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    MCA2 PLAC8 family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816287, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MCA2
    Official Full Name
    PLAC8 family protein
    Primary source
    TAIR:AT2G17780
    Locus tag
    AT2G17780
    See related
    Araport:AT2G17780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    mid1-complementing activity 2; T17A5.4; T17A5_4
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    Genomic context

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    See MCA2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (7724406..7727503, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Eukaryotic aspartyl protease family protein Neighboring gene basic region/leucine zipper motif 27 Neighboring gene zinc-binding protein-like protein Neighboring gene cylicin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MCAs in Arabidopsis are Ca(2+)-permeable mechanosensitive channels inherently sensitive to membrane tension. Yoshimura K, et al. Nat Commun, 2021 Oct 19. PMID 34667173, Free PMC Article
    2. Ca(2+)-permeable mechanosensitive channels MCA1 and MCA2 mediate cold-induced cytosolic Ca(2+) increase and cold tolerance in Arabidopsis. Mori K, et al. Sci Rep, 2018 Jan 11. PMID 29323146, Free PMC Article
    3. Transmembrane Topologies of Ca2+-permeable Mechanosensitive Channels MCA1 and MCA2 in Arabidopsis thaliana. Kamano S, et al. J Biol Chem, 2015 Dec 25. PMID 26555262, Free PMC Article
    4. Structural characterization of the mechanosensitive channel candidate MCA2 from Arabidopsis thaliana. Shigematsu H, et al. PLoS One, 2014. PMID 24475319, Free PMC Article
    5. Determination of structural regions important for Ca(2+) uptake activity in Arabidopsis MCA1 and MCA2 expressed in yeast. Nakano M, et al. Plant Cell Physiol, 2011 Nov. PMID 21949028

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MCAs in Arabidopsis are Ca(2+)-permeable mechanosensitive channels inherently sensitive to membrane tension.
      Title: MCAs in Arabidopsis are Ca(2+)-permeable mechanosensitive channels inherently sensitive to membrane tension.
    2. VIP1 and its close homologues can interact with calmodulins. Their nuclear-cytoplasmic shuttling requires neither MCA1 nor MCA2, but does require calcium signalling. Salt stress affects the VIP1-dependent regulation of root bending.
      Title: Calcium signalling regulates the functions of the bZIP protein VIP1 in touch responses in Arabidopsis thaliana.
    3. MCA2 is involved in the cold-induced elevation of [Ca2+]cyt, cold tolerance, and CBF/DREB1-independent cold signaling.
      Title: Ca(2+)-permeable mechanosensitive channels MCA1 and MCA2 mediate cold-induced cytosolic Ca(2+) increase and cold tolerance in Arabidopsis.
    4. Transmembrane Topologies of Ca2+-permeable Mechanosensitive Channels MCA1 and MCA2 in Arabidopsis thaliana.
      Title: Transmembrane Topologies of Ca2+-permeable Mechanosensitive Channels MCA1 and MCA2 in Arabidopsis thaliana.
    5. MCA2 from Arabidopsis thaliana is involved in mechanical stress-induced Ca2+ influx.
      Title: Structural characterization of the mechanosensitive channel candidate MCA2 from Arabidopsis thaliana.
    6. The N-terminal half of both proteins with the EF hand-like region is necessary and sufficient for Ca(2+) uptake and that the coiled-coil motif regulates MCA1 negatively and MCA2 positively.
      Title: Determination of structural regions important for Ca(2+) uptake activity in Arabidopsis MCA1 and MCA2 expressed in yeast.
    7. MCA2 has a distinct role in Ca2+ uptake in roots and an overlapping role with MCA1 in plant growth.
      Title: MCA1 and MCA2 that mediate Ca2+ uptake have distinct and overlapping roles in Arabidopsis.
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    General gene information

