Dus4l dihydrouridine synthase 4-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dus4lprovided by RGD
Official Full Name: dihydrouridine synthase 4-likeprovided by RGD
Primary source: RGD:1311445
See related: EnsemblRapid:ENSRNOG00000008155 AllianceGenome:RGD:1311445
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311445
Summary: Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. Orthologous to human DUS4L (dihydrouridine synthase 4 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 13.8), Thymus (RPKM 13.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (53955609..53970050, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (48228111..48242553, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (50925987..50943546, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables tRNA dihydrouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in tRNA dihydrouridine synthesis	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

NP_001129275.1

EC 1.3.1.-

EC 1.3.1.90

XP_038968553.1

EC 1.3.1.-

EC 1.3.1.90

XP_038968554.1

EC 1.3.1.-

EC 1.3.1.90

XP_038968555.1

EC 1.3.1.-

EC 1.3.1.90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135803.2 → NP_001129275.1 tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

See identical proteins and their annotated locations for NP_001129275.1

Status: INFERRED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2K3I5, A6HB53

Related

ENSRNOP00000072651.2, ENSRNOT00000084533.3

Conserved Domains (2) summary

COG0042
Location:32 → 311

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]

cd02801
Location:28 → 257

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

53955609..53970050 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112625.1 → XP_038968553.1 tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform X1

UniProtKB/TrEMBL

D4A0T1

Related

ENSRNOP00000061112.2, ENSRNOT00000068419.3

Conserved Domains (1) summary

cd02801
Location:28 → 286

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
XM_039112626.1 → XP_038968554.1 tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform X2

Conserved Domains (1) summary

cd02801
Location:2 → 219

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
XM_039112627.1 → XP_038968555.1 tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform X3

Conserved Domains (1) summary

cd02801
Location:28 → 188

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...