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Conserved domains on  [gi|568973729|ref|XP_006533275|]
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dynein axonemal heavy chain 9 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MT super family cl37598
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
2985-3330 0e+00

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


The actual alignment was detected with superfamily member pfam12777:

Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 667.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2985 EALESVSLRfLQNTKNiEVDDLKAKLATQEVELRHKNEDTDKLIQVVGVETSKVSREKAIADEEEQKVALIMLEVQQKQK 3064
Cdd:pfam12777    1 ERLENGLLK-LHSTAA-QVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3065 DCEEDLAKAEPALTAAQAALNTLNKTNLTELKSFGSPPLAVSNVSAAVMVLMAPGGKVPKDRSWKAAKITMAKVDSFLDS 3144
Cdd:pfam12777   79 ACEEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDS 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3145 LIHFDKENIHENCLKAIRPYLQDPAFNPEFVATKSYAAAGLCSWVINIVRFYEVFCDVEPKRQALNKATSDLTTAQEKLA 3224
Cdd:pfam12777  159 LIKFDKEHIHEACLKAFKPYLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLA 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3225 AIKAKITHLNENLAKLTTKFEKATAEKLKCQQEAELTAGTISLANRLVGGLASENIRWAEAVQNFRQQERTLCGDILLTT 3304
Cdd:pfam12777  239 AIKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLIS 318
                          330       340
                   ....*....|....*....|....*.
gi 568973729  3305 AFISYLGFFTKKYRKSLMDGTWRPYL 3330
Cdd:pfam12777  319 AFISYLGFFTKKYRNELLDKFWIPYI 344
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1830-2156 0e+00

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


:

Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 649.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1830 YSYEYLGNTPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGIMVYVFNCSEQMDYKSCGNIYKG 1909
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1910 LAQTGAWGCFDEFNRISVEVLSVVAVQVKSIQDAIRDKKQRFSFLGEEISLDPSVGIFITMNPGYAGRTELPENLKALFR 1989
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1990 PCAMVVPDFELISEIMLVAEGFIEARLLARKFITLYRLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPDRPEDQVLM 2069
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2070 RSLRDFNIPKIVTDDMPVFMGLIGDLFPALDVPRKRDLDFEAVVRKAIVDLKLQAEDNFVLKVVQLEELLAVRHSVFVVG 2149
Cdd:pfam12774  241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320

                   ....*..
gi 568973729  2150 GAGTGKS 2156
Cdd:pfam12774  321 PTGSGKT 327
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
212-787 0e+00

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


:

Pssm-ID: 462457  Cd Length: 560  Bit Score: 631.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   212 LYAVESAVIKWSHQVQVVLKRESsqaliQGQNPTPKVELEFWKSRCEDLEHIYNQLMTIKVKGMAELLDKLQSSYLPAFK 291
Cdd:pfam08385    1 LHALESVVIKWTKQIQDVLKEDS-----QGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   292 AMFRDVEAALTEAQDIHVHLLPLQQHLDILENV-EFPKVKGRLRPLLHVVCLIWATCKWYRSPGRLTVLLQEICNLLIQQ 370
Cdd:pfam08385   76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEELtDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   371 ASNYLSPEDLLRSEVEESQKKLQVVSDTLSFFKQAFQDRREHLHTYFKEdsevRVWDFQASLVFVRLDGFLGRVHMVEDL 450
Cdd:pfam08385  156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRE----RPWDFSERYIFGRFDAFLERLEKILEL 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   451 LKTALDLNNLEKLefSGLRGNSLSQKVQRMHEEFEEMYKVFLDCSYDCLDPKGTEFENDVCEFNKRVEDLDRRLGTILIQ 530
Cdd:pfam08385  232 FETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQ 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   531 AFDDAPDVEHAFKLLDITGTLIKRPLVAQDVSQKYLALIRMFSTELDAVRVIYSQHIQKEaehgfSPVHKNMPTMAGGIC 610
Cdd:pfam08385  310 AFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYNP-----SPIAKNMPPVAGAII 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   611 WAQELRQRVKGPFGNFKNIPHLyLQSAEGKRMIQKYEDLLSLLEEYERRLYEDWCQTVSEKSQYNLSLPLLHRDP-NTKQ 689
Cdd:pfam08385  385 WARQLFRRIQEPMKRFKEELGL-LKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLLVRHPeTGKL 463
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   690 LSVNFNPQLISVLKEMNYLQPSEVKtIPETAAAMFSSREFYRQLVANLELMANWYNKVIKILLEVEFPLVEEELQNIDLR 769
Cdd:pfam08385  464 LSVNFDPQLLALLREVKYLQKLGFE-IPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEK 542
                          570
                   ....*....|....*...
gi 568973729   770 LRAAEETLSWKTEGIWDY 787
Cdd:pfam08385  543 LEPGLTTLTWNSLGIDEY 560
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
1290-1696 2.42e-152

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


:

Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 479.83  E-value: 2.42e-152
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1290 LRQCRKEACQLKELWDTIGMVTSSIRAWEATSWRNISVEAMDSECKQFARHIRNLDKEFRSWDAFTGLESTVLNTLTSLR 1369
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1370 AVAELQNPAIRDRHWRQLMQATGVNFTMNQDT-TLAHLLQLQLHHFEDEVRGIVDRAVKEMSMEKTLKELQTTWASMEFQ 1448
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFDPLSEFfTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1449 YESHARTRVPLLQSDEDLIEVLEDNQVQLQNLMMSKYVAFFLEEVSSWQKKLSTADSVISIWFEVQRTWSHLESIFIgSE 1528
Cdd:pfam08393  161 LVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS-SE 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1529 DIRAQLPQDSKRFEGIDSDFRELAYDAQKTPNVVEATNKSGLYEKLEDIQSRLCLCEKALAEYLDTKRLSFPRFYFLSSS 1608
Cdd:pfam08393  240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1609 DLLDILSNGTAPQQVQRHLSKLFDNMAKMQFqldasqNPTKTSLGMYSKEEEYVAFSE-ACDCSGQVEIWLNRVLRHMKA 1687
Cdd:pfam08393  320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEF------DENKEITGMISKEGEVVPFSKpPVEAKGNVEEWLNELEEEMRE 393

