|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
44-720 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 817.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 44 AAKYEKKSPTEHVLLRPDTYIGGVAMREDQIiWLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSS---MNRL 120
Cdd:PTZ00108 7 EERYQKKTQIEHILLRPDTYIGSIETQTEDM-WVYDEEKNRMVYKTITYVPGLYKIFDEILVNAADNKARDKGghrMTYI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 121 EVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTR 200
Cdd:PTZ00108 86 KVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVECVDSK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 201 IKRRFRQKWYDNMKKCNEAEVVEIldETVKDYTKVEFVPDLERFQIDKLSDDVIDLIGRRVFEVAATLPRdVDVYLNGQK 280
Cdd:PTZ00108 166 SGKKFKMTWTDNMSKKSEPRITSY--DGKKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGK-LKVYLNGER 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 281 CDVDGFEDYVKMF--------NDSSSLLFLHPTPRWHVGVAKRNNFFgeshvvlpKIVSFVNNINTEKGGSHVDYVMDKI 352
Cdd:PTZ00108 243 IAIKSFKDYVDLYlpdgeegkKPPYPFVYTSVNGRWEVVVSLSDGQF--------QQVSFVNSICTTKGGTHVNYILDQL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 353 VNIIKPIVDSKlGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGSifECD-AKKTAEWAEQSGLIED 431
Cdd:PTZ00108 315 ISKLQEKAKKK-KKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGS--TCElSEKLIKYVLKSPILEN 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 432 IVEEV---LNMK-KKKLPGKRvsVSSVRDIVKLEDAEWAGiTGTAEKCTLILTEGDSAKALALAGLEVLGRETYGVFPLK 507
Cdd:PTZ00108 392 IVEWAqakLAAElNKKMKAGK--KSRILGIPKLDDANDAG-GKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLR 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 508 GKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSiTRESLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTDG 587
Cdd:PTZ00108 469 GKLLNVRDASLKQLMNNKEIQNLFKILGLDIGKKYE-DPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPG 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 588 FIQSFRTPLLKA-KKGDKVRSFFSMNEYRKWADVEEGGKWKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDDDA 666
Cdd:PTZ00108 548 FLKEFITPIVKAtKKGNQVISFFTIPDFEKWKQTVGLKGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDS 627
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....
gi 1831511044 667 IRMAFDRDKSDERKEWIrRSENEITNEDDGKTEISYQEFVDGQLMQFGMVDLKR 720
Cdd:PTZ00108 628 IDLAFSKKRVEDRKEWI-TNYKGGTYVDHSKKKLTYSDFVNKELILFSIADNER 680
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
95-688 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 681.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 95 GLLKIFDEILVNAADNKARDSsMNRLEVWLDREtARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTV 174
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 175 GGRNGYGAKLCNIFSKEFIVETVDTriKRRFRQKWYDNMKKCNEAEVVEildETVKDYTKVEFVPDLERFQIDKlsDDVI 254
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIG---DTKKDGTKVTFKPDLEIFGMTT--DDDF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 255 DLIGRRVFEVAATLpRDVDVYLNGQK-------CDVDGFEDYVKMFNDSSSLLFLHPTPRWHVGVAKRNNF-FGESHVVL 326
Cdd:smart00433 152 ELLKRRLRELAFLN-KGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVaFQYTDGYS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 327 PKIVSFVNNINTEKGGSHVDYVMDKIVNIIKPIVDSKLGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAK 406
Cdd:smart00433 231 ENIVSFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKNIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 407 NFGS---IFECDAKKTAEWA-EQSGLIEDIVEEV---LNMKKKKLPGKRVSVSSVRDIVKLEDAEWAGitgtAEKCTLIL 479
Cdd:smart00433 311 RFGVekiVSECLLSFLEENPvEASKIVEKVLLAAkarAAAKKARELTRKKKLSSISLPGKLADASSAG----PKKCELFL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 480 TEGDSAKALALAGLEvlgRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSItrESLRYGRLLILAD 559
Cdd:smart00433 387 VEGDSAGGSAKSGRD---RDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDFDI--EKLRYGKIIIMTD 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 560 QDEDGSHIKGLIVNFIHKFWPSLVHTdGFIQSFRTPLLKAKKGDK--VRSFFSMNEYRKWADVEEGG--KWKIKYYKGLG 635
Cdd:smart00433 462 ADVDGSHIKGLLLTFFYRYMPPLIEA-GFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEGNksKYEIQRYKGLG 540
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 1831511044 636 TSTSNEAREYFSDLDHHTVNFKYTGTTDD-DAIRMAFDRDKSDERKEWIRRSEN 688
Cdd:smart00433 541 EMNADQLWETTMDPERRTLLFVTLDDADEaDLIFSALMGDKVEPRKEWIEENAP 594
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
92-240 |
1.32e-89 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 277.30 E-value: 1.32e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 92 YPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEI 171
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831511044 172 KTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFRQKWYDNMKKCNEAEVVEILDEtvKDYTKVEFVPD 240
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYEKG--KDYTKVTFKPD 147
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
592-718 |
1.52e-56 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 188.88 E-value: 1.52e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 592 FRTPLLKAKKGDKVRSFFSMNEYRKWAD-VEEGGKWKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDDDAIRMA 670
