NCBI Conserved Domain Search

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 352.68 E-value: 1.01e-111

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  869 NSISLDFTNLVEVTQSLGFYLGNIQPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDN 948
Cdd:cd10038      1 NSISLDFSNLVEVTQSLGFYLGNVQPYCNHDWTLCFTGDSKHASSARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMDN 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  949 QVKLEYSTNHGLTWHLVQDECLPSMPSCQEFTSASIYHASEFTQWRRVTVILPQKTWSGATRFRWSQSYYTAQDEWALDD 1028
Cdd:cd10038     81 QVKLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQDEWALDN 160


                   ....*...
gi 1958768177 1029 IYIGQQCP 1036
Cdd:cd10038    161 IYIGQQCP 168

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 352.29 E-value: 1.37e-111

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1607 GFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASSFLQFDMSMGCSKPFSATHSVQL 1686
Cdd:cd10040      1 GFQDKFDGSVDLQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSHSVQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1687 QYSLNNGKDWHPVTEECVPPTIGCVHYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQANYTVGADAWAIDNVLL 1766
Cdd:cd10040     81 QYSLNNGRDWHLVTEECVPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGADSWAIDNVVL 160

                          170
                   ....*....|
gi 1958768177 1767 ASGCPWLCSG 1776
Cdd:cd10040    161 ASGCPWMCSG 170

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 341.00 E-value: 1.19e-107

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1958 MLLDTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEIGEHSITTRDLSVNENTIIQFEINVGCSTDSSS 2037
Cdd:cd10041      1 LLLDTFDFGPNESNWLFYPGGNTGLYCPYQSKGAPEEDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCTTESSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2038 ADPVRLEFSRDFGATWHLLLPLCYHsSSLVSSLCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPAG 2117
Cdd:cd10041     81 ADPVRLEFSRDFGATWHLLLPLCYG-SSSISSLCSTELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGFHPAG 159

                          170
                   ....*....|....*
gi 1958768177 2118 SQPVTWAIDNVYIGP 2132
Cdd:cd10041    160 SQPVTWAIDNVYIGP 174

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 336.00 E-value: 4.33e-106

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3268 PSYIKDNFESARVTEANWETIQGGAIGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSTAQTDSC 3347
Cdd:cd10052      1 PSYIKDNFESGSVSELKWSLIQGGGIGSGCGQLAPHAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3348 NSDLSGPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHVEV 3427
Cdd:cd10052     81 NINLSSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNVEV 160


                   .
gi 1958768177 3428 V 3428
Cdd:cd10052    161 V 161

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 334.95 E-value: 9.92e-106

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2324 VLEDDFSTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVTTDIAVNEDSFLQIDFAASCSVTDSCYAIELEYSV 2403
Cdd:cd10042      1 VLEDDFSTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCYAIELEYSV 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768177 2404 DLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPAYTRSQATRFRWHQPAPFDKQQTWAIDNVYIG 2480
Cdd:cd10042     81 DLGLSWHPLLRDCLPTNVECSSYHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAIDNVYIG 157

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 330.63 E-value: 5.54e-104

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1242 YEKPAFDYPINQMSVWLMLANEGMAKNDSfCATTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCASQFSSTAPV 1321
Cdd:cd10039      1 YEKPAFDYPLNQMSVWLMLSNEGMGKNES-CSPTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1322 LLQYSHDAGMSWFLVKEGCFPASAG-KGCEGNSRELSEPTVYYTGDFEEWTRVTIAIPRSLASSKTRFRWIQESSSQKNV 1400
Cdd:cd10039     80 LLQYSHDAGLTWSLVREGCYPASPGsKGCEGSSRELREPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNA 159

                          170
                   ....*....|.
gi 1958768177 1401 PPFGLDGVYIS 1411
Cdd:cd10039    160 PPFGLDGVYIS 170

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 325.97 E-value: 1.68e-102

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2891 KTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNMTSCHRP 2970
Cdd:cd10051      1 KTFLKERFDSEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLRP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2971 VCRKEGVLLDYSKDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFVISNGLVVSGVERAQWALDNILI 3050
Cdd:cd10051     81 TCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFTISNGLVVSGTERAQWALDNILI 160


                   ..
gi 1958768177 3051 GG 3052
Cdd:cd10051    161 GG 162

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 322.56 E-value: 4.43e-101

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3057 PSQLVDTFDDEGSSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVGCEAT-SC 3135
Cdd:cd10044      1 PSSLVETFEDEGTSHDENWEFYPNGVRTDEFCGNPSFHLTWPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVsSC 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3136 GDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNAVNSSSWKRITIQLPDHVSSSATQFRWIQKGE 3215
Cdd:cd10044     81 GDLHPVMLEYTTDPRSDHWQLVQTECLPSSSNSIDCSPFQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTE 160

                          170
                   ....*....|....*.
gi 1958768177 3216 ETEKQSWAIDHVYIGE 3231
Cdd:cd10044    161 STEAPSWAIDDVYIGE 176

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 321.03 E-value: 7.44e-101

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1067 LPSTIMSDFENPSSWDSDWQEVIGGEVVKPEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESAACN 1146
Cdd:cd10046      1 LPSTVMSDFENQDSLETEWQEVIGGEIVKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSASCN 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 1147 KPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFGKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIIIL 1222
Cdd:cd10046     81 YPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIIIL 156

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 319.86 E-value: 1.33e-100

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2516 LPTQLKDNFNRAPSNQNWLTVNGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPSNRNQG 2595
Cdd:cd10050      1 LPTQLKDTFNRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNRNQG 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177 2596 VLLEYSVNGGITWTLLMEIFYDQYSKPGFVNILLPPDAKEIGTRFRWWQPRHDGLDQNDWAIDNVLIS 2663
Cdd:cd10050     81 VLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLIG 148

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 320.34 E-value: 2.04e-100

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2671 VMLDTFSSAPVPQHERSPadagpvgriafdmfmEDKTSVNENWLFHDDCTVERFCDSPDGVMLCGSH-DGREVYAVTHDL 2749
Cdd:cd10043      1 VLLDTFSSANLPQHERSP---------------EDKTTVNDHWLFHDNCSIERFCDSPDGVMICGSHdDGREVSAVTHDL 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2750 TPTENWIMQFKISVGCKVPEKIAQNQIHVQFSTDFGVSWSYLVPQCLPADPKCSGTVSQPSVFFPTKGWKRITYPLPESL 2829
Cdd:cd10043     66 TPTEGWILQFKISVGCKSSEKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKCGGSVTQPSVFFPSKGWRRVTIPLPDKL 145

                          170       180
                   ....*....|....*....|....*.
gi 1958768177 2830 MGNPVRFRFYQKYSDVQWAIDNFYLG 2855
Cdd:cd10043    146 VGRPIRFRFYQKASDMQWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 316.80 E-value: 1.40e-99

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  528 VINPELQTPATKFCLRQKNHQGHNQNVWAVDFFHVLPILPSTMSHMIQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLH 607
Cdd:cd10037      1 PIPPDLQTPATKFCLRQKSHGGHNRNVWAVDFFHLLPVLPSTVTHFAQFSINLGCGSHQPGNSVSLEFSTNHGRSWSLLH 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177  608 TECLPEICAGPHLPHSTIYSSENYSGWNRVTIPLPNAALTRDTRIRWRQTGPILGNMWAIDNVYIG 673
Cdd:cd10037     81 TECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALTSATRFRWRQTGSVVGSMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 316.76 E-value: 1.60e-99

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1449 HSEMFDRFEGKLSPLWYKISGGQVGTGCGTLSDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRA 1528
Cdd:cd10047      1 PSEFFDRFEGKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRS 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958768177 1529 RNEGLVVQYSNDNGILWHLLRELDFLSFLEPQIISIDLPREAKTPATAFRWWQPQHGKHSAQWALDDVLIG 1599
Cdd:cd10047     81 RNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQWALDDVLIG 151

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 316.45 E-value: 2.24e-99

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2167 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLGCGKGVPDPRSQ 2246
Cdd:cd10049      1 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDPRSQ 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2247 PVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2316
Cdd:cd10049     81 PVLLQYSLNGGLTWSLLQEFLFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILIG 150

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 312.89 E-value: 4.33e-98

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  710 PMFISESFGSSRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRA 789
Cdd:cd10045      1 PGFLSESFNSSRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPP 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177  790 PDQPGEGVLLHYSYDNGITWKLLEHYSYLNYHEPRIISVELPDDAKQFGIQFRWWQPYHSSQGEDVWAIDEILMT 864
Cdd:cd10045     81 PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 281.77 E-value: 2.92e-87

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1802 LPSILKDDFNGNLHPDLWPEVYGAERGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKGTPERSHS 1881
Cdd:cd10048      1 LPSVLKDDFNGNLRPDLWPEVYGAERGNLNGETIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHS 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177 1882 ILLQSSINGGVTWRLMDEFYFPQTTSILFINVPLPYSAQTNATRFRLWQPYNNGKKEE 1939
Cdd:cd10048     81 VLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEE 138

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 259.85 E-value: 1.41e-79

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1071 IMSDFENPSSWDSDWQEVIGGEVVkpeQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESAA--CNKP 1148
Cdd:cd08526      2 LKDSFEGSLSSSDNWSLVSGGEVG---TGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTstCNPP 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958768177 1149 DSREEGVLLQYSNNGGIQWHLLAEMYFSDFGKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1221
Cdd:cd08526     79 DSRSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILI 151

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 255.86 E-value: 3.24e-78

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  204 LRDDFDSYHQLELNPNIWAECSNCDTGEQCGTIMHGNAVTFCEPYGPRELTTTYLNTTTASVLQFSIGSGSCRFSYSDPS 283
Cdd:cd10036      1 LRDDFDSYPLLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEPYGPRELITVPLNTTTASVLQFAIGSGSCRFSYSDPS 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958768177  284 IIVSYAKNNT-ADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQDSLRVGEVYEACWALDNILVI 353
Cdd:cd10036     81 IIVSYAVNNTsSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQEAPNAGEVYESCWALDNVLII 151

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 251.76 E-value: 8.56e-77

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1451 EMFDRFEGKLSP--LWYKISGGQVGTGCGTLSDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRA 1528
Cdd:cd08526      1 FLKDSFEGSLSSsdNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNPPDS 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958768177 1529 RNEGLVVQYSNDNGILWHLLRELDFLSFLEPQIISIDLPREAKTPATAFRWWQPQH-GKHSAQWALDDVLIG 1599
Cdd:cd08526     81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHsGKGQDQWALDNILIG 152

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 247.14 E-value: 3.49e-75

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2519 QLKDNFNRAPSN-QNWLTVNGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLIT------PSN 2591
Cdd:cd08526      1 FLKDSFEGSLSSsDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQtstcnpPDS 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958768177 2592 RNQGVLLEYSVNGGITWTLLMEIFYDQYSKPGFVNILLPPDAKEIGTRFRWWQPRHDGLDQNDWAIDNVLI 2662
Cdd:cd08526     81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILI 151

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 245.60 E-value: 1.16e-74

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2893 FLKERFDSEEIKPDLWMSLEGGSTCTECGILAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNMTSCHRPVC 2972
Cdd:cd08526      1 FLKDSFEGSLSSSDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNPPDS 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 2973 RKEGVLLDYSKDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFvisnglvVSGVERAQWALDNILIG 3051
Cdd:cd08526     81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPS-------HSGKGQDQWALDNILIG 152

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 244.06 E-value: 3.93e-74

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  712 FISESFGSSRLSSyHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRAPD 791
Cdd:cd08526      1 FLKDSFEGSLSSS-DNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNPPD 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958768177  792 QPGEGVLLHYSYDNGITWKLLEHYSYLNYHEPRIISVELPDDAKQFGIQFRWWQPYHSSQGEDVWAIDEILMT 864
Cdd:cd08526     80 SRSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 236.88 E-value: 1.68e-71

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1607 GFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASSFLQFDMSMGCSKPFSATHSVQL 1686
Cdd:cd08525      1 VLLDTFDTLPDSNENWFFYPGGVVKNDCGSTDSALVFTENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSSSNSVML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1687 QYSLNNGKDWHPVTEECVPPTIGCVHYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQANYTVGADAWAIDNVLL 1766
Cdd:cd08525     81 EYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGVQTWAIDNVYI 160


                   .
gi 1958768177 1767 A 1767
Cdd:cd08525    161 G 161

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 234.04 E-value: 1.51e-70

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3270 YIKDNFESARVTEANWETIQGGAIGSGCGQLApyaHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSTAQTDSCNS 3349
Cdd:cd08526      1 FLKDSFEGSLSSSDNWSLVSGGEVGTGCGVLA---SGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNP 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 3350 dlsgPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHVEVV 3428
Cdd:cd08526     78 ----PDSRSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 231.93 E-value: 6.35e-70

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2520 LKDNFNRAPSNQNWLTVNGGKLSTVCGAVASGLALHFSGG-CSRLLVTVDLNLTNAEFIQFYFMYGCLiTPSNRNQGVLL 2598
Cdd:cd08524      1 LKDDFDGYPSPDNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCS-TPSYSNQPVLL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177 2599 EYSVNGGITWTLLMEIFYDQYSKPGFVNILLPPDAKEIGTRFRWWQPRHDGLDQNDWAIDNVLIS 2663
Cdd:cd08524     80 EYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLIG 144

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 231.73 E-value: 9.04e-70

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2170 FLKDDFEGQLES-DRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLGCGK-----GVPDP 2243
Cdd:cd08526      1 FLKDSFEGSLSSsDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSqtstcNPPDS 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958768177 2244 RSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVgRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2316
Cdd:cd08526     81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEP-RFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 228.02 E-value: 2.44e-68

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2324 VLEDDFSTLDS--RKWLLHPGGTKMPVCGSTGDALVFIEK-ASTRYVVTTDIAVNEDSFLQIDFAASC-SVTDSCYAIEL 2399
Cdd:cd08525      1 VLLDTFDTLPDsnENWFFYPGGVVKNDCGSTDSALVFTENiGGERYAVTRDLTVNEGYMLQFKINVGCsSTFSSSNSVML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2400 EYSVDLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPAYTRSQATRFRWHQPAPFDKQQTWAIDNVYI 2479
Cdd:cd08525     81 EYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGVQTWAIDNVYI 160


                   .
gi 1958768177 2480 G 2480
Cdd:cd08525    161 G 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 221.53 E-value: 2.30e-66

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2171 LKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNED-GLRMLVTRDLDLSHARFVQFFMRLGCGKgvPDPRSQPVL 2249
Cdd:cd08524      1 LKDDFDGYPSPDNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCST--PSYSNQPVL 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768177 2250 LQYSLNGGLSWSLLQEFLFSnSSNVGRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2316
Cdd:cd08524     79 LEYSVDNGASWHLLEEIRAD-SFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLIG 144

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 218.78 E-value: 4.10e-65

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1959 LLDTFDFGPRE-DNWFFYPGGNIGLYCPysskgapEEDSAMVFVSNEIGEHSITTRDLSVNENTIIQFEINVGCSTDSSS 2037
Cdd:cd08525      2 LLDTFDTLPDSnENWFFYPGGVVKNDCG-------STDSALVFTENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSS 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2038 ADPVRLEFSRDFGATWHLLLPLCYHSSSLVSslcstEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPag 2117
Cdd:cd08525     75 SNSVMLEYSTDAGLSWHLVQEECLPSSPGCS-----ELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYT-- 147

                          170
                   ....*....|....
gi 1958768177 2118 SQPVTWAIDNVYIG 2131
Cdd:cd08525    148 SGVQTWAIDNVYIG 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 211.13 E-value: 1.08e-62

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1959 LLDTFDFGPREDNWFFYPGGNIGLYCpysskGAPEEDSAMVFVSNEiGEHSITTRDLSVNENTIIQFEINVGCSTDSSSA 2038
Cdd:cd08524      1 LKDDFDGYPSPDNWLLCPGGKTGTVC-----GALSSGNALVFNEPY-GPRELVTTDLNTNEASFLQFYIGSGCSTPSYSN 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2039 DPVRLEFSRDFGATWHLLLplcyhssslvsslcstehhpssTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPaGS 2118
Cdd:cd08524     75 QPVLLEYSVDNGASWHLLE----------------------EIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHR-GV 131

                          170
                   ....*....|...
gi 1958768177 2119 QPVTWAIDNVYIG 2131
Cdd:cd08524    132 YQATWAIDNVLIG 144

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 211.46 E-value: 1.45e-62

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  870 SISLDFTNLVEVTQSLGFYL-GNIQPYCG-HDWTLCFTGDSKlasSMRYVETQSMQIGASYMIQFSLVMGCGqkYTPHMD 947
Cdd:cd08525      1 VLLDTFDTLPDSNENWFFYPgGVVKNDCGsTDSALVFTENIG---GERYAVTRDLTVNEGYMLQFKINVGCS--STFSSS 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  948 NQVKLEYSTNHGLTWHLVQDECLPSMPSCQEFTSASIYHASEFTQWRRVTVILPQKTWSGATRFRWSQ-SYYTAQDEWAL 1026
Cdd:cd08525     76 NSVMLEYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQyGYTSGVQTWAI 155


                   ....*.
gi 1958768177 1027 DDIYIG 1032
Cdd:cd08525    156 DNVYIG 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 210.36 E-value: 2.24e-62

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1452 MFDRFEGKLSP-LWYKISGGQVGTGCGTLSDGRSLYFNGL-GKREARTVPLDTRNIRLVQFYIQIGSKTsgitcikPRAR 1529
Cdd:cd08524      1 LKDDFDGYPSPdNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCST-------PSYS 73

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958768177 1530 NEGLVVQYSNDNGILWHLLRELDFLSFLEPQIISIDLPREAKTPATAFRWWQPQHGK-HSAQWALDDVLIG 1599
Cdd:cd08524     74 NQPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGvYQATWAIDNVLIG 144

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 208.76 E-value: 1.22e-61

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1242 YEKPAFDYPINQmSVWLMLANEGMAKNDsfCATTPSAMVF-GKSDGDRFAVTRDLTLKPGYVLQFKLNIGCASQFSSTAP 1320
Cdd:cd08525      1 VLLDTFDTLPDS-NENWFFYPGGVVKND--CGSTDSALVFtENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSSSNS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1321 VLLQYSHDAGMSWFLVKEGCFPASAGKGcegnsrELSEPTVYYTGDFEEWTRVTIAIPRSLASSKTRFRWIQESSSQkNV 1400
Cdd:cd08525     78 VMLEYSTDAGLSWHLVQEECLPSSPGCS------ELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTS-GV 150

                          170
                   ....*....|.
gi 1958768177 1401 PPFGLDGVYIS 1411
Cdd:cd08525    151 QTWAIDNVYIG 161

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 208.38 E-value: 1.76e-61

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3059 QLVDTFDDEGSSHEeNWSFYPNAVRTAgFCGNPSFHLYWPNKKKDktHNALSSRELIIQPGYMMQFKIVVGCEaTSCGDL 3138
Cdd:cd08525      1 VLLDTFDTLPDSNE-NWFFYPGGVVKN-DCGSTDSALVFTENIGG--ERYAVTRDLTVNEGYMLQFKINVGCS-STFSSS 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3139 HSVMLEYTKDArSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNavnssSWKRITIQLPDHVSSSATQFRWIQKGEETE 3218
Cdd:cd08525     76 NSVMLEYSTDA-GLSWHLVQEECLPSSPGCSELHPSSVYESSTFN-----GWKRITIPLPNATLSSATRFRWIQYGYTSG 149

                          170
                   ....*....|..
gi 1958768177 3219 KQSWAIDHVYIG 3230
Cdd:cd08525    150 VQTWAIDNVYIG 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 200.73 E-value: 5.04e-59

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2325 LEDDFSTLDS-RKWLLHPGGTKMPVCG--STGDALVFIEKASTRYVVTTDIAVNEDSFLQIDFAASCS-VTDSCYAIELE 2400
Cdd:cd08524      1 LKDDFDGYPSpDNWLLCPGGKTGTVCGalSSGNALVFNEPYGPRELVTTDLNTNEASFLQFYIGSGCStPSYSNQPVLLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2401 YSVDLGLSWHPLvrdclptnvecsryhlqRILVSDTFNKWTRITLPLPAYTRSQATRFRWHQPAPFD-KQQTWAIDNVYI 2479
Cdd:cd08524     81 YSVDNGASWHLL-----------------EEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGvYQATWAIDNVLI 143


                   .
gi 1958768177 2480 G 2480
Cdd:cd08524    144 G 144

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 193.21 E-value: 2.36e-56

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1806 LKDDFNGNLHP-DLWPEVYGAERGNLNGEtIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAK-------GTPE 1877
Cdd:cd08526      2 LKDSFEGSLSSsDNWSLVSGGEVGTGCGV-LASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKsqtstcnPPDS 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958768177 1878 RSHSILLQSSINGGVTWRLMDEFYFPQTTSILFINVPLPYSAQTNATRFRLWQPYNNGKKEE 1939
Cdd:cd08526     81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQD 142

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 190.33 E-value: 2.24e-55

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  204 LRDDFDSYHQlelnPNIWAECSNCDTGEQCGTIMHGNAVTFCEPYGPRELTTTYLNTTTASVLQFSIGSGSCRFSYSDPS 283
Cdd:cd08524      1 LKDDFDGYPS----PDNWLLCPGGKTGTVCGALSSGNALVFNEPYGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQP 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  284 IIVSYAKNNTADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQDSLRVgeVYEACWALDNILVI 353
Cdd:cd08524     77 VLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRG--VYQATWAIDNVLIG 144

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 189.50 E-value: 6.16e-55

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  528 VINPELQTP----ATKFCLRQKNHQ-----GHNQNVWAV---DFFHVLPILPSTM-SHMIQFSINLGCG-THQPGNSVSL 593
Cdd:cd08525      1 VLLDTFDTLpdsnENWFFYPGGVVKndcgsTDSALVFTEnigGERYAVTRDLTVNeGYMLQFKINVGCSsTFSSSNSVML 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  594 EFSTNHGRSWSLLHTECLPEICAGPHLPHSTIYSSENYSGWNRVTIPLPNAALTRDTRIRWRQTGPILG-NMWAIDNVYI 672
Cdd:cd08525     81 EYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGvQTWAIDNVYI 160