                   ....*....
gi 568973729  1688 TVRHEMTEG 1696
Cdd:pfam08393  394 TLRDLLKEA 402
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4109-4404 2.88e-125

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


:

Pssm-ID: 465677  Cd Length: 301  Bit Score: 397.38  E-value: 2.88e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  4109 TQTSEKLFRTVLEMQPRDSQAGDGAGITREEKVKTFLEEILDRMTDEFNIAELMAK--VEERTPYIVVALQECERMNILT 4186
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  4187 REIQRSLRELHLGLQGELTMTSEMENLQNALYLDVVPESWARRAYPSTAGLAAWFLDLLNRIKELESWTGDFLMPSTVWL 4266
Cdd:pfam18199   81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  4267 TGFFNPQSFLTAIMQSMARKNEWPLDQMALQCDVTKKNR-EEFRSPPREGAYIYGLFMEGACWDTQTGIIAEAKLKDLTP 4345
Cdd:pfam18199  161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSpEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568973729  4346 PMPVMFLKAIPADKQDCR-SVYACPVYKTCQRG-PTYVWTFNLKTKENPSKWVLAGVALLL 4404
Cdd:pfam18199  241 PLPVIHLKPVESDKKKLDeNTYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3356-3574 2.18e-108

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


:

Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 345.58  E-value: 2.18e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3356 AAWQNEGLPADRMSMENATILINCERWPLMVDPQLQGIKWIKNKYGEE-LRVTQIGQKGCLQTIERALEAGDVVLIENLE 3434
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNgLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3435 ESIDPVLGPLLGREVIKKGR--FIKIGDKECEFNPKFRLILHTKLANPHYQPELQAQATLINFTVTRDGLEDQLLAAVVS 3512
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGGrkVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568973729  3513 MERPDLEQLKSDLTKQQNGFKITLKTLEDNLLSRLSSASGNFLGETALVENLEVTKQTAADV 3574
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
DYN1 super family cl34955
Dynein, heavy chain [Cytoskeleton];
1517-4070 1.37e-102

Dynein, heavy chain [Cytoskeleton];


The actual alignment was detected with superfamily member COG5245:

Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 372.40  E-value: 1.37e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1517 WSHLESIFIGSEDIRAQLPQDSKRFEGIDSDFREL---AYDAQKTPNVVEATNKSGL---YEKLEDIQSrlclcekALAE 1590
Cdd:COG5245   627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIykrVVSGCEAINTILEDVGDDLdlfYKEMDQVFM-------SIEK 699
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1591 YLDTKRLSFPRFyfLSSSDLLDILSNGTAPQQVQRHLSKLFDNMAKMQFQLDASQNPTKTSLgmysKEEEYVAFSEACDc 1670
Cdd:COG5245   700 VLGLRWREVERA--SEVEELMDRVRELENRVYSYRFFVKKIAKEEMKTVFSSRIQKKEPFSL----DSEAYVGFFRLYE- 772
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1671 SGQVEIWLNRVLRHMKATVRHEMTEgvtAYEEKPRDQWLFDYPAQVALTCTQIWwtTEVgiafarLEEGYESAMKDYYKk 1750
Cdd:COG5245   773 KSIVIRGINRSMGRVLSQYLESVQE---ALEIEDGSFFVSRHRVRDGGLEKGRG--CDA------WENCFDPPLSEYFR- 840
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1751 qvaQLKTLITMLIGPLSKGDRQKIMTICTIDVHARDVVaKMIAQKVDNAQAFLWLSQLRHRWDDEAKHCFANICDAQFLY 1830
Cdd:COG5245   841 ---ILEKIFPSEEGYFFDEVLKRLDPGHEIKSRIEEII-RMVTVKYDFCLEVLGSVSISELPQGLYKRFIKVRSSYRSAE 916
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1831 SYEYLGNTPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGIMVyvfncsEQMDYKScgNIYKGL 1910
Cdd:COG5245   917 MFAKNTIPFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGP 984
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1911 AQTGAWGcFDEFNRISvEVLSVVAVQVKSIQDAIRDKKQRFSFLGEEISLDPSVGIFITMNPgyagRTELPENLKALFRP 1990
Cdd:COG5245   985 ICEEERG-TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDM 1058
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1991 CAMVVPdFELISEIMlvaegfieaRLLARKFITLYRLCKELLSKQDHYDWglRAIKsvlvvaGSLKRGDPDRPE-DQVLM 2069
Cdd:COG5245  1059 FLSNIP-FGAIKSRR---------ESLDREIGAFNNEVDGIAREEDELMF--YPMF------KSLKAKHRMLEEkTEYLN 1120
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2070 RSLRDFNIPkivtddmpvfmgLIGDLFpaldVPRKRDLDFE--AVVRKAIVDLKLQAEDNFVLKVVQLEELLAVRHS--- 2144
Cdd:COG5245  1121 KILSITGLP------------LISDTL----RERIDTLDAEwdSFCRISESLKKYESQQVSGLDVAQFVSFLRSVDTgaf 1184
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2145 VFVVGGAGTGKSqvlrslhKTYQIMrrrpVWTDLNPKAV-TNDELFgiinPATREWKdGLFSSIMRE-LAIISHDGPKWI 2222
Cdd:COG5245  1185 HAEYFRVFLCKI-------KHYTDA----CDYLWHVKSPyVKKKYF----DADMELR-QFFLMFNREdMEARLADSKMEY 1248
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2223 LLDGdidpmWIESLNTVMDDNKVLTLASNERiplnptmRLLFEisHLRTaTPATVSRAGILYINPADLGwnppVSSWIDQ 2302
Cdd:COG5245  1249 EVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYDSISRLS----TKGVFLD 1309
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2303 REVQTERanltilfdkYLPTCLDTLRT-RFKKIIpvpeqSMIQMLCYLLECLLTKEDIPADCPKEIYE--LYFVFAAIWA 2379
Cdd:COG5245  1310 ELGDTKR---------YLDECLDFFSCfEEVQKE-----IDELSMVFCADALRFSADLYHIVKERRFSgvLAGSDASESL 1375
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2380 FGS-----AVIQDQ-LVDY---------------------RAEFSKWWLTEF----KTVKFPSQGTVFDYYIDPETKKFE 2428
Cdd:COG5245  1376 GGKsielaAILEHKdLIVEmkrgindvlklrifgdkcresTPRFYLISDGDLikdlNERSDYEEMLIMMFNISAVITNNG 1455
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2429 PwaklIPQFEFDPE--MPLQACLVHTSETIRVCYFMERLMQWRRPVMLVGPAGSGKSVLVGAKLssLNPEEYMVKNVPFN 2506
Cdd:COG5245  1456 S----IAGFELRGErvMLRKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSL--RSELITEVKYFNFS 1529
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2507 YYTTSAMLQAVLEKPLEK----KAGRNYGPPGNRKLIYFIDDMNMPEVDAYGtvqPHTVI---RQHLDYGHWYDRNKLSL 2579
Cdd:COG5245  1530 TCTMTPSKLSVLERETEYypntGVVRLYPKPVVKDLVLFCDEINLPYGFEYY---PPTVIvflRPLVERQGFWSSIAVSW 1606
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2580 KEIMNVQYISCMNP--TAGSFTINPRLQRHFSVFALCFPGADALSSIYSTILTH-HLKFGNFPTTlqksIPPLINLAVTF 2656
Cdd:COG5245  1607 VTICGIILYGACNPgtDEGRVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMGsYLCFDEFNRL----SEETMSASVEL 1682
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2657 HQKIATTFlPTAIKFHYIFNLRDFANIFQGIlFSSVECVKSTQD--LVKLYLHESSRVYRDKMVEEKDFNLFDKIQTEFL 2734
Cdd:COG5245  1683 YLSSKDKT-KFFLQMNYGYKPRELTRSLRAI-FGYAETRIDTPDvsLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFG 1760
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2735 KKNFDDSEEVLKQTQNLNMYCHFANGIGEpkympvqswdLLNQTLVEALE--------SHNEVnavmDLVLFEDAIRHIC 2806
Cdd:COG5245  1761 LRAIREMIAGHIGEAEITFSMILFFGMAC----------LLKKDLAVFVEevrkifgsSHLDV----EAVAYKDALLHIL 1826
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2807 HINRILESPRGNALLVGVGGSGKQSLTKLAAFISSMDVFQITLRKGYQIPDFKVDLASLCLKAGVKNLSTVFLMTDAHVA 2886
Cdd:COG5245  1827 RSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPV 1906
                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2887 DERFLVLINDLLASGEIPDLYSDEEEENIINNVRNEVKSQGL-MDSRENCWKFFIERVQRQLKV--TLCfSPVGNKLRIR 2963
Cdd:COG5245  1907 ESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVvfSAC-CSQDTSVLAG 1985
                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2964 SRkFPAIVNCTAINWFHEWPQEALESVSLRFLQ-------------NTKNIE---------------------------- 3002
Cdd:COG5245  1986 IR-SPALKNRCFIDFKKLWDTEEMSQYANSVETlsrdggrvffingELGVGKgalisevfgddavviegrgfeismiegs 2064
                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3003 ----------------------------------------------VDDLKAKLATQEVELRHKNEDTDKLIQVVGVETS 3036
Cdd:COG5245  2065 lgeskikfigglkvydarcviyieeldctnvnlvegvrkyneygrgMGELKEQLSNTVVILGVKEKNADDALSGTPGERL 2144
                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3037 KVSREKAIADEEEQKVALIMLEVQQKQKDCEEDLAKAEPALTAAQAALNTLNKTNLTELKSFGSPPLAVSNVSAAVMVLM 3116
Cdd:COG5245  2145 EREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL 2224
                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3117 APGGKVpkdrsWKAAKITMaKVDSFLDSLIHFDKE-NIHENCLKAIRP-YLQDPAFNPEFVATKSYAAAGLCSWVINIVR 3194
Cdd:COG5245  2225 GFEAKI-----WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREArECSDPSFTGSILNRASKACGPLKRWLVRECN 2298
                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3195 FYEVFCDVEPKRQALNKATSDLTTAQEKLAAIKAKITHLNENLAKLTTKFE---------KATAEKLKCQQEAELTAGTI 3265
Cdd:COG5245  2299 RSKVLEVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSldilrvhgkIADMDTVHKDVLRSIFVSEI 2378
                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3266 slanrlvggLASENIRWAEAVQNFRQQERTLCGDILLTTAFISYLGFfTKKYRKSLMDGTWRPYLSQlKVPIPTTPTLDP 3345
Cdd:COG5245  2379 ---------LINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGT-LGFLCRAIEFGMSFIRISK-EFRDKEIRRRQF 2447
                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3346 L-RMLTDDAEVAAWQNeglpADRMSMENATILINCER-WPLMVDPQLQGIKWIKNKYGEELRV-TQIGQKGCLQTIERAL 3422
Cdd:COG5245  2448 ItEGVQKIEDFKEEAC----STDYGLENSRIRKDLQDlTAVLNDPSSKIVTSQRQMYDEKKAIlGSFREMEFAFGLSQAR 2523
                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3423 EAGDVVLIENlEESIDPVLGPLLGREVIKKGRFIK--IGDKECEFNPKFRLILHTKLANPHYQPELQAQATLINFTVTRD 3500
Cdd:COG5245  2524 REGSDKIIGD-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVL 2602
                        2170      2180      2190      2200      2210      2220      2230      2240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3501 GLEDQLLAAVVSMERPDLEQLKSDLTKQQNGFKITLKTLEDNLLSRLSSASGNFLGETALVENLEVTKQTAADVEEKVQE 3580
Cdd:COG5245  2603 GCETEIPDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESE 2682
                        2250      2260      2270      2280      2290      2300      2310      2320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3581 AKLTEVKINEAREHYRPAAARASLLYFIMNDLSKIHPMYQFSLKAFSIVFQKAVEKAApseSVTERVTNLIDSITFSVYQ 3660
Cdd:COG5245  2683 SMEIEDRIDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEKWRRMKS---KYLCAIRYMLMSSEWILDH 2759
                        2330      2340      2350      2360      2370      2380      2390      2400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3661 YTTRG-LFECDKLTYL--AQLTFQILLVN---QEVNAAELDFLlrapvqtgtpspmEFLSHQAWGG-------IKALSSM 3727
Cdd:COG5245  2760 EDRSGfIHRLDVSFLLrtKRFVSTLLEDKnyrQVLSSCSLYGN-------------DVISHSCDRFdrdvyraLKHQMDN 2826
                        2410      2420      2430      2440      2450      2460      2470      2480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3728 EEFCNLDRDIegSAKSWKKfvesecpeKEKFPQEWKNKtalqrlcmmramrpdrmtyamrdFVEEKLGSKYVMGRALDfv 3807
Cdd:COG5245  2827 RTHSTILTSN--SKTNPYK--------EYTYNDSWAEA-----------------------FEVEDSGDLYKFEEGLL-- 2871
                        2490      2500      2510      2520      2530      2540      2550      2560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3808 tsfEESGPATPMFFILSPGVDPLKDVENQGKKlgytfnnrnfhnvslgqGQEVVAEAALDLAAKKGHWVILQNIHLVAKW 3887
Cdd:COG5245  2872 ---ELIVGHAPLIYAHKKSLENERNVDRLGSK-----------------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGW 2931
                        2570      2580      2590      2600      2610      2620      2630      2640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3888 LST--LEKKLEELSEESHPDFRVFISAepapSPEGHIIPQGILENSIKITNEPPTGMHANLHK--ALDNFTQDTLEMCSR 3963
Cdd:COG5245  2932 FKRyvEDVVYPIKASRVCGKVKNMWTS----MVDADMLPIQLLIAIDSFVSSTYPETGCGYADlvEIDRYPFDYTLVIAC 3007
                        2650      2660      2670      2680      2690      2700      2710      2720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3964 EtefktILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANT--KVPYDDLRYLFGEIMYGGHITDD 4041
Cdd:COG5245  3008 D-----DAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLM 3082
                        2730      2740      2750
                  ....*....|....*....|....*....|...
gi 568973729 4042 WD----RRLCRTYLEEFIRPEMLEGELSLAPGF 4070
Cdd:COG5245  3083 EDskvvDKYCRGYGAHETSSQILASVPGGDPEL 3115
 