Cdd:pfam16898 1 FITPIVKVTKGKEVISFFSLPEYEEWKEsTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1831511044 671 FDRDKSDERKEWIRRSENEiTNEDDGKTEISYQEFVDGQLMQFGMVDL 718
Cdd:pfam16898 81 FSKKKADDRKEWLRNFNPG-TYLDHSTKEISYSDFINKELILFSMADN 127
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
54-694 |
3.78e-42 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 162.89 E-value: 3.78e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 54 EHVLLRPDTYIGGVAMRedqiiwlrdsenrkmiakevtyppGLLKIFDEILvnaaDNkARDSSM----NRLEVWLDRETA 129
Cdd:COG0187 18 EAVRKRPGMYIGSTDER------------------------GLHHLVWEIV----DN-SIDEALagycDRIEVTLHADGS 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 130 rISVWNNGSGLPVEIHPTEGIYVPTLVFGNL-----FTSSNYddseiKTVGGRNGYGAKLCNIFSKEFIVEtvdtrIKR- 203
Cdd:COG0187 69 -VTVEDNGRGIPVDIHPKEGKSALEVVLTVLhaggkFDGGSY-----KVSGGLHGVGASVVNALSERLEVE-----VKRd 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 204 --RFRQKwYDNMKKCNEAEVVEILDETvkdYTKVEFVPDLERFQIDKLSDDVIDligRRVFEVAatlprdvdvYLNGQ-- 279
Cdd:COG0187 138 gkIYRQR-FERGKPVGPLEKIGKTDRT---GTTVRFKPDPEIFETTEFDYETLA---ERLRELA---------FLNKGlt 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 280 ---KCDVD------------GFEDYVKMFNDSSSLlfLHPTPrWHVGVAKR----------NNFFGEShvvlpkIVSFVN 334
Cdd:COG0187 202 itlTDEREeepkeetfhyegGIKDFVEYLNEDKEP--LHPEV-IYFEGEKDgievevalqwNDGYSEN------IHSFVN 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 335 NINTEKGGSHV------------DYVmdKIVNIIKPiVDSKL-GDPtksvkpavIKNNLSIFINCLIENPSFESQTKETL 401
Cdd:COG0187 273 NINTPEGGTHEtgfrtaltrvinDYA--RKNGLLKE-KDKNLtGDD--------VREGLTAVISVKLPEPQFEGQTKTKL 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 402 TTK-AKNF-GSIFEcdaKKTAEW-AEQSGLIEDIVEEVLN-------------MKKKK-------LPGKRVSVSSvRDiv 458
Cdd:COG0187 342 GNSeARGIvESVVS---EKLEHYlEENPAEAKKILEKAILaarareaarkareLVRRKsalessgLPGKLADCSS-KD-- 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 459 kledaewagitgtAEKCTLILTEGDSAkalalAGLEVLGR--ETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGL 536
Cdd:COG0187 416 -------------PEESELFIVEGDSA-----GGSAKQGRdrEFQAILPLRGKILNVEKARLDKILKNEEIRDLITALGT 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 537 KFEDSNSItrESLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVhTDGFI---QSfrtPLLKAKKGDKVRSFFSMNE 613
Cdd:COG0187 478 GIGDDFDL--EKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLI-EAGHVyiaQP---PLYRIKKGKKTYYAYSDAE 551
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 614 YRKW-ADVEEGGKWKIKYYKGLGTSTSNEAREYFSDLDHHT---VnfkytgtTDDDAIRMA--FDR---DKSDERKEWIR 684
Cdd:COG0187 552 LDELlKELKGKKKVEIQRYKGLGEMNPEQLWETTMDPETRTllqV-------TIEDAAEADeiFSLlmgDKVEPRREFIE 624
|
730
....*....|
gi 1831511044 685 RSENEITNED 694
Cdd:COG0187 625 ENAKFVRNLD 634
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
44-720 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 817.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 44 AAKYEKKSPTEHVLLRPDTYIGGVAMREDQIiWLRDSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSS---MNRL 120
Cdd:PTZ00108 7 EERYQKKTQIEHILLRPDTYIGSIETQTEDM-WVYDEEKNRMVYKTITYVPGLYKIFDEILVNAADNKARDKGghrMTYI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 121 EVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTR 200
Cdd:PTZ00108 86 KVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVECVDSK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 201 IKRRFRQKWYDNMKKCNEAEVVEIldETVKDYTKVEFVPDLERFQIDKLSDDVIDLIGRRVFEVAATLPRdVDVYLNGQK 280
Cdd:PTZ00108 166 SGKKFKMTWTDNMSKKSEPRITSY--DGKKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGK-LKVYLNGER 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 281 CDVDGFEDYVKMF--------NDSSSLLFLHPTPRWHVGVAKRNNFFgeshvvlpKIVSFVNNINTEKGGSHVDYVMDKI 352
Cdd:PTZ00108 243 IAIKSFKDYVDLYlpdgeegkKPPYPFVYTSVNGRWEVVVSLSDGQF--------QQVSFVNSICTTKGGTHVNYILDQL 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 353 VNIIKPIVDSKlGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGSifECD-AKKTAEWAEQSGLIED 431
Cdd:PTZ00108 315 ISKLQEKAKKK-KKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGS--TCElSEKLIKYVLKSPILEN 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 432 IVEEV---LNMK-KKKLPGKRvsVSSVRDIVKLEDAEWAGiTGTAEKCTLILTEGDSAKALALAGLEVLGRETYGVFPLK 507
Cdd:PTZ00108 392 IVEWAqakLAAElNKKMKAGK--KSRILGIPKLDDANDAG-GKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLR 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 508 GKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSiTRESLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTDG 587
Cdd:PTZ00108 469 GKLLNVRDASLKQLMNNKEIQNLFKILGLDIGKKYE-DPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPG 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 588 FIQSFRTPLLKA-KKGDKVRSFFSMNEYRKWADVEEGGKWKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDDDA 666
Cdd:PTZ00108 548 FLKEFITPIVKAtKKGNQVISFFTIPDFEKWKQTVGLKGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDS 627
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....
