELEAAMRRR-GAEGPSFDTIVASGENAAIPHYTP---TDRPLKPGDLVLIDAGAEYDGY 166
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 424 TTDVTRTVHFGTPSEYEKECFTYVLKGHIAVSAAVfPNGTKGHLLDSFARAALWDSGL--DYLHGTGHGVGcfLNVHEGP 501
Cdd:COG0006 167 TSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAAL-KPGVTGGEVDAAARDVLAEAGYgeYFPHGTGHGVG--LDVHEGP 243
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47085707 502 cgiSYKTFADEPLEAGMIVSDEPGYYEDGSFGIRLENVVLVVPAttkynyrnrgslTFEPLTLVPIQL 569
Cdd:COG0006 244 ---QISPGNDRPLEPGMVFTIEPGIYIPGIGGVRIEDTVLVTED------------GAEVLTRLPREL 296
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
157-326 2.41e-66

Creatinase/Prolidase N-terminal domain;


Pssm-ID: 465053  Cd Length: 159  Bit Score: 213.89  E-value: 2.41e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707   157 DRPSRPSTKLTALALKYTGFTWQDKITTLRGKMSERKISWFVVTALDEIAWLFNLRGSDIEYNPVFFAYAIIGMNSIRLF 236
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKGADALVLSALDEIAWLLNLRGSDVPYNPVFLSYALVTDDEATLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707   237 VDSKRLSDpAIREHLELDspskpdlSVQCFPYESVYTELqavcAALEPKDKMWI-CDKASCALTQAIPKSHRSAIPYTPL 315
Cdd:pfam16189  81 VDPEKLSD-EVRAHLEEN-------GVEIRPYDDIYEDL----AALAAGKKVLLdPSRTSYALYSALPAGAKVVEAPSPI 148
                         170
                  ....*....|.
gi 47085707   316 CLAKAVKNATE 326
Cdd:pfam16189 149 TLMKAVKNETE 159
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
328-544 6.53e-60

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 198.62  E-value: 6.53e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707   328 QGMKMAHIKDAVALCELFAWLEKEipkgtVTEISAADKAEELRSQQKEFVGLSFPTISSVGPNGAIIHYRPlpeTNRTLS 407
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPG-----VTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHYIP---NDRVLK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707   408 LNEVYLIDSGAQYTDG-TTDVTRTVHFGTPSEYEKECFTYVLKGHIAVSAAVFPnGTKGHLLDSFARAALWDSGLD--YL 484
Cdd:pfam00557  73 PGDLVLIDVGAEYDGGyCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKP-GVTGGDVDAAAREVLEEAGLGeyFP 151
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47085707   485 HGTGHGVGcfLNVHEGPcgISYKTFADEPLEAGMIVSDEPGYYE-DGSFGIRLENVVLVVP 544
Cdd:pfam00557 152 HGLGHGIG--LEVHEGP--YISRGGDDRVLEPGMVFTIEPGIYFiPGWGGVRIEDTVLVTE 208
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
557-619 5.70e-28

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


Pssm-ID: 465052  Cd Length: 63  Bit Score: 106.34  E-value: 5.70e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47085707   557 LTFEPLTLVPIQLKMINTDLLTQKERDWVNDYHRKCRETIGAELERQGrkEARDWLIRETQPI 619
Cdd:pfam16188   3 LGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEE--DALEWLKRATRPI 63
PRK09795 PRK09795
aminopeptidase; Provisional
319-544 8.16e-17