Name Accession Description Interval E-value
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
2985-3330 0e+00

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 667.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2985 EALESVSLRfLQNTKNiEVDDLKAKLATQEVELRHKNEDTDKLIQVVGVETSKVSREKAIADEEEQKVALIMLEVQQKQK 3064
Cdd:pfam12777    1 ERLENGLLK-LHSTAA-QVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3065 DCEEDLAKAEPALTAAQAALNTLNKTNLTELKSFGSPPLAVSNVSAAVMVLMAPGGKVPKDRSWKAAKITMAKVDSFLDS 3144
Cdd:pfam12777   79 ACEEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDS 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3145 LIHFDKENIHENCLKAIRPYLQDPAFNPEFVATKSYAAAGLCSWVINIVRFYEVFCDVEPKRQALNKATSDLTTAQEKLA 3224
Cdd:pfam12777  159 LIKFDKEHIHEACLKAFKPYLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLA 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3225 AIKAKITHLNENLAKLTTKFEKATAEKLKCQQEAELTAGTISLANRLVGGLASENIRWAEAVQNFRQQERTLCGDILLTT 3304
Cdd:pfam12777  239 AIKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLIS 318
                          330       340
                   ....*....|....*....|....*.
gi 568973729  3305 AFISYLGFFTKKYRKSLMDGTWRPYL 3330
Cdd:pfam12777  319 AFISYLGFFTKKYRNELLDKFWIPYI 344
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1830-2156 0e+00

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 649.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1830 YSYEYLGNTPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGIMVYVFNCSEQMDYKSCGNIYKG 1909
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1910 LAQTGAWGCFDEFNRISVEVLSVVAVQVKSIQDAIRDKKQRFSFLGEEISLDPSVGIFITMNPGYAGRTELPENLKALFR 1989
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1990 PCAMVVPDFELISEIMLVAEGFIEARLLARKFITLYRLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPDRPEDQVLM 2069
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2070 RSLRDFNIPKIVTDDMPVFMGLIGDLFPALDVPRKRDLDFEAVVRKAIVDLKLQAEDNFVLKVVQLEELLAVRHSVFVVG 2149
Cdd:pfam12774  241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320