gi 1831511044 667 IRMAFDRDKSDERKEWIrRSENEITNEDDGKTEISYQEFVDGQLMQFGMVDLKR 720
Cdd:PTZ00108 628 IDLAFSKKRVEDRKEWI-TNYKGGTYVDHSKKKLTYSDFVNKELILFSIADNER 680
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
47-721 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 798.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 47 YEKKSPTEHVLLRPDTYIGGVAmREDQIIWLrdSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDR 126
Cdd:PLN03128 7 YQKKTQLEHILLRPDTYIGSTE-KHTQTLWV--YEGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVDIDV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 127 ETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFR 206
Cdd:PLN03128 84 EQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGKKYK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 207 QKWYDNMKKCNEAEVVEIldETVKDYTKVEFVPDLERFQIDKLSDDVIDLIGRRVFEVAATLPRDVDVYLNGQKCDVDGF 286
Cdd:PLN03128 164 QVFTNNMSVKSEPKITSC--KASENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGCLGKKLKVELNGKKLPVKSF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 287 EDYVKMFNDSSSLLFLHP------TPRWHVGVAKRNNFFgeshvvlpKIVSFVNNINTEKGGSHVDYVMDKIVNIIKPIV 360
Cdd:PLN03128 242 QDYVGLYLGPNSREDPLPriyekvNDRWEVCVSLSDGSF--------QQVSFVNSIATIKGGTHVDYVADQIVKHIQEKV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 361 DSKLGDPTKsVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGSIFECDA---KKTAEwaeqSGliedIVEEVL 437
Cdd:PLN03128 314 KKKNKNATH-VKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEeflKKVEK----CG----VVENIL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 438 NMK--------KKKLPGKRVSVSSvrdIVKLEDAEWAGiTGTAEKCTLILTEGDSAKALALAGLEVLGRETYGVFPLKGK 509
Cdd:PLN03128 385 SWAqfkqqkelKKKDGAKRQRLTG---IPKLDDANDAG-GKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGK 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 510 LLNVSNLDDARASKNEEISNLLRILGLKFEDSNSIT-RESLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTDGF 588
Cdd:PLN03128 461 LLNVREASHKQIMKNAEITNIKQILGLQFGKTYDEEnTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKIPGF 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 589 IQSFRTPLLKAKKGDKVRSFFSMNEYRKWADVEEG--GKWKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDDDA 666
Cdd:PLN03128 541 LVEFITPIVKATKGGKSLSFYTMPEYEAWKESLEGetKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDL 620
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*
gi 1831511044 667 IRMAFDRDKSDERKEWIRRSEnEITNEDDGKTEISYQEFVDGQLMQFGMVDLKRT 721
Cdd:PLN03128 621 IDMAFSKKRVEDRKIWLNNYE-PGTFLDQTGNGISYSDFINKELILFSQADLARS 674
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
95-688 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 681.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 95 GLLKIFDEILVNAADNKARDSsMNRLEVWLDREtARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTV 174
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 175 GGRNGYGAKLCNIFSKEFIVETVDTriKRRFRQKWYDNMKKCNEAEVVEildETVKDYTKVEFVPDLERFQIDKlsDDVI 254
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIG---DTKKDGTKVTFKPDLEIFGMTT--DDDF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 255 DLIGRRVFEVAATLpRDVDVYLNGQK-------CDVDGFEDYVKMFNDSSSLLFLHPTPRWHVGVAKRNNF-FGESHVVL 326
Cdd:smart00433 152 ELLKRRLRELAFLN-KGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVaFQYTDGYS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 327 PKIVSFVNNINTEKGGSHVDYVMDKIVNIIKPIVDSKLGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAK 406
Cdd:smart00433 231 ENIVSFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKNIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 407 NFGS---IFECDAKKTAEWA-EQSGLIEDIVEEV---LNMKKKKLPGKRVSVSSVRDIVKLEDAEWAGitgtAEKCTLIL 479
Cdd:smart00433 311 RFGVekiVSECLLSFLEENPvEASKIVEKVLLAAkarAAAKKARELTRKKKLSSISLPGKLADASSAG----PKKCELFL 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 480 TEGDSAKALALAGLEvlgRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSItrESLRYGRLLILAD 559
Cdd:smart00433 387 VEGDSAGGSAKSGRD---RDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDFDI--EKLRYGKIIIMTD 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 560 QDEDGSHIKGLIVNFIHKFWPSLVHTdGFIQSFRTPLLKAKKGDK--VRSFFSMNEYRKWADVEEGG--KWKIKYYKGLG 635
Cdd:smart00433 462 ADVDGSHIKGLLLTFFYRYMPPLIEA-GFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEGNksKYEIQRYKGLG 540
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 1831511044 636 TSTSNEAREYFSDLDHHTVNFKYTGTTDD-DAIRMAFDRDKSDERKEWIRRSEN 688
Cdd:smart00433 541 EMNADQLWETTMDPERRTLLFVTLDDADEaDLIFSALMGDKVEPRKEWIEENAP 594
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
47-721 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 675.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 47 YEKKSPTEHVLLRPDTYIGGVAMREdQIIWLrdSENRKMIAKEVTYPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDR 126