                   .
gi 1958768177  673 G 673
Cdd:cd08525    161 G 161

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 182.57 E-value: 1.78e-52

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2708 SVNENWLFHDDCTVERFC-DSPDGVMLCGSHDGrEVYAVTHDLTPTENWIMQFKISVGCKvPEKIAQNQIHVQFSTDFGV 2786
Cdd:cd08525     11 DSNENWFFYPGGVVKNDCgSTDSALVFTENIGG-ERYAVTRDLTVNEGYMLQFKINVGCS-STFSSSNSVMLEYSTDAGL 88

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 2787 SWSYLVPQCLPADPKCSG----TVSQPSVFFptkGWKRITYPLPESLMGNPVRFRFYQKYS---DVQWAIDNFYLG 2855
Cdd:cd08525     89 SWHLVQEECLPSSPGCSElhpsSVYESSTFN---GWKRITIPLPNATLSSATRFRWIQYGYtsgVQTWAIDNVYIG 161

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 168.84 E-value: 9.04e-48

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1068 PSTIMSDFENPSSwdSDWQEVIGGEVvkpEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESA--AC 1145
Cdd:cd10047      1 PSEFFDRFEGKLS--PLWYKITGGQV---GTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNgeTC 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 1146 NKPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFGKPRFVYLELPAAAKTPCTRFRWWQPvFSGEDYDQWAVDDIII 1221
Cdd:cd10047     76 LRPRSRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQP-QHGKPSAQWALDDVLI 150

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 162.66 E-value: 1.44e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1448 NHSEMFDRFEGKLSPLWYKISGGQVGTGCGTLSDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPR 1527
Cdd:cd10045      3 FLSESFNSSRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPPPD 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958768177 1528 ARNEGLVVQYSNDNGILWHLLRELDFLSFLEPQIISIDLPREAKTPATAFRWWQPQH-GKHSAQWALDDVLI 1598
Cdd:cd10045     83 RPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHsGQNQDVWALDEISM 154

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 161.49 E-value: 3.94e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1452 MFDRF--EGKLSPLWYKISGGQVGTGCGTLSDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRAR 1529
Cdd:cd10051      4 LKERFdsEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLRPTCR 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177 1530 NEGLVVQYSNDNGILWHLLRELDFLSFLEPQIISIDLPREAKTPATAFRWWQP--------QHGKHSAQWALDDVLIG 1599
Cdd:cd10051     84 KEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftisnglvVSGTERAQWALDNILIG 161

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 160.00 E-value: 9.74e-45

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1067 LPSTIMSDFENpSSWDSDWQEVIGGevvKPEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGgesaaCN 1146
Cdd:cd10050      1 LPTQLKDTFNR-APSSSNWLTVVGG---KLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYG-----CL 71

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 1147 -KPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFGKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1221
Cdd:cd10050     72 iPPSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLI 147

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 154.18 E-value: 1.70e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1454 DRFEGKLSPL--WYKISGGQVGTGCGTLS---DGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITC----I 1524
Cdd:cd10052      6 DNFESGSVSElkWSLIQGGGIGSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSCninlS 85

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958768177 1525 KPRARNEGLVVQYSNDNGILWHLLRELDFLSFLEPQIISIDLPREAKTPATAFRWWQPQH-GKHSAQWALDDV 1596
Cdd:cd10052     86 SPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHdGTGHDQWALDNV 158

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 152.97 E-value: 2.68e-42

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1074 DFENPSSWDsDWQEVIGGevvKPEQGCGVVSSGSSLYF-SKAGKRQLVSWDLDTSWVDFVQFYIQIGgesaaCNKPDSRE 1152
Cdd:cd08524      4 DFDGYPSPD-NWLLCPGG---KTGTVCGALSSGNALVFnEPYGPRELVTTDLNTNEASFLQFYIGSG-----CSTPSYSN 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 1153 EGVLLQYSNNGGIQWHLLAEMYFSDFGKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1221
Cdd:cd08524     75 QPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLI 143

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 150.38 E-value: 2.92e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1464 WYKISGGQVGT---GCGTLSDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSgiTCIKPRARNEGLVVQYSND 1540
Cdd:cd10046     19 WQEVIGGEIVKpemGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSA--SCNYPDSREEGVLLQYSNN 96

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1541 NGILWHLLRELDFLSFLEPQIISIDLPREAKTPATAFRWWQPQH-GKHSAQWALDDVLIG 1599
Cdd:cd10046     97 GGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFsGEGYDQWALDDIIIL 156

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 149.54 E-value: 6.31e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1083 SDWQEVIGGevvKPEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGES--AACNKPDSREEGVLLQYS 1160
Cdd:cd10051     16 DQWLSLEGG---VTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENnmTLCLRPTCRKEGVLLQYS 92

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177 1161 NNGGIQWHLLAEMYFSDFGKPRFVYLELPAAAKTPCTRFRWWQP-------VFSGEDYDQWAVDDIII 1221
Cdd:cd10051     93 TDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftisnglVVSGTERAQWALDNILI 160

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 148.84 E-value: 9.79e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2168 PDFLKDDFEGQ--LESDRFLLMSGG--KPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLG-----CGK 2238
Cdd:cd10046      2 PSTVMSDFENQdsLETEWQEVIGGEivKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGggsasCNY 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177 2239 gvPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVgRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2316
Cdd:cd10046     82 --PDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKP-RFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIIIL 156

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 148.90 E-value: 1.43e-40

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  896 CGHDWTLCFTGDSKlasSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPhmDNQVKLEYSTNHGLTWHLVQDECLPSMPS 975
Cdd:cd10040     29 LSMDTALMFTENIG---KPRYAETWDFHVSASTFLQFELSMGCSKPYSN--SHSVQLQYSLNNGRDWHLVTEECVPPAIG 103

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768177  976 CQEFTSASIYHASEFTQWRRVTVILPQKTWSGATRFRWSQSYYT-AQDEWALDDIYIGQQCPNMCSG 1041
Cdd:cd10040    104 CLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYApGADSWAIDNVVLASGCPWMCSG 170

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 144.92 E-value: 2.78e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2517 PTQLKDNF-NRAPSNQNWLTVNGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYG-------CLiT 2588
Cdd:cd10051      1 KTFLKERFdSEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGsennmtlCL-R 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2589 PSNRNQGVLLEYSVNGGITWTLLMEIFYDQYSKPGFVNILLPPDAKEIGTRFRWWQP---RHD----GLDQNDWAIDNVL 2661
Cdd:cd10051     80 PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftiSNGlvvsGTERAQWALDNIL 159


                   ...
gi 1958768177 2662 ISG 2664
Cdd:cd10051    160 IGG 162

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 144.19 E-value: 3.16e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  728 FYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRAPDQPGEGVLLHYSYDNGI 807
Cdd:cd10047     16 WYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRSRNEGIIVQYSNDNGI 95

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177  808 TWKLLEHYSYLNYHEPRIISVELPDDAKQFGIQFRWWQPYHSSQGEDvWAIDEILM 863
Cdd:cd10047     96 TWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQ-WALDDVLI 150

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 143.79 E-value: 5.61e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2517 PTQLKDNFN--RAPSNQNWLTVNGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLIT------ 2588
Cdd:cd10045      1 PGFLSESFNssRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVlgtcpp 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177 2589 PSNRNQGVLLEYSVNGGITWTLLMEIFYDQYSKPGFVNILLPPDAKEIGTRFRWWQPRHDGLDQNDWAIDNVLIS 2663
Cdd:cd10045     81 PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 143.03 E-value: 1.00e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2896 ERFdsEEIKPDLWMSLEGGSTCTECGILAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNMTSCHRPVCRKE 2975
Cdd:cd10047      6 DRF--EGKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRSRNE 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 2976 GVLLDYSKDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFVisnglvvsGVERAQWALDNILIG 3051
Cdd:cd10047     84 GIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH--------GKPSAQWALDDVLIG 151

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 142.25 E-value: 2.09e-38

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1090 GGEVvkpEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGES--AACNKPDSREEGVLLQYSNNGGIQW 1167
Cdd:cd10045     24 GGEV---GFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSvlGTCPPPDRPGEGVLLHYSCDNGITW 100

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958768177 1168 HLLAEMYFSDFGKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1221
Cdd:cd10045    101 KLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISM 154

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 139.25 E-value: 1.55e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2168 PDFLKDDFEGQLESDRFLLMSGGKPSRKCG-ILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLGCgKGVPDpRSQ 2246
Cdd:cd10048      2 PSVLKDDFNGNLRPDLWPEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFIT-KGTPE-RSH 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958768177 2247 PVLLQYSLNGGLSWSLLQEFLFSNSSNVgRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIGGN 2318
Cdd:cd10048     80 SVLLQYSINGGITWHLIDEFYFPTTTDV-LFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVIDGN 150

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 138.11 E-value: 4.47e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1068 PSTIMSDFENPSSWDSdWQEVIGGevvKPEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGgesaaCNK 1147
Cdd:cd10049      2 PDFLKDDFEGQLESDR-FLLMSGG---KPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-----CGK 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768177 1148 --PDSREEGVLLQYSNNGGIQWHLLAEMYFSDFGK-PRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1221
Cdd:cd10049     73 gvPDPRSQPVLLQYSLNGGLTWSLLQEFLFSNSSNvGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 138.09 E-value: 4.83e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2516 LPTQLKDNFNRAPSNQNWLTVNGGKLSTVCG-AVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPSnRNQ 2594
Cdd:cd10048      1 LPSVLKDDFNGNLRPDLWPEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPE-RSH 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958768177 2595 GVLLEYSVNGGITWTLLMEIFYDQYSKPGFVNILLPPDAKEIGTRFRWWQPRHDGLDQNDWAIDNVLISGS 2665
Cdd:cd10048     80 SVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVIDGN 150

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 138.06 E-value: 6.32e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  710 PMFISESFGSSRlSSYHNFYSIRGAEVSF---GCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSvlST 786
Cdd:cd10046      2 PSTVMSDFENQD-SLETEWQEVIGGEIVKpemGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGS--AS 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768177  787 CRAPDQPGEGVLLHYSYDNGITWKLLEHYSYLNYHEPRIISVELPDDAKQFGIQFRWWQPYHSSQGEDVWAIDEILM 863
Cdd:cd10046     79 CNYPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIII 155

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 136.95 E-value: 1.13e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2517 PTQLKDNFNRAPSNQNWLTVNGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGC-LITPSNRNQG 2595
Cdd:cd10049      2 PDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCgKGVPDPRSQP 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177 2596 VLLEYSVNGGITWTLLMEIFYDQYSKPG-FVNILLPPDAKEIGTRFRWWQPRHDGLDQNDWAIDNVLI 2662
Cdd:cd10049     82 VLLQYSLNGGLTWSLLQEFLFSNSSNVGrYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 136.10 E-value: 2.55e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2517 PTQLKDNFNRAPSNQnWLTVNGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYG-------CLiTP 2589
Cdd:cd10047      1 PSEFFDRFEGKLSPL-WYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGsklngetCL-RP 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958768177 2590 SNRNQGVLLEYSVNGGITWTLLMEIFYDQYSKPGFVNILLPPDAKEIGTRFRWWQPRHdGLDQNDWAIDNVLIS 2663
Cdd:cd10047     79 RSRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH-GKPSAQWALDDVLIG 151

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 135.35 E-value: 4.06e-36

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2168 PDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLGCgKGVPDPRSQP 2247
Cdd:cd10050      2 PTQLKDTFNRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGC-LIPPSNRNQG 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 2248 VLLQYSLNGGLSWSLLQEfLFSNSSNVGRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIG 2316
Cdd:cd10050     81 VLLEYSVNGGITWNLLME-IFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLIG 148

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 134.52 E-value: 1.12e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2168 PDFLKDDFEGQ-LESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLG-------CGKg 2239
Cdd:cd10051      1 KTFLKERFDSEeISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGsennmtlCLR- 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2240 vPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVGR-YIALemPLKARSGSTRLRWWQP--SENGHFYSP-----WVID 2311
Cdd:cd10051     80 -PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYdYITL--PENARTNSTRLRWWQPftISNGLVVSGteraqWALD 156


                   ....*.
gi 1958768177 2312 QILIGG 2317
Cdd:cd10051    157 NILIGG 162

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 133.05 E-value: 3.35e-35

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2531 QNWLTVNGGKLSTV---CGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLIT----PSNRNQGVLLEYSVN 2603
Cdd:cd10046     17 TEWQEVIGGEIVKPemgCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSAscnyPDSREEGVLLQYSNN 96

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 2604 GGITWTLLMEIFYDQYSKPGFVNILLPPDAKEIGTRFRWWQPRHDGLDQNDWAIDNVLI 2662
Cdd:cd10046     97 GGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIII 155

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 130.30 E-value: 3.01e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2517 PTQLKDNFNRAP-SNQNWLTVNGGKLSTVCGAV---ASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYG-------C 2585
Cdd:cd10052      1 PSYIKDNFESGSvSELKWSLIQGGGIGSGCGQLaphAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsC 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177 2586 ---LITPSNRNQGVLLEYSVNGGITWTLLMEIFYDQYSKPGFVNILLPPDAKEIGTRFRWWQPRHDGLDQNDWAIDNV 2660
Cdd:cd10052     81 ninLSSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 129.86 E-value: 3.21e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  720 SRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKD-GRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCrapdqpgEGVL 798
Cdd:cd08524      6 DGYPSPDNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSN-------QPVL 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177  799 LHYSYDNGITWKLLEHYSYLNYHEPRIISVELPDDAKQFGIQFRWWQPYHSSQGEDVWAIDEILM 863
Cdd:cd08524     79 LEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLI 143

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 130.28 E-value: 3.29e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  710 PMFISESFGSSRLSSyHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRA 789
Cdd:cd10051      1 KTFLKERFDSEEISS-DQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  790 PDQPGEGVLLHYSYDNGITWKLLEHYSYLNYHEPRIISVELPDDAKQFGIQFRWWQPYHSSQGEDV-------WAIDEIL 862
Cdd:cd10051     80 PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFTISNGLVVsgteraqWALDNIL 159


                   .
gi 1958768177  863 M 863
Cdd:cd10051    160 I 160

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 129.09 E-value: 4.87e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2894 LKERFDSEEiKPDLWMSLEGGSTCTECGILAENTALYF-GGSTVRQAITQDLDLRGAKFLQYWGRIGsennmtsCHRPVC 2972
Cdd:cd08524      1 LKDDFDGYP-SPDNWLLCPGGKTGTVCGALSSGNALVFnEPYGPRELVTTDLNTNEASFLQFYIGSG-------CSTPSY 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 2973 RKEGVLLDYSKDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFvisnglvVSGVERAQWALDNILIG 3051
Cdd:cd08524     73 SNQPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPN-------HRGVYQATWAIDNVLIG 144

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 129.17 E-value: 5.61e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3268 PSYIKDNFESARVTEanWETIQGGAIGSGCGQLApyaHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSTAQTDSC 3347
Cdd:cd10047      1 PSEFFDRFEGKLSPL--WYKITGGQVGTGCGVIK---DGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETC 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177 3348 NSdlsgPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHnGTGHDQWALDHV 3425
Cdd:cd10047     76 LR----PRSRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH-GKPSAQWALDDV 148

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 127.73 E-value: 2.93e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1628 GQVDIDClSMDTALIFT---ENIGKPRYAETWDFHVSASSFLQFDMSMGCSKPFSATH--SVQLQYSLNNGKDWHPVTEE 1702
Cdd:cd10038     22 GNVQPYC-NHDWTLCFTgdsKHASSARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMdnQVKLEYSTNHGLTWHLVQEE 100

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 1703 CVPPTIGCVHYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQANYTVGaDAWAIDNVLLASGCP 1771
Cdd:cd10038    101 CLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQ-DEWALDNIYIGQQCP 168

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 127.60 E-value: 3.07e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1068 PSTIMSDFENPSSWDSDWQEVIGGEVvkpEQGCGVVS---SGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGG--ES 1142
Cdd:cd10052      1 PSYIKDNFESGSVSELKWSLIQGGGI---GSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSrsQT 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1143 AACN----KPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFGKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDD 1218
Cdd:cd10052     78 DSCNinlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDN 157


                   .
gi 1958768177 1219 I 1219
Cdd:cd10052    158 V 158

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 126.49 E-value: 5.02e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2890 LKTFLKERFDSEEIKpDLWMSLEGGSTCTECGILAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNmtschr 2969
Cdd:cd10050      1 LPTQLKDTFNRAPSS-SNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIP------ 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2970 PVCRKEGVLLDYSKDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPfvisnglVVSGVERAQWALDNIL 3049
Cdd:cd10050     74 PSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQP-------SHDGLDQNDWAIDNVL 146


                   ..
gi 1958768177 3050 IG 3051
Cdd:cd10050    147 IG 148

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 126.83 E-value: 5.38e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  710 PMFISESFGSSRLSSYhNFYSIRGAEVSFGCGVL---ASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLST 786
Cdd:cd10052      1 PSYIKDNFESGSVSEL-KWSLIQGGGIGSGCGQLaphAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDS 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177  787 CR----APDQPGEGVLLHYSYDNGITWKLLEHYSYLNYHEPRIISVELPDDAKQFGIQFRWWQPYHSSQGEDVWAIDEI 861
Cdd:cd10052     80 CNinlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 124.95 E-value: 1.53e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1450 SEMFDRFE-GKLSPLWYKISGGQVGTGCGTLSDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGsktsgitC-IKPR 1527
Cdd:cd10050      3 TQLKDTFNrAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYG-------ClIPPS 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958768177 1528 ARNEGLVVQYSNDNGILWHLLRELDFLSFLEPQIISIDLPREAKTPATAFRWWQPQH-GKHSAQWALDDVLIG 1599
Cdd:cd10050     76 NRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHdGLDQNDWAIDNVLIG 148

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 124.96 E-value: 2.33e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2920 CGILAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENnmTSCHRPVCRKEGVLLDYSKDGGITWTLLHEMDFQK 2999
Cdd:cd10046     34 CGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGS--ASCNYPDSREEGVLLQYSNNGGISWKLLAEMYFSD 111

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958768177 3000 YISVRHDYILLPEGALTNTTRLRWWQPfvisnglVVSGVERAQWALDNILIG 3051
Cdd:cd10046    112 FSKPRFVYLELPTAAKTPCTRFRWWQP-------VFSGEGYDQWALDDIIIL 156

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 124.14 E-value: 4.55e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3268 PSYIKDNFESARVT-EANWETIQGGAIGSGCGQLAPyahGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSTAQTDS 3346
Cdd:cd10045      1 PGFLSESFNSSRLSsYHNFSSIRGGEVGFGCGVLAS---GKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGT 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 3347 CNSdlsgPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHV 3425
Cdd:cd10045     78 CPP----PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEI 152

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 123.47 E-value: 5.99e-32

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1803 PSILKDDFNGNLHPDLWPEVYGAERGNLNGeTIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRF-IAKGTPE-RSH 1880
Cdd:cd10049      2 PDFLKDDFEGQLESDRFLLMSGGKPSRKCG-ILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLgCGKGVPDpRSQ 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 1881 SILLQSSINGGVTWRLMDEFYF-PQTTSILFINVPLPYSAQTNATRFRLWQPYNNGKKEEIWIIDDFII 1948
Cdd:cd10049     81 PVLLQYSLNGGLTWSLLQEFLFsNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 122.60 E-value: 1.44e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2893 FLKERFDSEEIK-PDLWMSLEGGSTCTECGILAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNMTSCHRPV 2971
Cdd:cd10045      3 FLSESFNSSRLSsYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPPPD 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 2972 CRKEGVLLDYSKDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFvisnglvVSGVERAQWALDNILI 3050
Cdd:cd10045     83 RPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPY-------HSGQNQDVWALDEISM 154

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 122.25 E-value: 1.48e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  710 PMFISESFgsSRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVlstcra 789
Cdd:cd10050      2 PTQLKDTF--NRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIP------ 73

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958768177  790 PDQPGEGVLLHYSYDNGITWKLLEHYSYLNYHEPRIISVELPDDAKQFGIQFRWWQPYHSSQGEDVWAIDEILM 863
Cdd:cd10050     74 PSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLI 147

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 120.77 E-value: 4.94e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  710 PMFISESFGSSRLSSyhNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSvlstcRA 789
Cdd:cd10049      2 PDFLKDDFEGQLESD--RFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGK-----GV 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177  790 PDQPGEGVLLHYSYDNGITWKLLEHYSYLNY-HEPRIISVELPDDAKQFGIQFRWWQPYHSSQGEDVWAIDEILM 863
Cdd:cd10049     75 PDPRSQPVLLQYSLNGGLTWSLLQEFLFSNSsNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 121.04 E-value: 5.40e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3268 PSYIKDNFESARVTEANWETIQGGAIGSGCGQLApyaHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSTAQTDSC 3347
Cdd:cd10051      1 KTFLKERFDSEEISSDQWLSLEGGVTCTDCGVLA---EGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLC 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3348 NSdlsgPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQP--RHNGTG-----HDQW 3420
Cdd:cd10051     78 LR----PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftISNGLVvsgteRAQW 153


                   ....*
gi 1958768177 3421 ALDHV 3425
Cdd:cd10051    154 ALDNI 158

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 120.71 E-value: 5.56e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3267 LPSYIKDNFESARVTEaNWETIQGGAIGSGCGqlaPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGstaqtds 3346
Cdd:cd10050      1 LPTQLKDTFNRAPSSS-NWLTVVGGKLSTVCG---AVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYG------- 69

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 3347 CNSDlsgPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHV 3425
Cdd:cd10050     70 CLIP---PSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNV 145