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    Homology

    NM_001036289.1
    NM_001036290.2
    NM_001036291.1
    NM_001335556.1
    NM_001335558.1
    NM_001335559.1
    NM_001335560.1
    NM_001335561.1
    NM_127332.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion import IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within post-embryonic root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PLAC8 family protein
    NP_001031366.1
    • mid1-complementing activity 2 (MCA2); CONTAINS InterPro DOMAIN/s: Protein of unknown function Cys-rich (InterPro:IPR006461); BEST Arabidopsis thaliana protein match is: PLAC8 family protein (TAIR:AT4G35920.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001031367.1
    • mid1-complementing activity 2 (MCA2); CONTAINS InterPro DOMAIN/s: Protein of unknown function Cys-rich (InterPro:IPR006461); BEST Arabidopsis thaliana protein match is: PLAC8 family protein (TAIR:AT4G35920.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001031368.1
    • mid1-complementing activity 2 (MCA2); BEST Arabidopsis thaliana protein match is: PLAC8 family protein (TAIR:AT4G35920.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_179369.2
    • mid1-complementing activity 2 (MCA2); CONTAINS InterPro DOMAIN/s: Protein of unknown function Cys-rich (InterPro:IPR006461); BEST Arabidopsis thaliana protein match is: PLAC8 family protein (TAIR:AT4G35920.2); Has 737 Blast hits to 732 proteins in 87 species: Archae - 0; Bacteria - 17; Metazoa - 44; Fungi - 45; Plants - 605; Viruses - 0; Other Eukaryotes - 26 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7724406..7727503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335557.1 → NP_001324198.1  PLAC8 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2PYH1, Q2V480, Q2V481, Q2V482, Q3EBY6
      UniProtKB/TrEMBL
      A0A178W023, A0A5S9WYT9, A0A654ETQ8
      Conserved Domains (2) summary
      TIGR01571
      Location:290 → 392
      A_thal_Cys_rich; uncharacterized Cys-rich domain
      cd21037
      Location:22 → 148
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

    2. NM_127332.3 → NP_179369.2  PLAC8 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179369.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2PYH1, Q2V480, Q2V481, Q2V482, Q3EBY6
      UniProtKB/TrEMBL
      A0A178W023, A0A5S9WYT9, A0A654ETQ8
      Conserved Domains (2) summary
      TIGR01571
      Location:290 → 392
      A_thal_Cys_rich; uncharacterized Cys-rich domain
      cd21037
      Location:22 → 148
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

    3. NM_001036290.2 → NP_001031367.1  PLAC8 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031367.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VYQ3
      Conserved Domains (2) summary
      TIGR01571
      Location:290 → 392
      A_thal_Cys_rich; uncharacterized Cys-rich domain
      cd21037
      Location:22 → 148
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

    4. NM_001335559.1 → NP_001324200.1  PLAC8 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2PYH1, Q2V480, Q2V481, Q2V482, Q3EBY6
      UniProtKB/TrEMBL
      A0A178W023, A0A5S9WYT9, A0A654ETQ8
      Conserved Domains (2) summary
      TIGR01571
      Location:290 → 392
      A_thal_Cys_rich; uncharacterized Cys-rich domain
      cd21037
      Location:22 → 148
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

    5. NM_001335558.1 → NP_001324199.1  PLAC8 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2PYH1, Q2V480, Q2V481, Q2V482, Q3EBY6
      UniProtKB/TrEMBL
      A0A178W023, A0A5S9WYT9, A0A654ETQ8
      Conserved Domains (2) summary
      TIGR01571
      Location:290 → 392
      A_thal_Cys_rich; uncharacterized Cys-rich domain
      cd21037
      Location:22 → 148
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

    6. NM_001335556.1 → NP_001324196.1  PLAC8 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2PYH1, Q2V480, Q2V481, Q2V482, Q3EBY6
      UniProtKB/TrEMBL
      A0A178W023, A0A5S9WYT9, A0A654ETQ8
      Conserved Domains (2) summary
      TIGR01571
      Location:290 → 392
      A_thal_Cys_rich; uncharacterized Cys-rich domain
      cd21037
      Location:22 → 148
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

    7. NM_001335561.1 → NP_001324195.1  PLAC8 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VYQ3
      Conserved Domains (2) summary
      TIGR01571
      Location:290 → 392
      A_thal_Cys_rich; uncharacterized Cys-rich domain
      cd21037
      Location:22 → 148
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins

    8. NM_001335560.1 → NP_001324197.1  PLAC8 family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VYQ3, A0A1P8AZD6

    9. NM_001036289.1 → NP_001031366.1  PLAC8 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031366.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W023
      Conserved Domains (1) summary
      TIGR01571
      Location:290 → 392
      A_thal_Cys_rich; uncharacterized Cys-rich domain

    10. NM_001036291.1 → NP_001031368.1  PLAC8 family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031368.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EBY6
      Conserved Domains (2) summary
      cd21037
      Location:22 → 148
      MLKL_NTD; N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins
      cl04722
      Location:290 → 306
      PLAC8; PLAC8 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3EBY6.1

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