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    pqe-1 Putative RNA exonuclease pqe-1 [ Caenorhabditis elegans ]

    Gene ID: 175731, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pqe-1
    Official Full Name
    Putative RNA exonuclease pqe-1
    Primary source
    WormBase:WBGene00004095
    Locus tag
    CELE_F52C9.8
    See related
    AllianceGenome:WB:WBGene00004095
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable exonuclease activity. Involved in negative regulation of gene expression. Located in nucleus. Is expressed in intestine and nervous system. Orthologous to several human genes including REXO1 (RNA exonuclease 1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pqe-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (5311240..5321745)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene tRNA-Thr Neighboring gene ncRNA Neighboring gene Pre-mRNA-splicing factor CWC25 homolog Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Suppressor of organelle fusion 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective inhibitors of death in mutant huntingtin cells. Varma H, et al. Nat Chem Biol, 2007 Feb. PMID 17195849
    2. Mutations in the pqe-1 gene enhance transgene expression in Caenorhabditis elegans. Yamada K, et al. G3 (Bethesda), 2012 Jul. PMID 22870397, Free PMC Article
    3. Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans. Voisine C, et al. PLoS One, 2007 Jun 6. PMID 17551584, Free PMC Article
    4. Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity. Faber PW, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12486229, Free PMC Article
    5. Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Chatterjee S, et al. Nature, 2009 Sep 24. PMID 19734881

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative RNA exonuclease pqe-1
    NP_001040854.1
    • Confirmed by transcript evidence
    NP_001370742.1
    • Confirmed by transcript evidence
    NP_498135.2
    • Confirmed by transcript evidence
    NP_498136.2
    • Confirmed by transcript evidence
    NP_741135.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5311240..5321745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065734.9 → NP_498135.2  Putative RNA exonuclease pqe-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498135.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G8JYC4, Q10124, Q8MQ26, Q8MQ27, Q8MQ28, Q8MQ29, Q8MQ30, Q8MQ31
      Conserved Domains (4) summary
      cd06145
      Location:1479 → 1629
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      PHA03160
      Location:285 → 405
      PHA03160; hypothetical protein; Provisional
      smart00818
      Location:377 → 502
      Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth
      pfam15870
      Location:1230 → 1364
      EloA-BP1; ElonginA binding-protein 1

    2. NM_065735.7 → NP_498136.2  Putative RNA exonuclease pqe-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498136.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10124
      Conserved Domains (2) summary
      cd06145
      Location:502 → 652
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      pfam15870
      Location:253 → 387
      EloA-BP1; ElonginA binding-protein 1

    3. NM_001382869.2 → NP_001370742.1  Putative RNA exonuclease pqe-1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      PHA03247
      Location:131 → 497
      PHA03247; large tegument protein UL36; Provisional

    4. NM_001047389.4 → NP_001040854.1  Putative RNA exonuclease pqe-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040854.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JYC4
      Conserved Domains (4) summary
      cd06145
      Location:504 → 654
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      pfam06991
      Location:171 → 208
      MFAP1; Microfibril-associated/Pre-mRNA processing
      pfam15870
      Location:255 → 387
      EloA-BP1; ElonginA binding-protein 1
      pfam16602
      Location:91 → 180
      USP19_linker; Linker region of USP19 deubiquitinase

    5. NM_171120.6 → NP_741135.1  Putative RNA exonuclease pqe-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741135.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10124
      Conserved Domains (1) summary
      cd06145
      Location:272 → 422
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10124.2

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