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 119.57 E-value: 1.65e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3267 LPSYIKDNFESARVTEANWETIQGGAI---GSGCGQLApyaHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGstAQ 3343
Cdd:cd10046      1 LPSTVMSDFENQDSLETEWQEVIGGEIvkpEMGCGVIS---SGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIG--GG 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3344 TDSCNSdlsgPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALD 3423
Cdd:cd10046     76 SASCNY----PDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALD 151


                   ..
gi 1958768177 3424 HV 3425
Cdd:cd10046    152 DI 153

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 119.14 E-value: 1.91e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2168 PDFLKDDFEGQLES--DRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLGcGKGV----- 2240
Cdd:cd10045      1 PGFLSESFNSSRLSsyHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLG-SKSVlgtcp 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 2241 -PDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNvGRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILI 2315
Cdd:cd10045     80 pPDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHE-PRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISM 154

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 119.63 E-value: 2.27e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2337 WLLHPGGTKMPVCGSTGDALVFIEKA-STRYVVTTDIAVNEDSFLQIDFAASCS-VTDSCYAIELEYSVDLGLSWHPLVR 2414
Cdd:cd10040     16 WYRIQGGQVDIDCLSMDTALMFTENIgKPRYAETWDFHVSASTFLQFELSMGCSkPYSNSHSVQLQYSLNNGRDWHLVTE 95

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177 2415 DCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPAYTRSQATRFRWHQPAPFDKQQTWAIDNVYIGDGCLDMCSG 2489
Cdd:cd10040     96 ECVPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGADSWAIDNVVLASGCPWMCSG 170

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 117.91 E-value: 4.57e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1610 DKFDGSIDLQaNWYRIQGGQVDIDC--LSMDTALIFTENIGkPRYAETWDFHVSASSFLQFDMSMGCSKPFSATHSVQLQ 1687
Cdd:cd08524      3 DDFDGYPSPD-NWLLCPGGKTGTVCgaLSSGNALVFNEPYG-PRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQPVLLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1688 YSLNNGKDWHPVTEecvpptigcvhytesstYTSERFQNWRRVTVYLPLATNSPRTRFRWIQANYTVGADA-WAIDNVLL 1766
Cdd:cd08524     81 YSVDNGASWHLLEE-----------------IRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQAtWAIDNVLI 143

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 113.76 E-value: 1.68e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2168 PDFLKDDFEGQLeSDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLG-------CGKgv 2240
Cdd:cd10047      1 PSEFFDRFEGKL-SPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGsklngetCLR-- 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 2241 PDPRSQPVLLQYSLNGGLSWSLLQEFLFSnSSNVGRYIALEMPLKARSGSTRLRWWQPSENGHfYSPWVIDQILIG 2316
Cdd:cd10047     78 PRSRNEGIIVQYSNDNGITWHLLRELDFM-SYLEPQVISIELPREAKTPATAFRWWQPQHGKP-SAQWALDDVLIG 151

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 113.44 E-value: 1.96e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1067 LPSTIMSDFENPSSWDSdWQEVIGGEvvKPEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIggesaACN 1146
Cdd:cd10048      1 LPSVLKDDFNGNLRPDL-WPEVYGAE--RGNLNGETIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF-----ITK 72

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177 1147 KPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFGKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIII 1221
Cdd:cd10048     73 GTPERSHSVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVI 147

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 112.91 E-value: 2.70e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3271 IKDNFESArVTEANWETIQGGAIGSGCGQLApyaHGDSLYFNGCQ-IRQAATKPLDLTRASKIMFVLQIGSTAQTDSCns 3349
Cdd:cd08524      1 LKDDFDGY-PSPDNWLLCPGGKTGTVCGALS---SGNALVFNEPYgPRELVTTDLNTNEASFLQFYIGSGCSTPSYSN-- 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 3350 dlsgphtvdKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHV 3425
Cdd:cd08524     75 ---------QPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNV 141

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 112.14 E-value: 4.30e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1806 LKDDFNGNLHPDLWPEVYGAERGNLNGeTIKSGTSLIFKG-EGLRMLISRDLDCTNTMYVQFSLRFIAKGTPERSHSILL 1884
Cdd:cd08524      1 LKDDFDGYPSPDNWLLCPGGKTGTVCG-ALSSGNALVFNEpYGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQPVLL 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958768177 1885 QSSINGGVTWRLMDEFYFPQTTSILFINVPLPYSAQTNATRFRLWQPYNNGKKE 1938
Cdd:cd08524     80 EYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQ 133

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 110.77 E-value: 3.22e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  560 FHVLPilpstmSHMIQFSINLGCG-THQPGNSVSLEFSTNHGRSWSLLHTECLPEICAGPHLPHSTIYSSENYSGWNRVT 638
Cdd:cd10040     52 FHVSA------STFLQFELSMGCSkPYSNSHSVQLQYSLNNGRDWHLVTEECVPPAIGCLHYTESSVYSSERFQNWKRIT 125

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1958768177  639 IPLPNAALTRDTRIRWRQTGPILG-NMWAIDNVYIGPSCLKFCSG 682
Cdd:cd10040    126 VYLPPATISPRTRFRWIQPNYAPGaDSWAIDNVVLASGCPWMCSG 170

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 110.27 E-value: 3.62e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2892 TFLKERFDSEEIKPDLWMSLEGGSTCTECGIL---AENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNMTSCH 2968
Cdd:cd10052      2 SYIKDNFESGSVSELKWSLIQGGGIGSGCGQLaphAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSCN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2969 ----RPVCRKEGVLLDYSKDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPfvisnglVVSGVERAQWA 3044
Cdd:cd10052     82 inlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQP-------RHDGTGHDQWA 154


                   ....
gi 1958768177 3045 LDNI 3048
Cdd:cd10052    155 LDNV 158

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 109.60 E-value: 3.66e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1454 DRFEGKL-SPLWYKISGGQVGTGCGTLSDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGsktsgitCIK--PRARN 1530
Cdd:cd10049      7 DDFEGQLeSDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-------CGKgvPDPRS 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958768177 1531 EGLVVQYSNDNGILWHLLRELDFL-SFLEPQIISIDLPREAKTPATAFRWWQP-QHGKHSAQWALDDVLIG 1599
Cdd:cd10049     80 QPVLLQYSLNGGLTWSLLQEFLFSnSSNVGRYVALEIPLKARSPSTRLRWWQPsENGHFYSPWVIDQILIG 150

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 109.23 E-value: 6.21e-27

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1619 QANWYRIQGGQVDIDCLSMDTALIFTENiGKPRYAETWDFHVSASSFLQFDMSMGCSKPfSATHSVQLQYSLNNGKDWHP 1698
Cdd:cd10042     11 SRKWLLHPGGTKMPVCGSTGDALVFIEK-ASTRYVVTTDIMVNEDSFLQIDFAASCSVT-DSCYAIELEYSVDLGLSWHP 88

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 1699 VTEECVPPTIGCVHYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQANYTVGADAWAIDNV 1764
Cdd:cd10042     89 LLRDCLPTNVECSSYHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAIDNV 154

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 108.34 E-value: 1.39e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2168 PDFLKDDFE-GQLESDRFLLMSGGKPSRKCGILS---SGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLG-------C 2236
Cdd:cd10052      1 PSYIKDNFEsGSVSELKWSLIQGGGIGSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsC 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 2237 GKGV--PDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNvGRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQI 2313
Cdd:cd10052     81 NINLssPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMR-AQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 107.25 E-value: 2.20e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  927 SYMIQFSLVMGCGqkyTPHMDNQVKLEYSTNHGLTWHLVQDECLPSMPSCQEFTSASIYHASEFTQWRRVTVILPQKTWS 1006
Cdd:cd10037     44 THFAQFSINLGCG---SHQPGNSVSLEFSTNHGRSWSLLHTECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALT 120

                           90       100
                   ....*....|....*....|....*.
gi 1958768177 1007 GATRFRWSQSYYTAQDEWALDDIYIG 1032
Cdd:cd10037    121 SATRFRWRQTGSVVGSMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 107.23 E-value: 2.40e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1802 LPSILKDDFNGNLHPDLWPEVYGAERGNLNGEtIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKGTPE-RSH 1880
Cdd:cd10050      1 LPTQLKDTFNRAPSSSNWLTVVGGKLSTVCGA-VASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSnRNQ 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177 1881 SILLQSSINGGVTWRLMDEFYFPQTTSILFINVPLPYSAQTNATRFRLWQPYNNG 1935
Cdd:cd10050     80 GVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDG 134

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 107.31 E-value: 4.98e-26

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2328 DFSTL-DSRKWLLHPGGTKMPVCGS------TGDALvfiEKASTRYVVTTDIAVNEDSFLQIDFAASCSVTDSC---YAI 2397
Cdd:cd10038      6 DFSNLvEVTQSLGFYLGNVQPYCNHdwtlcfTGDSK---HASSARYVETQSMQIGASYMIQFSLVMGCGQQYTPhmdNQV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2398 ELEYSVDLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPAYTRSQATRFRWHQpAPFDKQQTWAIDNV 2477
Cdd:cd10038     83 KLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQ-SYYTDQDEWALDNI 161


                   ....*.
gi 1958768177 2478 YIGDGC 2483
Cdd:cd10038    162 YIGQQC 167

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 104.99 E-value: 2.64e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1241 FYEKpaFDYPINQMSVWLMLANegmAKNDSFCATTPSAMVFGKS-DGDRFAVTRDLTLKPGYVLQFKLNIGCASQFSSTA 1319
Cdd:cd10040      2 FQDK--FDGSVDLQANWYRIQG---GQVDIDCLSMDTALMFTENiGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSH 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1320 PVLLQYSHDAGMSWFLVKEGCFPASAgkGCEgnsrELSEPTVYYTGDFEEWTRVTIAIPRSLASSKTRFRWIQESSSqKN 1399
Cdd:cd10040     77 SVQLQYSLNNGRDWHLVTEECVPPAI--GCL----HYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYA-PG 149

                          170       180
                   ....*....|....*....|.
gi 1958768177 1400 VPPFGLDGVYISEPCPSYCSG 1420
Cdd:cd10040    150 ADSWAIDNVVLASGCPWMCSG 170

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 103.82 E-value: 4.12e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2893 FLKERFDSEeIKPDLWMSLEGGSTCTECGILAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGsennmtsCHR--P 2970
Cdd:cd10049      4 FLKDDFEGQ-LESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-------CGKgvP 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2971 VCRKEGVLLDYSKDGGITWTLLHEMDFQKYISVRHdYILL--PEGALTNTTRLRWWQPfvisnglVVSGVERAQWALDNI 3048
Cdd:cd10049     76 DPRSQPVLLQYSLNGGLTWSLLQEFLFSNSSNVGR-YVALeiPLKARSPSTRLRWWQP-------SENGHFYSPWVIDQI 147


                   ...
gi 1958768177 3049 LIG 3051
Cdd:cd10049    148 LIG 150

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 104.15 E-value: 6.21e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1266 AKNDSFCATTPSAMVFGKSDGDRF---AVTRDLTLKPGYVLQFKLNIGCASQFS--STAPVLLQYSHDAGM-SWFLVKEG 1339
Cdd:cd10044     26 VRTDEFCGNPSFHLTWPNKKKDKThnaLTTRQLIVQPGYMIQFKIVVGCGSVSScgDLHPVMLEYTTDPRSdHWQLVQTE 105

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958768177 1340 CFPASAGK-GCEGNSreLSEPTVYYTGDFEEWTRVTIAIPRSLASSKTRFRWIQESSSQKNvPPFGLDGVYISE 1412
Cdd:cd10044    106 CLPSSSNSiDCSPFQ--YHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTESTEA-PSWAIDDVYIGE 176

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 103.84 E-value: 6.89e-25

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  571 SHMIQFSINLGCGTH-QPG--NSVSLEFSTNHGRSWSLLHTECLPEICAGPHLPHSTIYSSENYSGWNRVTIPLPNAALT 647
Cdd:cd10038     59 SYMIQFSLVMGCGQQyTPHmdNQVKLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWS 138

                           90       100
                   ....*....|....*....|....*....
gi 1958768177  648 RDTRIRWRQTGPILGNMWAIDNVYIGPSC 676
Cdd:cd10038    139 SATRFRWSQSYYTDQDEWALDNIYIGQQC 167

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 102.62 E-value: 1.51e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1802 LPSILKDDF-NGNLHPDLWPEVYGAE--RGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRfIAKGTPE- 1877
Cdd:cd10046      1 LPSTVMSDFeNQDSLETEWQEVIGGEivKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQ-IGGGSASc 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768177 1878 -----RSHSILLQSSINGGVTWRLMDEFYFPQTTSILFINVPLPYSAQTNATRFRLWQPYNNGKKEE 1939
Cdd:cd10046     80 nypdsREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYD 146

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 102.68 E-value: 1.68e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3062 DTFDdeGSSH-EENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKThnaLSSRELIIQPGYMMQFKIVVGCeATSCGDLHS 3140
Cdd:cd10040      4 DKFD--GSVDlQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRY---AETWDFHVSASTFLQFELSMGC-SKPYSNSHS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3141 VMLEYTKDARSDsWQLVQTQCLPSSsnsIGCSPFQfhEATIYNAVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEKQ 3220
Cdd:cd10040     78 VQLQYSLNNGRD-WHLVTEECVPPA---IGCLHYT--ESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGAD 151

                          170
                   ....*....|....*....
gi 1958768177 3221 SWAIDHVYIGEACPRLCSG 3239
Cdd:cd10040    152 SWAIDNVVLASGCPWMCSG 170

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 102.95 E-value: 1.77e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1277 SAMVFGKSD-GDRFAVTRDLTLKPGYVLQFKLNIGCASQFSSTAPVLLQYSHDAGMSWFLVKEGCFpaSAGKGCEGNSRE 1355
Cdd:cd10041     39 SAMVFVSSElGEHSITTRDLDVNENTIIQFEINVGCTTESSSADPVRLEFSRDFGATWHLLLPLCY--GSSSISSLCSTE 116

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 1356 LSEPTVYYTGDFEEWTRVTIAIPRSLASSKTRFRWIQE-SSSQKNVPPFGLDGVYI 1410
Cdd:cd10041    117 LHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGfHPAGSQPVTWAIDNVYI 172

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 102.22 E-value: 3.43e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  893 QPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDNQVKLEYSTN-HGLTWHLVQDECLP 971
Cdd:cd10044     29 DEFCGNPSFHLTWPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVSSCGDLHPVMLEYTTDpRSDHWQLVQTECLP 108

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177  972 S---MPSCQEFT--SASIYHASEFTQWRRVTVILPQKTWSGATRFRWSQ-SYYTAQDEWALDDIYIGQ 1033
Cdd:cd10044    109 SssnSIDCSPFQyhEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQkTESTEAPSWAIDDVYIGE 176

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 101.82 E-value: 3.73e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3111 SRELIIQPGYMMQFKIVVGCEATSCGdLHSVMLEYTKDArSDSWQLVQTQCLPSSSNSIGC--SPFQFHEATIYNAVNSS 3188
Cdd:cd10039     50 TRDLTLKPGYVLQFKVNIGCTSEFSS-FAPVLLQYSHDA-GLTWSLVREGCYPASPGSKGCegSSRELREPTVYHTGDYE 127

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958768177 3189 SWKRITIQLPDHVSSSATQFRWIQKGE-ETEKQSWAIDHVYIG 3230
Cdd:cd10039    128 DWTRITIPIPRSLAASKTRFRWIQESSsLKNAPPFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 99.98 E-value: 9.87e-24

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  912 SSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHmdnQVKLEYSTNHGLTWHLVQDECLPSMPSCQEFTSASIYHASEFT 991
Cdd:cd10042     39 ASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCY---AIELEYSVDLGLSWHPLLRDCLPTNVECSSYHLQRILVSDTFN 115

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1958768177  992 QWRRVTVILPQKTWSGATRFRWSQ-SYYTAQDEWALDDIYIG 1032
Cdd:cd10042    116 KWTRVTLPLPHYTRSQATRFRWHQpAPFDKQQTWAIDNVYIG 157

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 100.66 E-value: 1.06e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  915 RYVETQSMQIGASYMIQFSLVMGCGQKYTpHMdNQVKLEYSTNHGLTWHLVQDECLPSMPS---CQ----EFTSASIYHA 987
Cdd:cd10039     46 RFAVTRDLTLKPGYVLQFKVNIGCTSEFS-SF-APVLLQYSHDAGLTWSLVREGCYPASPGskgCEgssrELREPTVYHT 123

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1958768177  988 SEFTQWRRVTVILPQKTWSGATRFRWSQ--SYYTAQDEWALDDIYIG 1032
Cdd:cd10039    124 GDYEDWTRITIPIPRSLAASKTRFRWIQesSSLKNAPPFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 100.38 E-value: 1.08e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3109 LSSRELIIQPGYMMQFKIVVGC-EATSCGDLHSVMLEYTKDaRSDSWQLVQTQCLPSSsnsIGCSpfQFHEATIYNAVNS 3187
Cdd:cd10038     49 VETQSMQIGASYMIQFSLVMGCgQQYTPHMDNQVKLEYSTN-HGLTWHLVQEECLPGM---PSCQ--EFTSGSIYHSSEF 122

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1958768177 3188 SSWKRITIQLPDHVSSSATQFRWIQKgEETEKQSWAIDHVYIGEACP 3234
Cdd:cd10038    123 TEWRRITLPLPQKTWSSATRFRWSQS-YYTDQDEWALDNIYIGQQCP 168

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 98.32 E-value: 7.35e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2710 NENWLFHDDCTVERFC-------DSPDGVMLCGSHDGREVYAVTHDLTPTENWIMQFKISVGCKVpEKIAQNQIHVQFST 2782
Cdd:cd10041     12 ESNWLFYPGGNTGLYCpyqskgaPEEDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCTT-ESSSADPVRLEFSR 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2783 DFGVSWSYLVPQCLPADP---KCSGTVSQPSVFFP--TKGWKRITYPLPESLMGNPVRFRFYQKY-----SDVQWAIDNF 2852
Cdd:cd10041     91 DFGATWHLLLPLCYGSSSissLCSTELHPSSVYYTgtTQGWRREVILFGKLHLCGSVRFRWYQGFhpagsQPVTWAIDNV 170


                   ....
gi 1958768177 2853 YLGP 2856
Cdd:cd10041    171 YIGP 174

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 97.60 E-value: 1.33e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2327 DDFSTLDSRKWLLHPGGTKMP-VCGSTGDALVFI--EKASTRYVVTT-DIAVNEDSFLQIDFAASCSVTDSC---YAIEL 2399
Cdd:cd10044      9 EDEGTSHDENWEFYPNGVRTDeFCGNPSFHLTWPnkKKDKTHNALTTrQLIVQPGYMIQFKIVVGCGSVSSCgdlHPVML 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2400 EYSVD-LGLSWHPLVRDCLPTNVE---CS--RYHLQRILVSDTFNKWTRITLPLPAYTRSQATRFRWHQPAPFDKQQTWA 2473
Cdd:cd10044     89 EYTTDpRSDHWQLVQTECLPSSSNsidCSpfQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTESTEAPSWA 168


                   ....*...
gi 1958768177 2474 IDNVYIGD 2481
Cdd:cd10044    169 IDDVYIGE 176

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 96.93 E-value: 2.25e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  916 YVETQSMQIGASYMIQFSLVMGCGQKyTPHMDNQVKLEYSTNHGLTWHLVQDECLPSMPSC-QEFTSASIYHASEftQWR 994
Cdd:cd10043     59 SAVTHDLTPTEGWILQFKISVGCKSS-EKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKCgGSVTQPSVFFPSK--GWR 135

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1958768177  995 RVTVILPQKTWSGATRFRWSQSYYTAQdeWALDDIYIG 1032
Cdd:cd10043    136 RVTIPLPDKLVGRPIRFRFYQKASDMQ--WALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 94.98 E-value: 9.27e-22

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2743 YAVTHDLTPTENWIMQFKISVGC-KVPEKIAQNQIHVQFSTDFGVSWSYLVPQCLPADPKCSgTVSQPSVFFPT--KGWK 2819
Cdd:cd10038     48 YVETQSMQIGASYMIQFSLVMGCgQQYTPHMDNQVKLEYSTNHGLTWHLVQEECLPGMPSCQ-EFTSGSIYHSSefTEWR 126

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1958768177 2820 RITYPLPESLMGNPVRFRFYQKY--SDVQWAIDNFYLGPGC 2858
Cdd:cd10038    127 RITLPLPQKTWSSATRFRWSQSYytDQDEWALDNIYIGQQC 167

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 94.60 E-value: 1.06e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1271 FCATTPSAMVFGKSD---GDRFAVTRDLTLKPGYVLQFKLNIGCASQFSS--TAPVLLQYSHDAGMSWFLVKEGCFPASA 1345
Cdd:cd10038     27 YCNHDWTLCFTGDSKhasSARYVETQSMQIGASYMIQFSLVMGCGQQYTPhmDNQVKLEYSTNHGLTWHLVQEECLPGMP 106

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1346 GkgCEgnsrELSEPTVYYTGDFEEWTRVTIAIPRSLASSKTRFRWIQESSSQKNvpPFGLDGVYISEPCP 1415
Cdd:cd10038    107 S--CQ----EFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQD--EWALDNIYIGQQCP 168

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 94.08 E-value: 1.46e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1803 PSILKDDF-NGNLHPDLWPEVYGAERGNLNGeTIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKGTPE---- 1877
Cdd:cd10051      1 KTFLKERFdSEEISSDQWLSLEGGVTCTDCG-VLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTlclr 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177 1878 ---RSHSILLQSSINGGVTWRLMDEFYFPQTTSILFINVPLPYSAQTNATRFRLWQPY 1932
Cdd:cd10051     80 ptcRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPF 137

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 94.23 E-value: 1.71e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1271 FCATTPSAMVFGKSDGDR--FAVTRDLTLKPGYVLQFKLNIGC-ASQFSSTAPVLLQYSHDAGMSWFLVKEGCFPASAGK 1347
Cdd:cd10043     39 FCDSPDGVMICGSHDDGRevSAVTHDLTPTEGWILQFKISVGCkSSEKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKC 118

