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    Dnah9 dynein, axonemal, heavy chain 9 [ Mus musculus (house mouse) ]

    Gene ID: 237806, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dnah9provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 9provided by MGI
    Primary source
    MGI:MGI:1289279
    See related
    Ensembl:ENSMUSG00000056752 AllianceGenome:MGI:1289279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnahc9; mKIAA0357; 9030022M04; A230091C01; C230051G16; D11Ertd686e
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Acts upstream of or within cerebrospinal fluid circulation; establishment of localization in cell; and mucociliary clearance. Located in 9+2 motile cilium and distal portion of axoneme. Part of outer dynein arm. Is expressed in central nervous system and testis. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 40. Orthologous to human DNAH9 (dynein axonemal heavy chain 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Dnah9 in Genome Data Viewer
    Location:
    11 B3; 11 40.53 cM
    Exon count:
    69
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (65722150..66059379, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (65831324..66168581, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase 4 Neighboring gene predicted gene, 53682 Neighboring gene zinc finger with KRAB and SCAN domains 6 Neighboring gene STARR-seq mESC enhancer starr_29773 Neighboring gene STARR-seq mESC enhancer starr_29774 Neighboring gene predicted gene, 40027 Neighboring gene predicted gene 12296 Neighboring gene shisa family member 6 Neighboring gene predicted gene, 45945 Neighboring gene STARR-seq mESC enhancer starr_29776 Neighboring gene STARR-seq mESC enhancer starr_29777 Neighboring gene predicted gene, 40028

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Clone Names

    • KIAA0357

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding  
    enables dynein light intermediate chain binding  
    enables minus-end-directed microtubule motor activity  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium  
    located_in 9+2 motile cilium PubMed 
    is_active_in axoneme  
    located_in axoneme  
    located_in distal portion of axoneme PubMed 
    located_in distal portion of axoneme  
    part_of dynein complex  
    located_in glial cell projection PubMed 
    located_in motile cilium  
    part_of outer dynein arm PubMed 

    General protein information

    Preferred Names
    dynein axonemal heavy chain 9
    Names
    dynein, axonemal, heavy polypeptide 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099633.2NP_001093103.1  dynein axonemal heavy chain 9

      See identical proteins and their annotated locations for NP_001093103.1

      Status: VALIDATED

      Source sequence(s)
      AL596025, AL596187
      Consensus CDS
      CCDS36182.1
      UniProtKB/TrEMBL
      B1AR51
      Related
      ENSMUSP00000079494.4, ENSMUST00000080665.10
      Conserved Domains (6) summary
      pfam03028
      Location:37854474
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:210787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:12931697
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:30653408
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:34363648
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:24372708
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      65722150..66059379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533213.5XP_006533276.1  dynein axonemal heavy chain 9 isoform X3

      Conserved Domains (7) summary
      COG5245
      Location:13633994
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:29113254
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:212633
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:11361542
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:16762002
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:26392898
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:40334328
      Dynein_C; Dynein heavy chain C-terminal domain
    2. XM_017314522.3XP_017170011.1  dynein axonemal heavy chain 9 isoform X5

      Conserved Domains (13) summary
      pfam12777
      Location:28593187
      MT; Microtubule-binding stalk of dynein motor
      pfam03028
      Location:36833799
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:212787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:12901696
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:18302156
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12775
      Location:24372616
      AAA_7; P-loop containing dynein motor region D3
      pfam12781
      Location:32153428
      AAA_9; ATP-binding dynein motor region D5
      pfam17852
      Location:23152430
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain
      pfam17857
      Location:26492748
      AAA_lid_1; AAA+ lid domain
      pfam18198
      Location:38013960
      AAA_lid_11; Dynein heavy chain AAA lid domain
      pfam18199
      Location:39664261
      Dynein_C; Dynein heavy chain C-terminal domain
      cl38936
      Location:21442279
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl38985
      Location:27932864
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_006533212.5XP_006533275.1  dynein axonemal heavy chain 9 isoform X2

      Conserved Domains (7) summary
      COG5245
      Location:15174070
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:29853330
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:212787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:12901696
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:18302156
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12781
      Location:33583571
      AAA_9; ATP-binding dynein motor region D5
      pfam18199
      Location:41094404
      Dynein_C; Dynein heavy chain C-terminal domain
    4. XM_017314521.3XP_017170010.1  dynein axonemal heavy chain 9 isoform X1

      Conserved Domains (7) summary
      COG5245
      Location:15174107
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:30653408
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:212787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:12901696
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:18302156
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:27933052
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:41464441
      Dynein_C; Dynein heavy chain C-terminal domain
    5. XM_006533214.3XP_006533277.1  dynein axonemal heavy chain 9 isoform X4

      Conserved Domains (7) summary
      COG5245
      Location:13193950
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:28673210
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:14589
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:10921498
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:16321958
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:25952854
      AAA_8; P-loop containing dynein motor region D4
      pfam18199
      Location:39894284
      Dynein_C; Dynein heavy chain C-terminal domain
    6. XM_036156656.1XP_036012549.1  dynein axonemal heavy chain 9 isoform X7

      Conserved Domains (5) summary
      COG5245
      Location:4373068
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:19852328
      MT; Microtubule-binding stalk of dynein motor
      pfam08393
      Location:210616
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:7501076
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:31073402
      Dynein_C; Dynein heavy chain C-terminal domain
    7. XM_036156657.1XP_036012550.1  dynein axonemal heavy chain 9 isoform X7

      Conserved Domains (5) summary
      COG5245
      Location:4373068
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:19852328
      MT; Microtubule-binding stalk of dynein motor
      pfam08393
      Location:210616
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:7501076
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:31073402
      Dynein_C; Dynein heavy chain C-terminal domain
    8. XM_017314523.3XP_017170012.1  dynein axonemal heavy chain 9 isoform X6

      Conserved Domains (6) summary
      COG5245
      Location:15174095
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:30653408
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:212787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:12901696
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:18302156
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:27933052
      AAA_8; P-loop containing dynein motor region D4
    9. XM_017314525.3XP_017170014.1  dynein axonemal heavy chain 9 isoform X8

      Conserved Domains (5) summary
      COG5245
      Location:15172899
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:212787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:12901696
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:18302156
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12775
      Location:24372616
      AAA_7; P-loop containing dynein motor region D3
    10. XM_006533218.5XP_006533281.1  dynein axonemal heavy chain 9 isoform X9

      Conserved Domains (4) summary
      pfam08385
      Location:212787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:12901696
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:18302156
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      cl38936
      Location:21442279
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_004936949.1 RNA Sequence

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