R05D3.12 DNA topoisomerase 2;Putative DNA topoisomerase 2, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: R05D3.12
Official Full Name: DNA topoisomerase 2;Putative DNA topoisomerase 2, mitochondrial
Primary source: WormBase:WBGene00019884
Locus tag: CELE_R05D3.12
See related: AllianceGenome:WB:WBGene00019884
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable several functions, including ATP binding activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; and metal ion binding activity. Predicted to be involved in resolution of meiotic recombination intermediates and sister chromatid segregation. Predicted to be located in mitochondrion. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See R05D3.12 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 16

Sequence:: Chromosome: III; NC_003281.10 (8380945..8387526)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase activity	IEA Inferred from Electronic Annotation more info
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in DNA topological change	IEA Inferred from Electronic Annotation more info
involved_in resolution of meiotic recombination intermediates	IBA Inferred from Biological aspect of Ancestor more info
involved_in sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA topoisomerase 2;Putative DNA topoisomerase 2, mitochondrial

NP_001129839.2

Confirmed by transcript evidence

NP_001254958.1

Confirmed by transcript evidence

NP_001368211.1

Confirmed by transcript evidence

NP_741252.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8380945..8387526

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171214.7 → NP_741252.2 Putative DNA topoisomerase 2, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741252.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34534, Q8MQ00

Conserved Domains (6) summary

cd03365
Location:475 → 594

TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...

PLN03128
Location:47 → 1163

PLN03128; DNA topoisomerase 2; Provisional

cd00187
Location:720 → 1160

TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...

cd03481
Location:285 → 442

TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...

pfam02518
Location:93 → 192

HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

pfam16898
Location:592 → 717

TOPRIM_C; C-terminal associated domain of TOPRIM
NM_001136367.4 → NP_001129839.2 Putative DNA topoisomerase 2, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001129839.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34534

Conserved Domains (1) summary

PTZ00108
Location:44 → 124

PTZ00108; DNA topoisomerase 2-like protein; Provisional
NM_001379830.2 → NP_001368211.1 DNA topoisomerase 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PQV7

Conserved Domains (1) summary

PTZ00108
Location:44 → 720

PTZ00108; DNA topoisomerase 2-like protein; Provisional
NM_001268029.3 → NP_001254958.1 Putative DNA topoisomerase 2, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254958.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P34534

Conserved Domains (1) summary

PTZ00108
Location:44 → 126

PTZ00108; DNA topoisomerase 2-like protein; Provisional