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958768177 1348 GcegnsRELSEPTVYYTgdFEEWTRVTIAIPRSLASSKTRFRWIQESSSQKnvppFGLDGVYI 1410
Cdd:cd10043    119 G-----GSVTQPSVFFP--SKGWRRVTIPLPDKLVGRPIRFRFYQKASDMQ----WALDNFYI 170

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 92.25 E-value: 4.50e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1450 SEMFDRFEGKLSP-LWYKISGGQVGTGCG-TLSDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGitcikpr 1527
Cdd:cd10048      3 SVLKDDFNGNLRPdLWPEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTP------- 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177 1528 ARNEGLVVQYSNDNGILWHLLRELDFLSFLEPQIISIDLPREAKTPATAFRWWQPQH-GKHSAQWALDDVLIGVN 1601
Cdd:cd10048     76 ERSHSVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNsGKKEEVWILDDLVIDGN 150

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 91.91 E-value: 6.24e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  423 SEEFESQPT----GWDILGAVVGSECGTIESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFAMGG-----TCDPGDSHE 493
Cdd:cd08526      3 KDSFEGSLSssdnWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSksqtsTCNPPDSRS 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177  494 NDVILYAKIEGKKEHIALDTLSYSSYKVPTLVSVVINPELQTPATKFCLRQKNHQGHNQNVWAVD 558
Cdd:cd08526     83 EGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALD 147

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 91.80 E-value: 7.27e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1803 PSILKDDFNGNLhPDLWPEVYGAERGNLNGeTIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKGTPE----- 1877
Cdd:cd10047      1 PSEFFDRFEGKL-SPLWYKITGGQVGTGCG-VIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGEtclrp 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 1878 --RSHSILLQSSINGGVTWRLMDEFYFPQTTSILFINVPLPYSAQTNATRFRLWQP 1931
Cdd:cd10047     79 rsRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQP 134

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 91.89 E-value: 7.56e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1971 NWFFYPGGNIGLYCpySSKGApeedsAMVFVSNEIGEHSITTrDLSVNENTIIQFEINVGCSTdSSSADPVRLEFSRDFG 2050
Cdd:cd10042     13 KWLLHPGGTKMPVC--GSTGD-----ALVFIEKASTRYVVTT-DIMVNEDSFLQIDFAASCSV-TDSCYAIELEYSVDLG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2051 ATWHLLLPLCYHSSSLVSSlcsteHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQgfyPAGSQP-VTWAIDNVY 2129
Cdd:cd10042     84 LSWHPLLRDCLPTNVECSS-----YHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQ---PAPFDKqQTWAIDNVY 155


                   ..
gi 1958768177 2130 IG 2131
Cdd:cd10042    156 IG 157

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 91.07 E-value: 9.67e-21

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3120 YMMQFKIVVGCeaTSCGDLHSVMLEYTKDaRSDSWQLVQTQCLPSSsnsigCSPFQFHEATIYNAVNSSSWKRITIQLPD 3199
Cdd:cd10037     45 HFAQFSINLGC--GSHQPGNSVSLEFSTN-HGRSWSLLHTECLPEL-----CAGPHLPHSTVYSSDNYSGWNRITIPLPN 116

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958768177 3200 HVSSSATQFRWIQKGEETEKQsWAIDHVYIG 3230
Cdd:cd10037    117 AALTSATRFRWRQTGSVVGSM-WAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 91.39 E-value: 1.60e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3060 LVDTFDDegSSHEENWSFYPNavrtagfcGNPSFHLYWPNKKKDKTHNAL------------SSRELIIQPGYMMQFKIV 3127
Cdd:cd10041      2 LLDTFDF--GPNESNWLFYPG--------GNTGLYCPYQSKGAPEEDSAMvfvsselgehsiTTRDLDVNENTIIQFEIN 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3128 VGCEATScGDLHSVMLEYTKDARSdSWQLVQTQCLPSSSNSIGCSpFQFHEATIYNAVNSSSWKRITIQLPDHVSSSATQ 3207
Cdd:cd10041     72 VGCTTES-SSADPVRLEFSRDFGA-TWHLLLPLCYGSSSISSLCS-TELHPSSVYYTGTTQGWRREVILFGKLHLCGSVR 148

                          170       180
                   ....*....|....*....|....*
gi 1958768177 3208 FRWIQ--KGEETEKQSWAIDHVYIG 3230
Cdd:cd10041    149 FRWYQgfHPAGSQPVTWAIDNVYIG 173

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 90.71 E-value: 1.68e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  743 LASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRApdqpgegVLLHYSYDNGITWKLLEHYSYLNYHE 822
Cdd:cd10048     34 IKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHS-------VLLQYSINGGITWHLIDEFYFPTTTD 106

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1958768177  823 PRIISVELPDDAKQFGIQFRWWQPYHSSQGEDVWAIDEILM 863
Cdd:cd10048    107 VLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVI 147

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 89.79 E-value: 2.94e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  890 GNIQPYCG---HDWTLCFTGDSklasSMRYVETQSMQIGASYMIQFSLVMGCGqkyTPHMDNQ-VKLEYSTNHGLTWHLV 965
Cdd:cd08524     20 GKTGTVCGalsSGNALVFNEPY----GPRELVTTDLNTNEASFLQFYIGSGCS---TPSYSNQpVLLEYSVDNGASWHLL 92

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177  966 QdeclpsmpscqeftsasIYHASEFTQWRRVTVILPQKTWSGATRFRWSQSYYTAQDE--WALDDIYIG 1032
Cdd:cd08524     93 E-----------------EIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQatWAIDNVLIG 144

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 89.96 E-value: 3.18e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3268 PSYIKDNFESArVTEANWETIQGGAIGSGCGQLAPyahGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSTAQTdsc 3347
Cdd:cd10049      2 PDFLKDDFEGQ-LESDRFLLMSGGKPSRKCGILSS---GNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGV--- 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 3348 nsdlsgPHTVDKAVLLQYSVNNGITWHVIAQ-HQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHV 3425
Cdd:cd10049     75 ------PDPRSQPVLLQYSLNGGLTWSLLQEfLFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQI 147

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 89.86 E-value: 3.44e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1803 PSILKDDFNGNL--HPDLWPEVYGAERGNLNGeTIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKGT----- 1875
Cdd:cd10045      1 PGFLSESFNSSRlsSYHNFSSIRGGEVGFGCG-VLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVlgtcp 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177 1876 -PER-SHSILLQSSINGGVTWRLMDEFYFPQTTSILFINVPLPYSAQTNATRFRLWQPYNNGKKE 1938
Cdd:cd10045     80 pPDRpGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQ 144

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 90.28 E-value: 4.35e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1956 PVMLLDTFDFGP--REDNWFFYPGGNIG-LYCpysskGAPEedSAMVFVSNEIG--EHSITTRDLSVNENTIIQFEINVG 2030
Cdd:cd10044      1 PSSLVETFEDEGtsHDENWEFYPNGVRTdEFC-----GNPS--FHLTWPNKKKDktHNALTTRQLIVQPGYMIQFKIVVG 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2031 CSTDSSSAD--PVRLEFSRDFGAT-WHLLLPLCYHSSSLVSSLCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRF 2107
Cdd:cd10044     74 CGSVSSCGDlhPVMLEYTTDPRSDhWQLVQTECLPSSSNSIDCSPFQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQF 153

                          170       180
                   ....*....|....*....|....
gi 1958768177 2108 RWYQGFYPAGSQPvtWAIDNVYIG 2131
Cdd:cd10044    154 RWIQKTESTEAPS--WAIDDVYIG 175

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 89.88 E-value: 4.92e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1967 PREDNWFFYPGGNIGLYCPYSSKGapeedSAMVFVSNEiGEHSITTRDLSVNENTIIQFEINVGCSTDSSSADPVRLEFS 2046
Cdd:cd10039     11 NQMSVWLMLSNEGMGKNESCSPTP-----SAMVFGKSD-GDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPVLLQYS 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2047 RDFGATWHLLLPLCYHSSSLVSS--LCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQPvTWA 2124
Cdd:cd10039     85 HDAGLTWSLVREGCYPASPGSKGceGSSRELREPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAP-PFG 163


                   ....*..
gi 1958768177 2125 IDNVYIG 2131
Cdd:cd10039    164 LDGVYIS 170

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 89.85 E-value: 5.65e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  917 VETQSMQIGASYMIQFSLVMGCGQKYTPhmDNQVKLEYSTNHGLTWHLVQDEC----LPSMPSCQEFTSASIYHASEFTQ 992
Cdd:cd10041     53 ITTRDLDVNENTIIQFEINVGCTTESSS--ADPVRLEFSRDFGATWHLLLPLCygssSISSLCSTELHPSSVYYTGTTQG 130

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958768177  993 WRRVTVILPQKTWSGATRFRWSQSYYTAQDE---WALDDIYIG 1032
Cdd:cd10041    131 WRREVILFGKLHLCGSVRFRWYQGFHPAGSQpvtWAIDNVYIG 173

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 89.49 E-value: 6.64e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1627 GGQVDIDCLSMDTALIFTENIGKpRYAETWDFHVSASSFLQFDMSMGCSKPFSATHSVQLQYSLNNGKDWHPVTEECVPP 1706
Cdd:cd10039     23 GMGKNESCSPTPSAMVFGKSDGD-RFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPVLLQYSHDAGLTWSLVREGCYPA 101

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 1707 TIGCVHYT-------ESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQANYT-VGADAWAIDNV 1764
Cdd:cd10039    102 SPGSKGCEgssrelrEPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSlKNAPPFGLDGV 167

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 89.61 E-value: 7.35e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1958 MLLDTFDFGP-------------REDNWFFYPGGNIGLYCPysskgapEEDSAMVFVSNEIGEH-SITTRDLSVNENTII 2023
Cdd:cd10043      1 VLLDTFSSANlpqherspedkttVNDHWLFHDNCSIERFCD-------SPDGVMICGSHDDGREvSAVTHDLTPTEGWIL 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2024 QFEINVGC-STDSSSADPVRLEFSRDFGATWHLLLPLCYhssslvsslcstehhPSSTYYAGT---------TQGWRREV 2093
Cdd:cd10043     74 QFKISVGCkSSEKSAQQPVHVQYSTDFGVSWSYVTPQCL---------------PSDPKCGGSvtqpsvffpSKGWRRVT 138

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1958768177 2094 VHFGKLHLCGSVRFRWYQGFypagsQPVTWAIDNVYIG 2131
Cdd:cd10043    139 IPLPDKLVGRPIRFRFYQKA-----SDMQWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 89.51 E-value: 8.71e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  572 HMIQFSINLGCGTHQPGN---SVSLEFSTN-HGRSWSLLHTECLP----EICAGPHLPH-STIYSSENYSGWNRVTIPLP 642
Cdd:cd10044     64 YMIQFKIVVGCGSVSSCGdlhPVMLEYTTDpRSDHWQLVQTECLPsssnSIDCSPFQYHeASIYSSVNSSVWKRVTIQLP 143

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1958768177  643 NAALTRDTRIRWRQ-TGPILGNMWAIDNVYIG 673
Cdd:cd10044    144 DHVSSSATQFRWIQkTESTEAPSWAIDDVYIG 175

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 88.45 E-value: 1.65e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3073 ENWSFYPNAVrTAGFCGNPSfHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKDaRSD 3152
Cdd:cd10043     26 DHWLFHDNCS-IERFCDSPD-GVMICGSHDDGREVSAVTHDLTPTEGWILQFKISVGCKSSEKSAQQPVHVQYSTD-FGV 102

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177 3153 SWQLVQTQCLPSSSNSIGcspfQFHEATIYNAvnSSSWKRITIQLPDHVSSSATQFRWIQKGEETEkqsWAIDHVYIG 3230
Cdd:cd10043    103 SWSYVTPQCLPSDPKCGG----SVTQPSVFFP--SKGWRRVTIPLPDKLVGRPIRFRFYQKASDMQ---WALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 88.04 E-value: 2.29e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1961 DTFD-FGPREDNWFFYPGGNIGLYCPYSskgapeeDSAMVFVSNEIGEHSITTRDLSVNENTIIQFEINVGCSTDSSSAD 2039
Cdd:cd10040      4 DKFDgSVDLQANWYRIQGGQVDIDCLSM-------DTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSH 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2040 PVRLEFSRDFGATWHLLLPLCyhsssLVSSLCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQ 2119
Cdd:cd10040     77 SVQLQYSLNNGRDWHLVTEEC-----VPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGAD 151

                          170       180
                   ....*....|....*....|.
gi 1958768177 2120 pvTWAIDNVYIGPQCEEMCCG 2140
Cdd:cd10040    152 --SWAIDNVVLASGCPWMCSG 170

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 86.84 E-value: 2.97e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1661 SASSFLQFDMSMGCSKpFSATHSVQLQYSLNNGKDWHPVTEECVPPTIGCVHYTESSTYTSERFQNWRRVTVYLPLATNS 1740
Cdd:cd10037     42 TVTHFAQFSINLGCGS-HQPGNSVSLEFSTNHGRSWSLLHTECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALT 120

                           90       100
                   ....*....|....*....|....*.
gi 1958768177 1741 PRTRFRWIQaNYTVGADAWAIDNVLL 1766
Cdd:cd10037    121 SATRFRWRQ-TGSVVGSMWAIDNVYI 145

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 86.86 E-value: 3.53e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2890 LKTFLKERFDsEEIKPDLWMSLEGGSTCTECGILAEN-TALYFGGSTVRQAITQDLDLRGAKFLQYWGRIgsennmtSCH 2968
Cdd:cd10048      1 LPSVLKDDFN-GNLRPDLWPEVYGAERGNLNGETIKSgTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF-------ITK 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2969 RPVCRKEGVLLDYSKDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFvisnglvVSGVERAQWALDNI 3048
Cdd:cd10048     73 GTPERSHSVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPY-------NSGKKEEVWILDDL 145


                   ....
gi 1958768177 3049 LIGG 3052
Cdd:cd10048    146 VIDG 149

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 87.54 E-value: 4.31e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2324 VLEDDFSTL-DSRKWLLHPGGTKMPVC-----GSTGD--ALVFIEKASTRYVVTT-DIAVNEDSFLQIDFAASCSV-TDS 2393
Cdd:cd10041      1 LLLDTFDFGpNESNWLFYPGGNTGLYCpyqskGAPEEdsAMVFVSSELGEHSITTrDLDVNENTIIQFEINVGCTTeSSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2394 CYAIELEYSVDLGLSWHPLVRDCL---PTNVECS-RYHLQRILVSDTFNKWTRITLPLPAYTRSQATRFRWHQ---PAPf 2466
Cdd:cd10041     81 ADPVRLEFSRDFGATWHLLLPLCYgssSISSLCStELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQgfhPAG- 159

                          170
                   ....*....|....
gi 1958768177 2467 DKQQTWAIDNVYIG 2480
Cdd:cd10041    160 SQPVTWAIDNVYIG 173

Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This domain is found at the N-terminus of F-spondin, a protein attached to the extracellular matrix, which plays roles in neuronal development and vascular remodelling. The F-spondin reeler domain has been reported to bind heparin. The reeler domain is also found at the N-terminus of reelin, an extracellular glycoprotein involved in the development of the brain cortex, and in a variety of other eukaryotic proteins with different domain architectures, including the animal ferric-chelate reductase 1 or stromal cell-derived receptor 2, a member of the cytochrome B561 family, which reduces ferric iron before its transport from the endosome to the cytoplasm. Also included is the insect putative defense protein 1, which is expressed upon bacterial infection and appears to contain a single reeler domain.

Pssm-ID: 260081 Cd Length: 135 Bit Score: 85.90 E-value: 4.51e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177   50 GDGEQGEVLISLHIAGNptYYVPGQEYHVTIS--TSTFFDGLLVTGLYTSTSIQSSQsiggssaFGFGIMSDHQFGNQFM 127
Cdd:cd08544     12 GDPQTTPSPYSITVSGN--TYKPGQTYTVTLSgsRPTPFRGFLLQARDASSNEPVGT-------FQLPPDSGTKLLTCCP 82

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1958768177  128 CSVVASHVSHLPTTNLSFVWIAPPAGTGCVNFMATATHRGQVIFKDALAQQLC 180
Cdd:cd08544     83 SGNAVTHTNNSPKTSVTVTWKAPSNGSGCVTFRATVVQSYDVFWVDVLSKTLC 135

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 86.45 E-value: 5.01e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2375 NEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLSWHPLVRDCLPTNveCSRYHL--QRILVSDTFNKWTRITLPLPAYTR 2452
Cdd:cd10037     42 TVTHFAQFSINLGCGSHQPGNSVSLEFSTNHGRSWSLLHTECLPEL--CAGPHLphSTVYSSDNYSGWNRITIPLPNAAL 119

                           90       100
                   ....*....|....*....|....*...
gi 1958768177 2453 SQATRFRWHQPAPFDKQQtWAIDNVYIG 2480
Cdd:cd10037    120 TSATRFRWRQTGSVVGSM-WAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 86.11 E-value: 7.52e-19

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  574 IQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLHTECLPEI--CAGPHLphSTIYSSENYSGWNRVTIPLPNAALTRDTR 651
Cdd:cd10042     57 LQIDFAASCSVTDSCYAIELEYSVDLGLSWHPLLRDCLPTNveCSSYHL--QRILVSDTFNKWTRVTLPLPHYTRSQATR 134

                           90       100
                   ....*....|....*....|...
gi 1958768177  652 IRWRQTGPI-LGNMWAIDNVYIG 673
Cdd:cd10042    135 FRWHQPAPFdKQQTWAIDNVYIG 157

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 85.64 E-value: 1.86e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2724 FCDSP-DGVMLCGSHDGrEVYAVTHDLTPTENWIMQFKISVGCKvPEKIAQNQIHVQFSTDFGVSWSYLVPQCLPADP-- 2800
Cdd:cd10039     28 ESCSPtPSAMVFGKSDG-DRFAVTRDLTLKPGYVLQFKVNIGCT-SEFSSFAPVLLQYSHDAGLTWSLVREGCYPASPgs 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177 2801 -KCSGT---VSQPSVFFPT--KGWKRITYPLPESLMGNPVRFRFYQKYSDVQ----WAIDNFYLG 2855
Cdd:cd10039    106 kGCEGSsreLREPTVYHTGdyEDWTRITIPIPRSLAASKTRFRWIQESSSLKnappFGLDGVYIS 170

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 84.02 E-value: 3.03e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2710 NENWLFHDDCTVERFCDSP---DGVMLCGSHDGREVyaVTHDLTPTENWIMQFKISVGCKVPEKIAQNqIHVQFSTDFGV 2786
Cdd:cd08524     11 PDNWLLCPGGKTGTVCGALssgNALVFNEPYGPREL--VTTDLNTNEASFLQFYIGSGCSTPSYSNQP-VLLEYSVDNGA 87

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958768177 2787 SWSYLVpqclpadpkcsgtvsqpSVFFPT-KGWKRITYPLPESLMGNPVRFRFYQ----KYSDVQWAIDNFYLG 2855
Cdd:cd08524     88 SWHLLE-----------------EIRADSfSKWRIIILYLPEDAKSGATRFRWWQpnhrGVYQATWAIDNVLIG 144

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 83.74 E-value: 5.16e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  425 EFESQ----PTGWDILGA-VVGSE--CGTIESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFAMGG---TCDPGDSHEN 494
Cdd:cd10046      8 DFENQdsleTEWQEVIGGeIVKPEmgCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGgsaSCNYPDSREE 87

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958768177  495 DVILYAKIEGKKEHIALDTLSYSSYKVPTLVSVVINPELQTPATKFCLRQKNHQGHNQNVWAVD 558
Cdd:cd10046     88 GVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALD 151

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 83.25 E-value: 5.97e-18

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1277 SAMVFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCASQFSSTAPVLLQYSHDAGMSWFLVKEgcfpasagkgcegnsrel 1356
Cdd:cd08524     33 NALVFNEPYGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQPVLLEYSVDNGASWHLLEE------------------ 94

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177 1357 septvYYTGDFEEWTRVTIAIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYIS 1411
Cdd:cd08524     95 -----IRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLIG 144

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 82.93 E-value: 1.02e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  423 SEEFE-----SQPTGWDILGAVVGSECGTIESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFAMG-----GTCDPGDSH 492
Cdd:cd10045      5 SESFNssrlsSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGsksvlGTCPPPDRP 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177  493 ENDVILYAKIEGKKEHIALDTLSYSSYKVPTLVSVVINPELQTPATKFCLRQKNHQGHNQNVWAVD 558
Cdd:cd10045     85 GEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALD 150

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 83.06 E-value: 1.23e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2325 LEDDfsTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTR--YVVTTDIAVNEDSFLQIDFAASCSVTD--SCYAIELE 2400
Cdd:cd10043     18 PEDK--TTVNDHWLFHDNCSIERFCDSPDGVMICGSHDDGRevSAVTHDLTPTEGWILQFKISVGCKSSEksAQQPVHVQ 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2401 YSVDLGLSWHPLVRDCLPTNVECSRYHLQRIlVSDTFNKWTRITLPLPAYTRSQATRFRWHQPApfdKQQTWAIDNVYIG 2480
Cdd:cd10043     96 YSTDFGVSWSYVTPQCLPSDPKCGGSVTQPS-VFFPSKGWRRVTIPLPDKLVGRPIRFRFYQKA---SDMQWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 82.65 E-value: 1.32e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1272 CATTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCASQfSSTAPVLLQYSHDAGMSWFLVKEGCFPASAgkgcEG 1351
Cdd:cd10042     26 CGSTGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVT-DSCYAIELEYSVDLGLSWHPLLRDCLPTNV----EC 100

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177 1352 NSRELSEptVYYTGDFEEWTRVTIAIPRSLASSKTRFRWIQESSSQKNvPPFGLDGVYI 1410
Cdd:cd10042    101 SSYHLQR--ILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQ-QTWAIDNVYI 156

