NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1063704018|ref|NP_001324200|]
View 

PLAC8 family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MCAfunc pfam19584
MCAfunc domain; MCAfunc domain (MCAfunc) is located in the N-terminal region of a ...
 25-167 1.08e-92

MCAfunc domain; MCAfunc domain (MCAfunc) is located in the N-terminal region of a mechanosensitive channel protein MID1-COMPLEMENTING ACTIVITY (MCA). MCAfunc represents the provisionally advocated ARPK domain (Amino-terminal domain of Rice putative Protein Kinases), overlapping with the EF hand-like region at the N-terminus. In MCA proteins, MCAfunc has Ca2+ influx activity and is proposed to be a functional domain of MCAs. MCAfunc is exclusively observed in streptophytes and exists not only in MCA but also in E3 ubiquitin ligase-like proteins, ARO3 like proteins and and protein kinases. In the most basal plant lineage, charophytes, MCAfunc is only found in E3 ubiquitin ligase-like proteins and protein of presently unknown function, while MCA proteins are exclusively found in land plants, from bryophytes to angiosperms.


:

Pssm-ID: 437416  Cd Length: 143  Bit Score: 275.22  E-value: 1.08e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704018  25 LIGMIVNAANTARMHKKNCRQFAHHLKLIRNLLEQIKNSEMNQRSEILEPLQGLDDALRRSYILVKSCQEKSYLYLLAMG 104
Cdd:pfam19584   1 LIGLIVEAANTARLHKKNCRQFAHHLKLIGNLLEQLKISELKKYPETREPLEQLEDALRRSYLLVNSCQDKSYLYLLAMG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063704018 105 WNIVNQFEKAQNEIDLFLKIVPLINMADNARIRERLEAIERDQREYTLDEEDRKVQDVILKQE 167
Cdd:pfam19584  81 WNIVNQFRKAQNEIDRYLRIVPLITLVDNARIRERLERIERDQYEYTLDEEDRKVQDAILNQE 143
A_thal_Cys_rich TIGR01571
uncharacterized Cys-rich domain; This model describes an uncharacterized domain of about 100 ...
 290-392 3.76e-33

uncharacterized Cys-rich domain; This model describes an uncharacterized domain of about 100 residues. It is common in plants but found also in Homo sapiens, Dictyostelium, and Leishmania; at least 12 distinct members are found in Arabidopsis. Most members of this family contain more than 10 per cent Cys, but no Cys residue is invariant across the family.


:

Pssm-ID: 273697  Cd Length: 104  Bit Score: 120.22  E-value: 3.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704018 290 GNWHADLLDCCSEPCLCLKTLFFPCGTLAKISTVATSRQISSTEVCKNLIVYSLILS-CCCYTCCIRKKLRKTLNITGGC 368
Cdd:TIGR01571   1 SNWSTGLFDCCEDIRLCLCGLFCPCCLFGQIAETLGTFAGECLCGGLTAIAMSALCGfCGCYTCFIRIKLREKYGIQGAP 80

                          90       100
                  ....*....|....*....|....
gi 1063704018 369 IDDFLSHLMCCCCALVQELREVEI 392
Cdd:TIGR01571  81 CDDCLTHLFCCFCALCQEHRELKM 104
 
Name Accession Description Interval E-value
MCAfunc pfam19584
MCAfunc domain; MCAfunc domain (MCAfunc) is located in the N-terminal region of a ...
 25-167 1.08e-92

MCAfunc domain; MCAfunc domain (MCAfunc) is located in the N-terminal region of a mechanosensitive channel protein MID1-COMPLEMENTING ACTIVITY (MCA). MCAfunc represents the provisionally advocated ARPK domain (Amino-terminal domain of Rice putative Protein Kinases), overlapping with the EF hand-like region at the N-terminus. In MCA proteins, MCAfunc has Ca2+ influx activity and is proposed to be a functional domain of MCAs. MCAfunc is exclusively observed in streptophytes and exists not only in MCA but also in E3 ubiquitin ligase-like proteins, ARO3 like proteins and and protein kinases. In the most basal plant lineage, charophytes, MCAfunc is only found in E3 ubiquitin ligase-like proteins and protein of presently unknown function, while MCA proteins are exclusively found in land plants, from bryophytes to angiosperms.