                   ....*..
gi 568973729  2150 GAGTGKS 2156
Cdd:pfam12774  321 PTGSGKT 327
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
212-787 0e+00

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


Pssm-ID: 462457  Cd Length: 560  Bit Score: 631.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   212 LYAVESAVIKWSHQVQVVLKRESsqaliQGQNPTPKVELEFWKSRCEDLEHIYNQLMTIKVKGMAELLDKLQSSYLPAFK 291
Cdd:pfam08385    1 LHALESVVIKWTKQIQDVLKEDS-----QGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   292 AMFRDVEAALTEAQDIHVHLLPLQQHLDILENV-EFPKVKGRLRPLLHVVCLIWATCKWYRSPGRLTVLLQEICNLLIQQ 370
Cdd:pfam08385   76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEELtDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   371 ASNYLSPEDLLRSEVEESQKKLQVVSDTLSFFKQAFQDRREHLHTYFKEdsevRVWDFQASLVFVRLDGFLGRVHMVEDL 450
Cdd:pfam08385  156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRE----RPWDFSERYIFGRFDAFLERLEKILEL 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   451 LKTALDLNNLEKLefSGLRGNSLSQKVQRMHEEFEEMYKVFLDCSYDCLDPKGTEFENDVCEFNKRVEDLDRRLGTILIQ 530
Cdd:pfam08385  232 FETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQ 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   531 AFDDAPDVEHAFKLLDITGTLIKRPLVAQDVSQKYLALIRMFSTELDAVRVIYSQHIQKEaehgfSPVHKNMPTMAGGIC 610
Cdd:pfam08385  310 AFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYNP-----SPIAKNMPPVAGAII 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   611 WAQELRQRVKGPFGNFKNIPHLyLQSAEGKRMIQKYEDLLSLLEEYERRLYEDWCQTVSEKSQYNLSLPLLHRDP-NTKQ 689
Cdd:pfam08385  385 WARQLFRRIQEPMKRFKEELGL-LKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLLVRHPeTGKL 463
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   690 LSVNFNPQLISVLKEMNYLQPSEVKtIPETAAAMFSSREFYRQLVANLELMANWYNKVIKILLEVEFPLVEEELQNIDLR 769
Cdd:pfam08385  464 LSVNFDPQLLALLREVKYLQKLGFE-IPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEK 542
                          570
                   ....*....|....*...
gi 568973729   770 LRAAEETLSWKTEGIWDY 787
Cdd:pfam08385  543 LEPGLTTLTWNSLGIDEY 560
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
1290-1696 2.42e-152

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 479.83  E-value: 2.42e-152
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1290 LRQCRKEACQLKELWDTIGMVTSSIRAWEATSWRNISVEAMDSECKQFARHIRNLDKEFRSWDAFTGLESTVLNTLTSLR 1369
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1370 AVAELQNPAIRDRHWRQLMQATGVNFTMNQDT-TLAHLLQLQLHHFEDEVRGIVDRAVKEMSMEKTLKELQTTWASMEFQ 1448
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFDPLSEFfTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1449 YESHARTRVPLLQSDEDLIEVLEDNQVQLQNLMMSKYVAFFLEEVSSWQKKLSTADSVISIWFEVQRTWSHLESIFIgSE 1528
Cdd:pfam08393  161 LVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS-SE 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1529 DIRAQLPQDSKRFEGIDSDFRELAYDAQKTPNVVEATNKSGLYEKLEDIQSRLCLCEKALAEYLDTKRLSFPRFYFLSSS 1608
Cdd:pfam08393  240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1609 DLLDILSNGTAPQQVQRHLSKLFDNMAKMQFqldasqNPTKTSLGMYSKEEEYVAFSE-ACDCSGQVEIWLNRVLRHMKA 1687
Cdd:pfam08393  320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEF------DENKEITGMISKEGEVVPFSKpPVEAKGNVEEWLNELEEEMRE 393

                   ....*....
gi 568973729  1688 TVRHEMTEG 1696
Cdd:pfam08393  394 TLRDLLKEA 402
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4109-4404 2.88e-125

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 397.38  E-value: 2.88e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  4109 TQTSEKLFRTVLEMQPRDSQAGDGAGITREEKVKTFLEEILDRMTDEFNIAELMAK--VEERTPYIVVALQECERMNILT 4186
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  4187 REIQRSLRELHLGLQGELTMTSEMENLQNALYLDVVPESWARRAYPSTAGLAAWFLDLLNRIKELESWTGDFLMPSTVWL 4266
Cdd:pfam18199   81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  4267 TGFFNPQSFLTAIMQSMARKNEWPLDQMALQCDVTKKNR-EEFRSPPREGAYIYGLFMEGACWDTQTGIIAEAKLKDLTP 4345
Cdd:pfam18199  161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSpEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568973729  4346 PMPVMFLKAIPADKQDCR-SVYACPVYKTCQRG-PTYVWTFNLKTKENPSKWVLAGVALLL 4404
Cdd:pfam18199  241 PLPVIHLKPVESDKKKLDeNTYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3356-3574 2.18e-108

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 345.58  E-value: 2.18e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3356 AAWQNEGLPADRMSMENATILINCERWPLMVDPQLQGIKWIKNKYGEE-LRVTQIGQKGCLQTIERALEAGDVVLIENLE 3434
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNgLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3435 ESIDPVLGPLLGREVIKKGR--FIKIGDKECEFNPKFRLILHTKLANPHYQPELQAQATLINFTVTRDGLEDQLLAAVVS 3512
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGGrkVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568973729  3513 MERPDLEQLKSDLTKQQNGFKITLKTLEDNLLSRLSSASGNFLGETALVENLEVTKQTAADV 3574
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1517-4070 1.37e-102

