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Conserved domains on  [gi|6981406|ref|NP_036762|]
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prolactin receptor isoform b precursor [Rattus norvegicus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414115)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 19-115 5.47e-33

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 117.52  E-value: 5.47e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406     19 GQSPPGKPEIHKCRSPDKETFTCWWNPGTDGGLPTNYSLTYSKEGEkTTYECPDYKTSGPNS-----CFFSKQYTSIWKI 93
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENE-TVKECPLYSTSGANStrlfiCFFPKNDVSLFVP 82

                          90       100
                  ....*....|....*....|..
gi 6981406     94 YIITVNATNQMGSSSSDPLYVD 115
Cdd:pfam09067  83 LHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 122-219 1.52e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 1.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406  122 PEPPRNLTLEVkqlkDKKTYLWVKWSPPTitdvKTGWFTMEYEIRLKPEEAEEWEIHFT--GHQTQFKVFDLYPGQKYLV 199
Cdd:cd00063   1 PSPPTNLRVTD----VTSTSVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEF 72

                        90       100
                ....*....|....*....|
gi 6981406  200 QTRCKPDHGyWSRWSQESSV 219
Cdd:cd00063  73 RVRAVNGGG-ESPPSESVTV 91
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 19-115 5.47e-33

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 117.52  E-value: 5.47e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406     19 GQSPPGKPEIHKCRSPDKETFTCWWNPGTDGGLPTNYSLTYSKEGEkTTYECPDYKTSGPNS-----CFFSKQYTSIWKI 93
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENE-TVKECPLYSTSGANStrlfiCFFPKNDVSLFVP 82

                          90       100
                  ....*....|....*....|..
gi 6981406     94 YIITVNATNQMGSSSSDPLYVD 115
Cdd:pfam09067  83 LHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 122-219 1.52e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 1.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406  122 PEPPRNLTLEVkqlkDKKTYLWVKWSPPTitdvKTGWFTMEYEIRLKPEEAEEWEIHFT--GHQTQFKVFDLYPGQKYLV 199
Cdd:cd00063   1 PSPPTNLRVTD----VTSTSVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEF 72

                        90       100
                ....*....|....*....|
gi 6981406  200 QTRCKPDHGyWSRWSQESSV 219
Cdd:cd00063  73 RVRAVNGGG-ESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
124-214 1.32e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406    124 PPRNLTLEVKQlkdkKTYLWVKWSPPTITDVK-TGwftmeYEIRLKPEEAEEWEIHFT--GHQTQFKVFDLYPGQKYLVQ 200
Cdd:pfam00041   2 APSNLTVTDVT----STSLTVSWTPPPDGNGPiTG-----YEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVR 72

                          90
                  ....*....|....
gi 6981406    201 TRCKPDHGyWSRWS 214
Cdd:pfam00041  73 VQAVNGGG-EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 122-209 3.13e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 3.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406     122 PEPPRNLTLEVKQlkdkKTYLWVKWSPPTITDvkTGWFTMEYEIRLKPEEAEEWEIHFTGHQTQFKVFDLYPGQKYLVQT 201
Cdd:smart00060   1 PSPPSNLRVTDVT----STSVTLSWEPPPDDG--ITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*...
gi 6981406     202 RCKPDHGY 209
Cdd:smart00060  75 RAVNGAGE 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
92-243 7.52e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.14  E-value: 7.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406   92 KIYIITVNATNQMGSSS--SDPLYVdVTYIVEPEPPRNLTLEVKQlkDKKTYLwvKWSPPTITDVKTgwftmeYEIRLKP 169
Cdd:COG3401 296 TTYYYRVTAVDAAGNESapSNVVSV-TTDLTPPAAPSGLTATAVG--SSSITL--SWTASSDADVTG------YNVYRST 364

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6981406  170 EEAEEWE-IHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWSQESSVEMPNDFTLKDTTVWIIVAILSAVI 243
Cdd:COG3401 365 SGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVA 439
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 19-115 5.47e-33

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 117.52  E-value: 5.47e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406     19 GQSPPGKPEIHKCRSPDKETFTCWWNPGTDGGLPTNYSLTYSKEGEkTTYECPDYKTSGPNS-----CFFSKQYTSIWKI 93
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENE-TVKECPLYSTSGANStrlfiCFFPKNDVSLFVP 82

                          90       100
                  ....*....|....*....|..
gi 6981406     94 YIITVNATNQMGSSSSDPLYVD 115
Cdd:pfam09067  83 LHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 122-219 1.52e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 1.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406  122 PEPPRNLTLEVkqlkDKKTYLWVKWSPPTitdvKTGWFTMEYEIRLKPEEAEEWEIHFT--GHQTQFKVFDLYPGQKYLV 199
Cdd:cd00063   1 PSPPTNLRVTD----VTSTSVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEF 72

                        90       100
                ....*....|....*....|
gi 6981406  200 QTRCKPDHGyWSRWSQESSV 219
Cdd:cd00063  73 RVRAVNGGG-ESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
124-214 1.32e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406    124 PPRNLTLEVKQlkdkKTYLWVKWSPPTITDVK-TGwftmeYEIRLKPEEAEEWEIHFT--GHQTQFKVFDLYPGQKYLVQ 200
Cdd:pfam00041   2 APSNLTVTDVT----STSLTVSWTPPPDGNGPiTG-----YEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVR 72

                          90
                  ....*....|....
gi 6981406    201 TRCKPDHGyWSRWS 214
Cdd:pfam00041  73 VQAVNGGG-EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 122-209 3.13e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 3.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406     122 PEPPRNLTLEVKQlkdkKTYLWVKWSPPTITDvkTGWFTMEYEIRLKPEEAEEWEIHFTGHQTQFKVFDLYPGQKYLVQT 201
Cdd:smart00060   1 PSPPSNLRVTDVT----STSVTLSWEPPPDDG--ITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*...
gi 6981406     202 RCKPDHGY 209
Cdd:smart00060  75 RAVNGAGE 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
92-243 7.52e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.14  E-value: 7.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406   92 KIYIITVNATNQMGSSS--SDPLYVdVTYIVEPEPPRNLTLEVKQlkDKKTYLwvKWSPPTITDVKTgwftmeYEIRLKP 169
Cdd:COG3401 296 TTYYYRVTAVDAAGNESapSNVVSV-TTDLTPPAAPSGLTATAVG--SSSITL--SWTASSDADVTG------YNVYRST 364

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6981406  170 EEAEEWE-IHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWSQESSVEMPNDFTLKDTTVWIIVAILSAVI 243
Cdd:COG3401 365 SGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVA 439
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 41-109 9.94e-04

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 37.77  E-value: 9.94e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6981406     41 CWWNPGTDGGLPTNYSLTYSKEGEKTTYECPDYKTSGPNSCFFSKQYTSI----WKIYIITVNATNQMGSSSS 109
Cdd:pfam09240  14 CEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGlsssFHQVYICVNGSSSAGPIRS 86
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
92-221 6.61e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 38.06  E-value: 6.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6981406   92 KIYIITVNATNQMGSSSSDPLYVDVTYIVEPEPPRNLTLEVkqlkDKKTYLWVKWSPPTITDVKTgwftmeYEIRLKPEE 171
Cdd:COG3401 203 TTYYYRVAATDTGGESAPSNEVSVTTPTTPPSAPTGLTATA----DTPGSVTLSWDPVTESDATG------YRVYRSNSG 272

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6981406  172 AEEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWSQESSVEM 221
Cdd:COG3401 273 DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTT 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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