Pssm-ID: 437416  Cd Length: 143  Bit Score: 275.22  E-value: 1.08e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704018  25 LIGMIVNAANTARMHKKNCRQFAHHLKLIRNLLEQIKNSEMNQRSEILEPLQGLDDALRRSYILVKSCQEKSYLYLLAMG 104
Cdd:pfam19584   1 LIGLIVEAANTARLHKKNCRQFAHHLKLIGNLLEQLKISELKKYPETREPLEQLEDALRRSYLLVNSCQDKSYLYLLAMG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063704018 105 WNIVNQFEKAQNEIDLFLKIVPLINMADNARIRERLEAIERDQREYTLDEEDRKVQDVILKQE 167
Cdd:pfam19584  81 WNIVNQFRKAQNEIDRYLRIVPLITLVDNARIRERLERIERDQYEYTLDEEDRKVQDAILNQE 143
A_thal_Cys_rich TIGR01571
uncharacterized Cys-rich domain; This model describes an uncharacterized domain of about 100 ...
 290-392 3.76e-33

uncharacterized Cys-rich domain; This model describes an uncharacterized domain of about 100 residues. It is common in plants but found also in Homo sapiens, Dictyostelium, and Leishmania; at least 12 distinct members are found in Arabidopsis. Most members of this family contain more than 10 per cent Cys, but no Cys residue is invariant across the family.


Pssm-ID: 273697  Cd Length: 104  Bit Score: 120.22  E-value: 3.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704018 290 GNWHADLLDCCSEPCLCLKTLFFPCGTLAKISTVATSRQISSTEVCKNLIVYSLILS-CCCYTCCIRKKLRKTLNITGGC 368
Cdd:TIGR01571   1 SNWSTGLFDCCEDIRLCLCGLFCPCCLFGQIAETLGTFAGECLCGGLTAIAMSALCGfCGCYTCFIRIKLREKYGIQGAP 80

                          90       100
                  ....*....|....*....|....
gi 1063704018 369 IDDFLSHLMCCCCALVQELREVEI 392
Cdd:TIGR01571  81 CDDCLTHLFCCFCALCQEHRELKM 104
PLAC8 pfam04749
PLAC8 family; This family includes the Placenta-specific gene 8 protein.
 292-389 3.99e-27

PLAC8 family; This family includes the Placenta-specific gene 8 protein.


Pssm-ID: 461417  Cd Length: 99  Bit Score: 103.95  E-value: 3.99e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704018 292 WHADLLDCCSEPCLCLKTLFFPCGTLAKISTVATSRQISSTEVCKNLIVYSLILSCCC-YTCCIRKKLRKTLNITGGCID 370
Cdd:pfam04749   1 WSTGLFDCFSDCGTCLLGCCCPCVLFGRNAERLDRGNTSCLLAGFAAFCGLTGCGLGWiYSCLQRGKIREKYGIEGSPCG 80

                          90
                  ....*....|....*....
gi 1063704018 371 DFLSHLMCCCCALVQELRE 389
Cdd:pfam04749  81 DCCVHCCCPCCALCQEYRE 99
MLKL_NTD cd21037
N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins; ...
 22-148 2.97e-11

N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins; MLKL is a pseudokinase that does not have protein kinase activity and plays a key role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process. The model corresponds to the MLKL N-terminal region that reveals a four-helix bundle with an additional helix at the top which is likely key for MLKL function. The N-terminal domain binds directly to phospholipids and induces membrane permeabilization.


Pssm-ID: 411030 [Multi-domain]  Cd Length: 138  Bit Score: 60.84  E-value: 2.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704018  22 ALKLIGMIVNAANTARMHKKNCRQFAHHLKLIRNLLEQ-IKNSEMNQRSEILEPLQGLDDALRRSYILVKSCQEKSYLYL 100
Cdd:cd21037     3 AAGLALEILEAVETVKSNKEACRRLAERVAELLLALEElLEGKEEDLSPELREALEELERTLEEIKEFVEKISKRSRLKR 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063704018 101 LAMGWNIVNQFEKAQNEIDLFLKIVPLINMADN--------ARIRERLEAIERDQR 148
Cdd:cd21037    83 FLKAKSIAEKLEELNERLDDALQLFQLALQIEIrawlledlEEIREDLEELLERLE 138
 
Name Accession Description Interval E-value
MCAfunc pfam19584
MCAfunc domain; MCAfunc domain (MCAfunc) is located in the N-terminal region of a ...
 25-167 1.08e-92

MCAfunc domain; MCAfunc domain (MCAfunc) is located in the N-terminal region of a mechanosensitive channel protein MID1-COMPLEMENTING ACTIVITY (MCA). MCAfunc represents the provisionally advocated ARPK domain (Amino-terminal domain of Rice putative Protein Kinases), overlapping with the EF hand-like region at the N-terminus. In MCA proteins, MCAfunc has Ca2+ influx activity and is proposed to be a functional domain of MCAs. MCAfunc is exclusively observed in streptophytes and exists not only in MCA but also in E3 ubiquitin ligase-like proteins, ARO3 like proteins and and protein kinases. In the most basal plant lineage, charophytes, MCAfunc is only found in E3 ubiquitin ligase-like proteins and protein of presently unknown function, while MCA proteins are exclusively found in land plants, from bryophytes to angiosperms.