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 372.40  E-value: 1.37e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1517 WSHLESIFIGSEDIRAQLPQDSKRFEGIDSDFREL---AYDAQKTPNVVEATNKSGL---YEKLEDIQSrlclcekALAE 1590
Cdd:COG5245   627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIykrVVSGCEAINTILEDVGDDLdlfYKEMDQVFM-------SIEK 699
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1591 YLDTKRLSFPRFyfLSSSDLLDILSNGTAPQQVQRHLSKLFDNMAKMQFQLDASQNPTKTSLgmysKEEEYVAFSEACDc 1670
Cdd:COG5245   700 VLGLRWREVERA--SEVEELMDRVRELENRVYSYRFFVKKIAKEEMKTVFSSRIQKKEPFSL----DSEAYVGFFRLYE- 772
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1671 SGQVEIWLNRVLRHMKATVRHEMTEgvtAYEEKPRDQWLFDYPAQVALTCTQIWwtTEVgiafarLEEGYESAMKDYYKk 1750
Cdd:COG5245   773 KSIVIRGINRSMGRVLSQYLESVQE---ALEIEDGSFFVSRHRVRDGGLEKGRG--CDA------WENCFDPPLSEYFR- 840
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1751 qvaQLKTLITMLIGPLSKGDRQKIMTICTIDVHARDVVaKMIAQKVDNAQAFLWLSQLRHRWDDEAKHCFANICDAQFLY 1830
Cdd:COG5245   841 ---ILEKIFPSEEGYFFDEVLKRLDPGHEIKSRIEEII-RMVTVKYDFCLEVLGSVSISELPQGLYKRFIKVRSSYRSAE 916
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1831 SYEYLGNTPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGIMVyvfncsEQMDYKScgNIYKGL 1910
Cdd:COG5245   917 MFAKNTIPFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGP 984
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1911 AQTGAWGcFDEFNRISvEVLSVVAVQVKSIQDAIRDKKQRFSFLGEEISLDPSVGIFITMNPgyagRTELPENLKALFRP 1990
Cdd:COG5245   985 ICEEERG-TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDM 1058
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1991 CAMVVPdFELISEIMlvaegfieaRLLARKFITLYRLCKELLSKQDHYDWglRAIKsvlvvaGSLKRGDPDRPE-DQVLM 2069
Cdd:COG5245  1059 FLSNIP-FGAIKSRR---------ESLDREIGAFNNEVDGIAREEDELMF--YPMF------KSLKAKHRMLEEkTEYLN 1120
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2070 RSLRDFNIPkivtddmpvfmgLIGDLFpaldVPRKRDLDFE--AVVRKAIVDLKLQAEDNFVLKVVQLEELLAVRHS--- 2144
Cdd:COG5245  1121 KILSITGLP------------LISDTL----RERIDTLDAEwdSFCRISESLKKYESQQVSGLDVAQFVSFLRSVDTgaf 1184
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2145 VFVVGGAGTGKSqvlrslhKTYQIMrrrpVWTDLNPKAV-TNDELFgiinPATREWKdGLFSSIMRE-LAIISHDGPKWI 2222
Cdd:COG5245  1185 HAEYFRVFLCKI-------KHYTDA----CDYLWHVKSPyVKKKYF----DADMELR-QFFLMFNREdMEARLADSKMEY 1248
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2223 LLDGdidpmWIESLNTVMDDNKVLTLASNERiplnptmRLLFEisHLRTaTPATVSRAGILYINPADLGwnppVSSWIDQ 2302
Cdd:COG5245  1249 EVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYDSISRLS----TKGVFLD 1309
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2303 REVQTERanltilfdkYLPTCLDTLRT-RFKKIIpvpeqSMIQMLCYLLECLLTKEDIPADCPKEIYE--LYFVFAAIWA 2379
Cdd:COG5245  1310 ELGDTKR---------YLDECLDFFSCfEEVQKE-----IDELSMVFCADALRFSADLYHIVKERRFSgvLAGSDASESL 1375
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2380 FGS-----AVIQDQ-LVDY---------------------RAEFSKWWLTEF----KTVKFPSQGTVFDYYIDPETKKFE 2428
Cdd:COG5245  1376 GGKsielaAILEHKdLIVEmkrgindvlklrifgdkcresTPRFYLISDGDLikdlNERSDYEEMLIMMFNISAVITNNG 1455
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2429 PwaklIPQFEFDPE--MPLQACLVHTSETIRVCYFMERLMQWRRPVMLVGPAGSGKSVLVGAKLssLNPEEYMVKNVPFN 2506
Cdd:COG5245  1456 S----IAGFELRGErvMLRKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSL--RSELITEVKYFNFS 1529
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2507 YYTTSAMLQAVLEKPLEK----KAGRNYGPPGNRKLIYFIDDMNMPEVDAYGtvqPHTVI---RQHLDYGHWYDRNKLSL 2579
Cdd:COG5245  1530 TCTMTPSKLSVLERETEYypntGVVRLYPKPVVKDLVLFCDEINLPYGFEYY---PPTVIvflRPLVERQGFWSSIAVSW 1606
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2580 KEIMNVQYISCMNP--TAGSFTINPRLQRHFSVFALCFPGADALSSIYSTILTH-HLKFGNFPTTlqksIPPLINLAVTF 2656
Cdd:COG5245  1607 VTICGIILYGACNPgtDEGRVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMGsYLCFDEFNRL----SEETMSASVEL 1682
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2657 HQKIATTFlPTAIKFHYIFNLRDFANIFQGIlFSSVECVKSTQD--LVKLYLHESSRVYRDKMVEEKDFNLFDKIQTEFL 2734
Cdd:COG5245  1683 YLSSKDKT-KFFLQMNYGYKPRELTRSLRAI-FGYAETRIDTPDvsLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFG 1760
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2735 KKNFDDSEEVLKQTQNLNMYCHFANGIGEpkympvqswdLLNQTLVEALE--------SHNEVnavmDLVLFEDAIRHIC 2806
Cdd:COG5245  1761 LRAIREMIAGHIGEAEITFSMILFFGMAC----------LLKKDLAVFVEevrkifgsSHLDV----EAVAYKDALLHIL 1826
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2807 HINRILESPRGNALLVGVGGSGKQSLTKLAAFISSMDVFQITLRKGYQIPDFKVDLASLCLKAGVKNLSTVFLMTDAHVA 2886
Cdd:COG5245  1827 RSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPV 1906
                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2887 DERFLVLINDLLASGEIPDLYSDEEEENIINNVRNEVKSQGL-MDSRENCWKFFIERVQRQLKV--TLCfSPVGNKLRIR 2963
Cdd:COG5245  1907 ESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVvfSAC-CSQDTSVLAG 1985