Cdd:PLN03237 32 YQKKSQLEHILLRPDTYIGSIEKHT-QTLWV--YETDKMVQRSVTYVPGLYKIFDEILVNAADNKQRDPKMDSLRVVIDV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 127 ETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFR 206
Cdd:PLN03237 109 EQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQKKYK 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 207 QKWYDNM--------KKCNEAEvveildetvkDYTKVEFVPDLERFQIDKLSDDVIDLIGRRVFEVAATLPRDVDVYLNG 278
Cdd:PLN03237 189 QVFSNNMgkksepviTKCKKSE----------NWTKVTFKPDLAKFNMTHLEDDVVALMKKRVVDIAGCLGKTVKVELNG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 279 QKCDVDGFEDYVKMFNDSSSLLFLHPTP--------RWHVGVAKRNNFFGEshvvlpkiVSFVNNINTEKGGSHVDYVMD 350
Cdd:PLN03237 259 KRIPVKSFSDYVDLYLESANKSRPENLPriyekvndRWEVCVSLSEGQFQQ--------VSFVNSIATIKGGTHVDYVTN 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 351 KIVNIIKPIVDSKlgDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGSIFECdAKKTAEWAEQSGLIE 430
Cdd:PLN03237 331 QIANHVMEAVNKK--NKNANIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCEL-SEDFLKKVMKSGIVE 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 431 DIVEEV---LNMKKKKLPGKRvsVSSVRDIVKLEDAEWAGiTGTAEKCTLILTEGDSAKALALAGLEVLGRETYGVFPLK 507
Cdd:PLN03237 408 NLLSWAdfkQSKELKKTDGAK--TTRVTGIPKLEDANEAG-GKNSEKCTLILTEGDSAKALAVAGLSVVGRNYYGVFPLR 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 508 GKLLNVSNLDDARASKNEEISNLLRILGLKfEDSNSITRESLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTDG 587
Cdd:PLN03237 485 GKLLNVREASHKQIMNNAEIENIKQILGLQ-HGKQYESVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPS 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 588 FIQSFRTPLLKA-KKGDKVRSFFSMNEYRKWADVEEGGK--WKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDD 664
Cdd:PLN03237 564 FLVEFITPIVKAtRRGKKVLSFYSMPEYEEWKESLGGNAtgWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDFVWEDEQDG 643
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*..
gi 1831511044 665 DAIRMAFDRDKSDERKEWIRRSENEiTNEDDGKTEISYQEFVDGQLMQFGMVDLKRT 721
Cdd:PLN03237 644 DAIELAFSKKKIEARKNWLRQYEPG-THLDQTQKDVKYSDFVNKELILFSMADLQRS 699
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
92-240 |
1.32e-89 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 277.30 E-value: 1.32e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 92 YPPGLLKIFDEILVNAADNKARDSSMNRLEVWLDRETARISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEI 171
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831511044 172 KTVGGRNGYGAKLCNIFSKEFIVETVDTRIKRRFRQKWYDNMKKCNEAEVVEILDEtvKDYTKVEFVPD 240
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYEKG--KDYTKVTFKPD 147
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
51-683 |
2.27e-84 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 278.95 E-value: 2.27e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 51 SPTEHVLLRPDTYIGGVAmredqiiwlRDSENRKMIAK--EVTYPPGLLKIFDEILVNAADNKARDS--SMNRLEVWLDR 126
Cdd:PHA02569 8 SDREHILKRPGMYIGSVA---------YEAHERFLFGKftQVEYVPGLVKIIDEIIDNSVDEAIRTNfkFANKIDVTIKN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 127 EtaRISVWNNGSGLPVEIHPT-EGIYVPTLVFGNLFT--SSNYDDSEIKTvGGRNGYGAKLCNIFSKEFIVETVDTRIKR 203
Cdd:PHA02569 79 N--QVTVSDNGRGIPQAMVTTpEGEEIPGPVAAWTRTkaGSNFDDTNRVT-GGMNGVGSSLTNFFSVLFIGETCDGKNEV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 204 RFRqkwydnmkkC-NEAEVVEILDETVKDY-TKVEFVPDLERFQIDKLSDDVIDLIGRRVFEVAATLPrDVDVYLNGQKc 281
Cdd:PHA02569 156 TVN---------CsNGAENISWSTKPGKGKgTSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLAVVFP-DIKFTFNGKK- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 282 dVDG-FEDYVKMFNDSSsllFLHPTPRWHVGVAKRNNFFgeshvvlpKIVSFVNNINTEKGGSHVDYVMDKIVNIIKPIV 360
Cdd:PHA02569 225 -VSGkFKKYAKQFGDDT---IVQENDNVSIALAPSPDGF--------RQLSFVNGLHTKNGGHHVDCVMDDICEELIPMI 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 361 DSKLG-DPTKsvkpAVIKNNLSI--FINCLIeNPSFESQTKETLTTKAKNFGSIFECDAKKTA-EWAEQSGLIEDIVEEV 436
Cdd:PHA02569 293 KKKHKiEVTK----ARVKECLTIvlFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDLDYKKIAkQILKTEAIIMPIIEAA 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 437 LNMK---------KKKlpgKRVSVSSVRDIVKledaewAGITGTAEKCTLILTEGDSAKALAlagLEVLGRETYGVFPLK 507
Cdd:PHA02569 368 LARKlaaekaaetKAA---KKAKKAKVAKHIK------ANLIGKDAETTLFLTEGDSAIGYL---IEVRDEELHGGYPLR 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 508 GKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNsitrESLRYGRLLILADQDEDG-SHIKGLIVNFIHKfWPSLvHTD 586
Cdd:PHA02569 436 GKVLNTWGMSYADILKNKELFDICAITGLVLGEKA----ENMNYKNIAIMTDADVDGkGSIYPLLLAFFSR-WPEL-FEQ 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 587 GFIQSFRTPLLKAKKGDKVRSFFSMNEYRKWADveEGGKWKIKYYKGLGTSTSNEAREYFSDLDHHTVnfkytgTTDDDA 666
Cdd:PHA02569 510 GRIRFVKTPVIIAQVGKETKWFYSLDEFEKAKD--SLKKWSIRYIKGLGSLRKSEYRRVINNPVYDVV------VLPDDW 581
