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Reln reelin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24718, updated on 9-Dec-2024

Summary

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Official Symbol: Relnprovided by RGD
Official Full Name: reelinprovided by RGD
Primary source: RGD:3553
See related: EnsemblRapid:ENSRNOG00000021441 AllianceGenome:RGD:3553
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rl; Reelen; reeler
Summary: Predicted to enable serine-type peptidase activity and very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including nervous system development; response to glucocorticoid; and response to progesterone. Located in several cellular components, including axon; dendrite; and perikaryon. Biomarker of hypothyroidism and status epilepticus. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; familial temporal lobe epilepsy 7; and schizophrenia. Orthologous to human RELN (reelin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 240.6), Brain (RPKM 232.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Reln in Genome Data Viewer

Location:: 4q11

Exon count:: 66

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (13628440..14055201)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (12736177..13162956)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (9347533..9774257)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced Reelin Expression Induces Memory Deficits through Dab-1/ NMDAR Signaling Pathway: Cronobacter sakazakii Infection in a Rat Model of Experimental Meningitis.
Title: Reduced Reelin Expression Induces Memory Deficits through Dab-1/ NMDAR Signaling Pathway: Cronobacter sakazakii Infection in a Rat Model of Experimental Meningitis.
Stigmasterol promotes neuronal migration via reelin signaling in neurosphere migration assays.
Title: Stigmasterol promotes neuronal migration via reelin signaling in neurosphere migration assays.
in diabetic rats, diabetes reduced the spatial memory without altering the reelin levels while exercise improved spatial memory without altering the reelin levels
Title: The effect of exercise on reelin level in the hippocampus of diabetic rats.
data provide evidence of a local increase of aromatase expression by reelin. Regarding reproduction, this crosstalk may contribute to follicular stability and counteract luteinization in ovaries.
Title: Reelin and aromatase cooperate in ovarian follicle development.
Maternal deprivation (MD) enhanced contextual fear memory in adulthood. Meanwhile, MD decreased DNA methyltransferase mRNA and Reelin gene methylation in the hippocampal CA1 on postnatal days 22 and 90. Reelin protein expression was increased in the hippocampal CA1 following contextual fear conditioning in adulthood. MD can epigenetically program second-hit stress-induced Reelin expression.
Title: Maternal Deprivation Enhances Contextual Fear Memory via Epigenetically Programming Second-Hit Stress-Induced Reelin Expression in Adult Rats.
Study found that reelin levels in the visual layers of the superior colliculus are the highest between the second and third postnatal weeks. Blocking reelin signaling with a neutralizing antibody (CR-50) from PND 7 to PND 14 induced a non-specific sprouting of ipsilateral retinocollicular axons outside their typical distribution of discrete patches of axon terminals.
Title: The fine tuning of retinocollicular topography depends on reelin signaling during early postnatal development of the rat visual system.
Melatonin ameliorated the neurotoxiciy and astrocyte activation induced by Abeta1-42 in the cerebral cortex. Melatonin also blocked the reduction in Reelin and Dab1 expression induced by Abeta1-42. Using in vitro study, Reelin inactivation completely abolished the protective effect of melatonin against Abeta1-42-induced neurotoxicity.
Title: Neuroprotective effect of melatonin on soluble Aβ(1-42)-induced cortical neurodegeneration via Reelin-Dab1 signaling pathway.
These results indicate that reelin/ApoER2/PSD95 signaling is important for neuronal structure maintenance in mature neurons.
Title: Interfering of the Reelin/ApoER2/PSD95 Signaling Axis Reactivates Dendritogenesis of Mature Hippocampal Neurons.
Golgi complex fragmentation and Reelin dysfunction are key contributors to neuronal cell death in the early stage of epilepsy pathophysiology.
Title: Kainic Acid-Induced Golgi Complex Fragmentation/Dispersal Shifts the Proteolysis of Reelin in Primary Rat Neuronal Cells: An In Vitro Model of Early Stage Epilepsy.
we analyzed the effect of relin on the process morphology of primary rat astrocytes
Title: Reelin induces process growth in cultured astrocytes: Implication for glia-synaptic plasticity.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Rat136 (e-PCR)
- UniSTS:118812