                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2964 SRkFPAIVNCTAINWFHEWPQEALESVSLRFLQ-------------NTKNIE---------------------------- 3002
Cdd:COG5245  1986 IR-SPALKNRCFIDFKKLWDTEEMSQYANSVETlsrdggrvffingELGVGKgalisevfgddavviegrgfeismiegs 2064
                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3003 ----------------------------------------------VDDLKAKLATQEVELRHKNEDTDKLIQVVGVETS 3036
Cdd:COG5245  2065 lgeskikfigglkvydarcviyieeldctnvnlvegvrkyneygrgMGELKEQLSNTVVILGVKEKNADDALSGTPGERL 2144
                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3037 KVSREKAIADEEEQKVALIMLEVQQKQKDCEEDLAKAEPALTAAQAALNTLNKTNLTELKSFGSPPLAVSNVSAAVMVLM 3116
Cdd:COG5245  2145 EREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL 2224
                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3117 APGGKVpkdrsWKAAKITMaKVDSFLDSLIHFDKE-NIHENCLKAIRP-YLQDPAFNPEFVATKSYAAAGLCSWVINIVR 3194
Cdd:COG5245  2225 GFEAKI-----WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREArECSDPSFTGSILNRASKACGPLKRWLVRECN 2298
                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3195 FYEVFCDVEPKRQALNKATSDLTTAQEKLAAIKAKITHLNENLAKLTTKFE---------KATAEKLKCQQEAELTAGTI 3265
Cdd:COG5245  2299 RSKVLEVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSldilrvhgkIADMDTVHKDVLRSIFVSEI 2378
                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3266 slanrlvggLASENIRWAEAVQNFRQQERTLCGDILLTTAFISYLGFfTKKYRKSLMDGTWRPYLSQlKVPIPTTPTLDP 3345
Cdd:COG5245  2379 ---------LINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGT-LGFLCRAIEFGMSFIRISK-EFRDKEIRRRQF 2447
                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3346 L-RMLTDDAEVAAWQNeglpADRMSMENATILINCER-WPLMVDPQLQGIKWIKNKYGEELRV-TQIGQKGCLQTIERAL 3422
Cdd:COG5245  2448 ItEGVQKIEDFKEEAC----STDYGLENSRIRKDLQDlTAVLNDPSSKIVTSQRQMYDEKKAIlGSFREMEFAFGLSQAR 2523
                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3423 EAGDVVLIENlEESIDPVLGPLLGREVIKKGRFIK--IGDKECEFNPKFRLILHTKLANPHYQPELQAQATLINFTVTRD 3500
Cdd:COG5245  2524 REGSDKIIGD-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVL 2602
                        2170      2180      2190      2200      2210      2220      2230      2240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3501 GLEDQLLAAVVSMERPDLEQLKSDLTKQQNGFKITLKTLEDNLLSRLSSASGNFLGETALVENLEVTKQTAADVEEKVQE 3580
Cdd:COG5245  2603 GCETEIPDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESE 2682
                        2250      2260      2270      2280      2290      2300      2310      2320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3581 AKLTEVKINEAREHYRPAAARASLLYFIMNDLSKIHPMYQFSLKAFSIVFQKAVEKAApseSVTERVTNLIDSITFSVYQ 3660
Cdd:COG5245  2683 SMEIEDRIDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEKWRRMKS---KYLCAIRYMLMSSEWILDH 2759
                        2330      2340      2350      2360      2370      2380      2390      2400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3661 YTTRG-LFECDKLTYL--AQLTFQILLVN---QEVNAAELDFLlrapvqtgtpspmEFLSHQAWGG-------IKALSSM 3727
Cdd:COG5245  2760 EDRSGfIHRLDVSFLLrtKRFVSTLLEDKnyrQVLSSCSLYGN-------------DVISHSCDRFdrdvyraLKHQMDN 2826
                        2410      2420      2430      2440      2450      2460      2470      2480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3728 EEFCNLDRDIegSAKSWKKfvesecpeKEKFPQEWKNKtalqrlcmmramrpdrmtyamrdFVEEKLGSKYVMGRALDfv 3807
Cdd:COG5245  2827 RTHSTILTSN--SKTNPYK--------EYTYNDSWAEA-----------------------FEVEDSGDLYKFEEGLL-- 2871
                        2490      2500      2510      2520      2530      2540      2550      2560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3808 tsfEESGPATPMFFILSPGVDPLKDVENQGKKlgytfnnrnfhnvslgqGQEVVAEAALDLAAKKGHWVILQNIHLVAKW 3887
Cdd:COG5245  2872 ---ELIVGHAPLIYAHKKSLENERNVDRLGSK-----------------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGW 2931
                        2570      2580      2590      2600      2610      2620      2630      2640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3888 LST--LEKKLEELSEESHPDFRVFISAepapSPEGHIIPQGILENSIKITNEPPTGMHANLHK--ALDNFTQDTLEMCSR 3963
Cdd:COG5245  2932 FKRyvEDVVYPIKASRVCGKVKNMWTS----MVDADMLPIQLLIAIDSFVSSTYPETGCGYADlvEIDRYPFDYTLVIAC 3007
                        2650      2660      2670      2680      2690      2700      2710      2720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3964 EtefktILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANT--KVPYDDLRYLFGEIMYGGHITDD 4041
Cdd:COG5245  3008 D-----DAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLM 3082
                        2730      2740      2750
                  ....*....|....*....|....*....|...
gi 568973729 4042 WD----RRLCRTYLEEFIRPEMLEGELSLAPGF 4070
Cdd:COG5245  3083 EDskvvDKYCRGYGAHETSSQILASVPGGDPEL 3115
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
2439-2616 1.52e-91