|
650 660
....*....|....*....|
gi 1831511044 667 I---RMAFDrDKSDERKEWI 683
Cdd:PHA02569 582 KelfEMLFG-DDADLRKDWM 600
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
475-594 |
1.38e-69 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 223.33 E-value: 1.38e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 475 CTLILTEGDSAKALALAGLEVLGRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSITRESLRYGRL 554
Cdd:cd03365 1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGKSDYESTKSLRYGRL 80
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1831511044 555 LILADQDEDGSHIKGLIVNFIHKFWPSLVHTDGFIQSFRT 594
Cdd:cd03365 81 MIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPGFLVEFIT 120
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
592-718 |
1.52e-56 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 188.88 E-value: 1.52e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 592 FRTPLLKAKKGDKVRSFFSMNEYRKWAD-VEEGGKWKIKYYKGLGTSTSNEAREYFSDLDHHTVNFKYTGTTDDDAIRMA 670
Cdd:pfam16898 1 FITPIVKVTKGKEVISFFSLPEYEEWKEsTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1831511044 671 FDRDKSDERKEWIRRSENEiTNEDDGKTEISYQEFVDGQLMQFGMVDL 718
Cdd:pfam16898 81 FSKKKADDRKEWLRNFNPG-TYLDHSTKEISYSDFINKELILFSMADN 127
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
285-442 |
2.32e-53 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 180.95 E-value: 2.32e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 285 GFEDYVKMFNDSSS------LLFLHPT--PRWHVGVAKRNnffgeshvVLPKIVSFVNNINTEKGGSHVDYVMDKIVNII 356
Cdd:cd03481 2 SFKDYVKLYLKDANkedgppPPVVYEPvnDRWEVAVALSD--------GQFQQVSFVNSIATTKGGTHVDYVADQIVKKL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 357 KPIVDSKLGDPtKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKAKNFGSIFECdAKKTAEWAEQSGliedIVEEV 436
Cdd:cd03481 74 DEVVKKKNKGG-INVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCEL-SEKFLKKAVKSG----IVESV 147
|
....*.
gi 1831511044 437 LNMKKK 442
Cdd:cd03481 148 LSWAKF 153
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
475-594 |
6.08e-49 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 167.68 E-value: 6.08e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 475 CTLILTEGDSAKALALAGLEvlgRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGLKFeDSNSITRESLRYGRL 554
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRD---RVFQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGI-GKDDFDLDKLRYGKI 76
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1831511044 555 LILADQDEDGSHIKGLIVNFIHKFWPSLVHTdGFIQSFRT 594
Cdd:cd01030 77 IIMTDADVDGSHIRTLLLTFFYRFWPSLLEN-GFLYIAQT 115
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
54-683 |
1.10e-44 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 170.28 E-value: 1.10e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 54 EHVLLRPDTYIGGVAMRedqiiwlrdsenrkmiakevtyppGLLKIFDEILVNAADnkarDSSM---NRLEVWLDrETAR 130
Cdd:PRK05559 20 EPVRKRPGMYIGSTDTR------------------------GLHHLVQEVIDNSVD----EALAghgKRIEVTLH-ADGS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 131 ISVWNNGSGLPVEIHPTEGIYVPTLVFGNL-----FTSSNYddseiKTVGGRNGYGAKLCNIFSKEFIVETV-DTRIKR- 203
Cdd:PRK05559 71 VSVRDNGRGIPVGIHPEEGKSGVEVILTKLhaggkFSNKAY-----KFSGGLHGVGVSVVNALSSRLEVEVKrDGKVYRq 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 204 RFRQkwydnmkkcneAEVVEILDETVKDY-----TKVEFVPDLERFQIDKLSDDvidligrRVFEVA---ATLPRDVDVY 275
Cdd:PRK05559 146 RFEG-----------GDPVGPLEVVGTAGkrktgTRVRFWPDPKIFDSPKFSPE-------RLKERLrskAFLLPGLTIT 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 276 LNGQKCDV-----DGFEDYVKMFNDSSSLLFLHPTPRW-------HVGVAKR-NNFFGEShvvlpkIVSFVNNINTEKGG 342
Cdd:PRK05559 208 LNDERERQtfhyeNGLKDYLAELNEGKETLPEEFVGSFegeaegeAVEWALQwTDEGGEN------IESYVNLIPTPQGG 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 343 SHV------------DYVmdKIVNIIKpivdsklgdptKSVK--PAVIKNNLSIFINCLIENPSFESQTKETL-TTKAKN 407
Cdd:PRK05559 282 THEngfregllkavrEFA--EKRNLLP-----------KGKKleGEDVREGLAAVLSVKIPEPQFEGQTKEKLgSREARR 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 408 FGSIFECDA-----KKTAEWAEQsgLIEDIV---EEVLNMKKKKlpGKRVSVSSVRDIVKLEDAEwagiTGTAEKCTLIL 479
Cdd:PRK05559 349 FVSGVVKDAfdlwlNQNPELAEK--LAEKAIkaaQARLRAAKKV--KRKKKTSGPALPGKLADCT----SQDPERTELFL 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 480 TEGDSAKALALAGLEvlgRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGLKFEDSNSItrESLRYGRLLILAD 559
Cdd:PRK05559 421 VEGDSAGGSAKQARD---REFQAILPLRGKILNTWEASLDDVLANEEIHDIIVAIGIGPGDSFDL--EDLRYGKIIIMTD 495
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 560 QDEDGSHIKGLIVNFIHKFWPSLVHtDGFIQSFRTPLLKAKKGDKVRSFFSMNEYRKWADVEE--GGKWKIKYYKGLGTS 637
Cdd:PRK05559 496 ADVDGAHIATLLLTFFYRHFPPLVE-AGHVYIALPPLYRVDKGKKKIYALDEEEKEELLKKLGkkGGKPEIQRFKGLGEM 574
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|..