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 81.11 E-value: 4.87e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3065 DDEGSSHEE-NWSFYPNAVRTAgFCGNPSFHLYWpnKKKDKTHNALSSrELIIQPGYMMQFKIVVGCEAT-SCgdlHSVM 3142
Cdd:cd10042      3 EDDFSTLDSrKWLLHPGGTKMP-VCGSTGDALVF--IEKASTRYVVTT-DIMVNEDSFLQIDFAASCSVTdSC---YAIE 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3143 LEYTKDArSDSWQLVQTQCLPSSsnsIGCSPFQFHEATIYNAVNSssWKRITIQLPDHVSSSATQFRWIQKGEETEKQSW 3222
Cdd:cd10042     76 LEYSVDL-GLSWHPLLRDCLPTN---VECSSYHLQRILVSDTFNK--WTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTW 149


                   ....*...
gi 1958768177 3223 AIDHVYIG 3230
Cdd:cd10042    150 AIDNVYIG 157

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 80.29 E-value: 5.52e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2736 SHDG--REVYAVTH-----DLTPTENWIMQFKISVGCKVPEKiaQNQIHVQFSTDFGVSWSYLVPQCLPAdpKCSGTVSQ 2808
Cdd:cd10037     19 SHGGhnRNVWAVDFfhllpVLPSTVTHFAQFSINLGCGSHQP--GNSVSLEFSTNHGRSWSLLHTECLPE--LCAGPHLP 94

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1958768177 2809 PSVFFPT---KGWKRITYPLPESLMGNPVRFRFYQKYSDV--QWAIDNFYLG 2855
Cdd:cd10037     95 HSTVYSSdnySGWNRITIPLPNAALTSATRFRWRQTGSVVgsMWAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 80.72 E-value: 6.02e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2710 NENWLFHDDCTVERFCDSpDGVMLCGSHDGREVYAVTHDLTPTENWIMQFKISVGCKVPEKIAQnqIHVQFSTDFGVSWS 2789
Cdd:cd10042     11 SRKWLLHPGGTKMPVCGS-TGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCYA--IELEYSVDLGLSWH 87

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2790 YLVPQCLPADPKCSGTVSQPSVFFPT-KGWKRITYPLPESLMGNPVRFRFYQKYS-DVQ--WAIDNFYLG 2855
Cdd:cd10042     88 PLLRDCLPTNVECSSYHLQRILVSDTfNKWTRVTLPLPHYTRSQATRFRWHQPAPfDKQqtWAIDNVYIG 157

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 81.02 E-value: 7.11e-17

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  558 DFFHVLPILPSTMSHMIQFSINLGCGTHQPG-NSVSLEFSTNHGRSWSLLHTECLP-----EIC--AGPHLPHSTIYSSE 629
Cdd:cd10039     45 DRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSfAPVLLQYSHDAGLTWSLVREGCYPaspgsKGCegSSRELREPTVYHTG 124

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1958768177  630 NYSGWNRVTIPLPNAALTRDTRIRWRQTGPILGNM--WAIDNVYIG 673
Cdd:cd10039    125 DYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAppFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 79.96 E-value: 1.31e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1978 GNIGLYCPYSS----KGAPEEDSAMVFVSneigehsitTRDLSVNENTIIQFEINVGCSTDSSSA--DPVRLEFSRDFGA 2051
Cdd:cd10038     22 GNVQPYCNHDWtlcfTGDSKHASSARYVE---------TQSMQIGASYMIQFSLVMGCGQQYTPHmdNQVKLEYSTNHGL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2052 TWHLLLPLCyhsssLVSSLCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSqpvTWAIDNVYIG 2131
Cdd:cd10038     93 TWHLVQEEC-----LPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQD---EWALDNIYIG 164


                   ...
gi 1958768177 2132 PQC 2134
Cdd:cd10038    165 QQC 167

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 79.86 E-value: 1.90e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2170 FLKDDFEGQL-ESDRFLLMSGGKPSRKCGILSSGNNLFFNE-DGLRMLVTRDLDLSHARFVQFFMRLGCGKGVPdpRSQP 2247
Cdd:cd10039      1 YEKPAFDYPLnQMSVWLMLSNEGMGKNESCSPTPSAMVFGKsDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFS--SFAP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2248 VLLQYSLNGGLSWSLLQEFLFSNSS------------------NVGRY-----IALEMPLKARSGSTRLRWWQPSENGHF 2304
Cdd:cd10039     79 VLLQYSHDAGLTWSLVREGCYPASPgskgcegssrelreptvyHTGDYedwtrITIPIPRSLAASKTRFRWIQESSSLKN 158

                          170
                   ....*....|..
gi 1958768177 2305 YSPWVIDQILIG 2316
Cdd:cd10039    159 APPFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 79.45 E-value: 2.27e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  571 SHMIQFSINLGCGTHQPG-NSVSLEFSTNHGRSWSLLHTEC-----LPEICAGPHLPHSTIYSSENySGWNRVTIPLPNA 644
Cdd:cd10041     63 NTIIQFEINVGCTTESSSaDPVRLEFSRDFGATWHLLLPLCygsssISSLCSTELHPSSVYYTGTT-QGWRREVILFGKL 141

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958768177  645 ALTRDTRIRWRQ---TGPILGNMWAIDNVYIGP 674
Cdd:cd10041    142 HLCGSVRFRWYQgfhPAGSQPVTWAIDNVYIGP 174

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 78.71 E-value: 3.58e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2342 GGTKMPVCGSTGDALVFIEKASTRYVVTTDIAVNEDSFLQIDFAASCSVTDSCYA-IELEYSVDLGLSWHpLVRD-CLP- 2418
Cdd:cd10039     23 GMGKNESCSPTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFApVLLQYSHDAGLTWS-LVREgCYPa 101

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177 2419 --TNVEC----------SRYHlqrilvSDTFNKWTRITLPLPAYTRSQATRFRWHQPA-PFDKQQTWAIDNVYIG 2480
Cdd:cd10039    102 spGSKGCegssrelrepTVYH------TGDYEDWTRITIPIPRSLAASKTRFRWIQESsSLKNAPPFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 78.41 E-value: 4.54e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2712 NWLFHDDCTVERFCDSPDGVMLCGSHDGREVYAVTHDLTPTENWIMQFKISVGCKVPEKiAQNQIHVQFSTDFGVSWSYL 2791
Cdd:cd10040     15 NWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYS-NSHSVQLQYSLNNGRDWHLV 93

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177 2792 VPQCLPADPKCSgTVSQPSVFFPTK--GWKRITYPLPESLMGNPVRFRFYQKYSDV---QWAIDNFYLGPGCLDNCGG 2864
Cdd:cd10040     94 TEECVPPAIGCL-HYTESSVYSSERfqNWKRITVYLPPATISPRTRFRWIQPNYAPgadSWAIDNVVLASGCPWMCSG 170

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 78.73 E-value: 5.03e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1613 DGSIDLQANWYRIQGGQV-DIDCLSMDTALIFT--ENIGKPRYAETWDFHVSASSFLQFDMSMGCSKPFSAT--HSVQLQ 1687
Cdd:cd10044     10 DEGTSHDENWEFYPNGVRtDEFCGNPSFHLTWPnkKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVSSCGdlHPVMLE 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1688 YSLNNGKD-WHPVTEECVPPT---IGCV--HYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQANYTVGADAWAI 1761
Cdd:cd10044     90 YTTDPRSDhWQLVQTECLPSSsnsIDCSpfQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTESTEAPSWAI 169


                   ...
gi 1958768177 1762 DNV 1764
Cdd:cd10044    170 DDV 172

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 77.23 E-value: 7.18e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3267 LPSYIKDNF-ESARVTEanWETIQGGAIGSGCGQlaPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIgstaqtd 3345
Cdd:cd10048      1 LPSVLKDDFnGNLRPDL--WPEVYGAERGNLNGE--TIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF------- 69

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958768177 3346 SCNSDLSGPHtvdkAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALD 3423
Cdd:cd10048     70 ITKGTPERSH----SVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILD 143

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 78.05 E-value: 8.07e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  573 MIQFSINLGCG--THQPGNSVSLEFSTNHGRSWSLLHTECLPE--ICAGPHLPHSTIYSSEnysGWNRVTIPLPNAALTR 648
Cdd:cd10043     72 ILQFKISVGCKssEKSAQQPVHVQYSTDFGVSWSYVTPQCLPSdpKCGGSVTQPSVFFPSK---GWRRVTIPLPDKLVGR 148

                           90       100
                   ....*....|....*....|....*
gi 1958768177  649 DTRIRWRQTGPILgnMWAIDNVYIG 673
Cdd:cd10043    149 PIRFRFYQKASDM--QWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 76.82 E-value: 9.02e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1287 DRFAVTRDLTLKPGYVLQFKLNIGCASQfSSTAPVLLQYSHDAGMSWFLVKEGCFPASagkgCEGNsrELSEPTVYYTGD 1366
Cdd:cd10037     31 DFFHLLPVLPSTVTHFAQFSINLGCGSH-QPGNSVSLEFSTNHGRSWSLLHTECLPEL----CAGP--HLPHSTVYSSDN 103

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958768177 1367 FEEWTRVTIAIPRSLASSKTRFRWIQESSSQKNVppFGLDGVYI 1410
Cdd:cd10037    104 YSGWNRITIPLPNAALTSATRFRWRQTGSVVGSM--WAIDNVYI 145

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 77.13 E-value: 9.06e-16

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1464 WYKISGGQVGTGCGTLSDGRSLYF-NGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITcikprarNEGLVVQYSNDNG 1542
Cdd:cd10036     18 WSECCGCNVGEQCGVIMHGNALTFcEPYGPRELITVPLNTTTASVLQFAIGSGSCRFSYS-------DPSIIVSYAVNNT 90

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1543 IL-WHLLRELDFLSFLEPQIISIDLPREAKTPATAFRWWQ--PQHGKH-SAQWALDDVLI 1598
Cdd:cd10036     91 SSdWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQeaPNAGEVyESCWALDNVLI 150

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 77.64 E-value: 1.06e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2522 DNFNRAPSNQ-NWLTVNGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPSNrNQGVLLEY 2600
Cdd:cd10040      4 DKFDGSVDLQaNWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSN-SHSVQLQY 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2601 SVNGGITWTLLME---------IFYDQ---YSKPGFVN-----ILLPPDAKEIGTRFRWWQPrHDGLDQNDWAIDNVLIS 2663
Cdd:cd10040     83 SLNNGRDWHLVTEecvppaigcLHYTEssvYSSERFQNwkritVYLPPATISPRTRFRWIQP-NYAPGADSWAIDNVVLA 161

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 76.80 E-value: 1.23e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2323 TVLEDDFSTLDS-RKWLLHPGGTKMPVCG--STGDALVFiEKASTRYVVTTDIAVNEDSFLQIDFAASCSVTDSC--YAI 2397
Cdd:cd10050      3 TQLKDTFNRAPSsSNWLTVVGGKLSTVCGavASGTALHF-SGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNrnQGV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2398 ELEYSVDLGLSWHPLVRdclptnvecsryhlqriLVSDTFNKWTRITLPLPAYTRSQATRFRWHQPApFD--KQQTWAID 2475
Cdd:cd10050     82 LLEYSVNGGITWNLLME-----------------IFYDQYSKPGFVNILLPPEARGVGTRFRWWQPS-HDglDQNDWAID 143


                   ....*
gi 1958768177 2476 NVYIG 2480
Cdd:cd10050    144 NVLIG 148

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 75.93 E-value: 2.12e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  574 IQFSINLGCGTHQPGN-SVSLEFSTNHGRSWSLLHTeclpeicagphlphstiYSSENYSGWNRVTIPLPNAALTRDTRI 652
Cdd:cd08524     59 LQFYIGSGCSTPSYSNqPVLLEYSVDNGASWHLLEE-----------------IRADSFSKWRIIILYLPEDAKSGATRF 121

                           90       100
                   ....*....|....*....|...
gi 1958768177  653 RWRQTGP--ILGNMWAIDNVYIG 673
Cdd:cd08524    122 RWWQPNHrgVYQATWAIDNVLIG 144

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 76.37 E-value: 3.26e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1609 QDKFD-GSIDlqANWYRIQGGQVDIDCLSM-------DTALIFTENIGKPRYAETWDFHVSASSFLQFDMSMGCSKPFSA 1680
Cdd:cd10041      3 LDTFDfGPNE--SNWLFYPGGNTGLYCPYQskgapeeDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCTTESSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1681 THSVQLQYSLNNGKDWHPVTEECV---PPTIGC-VHYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQANYTVGA 1756
Cdd:cd10041     81 ADPVRLEFSRDFGATWHLLLPLCYgssSISSLCsTELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGFHPAGS 160

                          170
                   ....*....|
gi 1958768177 1757 DA--WAIDNV 1764
Cdd:cd10041    161 QPvtWAIDNV 170

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 74.87 E-value: 4.67e-15

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1606 TGFQDKFDGSIDLQaNWYRIQGGQVDIDC--LSMDTALIFTEniGKPRYAETWDFHVSASSFLQFDMSMGC-SKPFSATH 1682
Cdd:cd10050      3 TQLKDTFNRAPSSS-NWLTVVGGKLSTVCgaVASGTALHFSG--GCSRQLVTVDLNLTNAEFVQFYFMYGClIPPSNRNQ 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1683 SVQLQYSLNNGKDWHPVTEecvpptigcVHYTEsstYTSERFqnwrrVTVYLPLATNSPRTRFRWIQANYT-VGADAWAI 1761
Cdd:cd10050     80 GVLLEYSVNGGITWNLLME---------IFYDQ---YSKPGF-----VNILLPPEARGVGTRFRWWQPSHDgLDQNDWAI 142


                   ....*.
gi 1958768177 1762 DNVLLA 1767
Cdd:cd10050    143 DNVLIG 148

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 73.34 E-value: 2.11e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1612 FDGSIDLQANWYRIQGGQV---DIDCLSMDTALIFTENIGKPRYAETWDFHVSASSFLQFDMSMG-----CSKPFSATHS 1683
Cdd:cd10046      9 FENQDSLETEWQEVIGGEIvkpEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGggsasCNYPDSREEG 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1684 VQLQYSLNNGKDWHPVTEecvpptigcVHYtesSTYTSERFqnwrrVTVYLPLATNSPRTRFRWIQANYT-VGADAWAID 1762
Cdd:cd10046     89 VLLQYSNNGGISWKLLAE---------MYF---SDFSKPRF-----VYLELPTAAKTPCTRFRWWQPVFSgEGYDQWALD 151


                   ....
gi 1958768177 1763 NVLL 1766
Cdd:cd10046    152 DIII 155

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 73.72 E-value: 2.37e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2700 DMFMEDKTSVNENWLFHDDCTV-ERFCDSPDGVMLCGSH--DGREVYAVTHDLTPTENWIMQFKISVGCK-VPEKIAQNQ 2775
Cdd:cd10044      6 ETFEDEGTSHDENWEFYPNGVRtDEFCGNPSFHLTWPNKkkDKTHNALTTRQLIVQPGYMIQFKIVVGCGsVSSCGDLHP 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2776 IHVQFSTD-FGVSWSYLVPQCLPAD---PKCSG-TVSQPSVFFPTKG--WKRITYPLPESLMGNPVRFRFYQKYSDV--- 2845
Cdd:cd10044     86 VMLEYTTDpRSDHWQLVQTECLPSSsnsIDCSPfQYHEASIYSSVNSsvWKRVTIQLPDHVSSSATQFRWIQKTESTeap 165

                          170
                   ....*....|
gi 1958768177 2846 QWAIDNFYLG 2855
Cdd:cd10044    166 SWAIDDVYIG 175

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 72.79 E-value: 4.20e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3270 YIKDNFESARVTEANWETIQGGAIGSGCGqlapyAHGDSLYFNGCQI--RQAATKPLDLTRASKIMFVLQIGSTAQTDSC 3347
Cdd:cd08525      1 VLLDTFDTLPDSNENWFFYPGGVVKNDCG-----STDSALVFTENIGgeRYAVTRDLTVNEGYMLQFKINVGCSSTFSSS 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3348 NSdlsgphtvdkaVLLQYSVNNGITWHVIAQ-----------------HQPKDFTQAQRVSYNVPLEARMKGVLLRWWQP 3410
Cdd:cd08525     76 NS-----------VMLEYSTDAGLSWHLVQEeclpsspgcselhpssvYESSTFNGWKRITIPLPNATLSSATRFRWIQY 144

                          170
                   ....*....|....*
gi 1958768177 3411 RHnGTGHDQWALDHV 3425
Cdd:cd08525    145 GY-TSGVQTWAIDNV 158

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 71.35 E-value: 9.60e-14

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2520 LKDNFNRAP----SNQNWLTVNGGKLSTVCGAVASGLALHFSGGC-SRLLVTVDLNLTNAEFIQFYFMYGClITPSNRNQ 2594
Cdd:cd10036      1 LRDDFDSYPllelNNNIWSECCGCNVGEQCGVIMHGNALTFCEPYgPRELITVPLNTTTASVLQFAIGSGS-CRFSYSDP 79

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958768177 2595 GVLLEYSVNGG-ITWTLLMEIFYDQYSKPGFVNILLPPDAKEIGTRFRWWQ--PRHDGLDQNDWAIDNVLI 2662
Cdd:cd10036     80 SIIVSYAVNNTsSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQeaPNAGEVYESCWALDNVLI 150

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 70.66 E-value: 1.36e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2018 NENTIIQFEINVGCSTdSSSADPVRLEFSRDFGATWHLL----LP-LCyhssslvsslcSTEHHPSSTYYAGTT-QGWRR 2091
Cdd:cd10037     42 TVTHFAQFSINLGCGS-HQPGNSVSLEFSTNHGRSWSLLhtecLPeLC-----------AGPHLPHSTVYSSDNySGWNR 109

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958768177 2092 EVVHFGKLHLCGSVRFRWYQGFYPAGSQpvtWAIDNVYIG 2131
Cdd:cd10037    110 ITIPLPNAALTSATRFRWRQTGSVVGSM---WAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 71.09 E-value: 1.83e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  726 HNFYSIRGAEVSFGCgvLASGKALVFNKDGRRQLITSFLD--SSQSRFLQFTLRLGsksvlstCRAPDQPGEGVLLHYSY 803
Cdd:cd10040     14 ANWYRIQGGQVDIDC--LSMDTALMFTENIGKPRYAETWDfhVSASTFLQFELSMG-------CSKPYSNSHSVQLQYSL 84

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177  804 DNGITWKLLEH-----------------YSYLNYHEPRIISVELPDDAKQFGIQFRWWQPYHSSqGEDVWAIDEILMTS 865
Cdd:cd10040     85 NNGRDWHLVTEecvppaigclhytessvYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAP-GADSWAIDNVVLAS 162

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 70.15 E-value: 2.32e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  424 EEFESQPTG--W-DILGAVVGSECGTIESGLSLVFLKD-GERKLCTPYMDTTGYGNLRFYFAMGgTCDPGDSHENDVILY 499
Cdd:cd08524      3 DDFDGYPSPdnWlLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSG-CSTPSYSNQPVLLEY 81

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1958768177  500 AKIEGKKEHIaLDTLSYSSYKVPTLVSVVINPELQTPATKFCLRQKNHQGHNQNVWAVD 558
Cdd:cd08524     82 SVDNGASWHL-LEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAID 139

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 69.71 E-value: 5.04e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1074 DFENPSSWDSDWQEVIGGEVvkpEQGCGvvSSGSSLYF--SKAGKRQLVSWDLDTSWVDFVQFYIQIGgesaaCNKPDSR 1151
Cdd:cd08525      5 TFDTLPDSNENWFFYPGGVV---KNDCG--STDSALVFteNIGGERYAVTRDLTVNEGYMLQFKINVG-----CSSTFSS 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1152 EEGVLLQYSNNGGIQWHLLAE-----------------MYFSDFGKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDyDQW 1214
Cdd:cd08525     75 SNSVMLEYSTDAGLSWHLVQEeclpsspgcselhpssvYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGV-QTW 153


                   ....*..
gi 1958768177 1215 AVDDIII 1221
Cdd:cd08525    154 AIDNVYI 160

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 69.58 E-value: 6.48e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1648 GKPRYAETWDFHVSASSFLQFDMSMGC-SKPFSATHSVQLQYSLNNGKDWHPVTEECVPPTIGCvhyTESSTYTSERF-- 1724
Cdd:cd10043     55 GREVSAVTHDLTPTEGWILQFKISVGCkSSEKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKC---GGSVTQPSVFFps 131

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958768177 1725 QNWRRVTVYLPLATNSPRTRFRWIQ-ANYTvgadAWAIDNVLL 1766
Cdd:cd10043    132 KGWRRVTIPLPDKLVGRPIRFRFYQkASDM----QWALDNFYI 170

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 69.05 E-value: 7.08e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1803 PSILKDDFNGNLHPDL-WPEVYGAERGNLNGETIK--SGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRF--------- 1870
Cdd:cd10052      1 PSYIKDNFESGSVSELkWSLIQGGGIGSGCGQLAPhaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIgsrsqtdsc 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958768177 1871 -IAKGTPE-RSHSILLQSSINGGVTWRLMDE-----FYFPQTtsiLFINVPLPysAQTNATRFRLWQPYNNGK 1936
Cdd:cd10052     81 nINLSSPRaVDKAVLLQYSVNNGITWYLIAQhqpkdFMRAQR---VSYNLPLE--ARTKGVVLRWWQPRHDGT 148