RH140445 (e-PCR)
- UniSTS:222520

RH138906 (e-PCR)
- UniSTS:220993

BE108114 (e-PCR)
- UniSTS:247648

BF391264 (e-PCR)
- UniSTS:249765

RH129604 (e-PCR)
- UniSTS:212903

U24703 (e-PCR)
- UniSTS:179142

Reln (e-PCR), detects polymorphism
- UniSTS:144342

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipoprotein particle receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info
enables lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables very-low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info
enables very-low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NMDA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in NMDA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in associative learning	IEA Inferred from Electronic Annotation more info
involved_in associative learning	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex tangential migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex tangential migration	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex tangential migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendrite development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
involved_in dentate gyrus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in glial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in hippocampus development	IEA Inferred from Electronic Annotation more info
involved_in hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in hypothalamus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in interneuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interneuron migration	ISO Inferred from Sequence Orthology more info
involved_in lateral motor column neuron migration	IEA Inferred from Electronic Annotation more info
involved_in lateral motor column neuron migration	ISO Inferred from Sequence Orthology more info
involved_in layer formation in cerebral cortex	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within layer formation in cerebral cortex	ISO Inferred from Sequence Orthology more info
involved_in layer formation in cerebral cortex	ISO Inferred from Sequence Orthology more info
involved_in layer formation in cerebral cortex	ISS Inferred from Sequence or Structural Similarity more info
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in long-term memory	IEA Inferred from Electronic Annotation more info
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in memory	IEP Inferred from Expression Pattern more info	PubMed
involved_in midgut development	IEP Inferred from Expression Pattern more info	PubMed
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within motor neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in orbitofrontal cortex development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of AMPA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CREB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lateral motor column neuron migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lateral motor column neuron migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of small GTPase mediated signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synapse maturation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density protein 95 clustering	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic density protein 95 clustering	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	IEA Inferred from Electronic Annotation more info
involved_in protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in receptor localization to synapse	IEA Inferred from Electronic Annotation more info
involved_in receptor localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in reelin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in reelin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in reelin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of NMDA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse maturation	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insecticide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to pain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to pain	ISO Inferred from Sequence Orthology more info
involved_in response to pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in social behavior	IEP Inferred from Expression Pattern more info	PubMed
involved_in spinal cord patterning	IEA Inferred from Electronic Annotation more info
involved_in spinal cord patterning	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within spinal cord patterning	ISO Inferred from Sequence Orthology more info
involved_in spinal cord patterning	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle exocytosis	EXP Inferred from Experiment more info	PubMed
involved_in synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thyroid hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ventral spinal cord development	IEA Inferred from Electronic Annotation more info
involved_in ventral spinal cord development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
part_of reelin complex	IEA Inferred from Electronic Annotation more info
part_of reelin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: reelin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080394.3 → NP_536319.3 reelin precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P58751, Q80T65

UniProtKB/TrEMBL

F1LM29

Related

ENSRNOP00000058574.6, ENSRNOT00000061858.6

Conserved Domains (22) summary

cd10036
Location:204 → 353

Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin

cd10037
Location:528 → 673

Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10038
Location:869 → 1036

Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10039
Location:1242 → 1411

Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10040
Location:1607 → 1776

Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10041
Location:1958 → 2132

Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10042
Location:2324 → 2480

Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10043
Location:2671 → 2855

Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10044
Location:3057 → 3231

Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cd10045
Location:710 → 864

Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10046
Location:1067 → 1222

Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10047
Location:1449 → 1599

Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10048
Location:1802 → 1939

Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10049
Location:2167 → 2316

Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10050
Location:2516 → 2663

Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10051
Location:2891 → 3052

Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10052
Location:3268 → 3428

Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cl15240
Location:423 → 558

Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins

cd00054
Location:2134 → 2162

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd08544
Location:50 → 180

Reeler; the N-terminal domain of reelin, F-spondin, and a variety of other proteins

pfam18720
Location:3233 → 3261

EGF_Tenascin; Tenascin EGF domain

pfam07974
Location:2862 → 2884

EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

13628440..14055201

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107060.2 → XP_038962988.1 reelin isoform X1