gi 1831511044 638 TSNEAREYFSDLDHHT---VNFkytgtTDDDAIRMAFDR---DKSDERKEWI 683
Cdd:PRK05559 575 NPDQLWETTMDPETRRlvrVTI-----DDAEETEKLVDMlmgKKAEPRREWI 621
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
54-694 |
3.78e-42 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 162.89 E-value: 3.78e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 54 EHVLLRPDTYIGGVAMRedqiiwlrdsenrkmiakevtyppGLLKIFDEILvnaaDNkARDSSM----NRLEVWLDRETA 129
Cdd:COG0187 18 EAVRKRPGMYIGSTDER------------------------GLHHLVWEIV----DN-SIDEALagycDRIEVTLHADGS 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 130 rISVWNNGSGLPVEIHPTEGIYVPTLVFGNL-----FTSSNYddseiKTVGGRNGYGAKLCNIFSKEFIVEtvdtrIKR- 203
Cdd:COG0187 69 -VTVEDNGRGIPVDIHPKEGKSALEVVLTVLhaggkFDGGSY-----KVSGGLHGVGASVVNALSERLEVE-----VKRd 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 204 --RFRQKwYDNMKKCNEAEVVEILDETvkdYTKVEFVPDLERFQIDKLSDDVIDligRRVFEVAatlprdvdvYLNGQ-- 279
Cdd:COG0187 138 gkIYRQR-FERGKPVGPLEKIGKTDRT---GTTVRFKPDPEIFETTEFDYETLA---ERLRELA---------FLNKGlt 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 280 ---KCDVD------------GFEDYVKMFNDSSSLlfLHPTPrWHVGVAKR----------NNFFGEShvvlpkIVSFVN 334
Cdd:COG0187 202 itlTDEREeepkeetfhyegGIKDFVEYLNEDKEP--LHPEV-IYFEGEKDgievevalqwNDGYSEN------IHSFVN 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 335 NINTEKGGSHV------------DYVmdKIVNIIKPiVDSKL-GDPtksvkpavIKNNLSIFINCLIENPSFESQTKETL 401
Cdd:COG0187 273 NINTPEGGTHEtgfrtaltrvinDYA--RKNGLLKE-KDKNLtGDD--------VREGLTAVISVKLPEPQFEGQTKTKL 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 402 TTK-AKNF-GSIFEcdaKKTAEW-AEQSGLIEDIVEEVLN-------------MKKKK-------LPGKRVSVSSvRDiv 458
Cdd:COG0187 342 GNSeARGIvESVVS---EKLEHYlEENPAEAKKILEKAILaarareaarkareLVRRKsalessgLPGKLADCSS-KD-- 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 459 kledaewagitgtAEKCTLILTEGDSAkalalAGLEVLGR--ETYGVFPLKGKLLNVSNLDDARASKNEEISNLLRILGL 536
Cdd:COG0187 416 -------------PEESELFIVEGDSA-----GGSAKQGRdrEFQAILPLRGKILNVEKARLDKILKNEEIRDLITALGT 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 537 KFEDSNSItrESLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVhTDGFI---QSfrtPLLKAKKGDKVRSFFSMNE 613
Cdd:COG0187 478 GIGDDFDL--EKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLI-EAGHVyiaQP---PLYRIKKGKKTYYAYSDAE 551
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 614 YRKW-ADVEEGGKWKIKYYKGLGTSTSNEAREYFSDLDHHT---VnfkytgtTDDDAIRMA--FDR---DKSDERKEWIR 684
Cdd:COG0187 552 LDELlKELKGKKKVEIQRYKGLGEMNPEQLWETTMDPETRTllqV-------TIEDAAEADeiFSLlmgDKVEPRREFIE 624
|
730
....*....|
gi 1831511044 685 RSENEITNED 694
Cdd:COG0187 625 ENAKFVRNLD 634
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
131-635 |
5.83e-38 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 150.24 E-value: 5.83e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 131 ISVWNNGSGLPVEIHPTEGIyvPTL--VF-----GNLFTSSNYddseiKTVGGRNGYGAKLCNIFSKEFIVEtvdtrIKR 203
Cdd:PRK05644 71 ITVTDNGRGIPVDIHPKTGK--PAVevVLtvlhaGGKFGGGGY-----KVSGGLHGVGVSVVNALSTWLEVE-----VKR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 204 ---RFRQKwYDNMKKCNEaevVEILDETVKDYTKVEFVPDLERFQIDKLSDDVIDligRRVFEVAatlprdvdvYLNGQ- 279
Cdd:PRK05644 139 dgkIYYQE-YERGVPVTP---LEVIGETDETGTTVTFKPDPEIFETTEFDYDTLA---TRLRELA---------FLNKGl 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 280 ------------KCDV----DGFEDYVKMFNDSSSLLflHPTPRW--------HVGVA-KRNNFFGEShvvlpkIVSFVN 334
Cdd:PRK05644 203 kitltderegeeKEETfhyeGGIKEYVEYLNRNKEPL--HEEPIYfegekdgiEVEVAmQYNDGYSEN------ILSFAN 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 335 NINTEKGGSHV------------DYVMDKivNIIKPIVDSKLGDPTK-------SVKpaviknnlsifinclIENPSFES 395
Cdd:PRK05644 275 NINTHEGGTHEegfktaltrvinDYARKN--KLLKEKDDNLTGEDVRegltaviSVK---------------HPEPQFEG 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 396 QTKETL-TTKAKNF-GSIFecdAKKTAEWAEQS-GLIEDIVEEVLN-------------MKKKK-------LPGKRVSVS 452
Cdd:PRK05644 338 QTKTKLgNSEVRGIvDSVV---SEALSEFLEENpNVAKKIVEKAILaarareaarkareLTRRKsalesssLPGKLADCS 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 453 SvRDivkledaewagitgtAEKCTLILTEGDSAKALALAGLEvlgRETYGVFPLKGKLLNVSNLDDARASKNEEISNLLR 532