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 68.40 E-value: 1.46e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1083 SDWQEVIGGEVvkpEQGCgvVSSGSSLYF-SKAGK-RQLVSWDLDTSWVDFVQFYIQIGgesaaCNKPDSREEGVLLQYS 1160
Cdd:cd10040     14 ANWYRIQGGQV---DIDC--LSMDTALMFtENIGKpRYAETWDFHVSASTFLQFELSMG-----CSKPYSNSHSVQLQYS 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1161 NNGGIQWHLLAE----------------MYFSD-FGKPRFVYLELPAAAKTPCTRFRWWQPVFsGEDYDQWAVDDIIILS 1223
Cdd:cd10040     84 LNNGRDWHLVTEecvppaigclhytessVYSSErFQNWKRITVYLPPATISPRTRFRWIQPNY-APGADSWAIDNVVLAS 162

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 67.88 E-value: 1.62e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1074 DFENPSSWDSD---WQEVIGGEVvkpEQGCGVVSSGSSLYFSKA-GKRQLVSWDLDTSWVDFVQFYIQIGgesaACnKPD 1149
Cdd:cd10036      4 DFDSYPLLELNnniWSECCGCNV---GEQCGVIMHGNALTFCEPyGPRELITVPLNTTTASVLQFAIGSG----SC-RFS 75

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 1150 SREEGVLLQYS-NNGGIQWHLLAEMYFSDFGKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQ--WAVDDIIIL 1222
Cdd:cd10036     76 YSDPSIIVSYAvNNTSSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQEAPNAGEVYEscWALDNVLII 151

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 67.92 E-value: 2.19e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2528 PSNQN--WLTVNGGKLSTVCGAVASGLALHF--SGGcSRLLVTVDLNLTNAEFIQFYFMYGCLITPSNRNQgVLLEYSVN 2603
Cdd:cd10039      9 PLNQMsvWLMLSNEGMGKNESCSPTPSAMVFgkSDG-DRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAP-VLLQYSHD 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2604 GGITWTLLMEIFY------------------------DQYSKPGFVNILLPPDAKEIGTRFRWWQPRHDGLDQNDWAIDN 2659
Cdd:cd10039     87 AGLTWSLVREGCYpaspgskgcegssrelreptvyhtGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAPPFGLDG 166


                   ....
gi 1958768177 2660 VLIS 2663
Cdd:cd10039    167 VYIS 170

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 67.50 E-value: 2.40e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1606 TGFQDKFDGSIDLQANWYRIQGGQVDIDC--LSMDTALIFteniGKP--RYAETWDFHVSASSFLQF-------DMSMGC 1674
Cdd:cd10051      2 TFLKERFDSEEISSDQWLSLEGGVTCTDCgvLAEGDALYF----GGSgaRQAVTQDLDLRGAKFVQYwarigseNNMTLC 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1675 SKPFSATHSVQLQYSLNNGKDWHPVTEecvpptigcVHYtesstytsERFQNWRRVTVYLPLATNSPRTRFRWIQ----A 1750
Cdd:cd10051     78 LRPTCRKEGVLLQYSTDGGISWTLLHE---------LDY--------QKYISVRYDYITLPENARTNSTRLRWWQpftiS 140

                          170       180
                   ....*....|....*....|
gi 1958768177 1751 NYTVGADA----WAIDNVLL 1766
Cdd:cd10051    141 NGLVVSGTeraqWALDNILI 160

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 67.11 E-value: 2.86e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3272 KDNFESARVTEAN---WETIQGGAIGSGCGQLApyaHGDSLYFngCQI---RQAATKPLDLTRASKIMFVLQIGstaqtd 3345
Cdd:cd10036      2 RDDFDSYPLLELNnniWSECCGCNVGEQCGVIM---HGNALTF--CEPygpRELITVPLNTTTASVLQFAIGSG------ 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3346 SCNSDLSGPHTVdkavlLQYSVNNG-ITWHVIAqhQPKDFTQAQRVSYNVPL--EARMKGVLLRWWQPRHNGTGHDQ--W 3420
Cdd:cd10036     71 SCRFSYSDPSII-----VSYAVNNTsSDWITLE--KIRAPSNGSTIIHIIPLptDAKQDNVSFRFRQEAPNAGEVYEscW 143


                   ....*...
gi 1958768177 3421 ALDHVEVV 3428
Cdd:cd10036    144 ALDNVLII 151

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 66.86 E-value: 5.16e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1453 FDRFEGK--LSPLWYKISGGQVGTGCGTLSDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGsktsgitCIKPRARN 1530
Cdd:cd10040      3 QDKFDGSvdLQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMG-------CSKPYSNS 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1531 EGLVVQYSNDNGILWHLLRE------LDFLSFLEPQI-----------ISIDLPREAKTPATAFRWWQPQHGKHSAQWAL 1593
Cdd:cd10040     76 HSVQLQYSLNNGRDWHLVTEecvppaIGCLHYTESSVysserfqnwkrITVYLPPATISPRTRFRWIQPNYAPGADSWAI 155


                   ....*.
gi 1958768177 1594 DDVLIG 1599
Cdd:cd10040    156 DNVVLA 161

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 66.34 E-value: 5.62e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1608 FQDKFDGSIDLQAN---WYRIQGGQVDIDC--LSMDTALIFTENIGkPRYAETWDFHVSASSFLQFDMSMGCSKPFSATH 1682
Cdd:cd10036      1 LRDDFDSYPLLELNnniWSECCGCNVGEQCgvIMHGNALTFCEPYG-PRELITVPLNTTTASVLQFAIGSGSCRFSYSDP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1683 SVQLQYSLNNGK-DWHPVTEECVPptigcvhyTESSTYTSerfqnwrrvTVYLPLATNSPRTRFRWIQANYTVGA---DA 1758
Cdd:cd10036     80 SIIVSYAVNNTSsDWITLEKIRAP--------SNGSTIIH---------IIPLPTDAKQDNVSFRFRQEAPNAGEvyeSC 142


                   ....*...
gi 1958768177 1759 WAIDNVLL 1766
Cdd:cd10036    143 WALDNVLI 150

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 66.08 E-value: 8.41e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2171 LKDDFEgQLESDRFLLMSGGKPSRKCGilSSGNNLFFNEDG-LRMLVTRDLDLSHARFVQFFMRLGCGkgVPDpRSQPVL 2249
Cdd:cd10042      2 LEDDFS-TLDSRKWLLHPGGTKMPVCG--STGDALVFIEKAsTRYVVTTDIMVNEDSFLQIDFAASCS--VTD-SCYAIE 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2250 LQYSLNGGLSWS----------------LLQEFLFSNSSNVGRYIALEMPLKARSGSTRLRWWQPS--ENGHfysPWVID 2311
Cdd:cd10042     76 LEYSVDLGLSWHpllrdclptnvecssyHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPApfDKQQ---TWAID 152


                   ....*
gi 1958768177 2312 QILIG 2316
Cdd:cd10042    153 NVYIG 157

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 65.14 E-value: 9.57e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3060 LVDTFDdeGSSHEENWSFYPNAvRTAGFCGNPSfhlywpnkkkdkTHNAL------SSRELIIQP-----GYMMQFKIVV 3128
Cdd:cd08524      1 LKDDFD--GYPSPDNWLLCPGG-KTGTVCGALS------------SGNALvfnepyGPRELVTTDlntneASFLQFYIGS 65

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3129 GCEATSCGDlHSVMLEYTKDArSDSWQLVQTqclpsssnsigcspfqfheatiYNAVNSSSWKRITIQLPDHVSSSATQF 3208
Cdd:cd08524     66 GCSTPSYSN-QPVLLEYSVDN-GASWHLLEE----------------------IRADSFSKWRIIILYLPEDAKSGATRF 121

                          170       180
                   ....*....|....*....|...
gi 1958768177 3209 RWIQKGEETEKQS-WAIDHVYIG 3230
Cdd:cd08524    122 RWWQPNHRGVYQAtWAIDNVLIG 144

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 64.15 E-value: 2.78e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1609 QDKFDGSIDLQaNWYRIQGGQVDIDC--LSMDTALIFTENigKPRYAETWDFHVSASSFLQFDMSMGCSK--PFSATHSV 1684
Cdd:cd10049      6 KDDFEGQLESD-RFLLMSGGKPSRKCgiLSSGNNLFFNED--GLRMLVTRDLDLSMARFVQFFMRLGCGKgvPDPRSQPV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1685 QLQYSLNNGKDWHPVTEecvpptigcVHYTESSTYTserfqnwRRVTVYLPLATNSPRTRFRWIQANYTvGA--DAWAID 1762
Cdd:cd10049     83 LLQYSLNGGLTWSLLQE---------FLFSNSSNVG-------RYVALEIPLKARSPSTRLRWWQPSEN-GHfySPWVID 145


                   ....
gi 1958768177 1763 NVLL 1766
Cdd:cd10049    146 QILI 149

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 64.17 E-value: 3.18e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  204 LRDDFDSYHQLELNpniWAECSNCDTGEQCGTIMHGNAVTFCEPyGPRELTTTYLNTTTASVLQFS--IGSGSCRFSYSD 281
Cdd:cd08526      2 LKDSFEGSLSSSDN---WSLVSGGEVGTGCGVLASGKALYFNGP-GLRQLVTVDLDLTNARFVQFYlrIGSKSQTSTCNP 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768177  282 P-----SIIVSYAKNNTADWIQLEKIR-APSNVSTIIHILyLPEDAKGENVQFQWKQDSlrVGEVYEACWALDNILV 352
Cdd:cd08526     78 PdsrseGVLLQYSVNGGITWHLLQELYyDQYSEPRFVSIE-LPLEARTNGTRFRWWQPS--HSGKGQDQWALDNILI 151

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 64.05 E-value: 4.38e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1608 FQDKFDGSIDLQANWYRIQGGQVDIDCLSMD-----TALIFteNIGKPRYAETWDFHVSASSFLQFDMSMGCSKPFSATH 1682
Cdd:cd10052      4 IKDNFESGSVSELKWSLIQGGGIGSGCGQLAphahgDSLYF--NGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSCN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1683 S-----------VQLQYSLNNGKDWHpVTEECVPPtigcvHYTESstytserfqnwRRVTVYLPLATNSPRTRFRWIQAN 1751
Cdd:cd10052     82 InlsspravdkaVLLQYSVNNGITWY-LIAQHQPK-----DFMRA-----------QRVSYNLPLEARTKGVVLRWWQPR 144

                          170
                   ....*....|....
gi 1958768177 1752 YT-VGADAWAIDNV 1764
Cdd:cd10052    145 HDgTGHDQWALDNV 158

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 63.26 E-value: 6.62e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  719 SSRLSSYHNFYS-IRGAEVSFGCGVLASGKALVF-NKDGRRQLITSFLDSSQSRFLQFTLRLGsksvlsTCR-APDQPGe 795
Cdd:cd10036      8 YPLLELNNNIWSeCCGCNVGEQCGVIMHGNALTFcEPYGPRELITVPLNTTTASVLQFAIGSG------SCRfSYSDPS- 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958768177  796 gvlLHYSYDNGIT---WKLLEHYSYLNYHEPRIISVELPDDAKQFGIQFRWWQ--PYHSSQGEDVWAIDEILMT 864
Cdd:cd10036     81 ---IIVSYAVNNTssdWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQeaPNAGEVYESCWALDNVLII 151

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 63.33 E-value: 7.09e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  901 TLCFTGDSKlassmRYVETQSMQIGASYMIQFSLVMGCGQK---YTPHMDNQVKLEYSTNHGLTWHLVQDeclpsmpscq 977
Cdd:cd10046     42 SLYFNKDGL-----RQLVSWDLDTTWVDFIQFYIQIGGGSAscnYPDSREEGVLLQYSNNGGISWKLLAE---------- 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768177  978 eftsasiYHASEFTQWRRVTVILPQKTWSGATRFRWSQSYYTAQ--DEWALDDIYIG 1032
Cdd:cd10046    107 -------MYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEgyDQWALDDIIIL 156

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 62.89 E-value: 9.62e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  884 SLGFYLGNIQPYcGHDWTLCFTGdsklaSSMRYVETQSMQIGASYMIQFSLVMG-------CGQKYT-PH-MDNQVKLEY 954
Cdd:cd10052     25 GIGSGCGQLAPH-AHGDSLYFNG-----CGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsCNINLSsPRaVDKAVLLQY 98

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958768177  955 STNHGLTWHLVQDeclpsmpscqeftsasiYHASEFTQWRRVTVILPQKTWSGATRFRWSQSYY--TAQDEWALDDI 1029
Cdd:cd10052     99 SVNNGITWYLIAQ-----------------HQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHdgTGHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 61.76 E-value: 2.06e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  423 SEEFE--SQPTGWDILGAVVGSECGTIESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFAMGG-----TC-DPGDSHEN 494
Cdd:cd10047      5 FDRFEgkLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSklngeTClRPRSRNEG 84

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958768177  495 DVILYAKIEGKKEHIaLDTLSYSSYKVPTLVSVVINPELQTPATKFCLRQKNHQGHNQNvWAVD 558
Cdd:cd10047     85 IIVQYSNDNGITWHL-LRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQ-WALD 146

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 62.14 E-value: 2.30e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2893 FLKERFDSEEIKPDLWMSLEGGSTCTECGILAENTALYFGGSTV-RQAITQDLDLRGAKFLQYWGRIGSENNMTSchrpv 2971
Cdd:cd10039      1 YEKPAFDYPLNQMSVWLMLSNEGMGKNESCSPTPSAMVFGKSDGdRFAVTRDLTLKPGYVLQFKVNIGCTSEFSS----- 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2972 crKEGVLLDYSKDGGITWTLL---------------------------HEMDFQKYISVrhdYILLPEGALTNTTRLRWW 3024
Cdd:cd10039     76 --FAPVLLQYSHDAGLTWSLVregcypaspgskgcegssrelreptvyHTGDYEDWTRI---TIPIPRSLAASKTRFRWI 150

                          170       180
                   ....*....|....*....|....*..
gi 1958768177 3025 QPfvISNGLVVsgverAQWALDNILIG 3051
Cdd:cd10039    151 QE--SSSLKNA-----PPFGLDGVYIS 170

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 61.45 E-value: 2.73e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  902 LCFTGDSklassMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDNQVKLEYSTNHGLTWHLVqdeclpsmpscQEFTs 981
Cdd:cd10049     39 LFFNEDG-----LRMLVTRDLDLSMARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGLTWSLL-----------QEFL- 101

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177  982 asiyHASEFTQWRRVTVILPQKTWSGATRFRWSQ-----SYYtaqDEWALDDIYIG 1032
Cdd:cd10049    102 ----FSNSSNVGRYVALEIPLKARSPSTRLRWWQpsengHFY---SPWVIDQILIG 150

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 60.23 E-value: 5.81e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  930 IQFSLVMGCgqKYTPHMDNQ-VKLEYSTNHGLTWHLVQDeclpsmpscqeftsasIYHaSEFTQWRRVTVILPQKTWSGA 1008
Cdd:cd10050     62 VQFYFMYGC--LIPPSNRNQgVLLEYSVNGGITWNLLME----------------IFY-DQYSKPGFVNILLPPEARGVG 122

                           90       100
                   ....*....|....*....|....*.
gi 1958768177 1009 TRFRWSQSYYTA--QDEWALDDIYIG 1032
Cdd:cd10050    123 TRFRWWQPSHDGldQNDWAIDNVLIG 148

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 60.23 E-value: 5.92e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  421 QWSEEFESQPTG--W-DILGAVVGSECGTIESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFAMGgtCDPGDSHEND-V 496
Cdd:cd10050      4 QLKDTFNRAPSSsnWlTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYG--CLIPPSNRNQgV 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958768177  497 ILYAKIEGKKEHIALDTLSYSSYKVPTLVSVVINPELQTPATKFCLRQKNHQGHNQNVWAVD 558
Cdd:cd10050     82 LLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAID 143

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 59.92 E-value: 1.19e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3273 DNFESARVTEANWETIQGGAIGSGCgqlapYAHGDSLYFNG--CQIRQAATKPLDLTRASKIMFVLQIGstaqtdsCNSD 3350
Cdd:cd10040      4 DKFDGSVDLQANWYRIQGGQVDIDC-----LSMDTALMFTEniGKPRYAETWDFHVSASTFLQFELSMG-------CSKP 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3351 LSGPHTVDkavlLQYSVNNGITWHVIAQ-----------------HQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPrHN 3413
Cdd:cd10040     72 YSNSHSVQ----LQYSLNNGRDWHLVTEecvppaigclhytessvYSSERFQNWKRITVYLPPATISPRTRFRWIQP-NY 146

                          170
                   ....*....|....*...
gi 1958768177 3414 GTGHDQWALDHVEVVLSC 3431
Cdd:cd10040    147 APGADSWAIDNVVLASGC 164

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 58.69 E-value: 1.92e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1956 PVMLLDTFDFGPREDNWFFYPGGNIGLYCpysskGAPEEDSAMVFVSNeiGEHSITTRDLSVNENTIIQFEINVGCSTDS 2035
Cdd:cd10050      2 PTQLKDTFNRAPSSSNWLTVVGGKLSTVC-----GAVASGTALHFSGG--CSRQLVTVDLNLTNAEFVQFYFMYGCLIPP 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2036 SSADP-VRLEFSRDFGATWHLLLPLCYHSSSLVSSLCSTehHPSSTYYAGTtqgwrrevvhfgklhlcgsvRFRWYQGFY 2114
Cdd:cd10050     75 SNRNQgVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNIL--LPPEARGVGT--------------------RFRWWQPSH 132

                          170
                   ....*....|....*..
gi 1958768177 2115 pAGSQPVTWAIDNVYIG 2131
Cdd:cd10050    133 -DGLDQNDWAIDNVLIG 148

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 58.64 E-value: 2.09e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2894 LKERFDS---EEIKPDLWMSLEGGSTCTECGILAENTALYFGGST-VRQAITQDLDLRGAKFLQYwgRIGSennmTSChR 2969
Cdd:cd10036      1 LRDDFDSyplLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEPYgPRELITVPLNTTTASVLQF--AIGS----GSC-R 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2970 PVCRKEGVLLDYSKDGG-ITWTLLHEMDFQKYIS-VRHDyILLPEGALTNTTRLRWWQpfvisNGLVVSGVERAQWALDN 3047
Cdd:cd10036     74 FSYSDPSIIVSYAVNNTsSDWITLEKIRAPSNGStIIHI-IPLPTDAKQDNVSFRFRQ-----EAPNAGEVYESCWALDN 147


                   ...
gi 1958768177 3048 ILI 3050
Cdd:cd10036    148 VLI 150

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 58.25 E-value: 3.05e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2171 LKDDFE----GQLESDRFLLMSGGKPSRKCGILSSGNNLFFNE-DGLRMLVTRDLDLSHARFVQFfmRLGCGKGVPDPRS 2245
Cdd:cd10036      1 LRDDFDsyplLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEpYGPRELITVPLNTTTASVLQF--AIGSGSCRFSYSD 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958768177 2246 QPVLLQYSLNGG-LSWSLLQEF-LFSNSSNVGRYIALemPLKARSGSTRLRWWQPSENG--HFYSPWVIDQILI 2315
Cdd:cd10036     79 PSIIVSYAVNNTsSDWITLEKIrAPSNGSTIIHIIPL--PTDAKQDNVSFRFRQEAPNAgeVYESCWALDNVLI 150

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 57.98 E-value: 3.81e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1272 CATTPSA-MVFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCASQFSS--TAPVLLQYSHDAGMSWFLVKEGCFPASAGKG 1348
Cdd:cd10049     30 CGILSSGnNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDprSQPVLLQYSLNGGLTWSLLQEFLFSNSSNVG 109

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958768177 1349 cegnsrelseptvyytgdfeewTRVTIAIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYI 1410
Cdd:cd10049    110 ----------------------RYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 57.87 E-value: 6.50e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1956 PVMLLDTFDFGP-REDNWFFYPGGNIGLYCpysskGAPEEDSAMVFVSNeiGEHSITTRDLSVNENTIIQFEINVG---- 2030
Cdd:cd10051      1 KTFLKERFDSEEiSSDQWLSLEGGVTCTDC-----GVLAEGDALYFGGS--GARQAVTQDLDLRGAKFVQYWARIGsenn 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2031 ---CSTDSSSADPVRLEFSRDFGATWHLLLPLCYhssslvsslcstEHHPSSTYyagttqgwrrEVVHFGKLHLCGSVRF 2107
Cdd:cd10051     74 mtlCLRPTCRKEGVLLQYSTDGGISWTLLHELDY------------QKYISVRY----------DYITLPENARTNSTRL 131

                          170       180       190
                   ....*....|....*....|....*....|
gi 1958768177 2108 RWYQ------GFYPAGSQPVTWAIDNVYIG 2131
Cdd:cd10051    132 RWWQpftisnGLVVSGTERAQWALDNILIG 161

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 57.49 E-value: 9.27e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2520 LKDNFNRAPSNQNWLTVNGGKLSTVC-----GAVASGLALHFS----GGCSrlLVTVDLNLTNAEFIQFYFMYGClITPS 2590
Cdd:cd10041      2 LLDTFDFGPNESNWLFYPGGNTGLYCpyqskGAPEEDSAMVFVsselGEHS--ITTRDLDVNENTIIQFEINVGC-TTES 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2591 NRNQGVLLEYSVNGGITWTLLM--------------------EIFYDQYSkPGFVN--ILLPPDAKEIGTRFRWWQPRHD 2648
Cdd:cd10041     79 SSADPVRLEFSRDFGATWHLLLplcygsssisslcstelhpsSVYYTGTT-QGWRRevILFGKLHLCGSVRFRWYQGFHP 157

                          170
                   ....*....|....*
gi 1958768177 2649 -GLDQNDWAIDNVLI 2662
Cdd:cd10041    158 aGSQPVTWAIDNVYI 172

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 56.71 E-value: 1.11e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2325 LEDDF-----STLDSRKWLLHPGGTKMPVCG--STGDALVFIEKASTRYVVTTDIAVNEDSFLQIDFAA-SCSVTDSCYA 2396
Cdd:cd10036      1 LRDDFdsyplLELNNNIWSECCGCNVGEQCGviMHGNALTFCEPYGPRELITVPLNTTTASVLQFAIGSgSCRFSYSDPS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2397 IELEYSVDLG-LSWHPLVRDCLPTNVECSrYHLqrilvsdtfnkwtritLPLPAYTRSQATRFRWHQPAPFDKQQ---TW 2472
Cdd:cd10036     81 IIVSYAVNNTsSDWITLEKIRAPSNGSTI-IHI----------------IPLPTDAKQDNVSFRFRQEAPNAGEVyesCW 143