UniProtKB/TrEMBL

A6K598

Related

ENSRNOP00000099957.1, ENSRNOT00000129632.1

Conserved Domains (22) summary

cd10036
Location:204 → 353

Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin

cd10037
Location:528 → 673

Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10038
Location:869 → 1036

Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10039
Location:1242 → 1411

Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10040
Location:1607 → 1776

Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10041
Location:1958 → 2132

Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10042
Location:2324 → 2480

Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10043
Location:2671 → 2855

Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10044
Location:3057 → 3231

Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cd10045
Location:710 → 864

Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10046
Location:1067 → 1222

Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10047
Location:1449 → 1599

Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10048
Location:1802 → 1939

Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10049
Location:2167 → 2316

Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10050
Location:2516 → 2663

Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10051
Location:2891 → 3052

Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10052
Location:3268 → 3428

Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cl15240
Location:423 → 558

Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins

cd00054
Location:2134 → 2162

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd08544
Location:50 → 180

Reeler; the N-terminal domain of reelin, F-spondin, and a variety of other proteins

pfam18720
Location:3233 → 3261

EGF_Tenascin; Tenascin EGF domain

pfam07974
Location:2862 → 2884

EGF_2; EGF-like domain
XM_006235873.4 → XP_006235935.1 reelin isoform X3

UniProtKB/Swiss-Prot

P58751, Q80T65

Related

ENSRNOP00000010521.9, ENSRNOT00000010521.10

Conserved Domains (20) summary

cd10036
Location:204 → 353

Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin

cd10037
Location:528 → 673

Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10038
Location:869 → 1036

Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10039
Location:1242 → 1411

Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10040
Location:1607 → 1776

Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10041
Location:1958 → 2132

Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10042
Location:2324 → 2480

Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10043
Location:2671 → 2855

Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10044
Location:3057 → 3231

Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cd10045
Location:710 → 864

Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10046
Location:1067 → 1222

Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10047
Location:1449 → 1599

Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10048
Location:1802 → 1939

Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10049
Location:2167 → 2316

Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10050
Location:2516 → 2663

Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10051
Location:2891 → 3052

Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10052
Location:3268 → 3428

Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cl15240
Location:423 → 558

Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins

cd08544
Location:50 → 180

Reeler; Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins

pfam07974
Location:2132 → 2161

EGF_2; EGF-like domain
XM_039107062.2 → XP_038962990.1 reelin isoform X2

UniProtKB/TrEMBL

A6K598

Conserved Domains (22) summary

cd10036
Location:204 → 353

Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin

cd10037
Location:528 → 673

Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10038
Location:869 → 1036

Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10039
Location:1242 → 1411

Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10040
Location:1607 → 1776

Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10041
Location:1958 → 2132

Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10042
Location:2324 → 2480

Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10043
Location:2671 → 2855

Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10044
Location:3057 → 3231

Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cd10045
Location:710 → 864

Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins

cd10046
Location:1067 → 1222

Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins

cd10047
Location:1449 → 1599

Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins

cd10048
Location:1802 → 1939

Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins

cd10049
Location:2167 → 2316

Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins

cd10050
Location:2516 → 2663

Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins

cd10051
Location:2891 → 3052

Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins

cd10052
Location:3268 → 3428

Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins

cl15240
Location:423 → 558

Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins

cd00054
Location:2134 → 2162

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd08544
Location:50 → 180

Reeler; the N-terminal domain of reelin, F-spondin, and a variety of other proteins

pfam18720
Location:3233 → 3261

EGF_Tenascin; Tenascin EGF domain

pfam07974
Location:2862 → 2884

EGF_2; EGF-like domain