Cdd:PRK05644 415 S-KD---------------PEESELYIVEGDSAGGSAKQGRD---RRFQAILPLRGKILNVEKARLDKILKNEEIRALIT 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 533 ILGLKFEDSNSItrESLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVhTDGFIQSFRTPLLKAKKGdKVRSFFS-- 610
Cdd:PRK05644 476 ALGTGIGDDFDI--SKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLI-EAGYVYIAQPPLYKIKKG-GKEYAYSde 551
|
570 580
....*....|....*....|....*.
gi 1831511044 611 -MNEYRKWADVEEGGKWKIKYYKGLG 635
Cdd:PRK05644 552 eLDEILAELKLKGNPKYGIQRYKGLG 577
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
285-449 |
2.09e-20 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 89.21 E-value: 2.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 285 GFEDYVKMFNDSSSLLF--------LHPTPRWHVGVAKR-NNFFGEShvvlpkIVSFVNNINTEKGGSHVDYVMDKIVNI 355
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHkeiiyfegESPDNRIEVEVALQwTDSYSEN------ILSFVNNIATPEGGTHVDGFKSALTRT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 356 IKPIVDSK--LGDPTKSVKPAVIKNNLSIFINCLIENPSFESQTKETLTTKA----------KNFGSIFEcdakktaewa 423
Cdd:pfam00204 75 INEYAKKKglLKKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEvksavekivsEKLEEFLE---------- 144
|
170 180
....*....|....*....|....*.
gi 1831511044 424 EQSGLIEDIVEEVLNMKKKKLPGKRV 449
Cdd:pfam00204 145 ENPEIAKKILEKALQAAKARLAARKA 170
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
131-606 |
8.07e-20 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 94.39 E-value: 8.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 131 ISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVetvdtRIKRRFrQKWY 210
Cdd:PRK14939 71 VSVSDNGRGIPTDIHPEEGVSAAEVIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLEL-----TIRRDG-KIHE 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 211 DNMKKCNEAEVVEILDETVKDYTKVEFVPDLERFQIDKLSDDVIDligRRVFEVAatlprdvdvYLN-----------GQ 279
Cdd:PRK14939 145 QEFEHGVPVAPLKVVGETDKTGTEVRFWPSPEIFENTEFDYDILA---KRLRELA---------FLNsgvrirlkderDG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 280 KCDV----DGFEDYVKMFNDSSSLLflHPTP------RWHVGV--A-KRNNFFGEshvvlpKIVSFVNNINTEKGGSHV- 345
Cdd:PRK14939 213 KEEEfhyeGGIKAFVEYLNRNKTPL--HPNIfyfsgeKDGIGVevAlQWNDSYQE------NVLCFTNNIPQRDGGTHLa 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 346 --DYVMDKIVNiiKPIVDSKLgdpTKSVKPAV----IKNNLSIFINCLIENPSFESQTKETL----------TTKAKNFG 409
Cdd:PRK14939 285 gfRAALTRTIN--NYIEKEGL---AKKAKVSLtgddAREGLTAVLSVKVPDPKFSSQTKDKLvssevrpaveSLVNEKLS 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 410 SIFE---CDAKKtaewaeqsgliedIVEEVLN-------------MKKKK-------LPGKRVSVSSvRDivkledaewa 466
Cdd:PRK14939 360 EFLEenpNEAKI-------------IVGKIIDaarareaarkareLTRRKgaldiagLPGKLADCQE-KD---------- 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 467 gitgtAEKCTLILTEGDSAKALALAGLEvlgRETYGVFPLKGKLLNVsnlDDARASK---NEEISNLLRILGlkfedsNS 543
Cdd:PRK14939 416 -----PALSELYLVEGDSAGGSAKQGRD---RKFQAILPLKGKILNV---EKARFDKmlsSQEIGTLITALG------CG 478
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831511044 544 ITRES-----LRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVhTDGFIQSFRTPLLKAKKGDKVR 606
Cdd:PRK14939 479 IGRDEfnpdkLRYHKIIIMTDADVDGSHIRTLLLTFFYRQMPELI-ERGHLYIAQPPLYKVKKGKQEQ 545
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
329-583 |
3.40e-18 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 89.56 E-value: 3.40e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 329 IVSFVNNINTeKGGSHVD---YVMDKIVN-IIKpivdsKLGDPTKSVKP---AVIKNNLSIFINCLIENPSFESQTKETL 401
Cdd:PTZ00109 424 IKSFANNVST-TAGTHIDgfkYAITRCVNgNIK-----KNGYFKGNFVNipgEFIREGMTAIISVKLNGAEFDGQTKTKL 497
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 402 ttkaknfGSIFecdAKKTAEWA--EQSGLIEDIVEEVLN-MKKKKLPGKRV--SVSSVRDIVKLEDAEW--AGITGTAEK 474
Cdd:PTZ00109 498 -------GNHL---LKTILESIvfEQLSEILEFEPNLLLaIYNKSLAAKKAfeEAKAAKDLIRQKNNQYysTILPGKLVD 567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 475 CT--------LILTEGDSAKALALaglEVLGRETYGVFPLKGKLLNVSNL-DDARASKNEEISNLLRILGL--------- 536
