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    Prlr prolactin receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24684, updated on 3-Dec-2024

    Summary

    Official Symbol
    Prlrprovided by RGD
    Official Full Name
    prolactin receptorprovided by RGD
    Primary source
    RGD:3407
    See related
    EnsemblRapid:ENSRNOG00000057557 AllianceGenome:RGD:3407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RATPRLR
    Summary
    Enables prolactin receptor activity and protein kinase binding activity. Involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus; positive regulation of B cell proliferation; and positive regulation of protein autophosphorylation. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 788.9), Liver (RPKM 174.3) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Prlr in Genome Data Viewer
    Location:
    2q16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (60861391..61051883)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (59134147..59324719)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (60131410..60325686)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100559 Neighboring gene uncharacterized LOC134485719 Neighboring gene alanine-glyoxylate aminotransferase 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C21

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC105486

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables prolactin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prolactin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables prolactin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables prolactin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in activation of Janus kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lactation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mammary gland alveolus development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mammary gland epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mammary gland epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mammary gland epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in prolactin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostate gland growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within prostate gland growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    prolactin receptor
    Names
    PRL-R
    lactogen receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034111.1NP_001029283.1  prolactin receptor isoform a precursor

      See identical proteins and their annotated locations for NP_001029283.1

      Status: PROVISIONAL

      Source sequence(s)
      M57668
      UniProtKB/Swiss-Prot
      P05710, Q62832, Q63451, Q63479, Q63723, Q64274
      UniProtKB/TrEMBL
      A6KJU2
      Related
      ENSRNOP00000072948.2, ENSRNOT00000080786.3
      Conserved Domains (2) summary
      cd00063
      Location:122219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:19115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. NM_012630.2NP_036762.1  prolactin receptor isoform b precursor

      See identical proteins and their annotated locations for NP_036762.1

      Status: PROVISIONAL

      Source sequence(s)
      M19304
      UniProtKB/TrEMBL
      A0A0G2K813, Q58DZ7
      Conserved Domains (2) summary
      cd00063
      Location:122219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:19115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      60861391..61051883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101746.2XP_038957674.2  prolactin receptor isoform X1

      UniProtKB/Swiss-Prot
      P05710, Q62832, Q63451, Q63479, Q63723, Q64274
      UniProtKB/TrEMBL
      A6KJU2
    2. XM_063281314.1XP_063137384.1  prolactin receptor isoform X2

      UniProtKB/TrEMBL
      A0A0G2K813, Q58DZ7
      Related
      ENSRNOP00000081286.1, ENSRNOT00000099452.2
    3. XM_063281310.1XP_063137380.1  prolactin receptor isoform X1

      UniProtKB/Swiss-Prot
      P05710, Q62832, Q63451, Q63479, Q63723, Q64274
      UniProtKB/TrEMBL
      A6KJU2
    4. XM_063281311.1XP_063137381.1  prolactin receptor isoform X1

      UniProtKB/Swiss-Prot
      P05710, Q62832, Q63451, Q63479, Q63723, Q64274
      UniProtKB/TrEMBL
      A6KJU2
    5. XM_039101753.2XP_038957681.1  prolactin receptor isoform X2

      UniProtKB/TrEMBL
      A0A0G2K813, Q58DZ7
      Related
      ENSRNOP00000074428.2, ENSRNOT00000080974.3
      Conserved Domains (2) summary
      cd00063
      Location:122219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:19115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    6. XM_039101749.2XP_038957677.2  prolactin receptor isoform X1

      UniProtKB/Swiss-Prot
      P05710, Q62832, Q63451, Q63479, Q63723, Q64274
      UniProtKB/TrEMBL
      A6KJU2
    7. XM_063281309.1XP_063137379.1  prolactin receptor isoform X1

      UniProtKB/Swiss-Prot
      P05710, Q62832, Q63451, Q63479, Q63723, Q64274
      UniProtKB/TrEMBL
      A6KJU2
    8. XM_039101752.2XP_038957680.1  prolactin receptor isoform X2

      UniProtKB/TrEMBL
      A0A0G2K813, Q58DZ7
      Conserved Domains (2) summary
      cd00063
      Location:122219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:19115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    9. XM_063281315.1XP_063137385.1  prolactin receptor isoform X2

      UniProtKB/TrEMBL
      A0A0G2K813, Q58DZ7
    10. XM_063281313.1XP_063137383.1  prolactin receptor isoform X1

      UniProtKB/Swiss-Prot
      P05710, Q62832, Q63451, Q63479, Q63723, Q64274
      UniProtKB/TrEMBL
      A6KJU2