Pssm-ID: 437416  Cd Length: 143  Bit Score: 275.22  E-value: 1.08e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704018  25 LIGMIVNAANTARMHKKNCRQFAHHLKLIRNLLEQIKNSEMNQRSEILEPLQGLDDALRRSYILVKSCQEKSYLYLLAMG 104
Cdd:pfam19584   1 LIGLIVEAANTARLHKKNCRQFAHHLKLIGNLLEQLKISELKKYPETREPLEQLEDALRRSYLLVNSCQDKSYLYLLAMG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063704018 105 WNIVNQFEKAQNEIDLFLKIVPLINMADNARIRERLEAIERDQREYTLDEEDRKVQDVILKQE 167
Cdd:pfam19584  81 WNIVNQFRKAQNEIDRYLRIVPLITLVDNARIRERLERIERDQYEYTLDEEDRKVQDAILNQE 143
A_thal_Cys_rich TIGR01571
uncharacterized Cys-rich domain; This model describes an uncharacterized domain of about 100 ...
 290-392 3.76e-33

uncharacterized Cys-rich domain; This model describes an uncharacterized domain of about 100 residues. It is common in plants but found also in Homo sapiens, Dictyostelium, and Leishmania; at least 12 distinct members are found in Arabidopsis. Most members of this family contain more than 10 per cent Cys, but no Cys residue is invariant across the family.


Pssm-ID: 273697  Cd Length: 104  Bit Score: 120.22  E-value: 3.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704018 290 GNWHADLLDCCSEPCLCLKTLFFPCGTLAKISTVATSRQISSTEVCKNLIVYSLILS-CCCYTCCIRKKLRKTLNITGGC 368
Cdd:TIGR01571   1 SNWSTGLFDCCEDIRLCLCGLFCPCCLFGQIAETLGTFAGECLCGGLTAIAMSALCGfCGCYTCFIRIKLREKYGIQGAP 80

                          90       100
                  ....*....|....*....|....
gi 1063704018 369 IDDFLSHLMCCCCALVQELREVEI 392
Cdd:TIGR01571  81 CDDCLTHLFCCFCALCQEHRELKM 104
PLAC8 pfam04749
PLAC8 family; This family includes the Placenta-specific gene 8 protein.
 292-389 3.99e-27

PLAC8 family; This family includes the Placenta-specific gene 8 protein.


Pssm-ID: 461417  Cd Length: 99  Bit Score: 103.95  E-value: 3.99e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704018 292 WHADLLDCCSEPCLCLKTLFFPCGTLAKISTVATSRQISSTEVCKNLIVYSLILSCCC-YTCCIRKKLRKTLNITGGCID 370
Cdd:pfam04749   1 WSTGLFDCFSDCGTCLLGCCCPCVLFGRNAERLDRGNTSCLLAGFAAFCGLTGCGLGWiYSCLQRGKIREKYGIEGSPCG 80

                          90
                  ....*....|....*....
gi 1063704018 371 DFLSHLMCCCCALVQELRE 389
Cdd:pfam04749  81 DCCVHCCCPCCALCQEYRE 99
MLKL_NTD cd21037
N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins; ...
 22-148 2.97e-11

N-terminal domain of mixed lineage kinase domain-like protein (MLKL) and similar proteins; MLKL is a pseudokinase that does not have protein kinase activity and plays a key role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process. The model corresponds to the MLKL N-terminal region that reveals a four-helix bundle with an additional helix at the top which is likely key for MLKL function. The N-terminal domain binds directly to phospholipids and induces membrane permeabilization.


Pssm-ID: 411030 [Multi-domain]  Cd Length: 138  Bit Score: 60.84  E-value: 2.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704018  22 ALKLIGMIVNAANTARMHKKNCRQFAHHLKLIRNLLEQ-IKNSEMNQRSEILEPLQGLDDALRRSYILVKSCQEKSYLYL 100
Cdd:cd21037     3 AAGLALEILEAVETVKSNKEACRRLAERVAELLLALEElLEGKEEDLSPELREALEELERTLEEIKEFVEKISKRSRLKR 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063704018 101 LAMGWNIVNQFEKAQNEIDLFLKIVPLINMADN--------ARIRERLEAIERDQR 148
Cdd:cd21037    83 FLKAKSIAEKLEELNERLDDALQLFQLALQIEIrawlledlEEIREDLEELLERLE 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH