Gcsh glycine cleavage system protein H (aminomethyl carrier) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gcshprovided by MGI
Official Full Name: glycine cleavage system protein H (aminomethyl carrier)provided by MGI
Primary source: MGI:MGI:1915383
See related: Ensembl:ENSMUSG00000034424 AllianceGenome:MGI:1915383
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1100001L02Rik; 5730591C18Rik
Summary: Predicted to enable aminomethyltransferase activity and enzyme binding activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system and protein lipoylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome. Orthologous to human GCSH (glycine cleavage system protein H). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 73.9), kidney adult (RPKM 41.7) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 63.43 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (117708706..117720237, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (116981967..116993498, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aminomethyltransferase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in glycine decarboxylation via glycine cleavage system	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine decarboxylation via glycine cleavage system	IEA Inferred from Electronic Annotation more info
involved_in protein lipoylation	ISO Inferred from Sequence Orthology more info
involved_in protein lipoylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of glycine cleavage complex	IBA Inferred from Biological aspect of Ancestor more info
part_of glycine cleavage complex	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycine cleavage system H protein, mitochondrial

Names: lipoic acid-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.