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 82.29  E-value: 8.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707  319 KAVKNATEIQGMKMA-HIKDAVAlcelfAWLEKEIPKGTVTEISAADKAEELRSQQKEfvGLSFPTISSVGPNGAIIHYR 397
Cdd:PRK09795 125 RQIKTPEEVEKIRLAcGIADRGA-----EHIRRFIQAGMSEREIAAELEWFMRQQGAE--KASFDTIVASGWRGALPHGK 197
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707  398 PlpeTNRTLSLNEVYLIDSGAQYTDGTTDVTRTVHF---GTPSEYEKECFTY--VLKGHIAVSAAVFPnGTKGHLLDSFA 472
Cdd:PRK09795 198 A---SDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVngeGVSAESHPLFNVYqiVLQAQLAAISAIRP-GVRCQQVDDAA 273
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47085707  473 RAALWDSGL-DYL-HGTGHGVGcfLNVHEGPcgiSYKTFADEPLEAGMIVSDEPGYYEDGSFGIRLENVVLVVP 544
Cdd:PRK09795 274 RRVITEAGYgDYFgHNTGHAIG--IEVHEDP---RFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTP 342
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
10-154 6.21e-09

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 54.62  E-value: 6.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707    10 LRQLRQAMKNSKyitepIQAYIVPSGDahqseyiapcdcRREFICGFNGSAGTAI-VTEQHAALWTD-GRYFLQASQQmd 87
Cdd:pfam01321   2 LEKLRKLMEEKG-----LDAALVTSPE------------NLRYLTGFTGSRGLLLlVTADGALLLVDaLEYERAAAES-- 62
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47085707    88 nnWTLMKM-GLKETPSQEDWLISVLPENSKVGVDPWIIAADQWKNMSKALSGAghSLVAVqDNLIDAI 154
Cdd:pfam01321  63 --APDFDVvPYRDYEALADLLKELGAGGKRVGFEADALTVAFYEALKEALPGA--ELVDV-SGLIERL 125
 
Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
329-550 8.11e-141

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 408.10  E-value: 8.11e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 329 GMKMAHIKDAVALCELFAWLEKEIPKG-TVTEISAADKAEELRSQQKEFVGLSFPTISSVGPNGAIIHYRPLPETNRTLS 407
Cdd:cd01085   1 GMRAAHIRDGVALVEFLAWLEQEVPKGeTITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESNRKIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 408 LNEVYLIDSGAQYTDGTTDVTRTVHFGTPSEYEKECFTYVLKGHIAVSAAVFPNGTKGHLLDSFARAALWDSGLDYLHGT 487
Cdd:cd01085  81 PDGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGT 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47085707 488 GHGVGCFLNVHEGPCGIsYKTFADEPLEAGMIVSDEPGYYEDGSFGIRLENVVLVVPATTKYN 550
Cdd:cd01085 161 GHGVGSFLNVHEGPQSI-SPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEF 222
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
185-569 7.22e-71

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 230.86  E-value: 7.22e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 185 LRGKMSERKISWFVVTALDEIAWLFNLRGSdieynPVFFAYAII-GMNSIRLFVDSkrlsdpaiREhleldspskpdlsv 263
Cdd:COG0006   3 LRALMAEAGLDALLLTDPSNFAYLTGFRGS-----PERLAALLVtADGEPVLFVDE--------LE-------------- 55
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 264 qcfpYESVYTELQAVCAALepkdkmwicdkascaltqaipkshrsaipytplclaKAVKNATEIQGMKMAHIKDAVALCE 343
Cdd:COG0006  56 ----AERELVDASDLLEEL------------------------------------RAIKSPEEIELMRKAARIADAAHEA 95
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 344 LFAWLEKEipkgtVTEISAADKAEELRSQQkEFVGLSFPTISSVGPNGAIIHYRPlpeTNRTLSLNEVYLIDSGAQYTDG 423
Cdd:COG0006  96 ALAALRPG-----VTEREVAAELEAAMRRR-GAEGPSFDTIVASGENAAIPHYTP---TDRPLKPGDLVLIDAGAEYDGY 166
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 424 TTDVTRTVHFGTPSEYEKECFTYVLKGHIAVSAAVfPNGTKGHLLDSFARAALWDSGL--DYLHGTGHGVGcfLNVHEGP 501
Cdd:COG0006 167 TSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAAL-KPGVTGGEVDAAARDVLAEAGYgeYFPHGTGHGVG--LDVHEGP 243
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47085707 502 cgiSYKTFADEPLEAGMIVSDEPGYYEDGSFGIRLENVVLVVPAttkynyrnrgslTFEPLTLVPIQL 569
Cdd:COG0006 244 ---QISPGNDRPLEPGMVFTIEPGIYIPGIGGVRIEDTVLVTED------------GAEVLTRLPREL 296
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
157-326 2.41e-66