                   ....*..
gi 1958768177 2473 AIDNVYI 2479
Cdd:cd10036    144 ALDNVLI 150

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 56.35 E-value: 1.44e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1621 NWYRIQGGQVDIDC--LSMDTALIFTENiGKpRYAETWDFHVSASSFLQFDMSMG-------CSKPFSATHSVQLQYSLN 1691
Cdd:cd10045     18 NFSSIRGGEVGFGCgvLASGKALVFNGD-GR-RQLITAPLDSTQSRYLQFTLRLGsksvlgtCPPPDRPGEGVLLHYSCD 95

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177 1692 NGKDWHPVTEecvpptigcvhytesstYTSERFQNWRRVTVYLPLATNSPRTRFRWIQANYT-VGADAWAIDNVLL 1766
Cdd:cd10045     96 NGITWKLLEH-----------------YSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSgQNQDVWALDEISM 154

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 55.64 E-value: 2.11e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2223 SHARFVQFFMRLGCGKGVPdprSQPVLLQYSLNGGLSWSLLQ-EFL--------------FSNSSNVG-RYIALEMPLKA 2286
Cdd:cd10037     42 TVTHFAQFSINLGCGSHQP---GNSVSLEFSTNHGRSWSLLHtECLpelcagphlphstvYSSDNYSGwNRITIPLPNAA 118

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958768177 2287 RSGSTRLRWWQPSENGHfySPWVIDQILIG 2316
Cdd:cd10037    119 LTSATRFRWRQTGSVVG--SMWAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 56.08 E-value: 2.48e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3292 AIGSGCGQLAPYA-HGDSLYFNG-----CQIRQAATKPLDLTRASKIMFVLQIGstaqtdsCNSDLSgPHtVDKAVLLQY 3365
Cdd:cd10038     16 SLGFYLGNVQPYCnHDWTLCFTGdskhaSSARYVETQSMQIGASYMIQFSLVMG-------CGQQYT-PH-MDNQVKLEY 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3366 SVNNGITWHVI-----------------AQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHngTGHDQWALDHVEVV 3428
Cdd:cd10038     87 STNHGLTWHLVqeeclpgmpscqeftsgSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYY--TDQDEWALDNIYIG 164


                   ...
gi 1958768177 3429 LSC 3431
Cdd:cd10038    165 QQC 167

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 55.56 E-value: 2.83e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  424 EEFESQP-----TGW--DILGAVVGSECGTIESGLSLVFLK-DGERKLCTPYMDTTGYGNLRFYFAMgGTCDPGDSHEND 495
Cdd:cd10036      3 DDFDSYPllelnNNIwsECCGCNVGEQCGVIMHGNALTFCEpYGPRELITVPLNTTTASVLQFAIGS-GSCRFSYSDPSI 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958768177  496 VILYAKIEGKKEHIALDTLSYSSYkVPTLVSVV-INPELQTPATKFCLRQKNHQG--HNQNVWAVD 558
Cdd:cd10036     82 IVSYAVNNTSSDWITLEKIRAPSN-GSTIIHIIpLPTDAKQDNVSFRFRQEAPNAgeVYESCWALD 146

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 55.69 E-value: 3.17e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2211 GLRMLVTRDLDLSHARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGLSWSLLQEFL---------FSNSSNVG------ 2275
Cdd:cd10038     45 SARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMDNQVKLEYSTNHGLTWHLVQEEClpgmpscqeFTSGSIYHssefte 124

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958768177 2276 -RYIALEMPLKARSGSTRLRWWQpsenGHFYSP--WVIDQILIG 2316
Cdd:cd10038    125 wRRITLPLPQKTWSSATRFRWSQ----SYYTDQdeWALDNIYIG 164

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 55.58 E-value: 3.28e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2349 CG--STGDALVFiEKASTRYVVTTDIAVNEDSFLQIDF-AASCSVTDSCYA-------IELEYSVDLGLSWHplvrdcLP 2418
Cdd:cd10045     31 CGvlASGKALVF-NGDGRRQLITAPLDSTQSRYLQFTLrLGSKSVLGTCPPpdrpgegVLLHYSCDNGITWK------LL 103

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958768177 2419 TNVECSRYHLQRIlvsdtfnkwtrITLPLPAYTRSQATRFRWHQP-APFDKQQTWAIDNVYI 2479
Cdd:cd10045    104 EHYSYDNYHEPRI-----------VSVELPEDARNFGVQFRWWQPyHSGQNQDVWALDEISM 154

Reeler domain;

Pssm-ID: 460411 Cd Length: 130 Bit Score: 54.28 E-value: 5.23e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177   63 IAGNPTYYVPGQEYHVTISTSTF---FDGLLVTGlytstsiqSSQSIGGSSAFGFGIMSDHQFGNQFM-CSVVASHVSH- 137
Cdd:pfam02014   22 ITVSSTSYRPGETITVTLSGASGgpsFKGFLLQA--------RDADSGDPDPVGSFSLPDDADTKFLLdCSGKGNAVTHs 93

                           90       100
                   ....*....|....*....|....*..
gi 1958768177  138 --LPTTNLSFVWIAPPAGTGCVNFMAT 162
Cdd:pfam02014   94 ntNKKSSVTVTWTAPASGSGCVVFRAT 120

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 54.50 E-value: 6.93e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  930 IQFSLVMGCgqKYTPHMDNQVKLEYSTNHGLTWHLVqDECLPSMPSCQEFtsasiyhaseftqwrrVTVILPQKTWSGAT 1009
Cdd:cd10048     63 IQFSFKFIT--KGTPERSHSVLLQYSINGGITWHLI-DEFYFPTTTDVLF----------------VNVPLPYTAQTNAT 123

                           90       100
                   ....*....|....*....|....*
gi 1958768177 1010 RFRWSQSYYTAQDE--WALDDIYIG 1032
Cdd:cd10048    124 RFRLWQPYNSGKKEevWILDDLVID 148

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 54.40 E-value: 8.28e-08

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  890 GNIQPYCG---HDWTLCFTGdsklaSSMRYVETQSMQIGASYMIQFSLVMGCGQK----YTPHMDNQ-VKLEYSTNHGLT 961
Cdd:cd10051     24 GVTCTDCGvlaEGDALYFGG-----SGARQAVTQDLDLRGAKFVQYWARIGSENNmtlcLRPTCRKEgVLLQYSTDGGIS 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  962 WHLVQDeclpsmpscqeftsasIYHASeFTQWRRVTVILPQKTWSGATRFRWSQSY---------YTAQDEWALDDIYIG 1032
Cdd:cd10051     99 WTLLHE----------------LDYQK-YISVRYDYITLPENARTNSTRLRWWQPFtisnglvvsGTERAQWALDNILIG 161

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 54.12 E-value: 1.02e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1609 QDKFDGSI--DLQANWYRIQGGQVDIDCLSMDTALIFTENigKPRYAETWDFHVSASSFLQFDMSMGCSKPFSATHSVQL 1686
Cdd:cd10048      6 KDDFNGNLrpDLWPEVYGAERGNLNGETIKSGTALIFKGE--GLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHSVLL 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1687 QYSLNNGKDWHPVTEECVPPTigcvhytesstyTSERFQNwrrvtVYLPLATNSPRTRFR-WIQANYTVGADAWAIDNVL 1765
Cdd:cd10048     84 QYSINGGITWHLIDEFYFPTT------------TDVLFVN-----VPLPYTAQTNATRFRlWQPYNSGKKEEVWILDDLV 146


                   .
gi 1958768177 1766 L 1766
Cdd:cd10048    147 I 147

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 54.02 E-value: 1.57e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2171 LKDDFEGQLESDRFLLMSGGKPSRKCGILSSG-----NNLFF--NEDGLRMLVTRDLDLSHARFVQFFMRLGCGkgVPDP 2243
Cdd:cd10041      2 LLDTFDFGPNESNWLFYPGGNTGLYCPYQSKGapeedSAMVFvsSELGEHSITTRDLDVNENTIIQFEINVGCT--TESS 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2244 RSQPVLLQYSLNGGLSWSLLQEFLFSNSS----------NVGRYIALEMPLKARS----------GSTRLRWWQ----PS 2299
Cdd:cd10041     80 SADPVRLEFSRDFGATWHLLLPLCYGSSSisslcstelhPSSVYYTGTTQGWRREvilfgklhlcGSVRFRWYQgfhpAG 159

                          170
                   ....*....|....*..
gi 1958768177 2300 ENGHfysPWVIDQILIG 2316
Cdd:cd10041    160 SQPV---TWAIDNVYIG 173

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 53.28 E-value: 1.95e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  215 ELNPNIWAECSNCDTGEQCGTIMHGNAVTFCEPyGPRELTTTYLNTTTASVLQFSIGSGS------C-RFSYSDPSIIVS 287
Cdd:cd10047     10 GKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGP-GKREARTVPLDTTNIRLVQFYIQIGSklngetClRPRSRNEGIIVQ 88

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958768177  288 YAKNNTADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQDslRVGEvYEACWALDNILV 352
Cdd:cd10047     89 YSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQP--QHGK-PSAQWALDDVLI 150

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 52.61 E-value: 4.49e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2553 ALHFSGGCS-----RLLVTVDLNLTNAEFIQFYFMYGC--LITPSNRNQgVLLEYSVNGGITWTLLME------------ 2613
Cdd:cd10038     33 TLCFTGDSKhassaRYVETQSMQIGASYMIQFSLVMGCgqQYTPHMDNQ-VKLEYSTNHGLTWHLVQEeclpgmpscqef 111

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958768177 2614 ----IFY-DQYSKPGFVNILLPPDAKEIGTRFRWWQPRHDglDQNDWAIDNVLI 2662
Cdd:cd10038    112 tsgsIYHsSEFTEWRRITLPLPQKTWSSATRFRWSQSYYT--DQDEWALDNIYI 163

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 52.13 E-value: 7.09e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  733 GAEVSFGCGvlASGKALVFNK-DGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTcRAPdqpgegVLLHYSYDNGITWKL 811
Cdd:cd10039     23 GMGKNESCS--PTPSAMVFGKsDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSS-FAP------VLLQYSHDAGLTWSL 93

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958768177  812 LEHYSYLN------------------------YHEPRIISVELPDDAKQFGIQFRWWQPYHSSQGEDVWAIDEI 861
Cdd:cd10039     94 VREGCYPAspgskgcegssrelreptvyhtgdYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAPPFGLDGV 167

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 51.05 E-value: 1.04e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1955 NPVMLLDTFDFGPREDNWFFYPGGNIGLYCPYSSKGapeedSAMVFvsNEIGEHSITTRDLSVNENTIIQFEINVGCS-- 2032
Cdd:cd10049      1 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSG-----NNLFF--NEDGLRMLVTRDLDLSMARFVQFFMRLGCGkg 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2033 TDSSSADPVRLEFSRDFGATWHLLLPLCYHSSSLVSSLCSTEHHPSSTyyagttqgwrrevvhfgklhlCGSVRFRWYQg 2112
Cdd:cd10049     74 VPDPRSQPVLLQYSLNGGLTWSLLQEFLFSNSSNVGRYVALEIPLKAR---------------------SPSTRLRWWQ- 131

                          170       180
                   ....*....|....*....|.
gi 1958768177 2113 fyPA--GSQPVTWAIDNVYIG 2131
Cdd:cd10049    132 --PSenGHFYSPWVIDQILIG 150

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 50.93 E-value: 1.51e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1278 AMVFGKSdGDRFAVTRDLTLKPGYVLQFKLNIGCASQFSSTAP-------VLLQYSHDAGMSWFLVKEGcfpasagkgce 1350
Cdd:cd10051     38 ALYFGGS-GARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLRptcrkegVLLQYSTDGGISWTLLHEL----------- 105

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1958768177 1351 gnsrelseptvyytgDFEEWTRVT---IAIPRSLASSKTRFRWIQ 1392
Cdd:cd10051    106 ---------------DYQKYISVRydyITLPENARTNSTRLRWWQ 135

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 50.95 E-value: 1.55e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2323 TVLEDDF--STLDSRKWLLHPGGTKMPVCGS-----TGDALVFiEKASTRYVVTTDIAVNEDSF----LQIdfaASCSVT 2391
Cdd:cd10052      2 SYIKDNFesGSVSELKWSLIQGGGIGSGCGQlaphaHGDSLYF-NGCGIRQAVTVELDLTRASKimfvLQI---GSRSQT 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2392 DSCY-----------AIELEYSVDLGLSWHpLVRDCLPTNvecsryhlqrilvsdtFNKWTRITLPLPAYTRSQATRFRW 2460
Cdd:cd10052     78 DSCNinlsspravdkAVLLQYSVNNGITWY-LIAQHQPKD----------------FMRAQRVSYNLPLEARTKGVVLRW 140

                          170
                   ....*....|....*...
gi 1958768177 2461 HQPAPFDK-QQTWAIDNV 2477
Cdd:cd10052    141 WQPRHDGTgHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 50.57 E-value: 1.60e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1278 AMVFGKsDGDRFAVTRDLTLKPGYVLQFKLNIGCASQFSSTAP-------VLLQYSHDAGMSWFLVKEgcfpasagkgce 1350
Cdd:cd10045     39 ALVFNG-DGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPPpdrpgegVLLHYSCDNGITWKLLEH------------ 105

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958768177 1351 gnsrelseptvYYTGDFEEWTRVTIAIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYIS 1411
Cdd:cd10045    106 -----------YSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 50.56 E-value: 1.78e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1286 GDRFAVTRDLTLKPGYVLQFKLNIG-------CASQFSSTAP----VLLQYSHDAGMSWFLVKEgcfpasagkgcegnsr 1354
Cdd:cd10052     48 GIRQAVTVELDLTRASKIMFVLQIGsrsqtdsCNINLSSPRAvdkaVLLQYSVNNGITWYLIAQ---------------- 111

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958768177 1355 elseptvYYTGDFEEWTRVTIAIPRSLASSKTRFRWIQESSSQKNVPPFGLDGV 1408
Cdd:cd10052    112 -------HQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 50.29 E-value: 1.98e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1100 CGvvSSGSSLYF-SKAGKRQLVSWDLDTSWVDFVQFYIqiggeSAACNKPDSREeGVLLQYSNNGGIQWH---------- 1168
Cdd:cd10042     26 CG--STGDALVFiEKASTRYVVTTDIMVNEDSFLQIDF-----AASCSVTDSCY-AIELEYSVDLGLSWHpllrdclptn 97

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958768177 1169 ------LLAEMYFSD-FGKPRFVYLELPAAAKTPCTRFRWWQPvfSGEDYDQ-WAVDDIII 1221
Cdd:cd10042     98 vecssyHLQRILVSDtFNKWTRVTLPLPHYTRSQATRFRWHQP--APFDKQQtWAIDNVYI 156

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 49.51 E-value: 3.14e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  437 GAVVGSECGTIESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFAMGGTCDPGDSHENDVILYAKIEGKKEHIALDTLSY 516
Cdd:cd10049     23 GGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGLTWSLLQEFLF 102

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1958768177  517 S-SYKVPTLVSVVINPELQTPATKFCLRQKNHQGHNQNVWAVD 558
Cdd:cd10049    103 SnSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVID 145

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 49.09 E-value: 4.71e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2977 VLLDYSKDGGITWTLLHE-----------------MDFQKYISVRHDYILLPEGALTNTTRLRWWQPFVISNglvvsgve 3039
Cdd:cd10037     64 VSLEFSTNHGRSWSLLHTeclpelcagphlphstvYSSDNYSGWNRITIPLPNAALTSATRFRWRQTGSVVG-------- 135

                           90
                   ....*....|..
gi 1958768177 3040 rAQWALDNILIG 3051
Cdd:cd10037    136 -SMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 49.06 E-value: 5.04e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  566 LPSTMSHMIQFSINLGCGT--HQPGNSVSLEFSTNHGRSWSLLHteclpEIcagphlphstIYSSENYSGWnrVTIPLPN 643
Cdd:cd10050     54 LNLTNAEFVQFYFMYGCLIppSNRNQGVLLEYSVNGGITWNLLM-----EI----------FYDQYSKPGF--VNILLPP 116

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1958768177  644 AALTRDTRIRWRQ---TGPIlGNMWAIDNVYIG 673
Cdd:cd10050    117 EARGVGTRFRWWQpshDGLD-QNDWAIDNVLIG 148

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 49.13 E-value: 6.11e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  740 CGVlaSGKALVF-NKDGRRQLITSFLDSSQSRFLQFTLRLGSkSVLSTCRApdqpgegVLLHYSYDNGITWKLL------ 812
Cdd:cd10042     26 CGS--TGDALVFiEKASTRYVVTTDIMVNEDSFLQIDFAASC-SVTDSCYA-------IELEYSVDLGLSWHPLlrdclp 95

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  813 EHYSYLNYHEPRI-----------ISVELPDDAKQFGIQFRWWQPYHSSQGEDvWAIDEI 861
Cdd:cd10042     96 TNVECSSYHLQRIlvsdtfnkwtrVTLPLPHYTRSQATRFRWHQPAPFDKQQT-WAIDNV 154

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 48.32 E-value: 7.25e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  764 LDSSQSRFLQFTLRLGSKSvlstcrapDQPGEGVLLHYSYDNGITWKLLEH-----------------YSYLNYHEPRII 826
Cdd:cd10037     39 LPSTVTHFAQFSINLGCGS--------HQPGNSVSLEFSTNHGRSWSLLHTeclpelcagphlphstvYSSDNYSGWNRI 110

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1958768177  827 SVELPDDAKQFGIQFRWWQPyHSSQGeDVWAIDEI 861
Cdd:cd10037    111 TIPLPNAALTSATRFRWRQT-GSVVG-SMWAIDNV 143

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 48.64 E-value: 9.45e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  204 LRDDFDSYHQLELNpniWAECSNCDTGEQCGTIM---HGNAVTF--CepyGPRELTTTYLNTTTASVLQF--SIGS---- 272
Cdd:cd10052      4 IKDNFESGSVSELK---WSLIQGGGIGSGCGQLAphaHGDSLYFngC---GIRQAVTVELDLTRASKIMFvlQIGSrsqt 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  273 GSCRFSYSDP-----SIIVSYAKNNTADWiQLEKIRAPSNVSTIIHILY-LPEDAKGENVQFQWKQDslRVGEVYEACWA 346
Cdd:cd10052     78 DSCNINLSSPravdkAVLLQYSVNNGITW-YLIAQHQPKDFMRAQRVSYnLPLEARTKGVVLRWWQP--RHDGTGHDQWA 154


                   ....*..
gi 1958768177  347 LDNILVI 353
Cdd:cd10052    155 LDNVEVV 161

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 47.95 E-value: 1.22e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  566 LPSTMSHMIQFSINLGC-GTHQPGNSVSLEFSTNHGRSWSLLHTECLPEicagphlPHSTIYssenysgwnrVTIPLPNA 644
Cdd:cd10048     55 LDCTHTLYIQFSFKFITkGTPERSHSVLLQYSINGGITWHLIDEFYFPT-------TTDVLF----------VNVPLPYT 117

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958768177  645 ALTRDTRIR-WR-QTGPILGNMWAIDNVYIG 673
Cdd:cd10048    118 AQTNATRFRlWQpYNSGKKEEVWILDDLVID 148

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 47.57 E-value: 1.51e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  429 QPTGW-DILGAVVGSECG-TIESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFAMggTCDPGDSHENDVILYAKIEGKK 506
Cdd:cd10048     14 RPDLWpEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF--ITKGTPERSHSVLLQYSINGGI 91

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958768177  507 EHIALDTLSYSSYKVPTLVSVVINPELQTPATKFCLRQKNHQGHNQNVWAVDFF 560
Cdd:cd10048     92 TWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDL 145

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 48.01 E-value: 1.82e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2192 PSRKCGILSSGNNlffnEDGLRM-LVTRDLDLSHARFVQFFMRLGCGKGVPDPRsQPVLLQYSLNGGLSWSLL-QEFLFS 2269
Cdd:cd10043     40 CDSPDGVMICGSH----DDGREVsAVTHDLTPTEGWILQFKISVGCKSSEKSAQ-QPVHVQYSTDFGVSWSYVtPQCLPS 114

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958768177 2270 NSSNVG--------------RYIALEMPLKARSGSTRLRWWQpsenGHFYSPWVIDQILIG 2316
Cdd:cd10043    115 DPKCGGsvtqpsvffpskgwRRVTIPLPDKLVGRPIRFRFYQ----KASDMQWALDNFYIG 171

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 47.49 E-value: 2.12e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1956 PVMLLDTFDFGPREDNWFFYP--GGNIGLYCPYSSKGapeedSAMVFvsNEIGEHSITTRDLSVNENTIIQFEINVGCST 2033
Cdd:cd10045      1 PGFLSESFNSSRLSSYHNFSSirGGEVGFGCGVLASG-----KALVF--NGDGRRQLITAPLDSTQSRYLQFTLRLGSKS 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2034 DSSSADP-------VRLEFSRDFGATWHLLLPLCYHSSslvsslcsteHHPsstyyagttqgwRREVVHFGKLHLCGSVR 2106
Cdd:cd10045     74 VLGTCPPpdrpgegVLLHYSCDNGITWKLLEHYSYDNY----------HEP------------RIVSVELPEDARNFGVQ 131

                          170       180
                   ....*....|....*....|....
gi 1958768177 2107 FRWYQGFYPAGSQPVtWAIDNVYI 2130
Cdd:cd10045    132 FRWWQPYHSGQNQDV-WALDEISM 154