Cdd:PTZ00109 568 CIsddierneLFIVEGESAAGNAK---QARNREFQAVLPLKGKILNIEKIkNNKKVFENSEIKLLITSIGLsvnpvtwrq 644
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831511044 537 ------------KFEDSNSIT---------RESLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLV 583
Cdd:PTZ00109 645 ydlshgtkaskdESVQNNNSTltkkknslfDTPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLY 712
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
131-265 |
3.18e-13 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 68.33 E-value: 3.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 131 ISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNYDDSEIKTVGGRNGYGAKLCNIFSKEFIVEtvdtrIKRRfRQKWY 210
Cdd:cd16928 34 ITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDGGSYKVSGGLHGVGVSVVNALSERLEVE-----VKRD-GKIYR 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1831511044 211 DNMKKCNEAEVVEILDETVKDYTKVEFVPDLERFQIDKLSddvIDLIGRRVFEVA 265
Cdd:cd16928 108 QEFSRGGPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEFD---FDTLKRRLRELA 159
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
286-402 |
5.44e-08 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 51.49 E-value: 5.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 286 FEDYVKMFNDSSSLLFL------HPTPRWHVGVAKRNNFFGEShvvlPKIVSFVNNINTEKGGSHVDYVMDKIvniikpi 359
Cdd:cd00329 1 LKDRLAEILGDKVADKLiyvegeSDGFRVEGAISYPDSGRSSK----DRQFSFVNGRPVREGGTHVKAVREAY------- 69
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1831511044 360 vdsklgdpTKSVKPAVIKNNLSIFINCLIEN--PSFE-SQTKETLT 402
Cdd:cd00329 70 --------TRALNGDDVRRYPVAVLSLKIPPslVDVNvHPTKEEVR 107
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
476-574 |
1.39e-06 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 46.97 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 476 TLILTEGDSaKALALAGLevLGRETYGVFPLKGKLLNVSNLDdaraskneeisnllrilglKFEDSNSITRESLRYGRLL 555
Cdd:pfam01751 1 ELIIVEGPS-DAIALEKA--LGGGFQAVVAVLGHLLSLEKGP-------------------KKKALKALKELALKAKEVI 58
|
90
....*....|....*....
gi 1831511044 556 ILADQDEDGSHIKGLIVNF 574
Cdd:pfam01751 59 LATDPDREGEAIALKLLEL 77
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
93-192 |
4.73e-06 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 45.82 E-value: 4.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 93 PPGLLKIFDEILVNAADNKARDSsmnRLEVWLDRE-TARISVWNNGSGLPVEIHPtegiyvptLVFGNLFTSSnyddsei 171
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHAAKAG---EITVTLSEGgELTLTVEDNGIGIPPEDLP--------RIFEPFSTAD------- 64
|
90 100
....*....|....*....|.
gi 1831511044 172 KTVGGRNGYGAKLCNIFSKEF 192
Cdd:pfam02518 65 KRGGGGTGLGLSIVRKLVELL 85
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
93-206 |
7.45e-05 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 42.64 E-value: 7.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831511044 93 PPGLLKIFDEILVNAADNKARDSSMnRLEVWLDRETARISVWNNGSGLPVEIHPTegiyvptlVFGNLFTSSNyddseIK 172
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTPEGGRI-TVTLERDGDHVEITVEDNGPGIPPEDLEK--------IFEPFFRTDK-----RS 68
|
90 100 110
....*....|....*....|....*....|....*..
gi 1831511044 173 TVGGRNGYGAKLCNIFSKEFIVE-TVDTRIKR--RFR 206
Cdd:smart00387 69 RKIGGTGLGLSIVKKLVELHGGEiSVESEPGGgtTFT 105
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
475-578 |
2.84e-03 |
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Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 37.41 E-value: 2.84e-03
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gi 1831511044 475 CTLILTEGDSAKALalagLEVLGRETYGVFPLKGKLLnvsnlddaraskNEEISNLLRILGlkfedsnsitreslRYGRL 554
Cdd:cd00188 1 KKLIIVEGPSDALA----LAQAGGYGGAVVALGGHAL------------NKTRELLKRLLG--------------EAKEV 50
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90 100
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gi 1831511044 555 LILADQDEDGSHIKGLIVNFIHKF 578
Cdd:cd00188 51 IIATDADREGEAIALRLLELLKSL 74
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