NOA1 P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: NOA1
Official Full Name: P-loop containing nucleoside triphosphate hydrolases superfamily protein
Primary source: TAIR:AT3G47450
Locus tag: AT3G47450
See related: Araport:AT3G47450
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATNOA1; ATNOS1; NITRIC OXIDE SYNTHASE 1; NO ASSOCIATED 1; NOS1; RESISTANT TO INHIBITION WITH FOSMIDOMYCIN 1; RESISTANT TO INHIBITION WITH FOSMIDOMYCIN 1; RIF1
Summary: Encodes a protein with similarity to the bacterial YqeH GTPase required for proper ribosome assembly. In Arabidopsis, mutant analyses show that this protein regulates growth and hormonal signaling in plants. It also attenuates oxidative stress and reactive oxygen species (ROS). It also seems to be involved in regulating leaf senescence and cell death. This gene product is also involved in nitric oxide biosynthesis in response to ABA but not exogenous H2O2. This protein also appears to be required for proper plastid biogenesis. Levels of several plastid-localized proteins, including RBCL, ClpP1, and the MEP biosynthesis enzymes DXS and DXR are altered in rif1-1 mutants. This protein was originally characterized as a mitrochondrial-localized nitric oxide synthase, but, the synthase activity was later disproven. In addition, new studies with GFP fusion proteins and chloroplast import assays suggest that this protein is found in chloroplasts.
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Genomic context

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See NOA1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 13

Sequence:: Chromosome: 3; NC_003074.8 (17483068..17486347, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

role in NO accumulation that blocks the ACS1-induced onset of leaf senescence
Title: The dependence of leaf senescence on the balance between 1-aminocyclopropane-1-carboxylate acid synthase 1 (ACS1)-catalysed ACC generation and nitric oxide-associated 1 (NOS1)-dependent NO accumulation in Arabidopsis.
SVR10 and BPG2 are functionally related with VAR2, likely through their potential roles in regulating chloroplast protein homeostasis.
Title: Mutations in circularly permuted GTPase family genes AtNOA1/RIF1/SVR10 and BPG2 suppress var2-mediated leaf variegation in Arabidopsis thaliana.
in response to carbon dioxide elevation, either the NR activity induction in low-nitrate plants or the NR activity inhibition in high-nitrate plants is regulated by NOS-generated nitric oxide.
Title: Elevated CO2-induced production of nitric oxide (NO) by NO synthase differentially affects nitrate reductase activity in Arabidopsis plants under different nitrate supplies.
The protein S-acyltransferases PAT13 and PAT14 are involved in leaf senescence control- possibly via NOA1 S-acylation-, providing a new sight into the regulation mechanism of S-acylation in leaf senescence.
Title: Two homologous protein S-acyltransferases, PAT13 and PAT14, cooperatively regulate leaf senescence in Arabidopsis.
Salicylic acid signaling through NPR1 and AtNOA1 is involved in the control of root waving.
Title: NITRIC OXIDE-ASSOCIATED PROTEIN1 (AtNOA1) is essential for salicylic acid-induced root waving in Arabidopsis thaliana.
NOA1 has a primary role in chloroplast function and its effects on the accumulation of nitric oxide are likely to be indirect.
Title: Nitric oxide accumulation in Arabidopsis is independent of NOA1 in the presence of sucrose.
NIA1/2/NOA1-dependent NO production mediates Arabidopsis salt tolerance.
Title: Roles of NIA/NR/NOA1-dependent nitric oxide production and HY1 expression in the modulation of Arabidopsis salt tolerance.
Data indicate that the double mutant pao1 nos1/noa1 retained the level of chlorophyll (Chl) during dark-induced leaf senescence.
Title: Nitric oxide deficiency accelerates chlorophyll breakdown and stability loss of thylakoid membranes during dark-induced leaf senescence in Arabidopsis.
Oleic levels regulate nitric oxide(NO) synthesis, and, thereby, NO-mediated signaling, by regulating NOA1 levels.
Title: Oleic acid-dependent modulation of NITRIC OXIDE ASSOCIATED1 protein levels regulates nitric oxide-mediated defense signaling in Arabidopsis.
AtNOA1 regulates salicylic acid-induced NO production and stomatal closure.
Title: AtNOA1 modulates nitric oxide accumulation and stomatal closure induced by salicylic acid in Arabidopsis.

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Pathways from PubChem

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General gene information

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NM_114613.3

Supported by ESTs:

NM_180335.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables nitric-oxide synthase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within leaf development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within plastid organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to ozone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thylakoid membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
NOT located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: P-loop containing nucleoside triphosphate hydrolases superfamily protein

NP_190329.2

NO ASSOCIATED 1 (NOA1); FUNCTIONS IN: GTPase activity; INVOLVED IN: in 8 processes; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT3G57180.1); Has 1573 Blast hits to 1527 proteins in 752 species: Archae - 6; Bacteria - 1199; Metazoa - 147; Fungi - 33; Plants - 109; Viruses - 0; Other Eukaryotes - 79 (source: NCBI BLink).

NP_850666.1

NO ASSOCIATED 1 (NOA1); FUNCTIONS IN: GTPase activity; INVOLVED IN: in 8 processes; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT3G57180.1); Has 1589 Blast hits to 1531 proteins in 754 species: Archae - 6; Bacteria - 1199; Metazoa - 159; Fungi - 35; Plants - 109; Viruses - 0; Other Eukaryotes - 81 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

17483068..17486347 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_180335.1 → NP_850666.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850666.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JBJ3, Q0WWY8, Q157M8, Q66GP9, Q9STX8

UniProtKB/TrEMBL

A0A654FHH3

Conserved Domains (2) summary

cd01855
Location:145 → 348

YqeH; Circularly permuted YqeH GTPase

TIGR03597
Location:108 → 533

GTPase_YqeH; ribosome biogenesis GTPase YqeH
NM_114613.3 → NP_190329.2 P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_190329.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A654FHH3

Conserved Domains (2) summary

cd01855
Location:145 → 348

YqeH; Circularly permuted YqeH GTPase

TIGR03597
Location:108 → 533

GTPase_YqeH; ribosome biogenesis GTPase YqeH