Creatinase/Prolidase N-terminal domain;


Pssm-ID: 465053  Cd Length: 159  Bit Score: 213.89  E-value: 2.41e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707   157 DRPSRPSTKLTALALKYTGFTWQDKITTLRGKMSERKISWFVVTALDEIAWLFNLRGSDIEYNPVFFAYAIIGMNSIRLF 236
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKGADALVLSALDEIAWLLNLRGSDVPYNPVFLSYALVTDDEATLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707   237 VDSKRLSDpAIREHLELDspskpdlSVQCFPYESVYTELqavcAALEPKDKMWI-CDKASCALTQAIPKSHRSAIPYTPL 315
Cdd:pfam16189  81 VDPEKLSD-EVRAHLEEN-------GVEIRPYDDIYEDL----AALAAGKKVLLdPSRTSYALYSALPAGAKVVEAPSPI 148
                         170
                  ....*....|.
gi 47085707   316 CLAKAVKNATE 326
Cdd:pfam16189 149 TLMKAVKNETE 159
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
328-544 6.53e-60

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 198.62  E-value: 6.53e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707   328 QGMKMAHIKDAVALCELFAWLEKEipkgtVTEISAADKAEELRSQQKEFVGLSFPTISSVGPNGAIIHYRPlpeTNRTLS 407
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPG-----VTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHYIP---NDRVLK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707   408 LNEVYLIDSGAQYTDG-TTDVTRTVHFGTPSEYEKECFTYVLKGHIAVSAAVFPnGTKGHLLDSFARAALWDSGLD--YL 484
Cdd:pfam00557  73 PGDLVLIDVGAEYDGGyCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKP-GVTGGDVDAAAREVLEEAGLGeyFP 151
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47085707   485 HGTGHGVGcfLNVHEGPcgISYKTFADEPLEAGMIVSDEPGYYE-DGSFGIRLENVVLVVP 544
Cdd:pfam00557 152 HGLGHGIG--LEVHEGP--YISRGGDDRVLEPGMVFTIEPGIYFiPGWGGVRIEDTVLVTE 208
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
332-542 4.14e-40

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 145.34  E-value: 4.14e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 332 MAHIKDAVAL-CELFAWLEKEIPKGtVTEISAADKAE-ELRSQQKEfvGLSFPTISSVGPNGAIIHYRPlpeTNRTLSLN 409
Cdd:cd01092   1 IELLRKAARIaDKAFEELLEFIKPG-MTEREVAAELEyFMRKLGAE--GPSFDTIVASGPNSALPHGVP---SDRKIEEG 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 410 EVYLIDSGAQYTDGTTDVTRTVHFGTPSEYEKECFTYVLKGHIAVSAAVFPnGTKGHLLDSFARAALWDSGL-DYL-HGT 487
Cdd:cd01092  75 DLVLIDFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKP-GVTAKEVDKAARDVIEEAGYgEYFiHRT 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 47085707 488 GHGVGcfLNVHEGPcGISykTFADEPLEAGMIVSDEPGYYEDGSFGIRLENVVLV 542
Cdd:cd01092 154 GHGVG--LEVHEAP-YIS--PGSDDVLEEGMVFTIEPGIYIPGKGGVRIEDDVLV 203
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
332-544 1.46e-37

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 138.36  E-value: 1.46e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 332 MAHIKDAVALCEL-FAWLEKEIPKGtVTEISAAdkAEELRSQQKEFVGLSFPTISSVGPNGAIIHYRPlpeTNRTLSLNE 410
Cdd:cd01066   1 IARLRKAAEIAEAaMAAAAEAIRPG-VTEAEVA--AAIEQALRAAGGYPAGPTIVGSGARTALPHYRP---DDRRLQEGD 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 411 VYLIDSGAQYTDGTTDVTRTVHFGTPSEYEKECFTYVLKGHIAVSAAVFPnGTKGHLLDSFARAALWDSGL--DYLHGTG 488
Cdd:cd01066  75 LVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRP-GVTAEEVDAAAREVLEEHGLgpNFGHRTG 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47085707 489 HGVGcfLNVHEGPcgiSYKTFADEPLEAGMIVSDEPGYYEDGSFGIRLENVVLVVP 544
Cdd:cd01066 154 HGIG--LEIHEPP---VLKAGDDTVLEPGMVFAVEPGLYLPGGGGVRIEDTVLVTE 204
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
557-619 5.70e-28

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


Pssm-ID: 465052  Cd Length: 63  Bit Score: 106.34  E-value: 5.70e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47085707   557 LTFEPLTLVPIQLKMINTDLLTQKERDWVNDYHRKCRETIGAELERQGrkEARDWLIRETQPI 619
Cdd:pfam16188   3 LGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEE--DALEWLKRATRPI 63
PRK09795 PRK09795
aminopeptidase; Provisional
319-544 8.16e-17

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 82.29  E-value: 8.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707  319 KAVKNATEIQGMKMA-HIKDAVAlcelfAWLEKEIPKGTVTEISAADKAEELRSQQKEfvGLSFPTISSVGPNGAIIHYR 397
Cdd:PRK09795 125 RQIKTPEEVEKIRLAcGIADRGA-----EHIRRFIQAGMSEREIAAELEWFMRQQGAE--KASFDTIVASGWRGALPHGK 197
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707  398 PlpeTNRTLSLNEVYLIDSGAQYTDGTTDVTRTVHF---GTPSEYEKECFTY--VLKGHIAVSAAVFPnGTKGHLLDSFA 472
Cdd:PRK09795 198 A---SDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVngeGVSAESHPLFNVYqiVLQAQLAAISAIRP-GVRCQQVDDAA 273
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47085707  473 RAALWDSGL-DYL-HGTGHGVGcfLNVHEGPcgiSYKTFADEPLEAGMIVSDEPGYYEDGSFGIRLENVVLVVP 544
Cdd:PRK09795 274 RRVITEAGYgDYFgHNTGHAIG--IEVHEDP---RFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTP 342
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
379-553 3.37e-14

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 72.61  E-value: 3.37e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 379 LSFPTISSVGPNGAIIHYRplpETNRTLSLNEVYLIDSGAQYTDGTTDVTRTVHF-GTPSEYEKECFTYVLKGHIAVSAA 457
Cdd:cd01087  46 LAYSYIVAAGSNAAILHYV---HNDQPLKDGDLVLIDAGAEYGGYASDITRTFPVnGKFTDEQRELYEAVLAAQKAAIAA 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707 458 VFPNGT--KGHLL-DSFARAALWDSGLD----------------YLHGTGHGVGcfLNVH--EGPCGISYKtfaDEPLEA 516
Cdd:cd01087 123 CKPGVSyeDIHLLaHRVLAEGLKELGILkgdvdeivesgayakfFPHGLGHYLG--LDVHdvGGYLRYLRR---ARPLEP 197
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 47085707 517 GMIVSDEPGYY---EDGSF-------GIRLENVVLVvpatTKYNYRN 553
Cdd:cd01087 198 GMVITIEPGIYfipDLLDVpeyfrggGIRIEDDVLV----TEDGPEN 240
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
10-154 6.21e-09

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 54.62  E-value: 6.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707    10 LRQLRQAMKNSKyitepIQAYIVPSGDahqseyiapcdcRREFICGFNGSAGTAI-VTEQHAALWTD-GRYFLQASQQmd 87
Cdd:pfam01321   2 LEKLRKLMEEKG-----LDAALVTSPE------------NLRYLTGFTGSRGLLLlVTADGALLLVDaLEYERAAAES-- 62
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47085707    88 nnWTLMKM-GLKETPSQEDWLISVLPENSKVGVDPWIIAADQWKNMSKALSGAghSLVAVqDNLIDAI 154
Cdd:pfam01321  63 --APDFDVvPYRDYEALADLLKELGAGGKRVGFEADALTVAFYEALKEALPGA--ELVDV-SGLIERL 125
PRK15173 PRK15173
peptidase; Provisional
356-542 5.67e-08

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 55.11  E-value: 5.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707  356 TVTEISAADKAEELRSQQKEFVGLSFPTIssvgpnGAIIHYRPLPETNRTLSlNEVYLIDSGAQYTDGTTDVTRTVHFGT 435
Cdd:PRK15173 127 TSAELTAAYKAAVMSKSETHFSRFHLISV------GADFSPKLIPSNTKACS-GDLIKFDCGVDVDGYGADIARTFVVGE 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707  436 PSEYEKECFTYVLKGHIAVSAAVFPNGTKGHLLDSfARAALWDSGL-DYLHG-TGHGVGCFLNVHEGPcgiSYKTFADEP 513
Cdd:PRK15173 200 PPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDS-TMEVIKKSGLpNYNRGhLGHGNGVFLGLEESP---FVSTHATES 275
                        170       180
                 ....*....|....*....|....*....
gi 47085707  514 LEAGMIVSDEPGYYEDGSFGIRLENVVLV 542
Cdd:PRK15173 276 FTSGMVLSLETPYYGYNLGSIMIEDMILI 304
PRK14575 PRK14575
putative peptidase; Provisional
356-542 1.05e-07

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 54.71  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707  356 TVTEISAADKAEELRSQQKEFVGLSFPTIssvgpnGAIIHYRPLPETNRTLSlNEVYLIDSGAQYTDGTTDVTRTVHFGT 435
Cdd:PRK14575 210 TSAELTAAYKAAVMSKSETHFSRFHLISV------GADFSPKLIPSNTKACS-GDLIKFDCGVDVDGYGADIARTFVVGE 282
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707  436 PSEYEKECFTYVLKGHIAVSAAVFPNGTKGHLLDSfARAALWDSGL-DYLHG-TGHGVGCFLNVHEGPcgiSYKTFADEP 513
Cdd:PRK14575 283 PPEITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDS-TMEVIKKSGLpNYNRGhLGHGNGVFLGLEESP---FVSTHATES 358
                        170       180
                 ....*....|....*....|....*....
gi 47085707  514 LEAGMIVSDEPGYYEDGSFGIRLENVVLV 542
Cdd:PRK14575 359 FTSGMVLSLETPYYGYNLGSIMIEDMILI 387
PRK14576 PRK14576
putative endopeptidase; Provisional
319-542 1.37e-07

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 54.25  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707  319 KAVKNATEIQgmkmaHIKDAVALCEL-FAWLEKEIPKG-TVTEISAADKAEELRSQQKEFvglSFPTISSVGPNgaiIHY 396
Cdd:PRK14576 175 RMIKSPWEIE-----HLRKSAEITEYgIASAAKKIRVGcTAAELTAAFKAAVMSFPETNF---SRFNLISVGDN---FSP 243
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47085707  397 RPLPETNRTlSLNEVYLIDSGAQYTDGTTDVTRTVHFGTPSEYEKECFTYVLKGHIAVSAAVFPNGTKGHLLDSfARAAL 476
Cdd:PRK14576 244 KIIADTTPA-KVGDLIKFDCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDS-TMAVI 321
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47085707  477 WDSGLDYLH--GTGHGVGCFLNVHEGPCgisYKTFADEPLEAGMIVSDEPGYYEDGSFGIRLENVVLV 542
Cdd:PRK14576 322 KTSGLPHYNrgHLGHGDGVFLGLEEVPF---VSTQATETFCPGMVLSLETPYYGIGVGSIMLEDMILI 386
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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