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 47.60 E-value: 2.33e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2908 WMSLEGGSTCTECgiLAENTALYFGGS--TVRQAITQDLDLRGAKFLQYwgrigsENNMtSCHRPVCRKEGVLLDYSKDG 2985
Cdd:cd10040     16 WYRIQGGQVDIDC--LSMDTALMFTENigKPRYAETWDFHVSASTFLQF------ELSM-GCSKPYSNSHSVQLQYSLNN 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2986 GITWTL------------LHEMDFQKYISVRHD-----YILLPEGALTNTTRLRWWQPFVisnglvvsGVERAQWALDNI 3048
Cdd:cd10040     87 GRDWHLvteecvppaigcLHYTESSVYSSERFQnwkriTVYLPPATISPRTRFRWIQPNY--------APGADSWAIDNV 158


                   ...
gi 1958768177 3049 LIG 3051
Cdd:cd10040    159 VLA 161

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 47.12 E-value: 2.54e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1956 PVMLLDTFDfGPREDNWFFYPGGNIGLYCpysskGAPEEDSAMVFvsNEIGEHSITTRDLSVNENTIIQFEINVGCSTDS 2035
Cdd:cd10047      1 PSEFFDRFE-GKLSPLWYKITGGQVGTGC-----GVIKDGKSLYF--NGPGKREARTVPLDTTNIRLVQFYIQIGSKLNG 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2036 SSADPVR-------LEFSRDFGATWHLLLPLCYhsSSLVSSLCSTEHHPSSTYYAGTTqgwrrevvhfgklhlcgsvrFR 2108
Cdd:cd10047     73 ETCLRPRsrnegiiVQYSNDNGITWHLLRELDF--MSYLEPQVISIELPREAKTPATA--------------------FR 130

                          170       180
                   ....*....|....*....|...
gi 1958768177 2109 WYQGFYpaGSQPVTWAIDNVYIG 2131
Cdd:cd10047    131 WWQPQH--GKPSAQWALDDVLIG 151

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 47.10 E-value: 2.59e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  229 TGEQCGTIMHGNAVTFCEPyGPRELTTTYLNTTTASVLQFS--IGS----GSCRF-SYSDPSIIVSYAKNNTADWIQLEK 301
Cdd:cd10045     27 VGFGCGVLASGKALVFNGD-GRRQLITAPLDSTQSRYLQFTlrLGSksvlGTCPPpDRPGEGVLLHYSCDNGITWKLLEH 105

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1958768177  302 IRAPSNVSTIIHILYLPEDAKGENVQFQWKQDslRVGEVYEACWALDNILV 352
Cdd:cd10045    106 YSYDNYHEPRIVSVELPEDARNFGVQFRWWQP--YHSGQNQDVWALDEISM 154

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 47.53 E-value: 2.81e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2215 LVTRDLDLSHARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGL-SWSLLQE--------------FLF-------SNSS 2272
Cdd:cd10044     53 LTTRQLIVQPGYMIQFKIVVGCGSVSSCGDLHPVMLEYTTDPRSdHWQLVQTeclpsssnsidcspFQYheasiysSVNS 132

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1958768177 2273 NVGRYIALEMPLKARSGSTRLRWWQPSENGhFYSPWVIDQILIG 2316
Cdd:cd10044    133 SVWKRVTIQLPDHVSSSATQFRWIQKTEST-EAPSWAIDDVYIG 175

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 46.70 E-value: 3.16e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1806 LKDDFN----GNLHPDLWPEVYGAERGNLNGeTIKSGTSLIFKG-EGLRMLISRDLDCTNTMYVQFSlrfIAKGTPERSH 1880
Cdd:cd10036      1 LRDDFDsyplLELNNNIWSECCGCNVGEQCG-VIMHGNALTFCEpYGPRELITVPLNTTTASVLQFA---IGSGSCRFSY 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1958768177 1881 S----ILLQSSINGGVTWRLMDEFYFPQTTSILFINVPLPYSAQTNATRFRLWQPYNNGKKE 1938
Cdd:cd10036     77 SdpsiIVSYAVNNTSSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQEAPNAGEV 138

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 46.70 E-value: 4.01e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  424 EEFESQ---PTGWDIL-GAVVGSECGTIESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFAMGGT-----CDPGDSHEN 494
Cdd:cd10051      6 ERFDSEeisSDQWLSLeGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSEnnmtlCLRPTCRKE 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1958768177  495 DVILYAKIEGKKEHIALDTLSYSSYKVPTLVSVVINPELQTPATKF 540
Cdd:cd10051     86 GVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRL 131

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 46.43 E-value: 4.44e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  204 LRDDFDSyhQLELNPniWAECSNCDTGEQCGTIMHGNAVTFCEPyGPRELTTTYLNTTTASVLQFSIGSGsCRFSYSDP- 282
Cdd:cd10049      5 LKDDFEG--QLESDR--FLLMSGGKPSRKCGILSSGNNLFFNED-GLRMLVTRDLDLSMARFVQFFMRLG-CGKGVPDPr 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958768177  283 --SIIVSYAKNNTADWIQLEKI--RAPSNVSTIIhILYLPEDAKGENVQFQWKQDSlRVGEVYEAcWALDNILV 352
Cdd:cd10049     79 sqPVLLQYSLNGGLTWSLLQEFlfSNSSNVGRYV-ALEIPLKARSPSTRLRWWQPS-ENGHFYSP-WVIDQILI 149

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 46.45 E-value: 4.65e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1470 GQVGTGCGTlsdGRSLYFNGLGKREARTVPLDTRNIR-----LVQFYIQIGSKTsgitciKPRARNEGLV-VQYSNDNGI 1543
Cdd:cd10038     22 GNVQPYCNH---DWTLCFTGDSKHASSARYVETQSMQigasyMIQFSLVMGCGQ------QYTPHMDNQVkLEYSTNHGL 92

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958768177 1544 LWHLLRE------LDFLSFLEPQI-----------ISIDLPREAKTPATAFRWWQPQHGKhSAQWALDDVLIG 1599
Cdd:cd10038     93 TWHLVQEeclpgmPSCQEFTSGSIyhsseftewrrITLPLPQKTWSSATRFRWSQSYYTD-QDEWALDNIYIG 164

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 46.01 E-value: 5.16e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2572 TNAEFIQFYFMYGCLI-TPSNrnqGVLLEYSVNGGITWTLLM---------------EIFY--DQYSKPGFVNILLPPDA 2633
Cdd:cd10037     42 TVTHFAQFSINLGCGShQPGN---SVSLEFSTNHGRSWSLLHteclpelcagphlphSTVYssDNYSGWNRITIPLPNAA 118

                           90       100
                   ....*....|....*....|....*....
gi 1958768177 2634 KEIGTRFRWWQPRhdGLDQNDWAIDNVLI 2662
Cdd:cd10037    119 LTSATRFRWRQTG--SVVGSMWAIDNVYI 145

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 46.31 E-value: 5.23e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  204 LRDDFDSYhqlELNPNIWAECSNCDTGEQCGTIMHGNAVTFCEPyGPRELTTTYLNTTTASVLQF--SIGS----GSCRF 277
Cdd:cd10051      4 LKERFDSE---EISSDQWLSLEGGVTCTDCGVLAEGDALYFGGS-GARQAVTQDLDLRGAKFVQYwaRIGSennmTLCLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  278 SYS-DPSIIVSYAKNNTADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQ-----DSLRVGEVYEACWALDNIL 351
Cdd:cd10051     80 PTCrKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQpftisNGLVVSGTERAQWALDNIL 159


                   .
gi 1958768177  352 V 352
Cdd:cd10051    160 I 160

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 46.05 E-value: 5.35e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3271 IKDNFESarVTEANWETIQGGAIGSGCGqlapyAHGDSLYF-NGCQIRQAATKPLDLTRASKIMFVLQIGSTAqTDSCns 3349
Cdd:cd10042      2 LEDDFST--LDSRKWLLHPGGTKMPVCG-----STGDALVFiEKASTRYVVTTDIMVNEDSFLQIDFAASCSV-TDSC-- 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3350 dlsgphtvdKAVLLQYSVNNGITWH-VIAQHQPKD----------------FTQAQRVSYNVPLEARMKGVLLRWWQPRH 3412
Cdd:cd10042     72 ---------YAIELEYSVDLGLSWHpLLRDCLPTNvecssyhlqrilvsdtFNKWTRVTLPLPHYTRSQATRFRWHQPAP 142

                          170
                   ....*....|...
gi 1958768177 3413 NGTGHdQWALDHV 3425
Cdd:cd10042    143 FDKQQ-TWAIDNV 154

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 45.64 E-value: 7.15e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1277 SAMVFgKSDGDRFAVTRDLTLKPGYVLQFKLNIGCASQFSSTAPVLLQYSHDAGMSWFLVKEGCFPASAgkgcegnsrel 1356
Cdd:cd10048     38 TALIF-KGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHSVLLQYSINGGITWHLIDEFYFPTTT----------- 105

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1958768177 1357 sePTVYytgdfeewtrVTIAIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYI 1410
Cdd:cd10048    106 --DVLF----------VNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVI 147

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 45.98 E-value: 7.69e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2517 PTQLKDNFNRAP--SNQNW-LTVNGGKLSTVCGAVASGL--ALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPS- 2590
Cdd:cd10044      1 PSSLVETFEDEGtsHDENWeFYPNGVRTDEFCGNPSFHLtwPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVSSc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2591 NRNQGVLLEYSVNGGIT-WTLLME---------------IFYDQ--YSKPGF-----VNILLPPDAKEIGTRFRWWQpRH 2647
Cdd:cd10044     81 GDLHPVMLEYTTDPRSDhWQLVQTeclpsssnsidcspfQYHEAsiYSSVNSsvwkrVTIQLPDHVSSSATQFRWIQ-KT 159

                          170
                   ....*....|....*
gi 1958768177 2648 DGLDQNDWAIDNVLI 2662
Cdd:cd10044    160 ESTEAPSWAIDDVYI 174

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 45.26 E-value: 8.99e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 2745 VTHDLTPTENWIMQFKISVGCK-VPEKiaQNQIHVQFSTDFGVSWsYLVPQCLPadpkcsgTVSQPSVFFptkgwkriTY 2823
Cdd:cd10048     51 VSRDLDCTHTLYIQFSFKFITKgTPER--SHSVLLQYSINGGITW-HLIDEFYF-------PTTTDVLFV--------NV 112

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1958768177 2824 PLPESLMGNPVRFRFYQKYSDVQ----WAIDNFYLG 2855
Cdd:cd10048    113 PLPYTAQTNATRFRLWQPYNSGKkeevWILDDLVID 148

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 44.89 E-value: 1.43e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  569 TMSHMIQFSINLGCGTHQP---GNSVSLEFSTNHGRSWSLLhteclpeicagphlpHSTIYSSENYSGwNRVTIPLPNAA 645
Cdd:cd10049     57 SMARFVQFFMRLGCGKGVPdprSQPVLLQYSLNGGLTWSLL---------------QEFLFSNSSNVG-RYVALEIPLKA 120

                           90       100       110
                   ....*....|....*....|....*....|
gi 1958768177  646 LTRDTRIRWRQTGPILGNM--WAIDNVYIG 673
Cdd:cd10049    121 RSPSTRLRWWQPSENGHFYspWVIDQILIG 150

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 44.77 E-value: 1.57e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  585 HQPGNSVSLEFSTNHGRSWSLLHteclpeicagpHLPHstiyssENYSGWNRVTIPLPNAALTRDTRIRWRQTGPI---L 661
Cdd:cd10051     81 TCRKEGVLLQYSTDGGISWTLLH-----------ELDY------QKYISVRYDYITLPENARTNSTRLRWWQPFTIsngL 143

                           90
                   ....*....|....*...
gi 1958768177  662 GNM------WAIDNVYIG 673
Cdd:cd10051    144 VVSgteraqWALDNILIG 161

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 44.91 E-value: 1.85e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  755 GRRQLITSFLDSSQSRFLQFTLRLGsksvlstCRAPDQPG--EGVLLHYSYDNGITWKLLEH-----------------Y 815
Cdd:cd10038     45 SARYVETQSMQIGASYMIQFSLVMG-------CGQQYTPHmdNQVKLEYSTNHGLTWHLVQEeclpgmpscqeftsgsiY 117

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1958768177  816 SYLNYHEPRIISVELPDDAKQFGIQFRWWQPYHSSQgeDVWAIDEI 861
Cdd:cd10038    118 HSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQ--DEWALDNI 161

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 44.08 E-value: 2.25e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1507 LVQFYIQIGSKTsgitcikpRARNEGLVVQYSNDNGILWHLLR-----ELDFLSFLePQI-------------ISIDLPR 1568
Cdd:cd10037     46 FAQFSINLGCGS--------HQPGNSVSLEFSTNHGRSWSLLHteclpELCAGPHL-PHStvyssdnysgwnrITIPLPN 116

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958768177 1569 EAKTPATAFRWWQPqHGKHSAQWALDDVLIG 1599
Cdd:cd10037    117 AALTSATRFRWRQT-GSVVGSMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 44.04 E-value: 2.84e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  566 LPSTMSHMIQFSINLG-------CGTHQPGN-SVSLEFSTNHGRSWSLLHtECLPEICAGPHLphstiyssenysgwnrV 637
Cdd:cd10047     52 LDTTNIRLVQFYIQIGsklngetCLRPRSRNeGIIVQYSNDNGITWHLLR-ELDFMSYLEPQV----------------I 114

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1958768177  638 TIPLPNAALTRDTRIRWRQtgPILGN---MWAIDNVYIG 673
Cdd:cd10047    115 SIELPREAKTPATAFRWWQ--PQHGKpsaQWALDDVLIG 151

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 43.62 E-value: 4.65e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3273 DNFESARVtEANWETIQGGAIGSGCGQLAPYAHGD--SLYFNGCQIRQAA--TKPLDLTRASKIMFVLQIGSTAQTDSCN 3348
Cdd:cd10041      4 DTFDFGPN-ESNWLFYPGGNTGLYCPYQSKGAPEEdsAMVFVSSELGEHSitTRDLDVNENTIIQFEINVGCTTESSSAD 82

                           90       100
                   ....*....|....*....|....*...
gi 1958768177 3349 sdlsgphtvdkAVLLQYSVNNGITWHVI 3376
Cdd:cd10041     83 -----------PVRLEFSRDFGATWHLL 99

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 42.54 E-value: 7.91e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1859 TNTMYVQFSLRfIAKGTPERSHSILLQSSINGGVTWRLMDEFYFPQTTSILF-----------------INVPLPYSAQT 1921
Cdd:cd10037     42 TVTHFAQFSIN-LGCGSHQPGNSVSLEFSTNHGRSWSLLHTECLPELCAGPHlphstvyssdnysgwnrITIPLPNAALT 120

                           90
                   ....*....|...
gi 1958768177 1922 NATRFRLWQPYNN 1934
Cdd:cd10037    121 SATRFRWRQTGSV 133

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 39.25 E-value: 8.50e-04

                           10        20
                   ....*....|....*....|....*
gi 1958768177 2138 CCGHGSCVNGT-KCICDPGYSGPTC 2161
Cdd:pfam07974    2 CSGRGTCVNQCgKCVCDSGYQGATC 26

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 9.37e-04

                           10        20
                   ....*....|....*....|....*
gi 1958768177 1039 CSGHGSCDH--GVCRCDQGYQGTEC 1061
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 42.15 E-value: 9.66e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1131 FVQFYIQIGGESAAcnkPDSreeGVLLQYSNNGGIQWHLL----------------AEMYFSD-FGKPRFVYLELPAAAK 1193
Cdd:cd10037     46 FAQFSINLGCGSHQ---PGN---SVSLEFSTNHGRSWSLLhteclpelcagphlphSTVYSSDnYSGWNRITIPLPNAAL 119

                           90       100
                   ....*....|....*....|....*....
gi 1958768177 1194 TPCTRFRWWQPvfSGEDYDQWAVDDIIIL 1222
Cdd:cd10037    120 TSATRFRWRQT--GSVVGSMWAIDNVYIG 146

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.22e-03

                           10        20
                   ....*....|....*....|....*
gi 1958768177 2862 CGGHGDCLKE--QCICDPGYSGPHC 2884
Cdd:pfam07974    2 CSGRGTCVNQcgKCVCDSGYQGATC 26

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 38.43 E-value: 1.33e-03

                           10        20
                   ....*....|....*....|....*....
gi 1958768177 3233 CPRLCSGHGYCTTGAvCICDESFQGDDCS 3261
Cdd:pfam18720    2 CPLGCSSRGVCVDGQ-CICDSEYSGDDCS 29

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 41.74 E-value: 1.58e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3057 PSQLVDTFDDEGSSHeeNWSFYpNAVRTAGFCGNPSFHLYWPNKKKdkthnalSSRELIIQP-----GYMMQFKIVVGCE 3131
Cdd:cd10050      2 PTQLKDTFNRAPSSS--NWLTV-VGGKLSTVCGAVASGTALHFSGG-------CSRQLVTVDlnltnAEFVQFYFMYGCL 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 3132 ATSCGDLHSVMLEYTKDArSDSWQLVqtqclpsssnsigcspfqfheATIYNAVNSSSwKRITIQLPDHVSSSATQFRWI 3211
Cdd:cd10050     72 IPPSNRNQGVLLEYSVNG-GITWNLL---------------------MEIFYDQYSKP-GFVNILLPPEARGVGTRFRWW 128

                          170       180
                   ....*....|....*....|
gi 1958768177 3212 QKGEETEKQS-WAIDHVYIG 3230
Cdd:cd10050    129 QPSHDGLDQNdWAIDNVLIG 148

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.58e-03

                           10        20
                   ....*....|....*....|....*.
gi 1958768177 1773 LCSGRGICDS--GRCVCDRGFGGPFC 1796
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 41.33 E-value: 2.09e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  566 LPSTMSHMIQFSINLG----CGT----HQPGNSVSLEFSTNHGRSWSLLHteclpeicagphlphstIYSSENYSGWNRV 637
Cdd:cd10045     55 LDSTQSRYLQFTLRLGsksvLGTcpppDRPGEGVLLHYSCDNGITWKLLE-----------------HYSYDNYHEPRIV 117

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1958768177  638 TIPLPNAALTRDTRIRWRQTGPILGN--MWAIDNVYI 672
Cdd:cd10045    118 SVELPEDARNFGVQFRWWQPYHSGQNqdVWALDEISM 154

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 40.93 E-value: 3.87e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177  562 VLPIlpSTMSHMIQFSINLGcGTHQPGNSVSLEFSTNHGRSWSLLHTeclpeicagpHLPhstiyssENYSGWNRVTIPL 641
Cdd:cd10052     68 VLQI--GSRSQTDSCNINLS-SPRAVDKAVLLQYSVNNGITWYLIAQ----------HQP-------KDFMRAQRVSYNL 127

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1958768177  642 PNAALTRDTRIRWRQT--GPILGNMWAIDNV 670
Cdd:cd10052    128 PLEARTKGVVLRWWQPrhDGTGHDQWALDNV 158

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 37.28 E-value: 4.21e-03

                           10        20
                   ....*....|....*....|....*..
gi 1958768177 1770 CPWLCSGRGICDSGRCVCDRGFGGPFC 1796
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 40.66 E-value: 4.39e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1454 DRFEGKLSPLWYKISGGQVGTGCGtlSDGRSLYF-NGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGiTCIkprarneG 1532
Cdd:cd10042      4 DDFSTLDSRKWLLHPGGTKMPVCG--STGDALVFiEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTD-SCY-------A 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1533 LVVQYSNDNGILWH-LLRE-----LDFLSFLEPQI-----------ISIDLPREAKTPATAFRWWQPQHGKHSAQWALDD 1595
Cdd:cd10042     74 IELEYSVDLGLSWHpLLRDclptnVECSSYHLQRIlvsdtfnkwtrVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAIDN 153


                   ....
gi 1958768177 1596 VLIG 1599
Cdd:cd10042    154 VYIG 157

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 5.28e-03

                           10        20
                   ....*....|....*....|....*.
gi 1958768177 3236 LCSGHGYC-TTGAVCICDESFQGDDC 3260
Cdd:pfam07974    1 ICSGRGTCvNQCGKCVCDSGYQGATC 26

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.85 E-value: 6.00e-03

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1958768177 2134 CEEM--CCGHGSCVN---GTKCICDPGYSGPTCK 2162
Cdd:cd00054      5 CASGnpCQNGGTCVNtvgSYRCSCPPGYTGRNCE 38

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 40.59 E-value: 6.29e-03

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958768177 1536 QYSNDNGILWhllreldflsflepQIISIDLPREAKTPATAFRWWQPQHGKHSAQWALDDVLIG 1599
Cdd:cd10044    126 IYSSVNSSVW--------------KRVTIQLPDHVSSSATQFRWIQKTESTEAPSWAIDDVYIG 175

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 39.89 E-value: 6.85e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1805 ILKDDFNGN------LHPdlwpevyGAERGNLNGETiksGTSLIF-KGEGLRMLISRDLDCTNTMYVQFSLRFIAKGTpE 1877
Cdd:cd10042      1 VLEDDFSTLdsrkwlLHP-------GGTKMPVCGST---GDALVFiEKASTRYVVTTDIMVNEDSFLQIDFAASCSVT-D 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958768177 1878 RSHSILLQSSINGGVTWRLMDEFYFP--------QTTSILF---------INVPLPYSAQTNATRFRLWQPYNNGKKEEi 1940
Cdd:cd10042     70 SCYAIELEYSVDLGLSWHPLLRDCLPtnvecssyHLQRILVsdtfnkwtrVTLPLPHYTRSQATRFRWHQPAPFDKQQT- 148


                   ....*...
gi 1958768177 1941 WIIDDFII 1948
Cdd:cd10042    149 WAIDNVYI 156

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.

Pssm-ID: 460294 Cd Length: 52 Bit Score: 36.64 E-value: 9.77e-03

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958768177 1408 VYISEPC--PSYCSGHGDCISGVCFCDLGYTAAQGTC 1442
Cdd:pfam01683   16 VAPGESCeaDEQCPGGSVCVNGVCQCPPGFTPVNGRC 52