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 295.46  E-value: 1.52e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2439 FDPEMPLQACLVHTSETIRVCYFMERLMQWRRPVMLVGPAGSGKSVLVGAKLSSLNPEEYMVKNVPFNYYTTSAMLQAVL 2518
Cdd:pfam12775    1 IPPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDKEKYLPLFINFSAQTTSNQTQDII 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2519 EKPLEKKAGRNYGPPGNRKLIYFIDDMNMPEVDAYGTVQPHTVIRQHLDYGHWYDRNKLSLKEIMNVQYISCMNPTAGS- 2597
Cdd:pfam12775   81 ESKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGGGr 160
                          170
                   ....*....|....*....
gi 568973729  2598 FTINPRLQRHFSVFALCFP 2616
Cdd:pfam12775  161 NDITPRLLRHFNVFNITFP 179
DEXSc_Pif1_like cd18037
DEAD-box helicase domain of Pif1; Pif1 and other members of this family are RecD-like ...
2142-2172 2.72e-03

DEAD-box helicase domain of Pif1; Pif1 and other members of this family are RecD-like helicases involved in maintaining genome stability through unwinding double-stranded DNAs (dsDNAs), DNA/RNA hybrids, and G quadruplex (G4) structures. The members of Pif1 helicase subfamily studied so far all appear to contribute to telomere maintenance. Pif1 is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350795 [Multi-domain]  Cd Length: 183  Bit Score: 41.85  E-value: 2.72e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568973729 2142 RHSVFVVGGAGTGKSQVLRSLHKTYQIMRRR 2172
Cdd:cd18037    12 GKNVFFTGSAGTGKSYLLRRIIRALPSRPKR 42
Surf_Exclu_PgrA TIGR04320
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ...
3201-3269 2.94e-03

SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.


Pssm-ID: 275124 [Multi-domain]  Cd Length: 356  Bit Score: 43.18  E-value: 2.94e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568973729  3201 DVEPKRQALNKATSDLTTAQEKLAAIKAKITHLNENLAKLTTKFEK------ATAEKLKCQQEAELTAGTISLAN 3269
Cdd:TIGR04320  269 DLAAAQTALNTAQAALTSAQTAYAAAQAALATAQKELANAQAQALQtaqnnlATAQAALANAEARLAKAKEALAN 343
 
Name Accession Description Interval E-value
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
2985-3330 0e+00

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 667.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2985 EALESVSLRfLQNTKNiEVDDLKAKLATQEVELRHKNEDTDKLIQVVGVETSKVSREKAIADEEEQKVALIMLEVQQKQK 3064
Cdd:pfam12777    1 ERLENGLLK-LHSTAA-QVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3065 DCEEDLAKAEPALTAAQAALNTLNKTNLTELKSFGSPPLAVSNVSAAVMVLMAPGGKVPKDRSWKAAKITMAKVDSFLDS 3144
Cdd:pfam12777   79 ACEEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDS 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3145 LIHFDKENIHENCLKAIRPYLQDPAFNPEFVATKSYAAAGLCSWVINIVRFYEVFCDVEPKRQALNKATSDLTTAQEKLA 3224
Cdd:pfam12777  159 LIKFDKEHIHEACLKAFKPYLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLA 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3225 AIKAKITHLNENLAKLTTKFEKATAEKLKCQQEAELTAGTISLANRLVGGLASENIRWAEAVQNFRQQERTLCGDILLTT 3304
Cdd:pfam12777  239 AIKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLIS 318
                          330       340
                   ....*....|....*....|....*.
gi 568973729  3305 AFISYLGFFTKKYRKSLMDGTWRPYL 3330
Cdd:pfam12777  319 AFISYLGFFTKKYRNELLDKFWIPYI 344
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1830-2156 0e+00

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 649.54  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1830 YSYEYLGNTPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGIMVYVFNCSEQMDYKSCGNIYKG 1909
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1910 LAQTGAWGCFDEFNRISVEVLSVVAVQVKSIQDAIRDKKQRFSFLGEEISLDPSVGIFITMNPGYAGRTELPENLKALFR 1989
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1990 PCAMVVPDFELISEIMLVAEGFIEARLLARKFITLYRLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPDRPEDQVLM 2069
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2070 RSLRDFNIPKIVTDDMPVFMGLIGDLFPALDVPRKRDLDFEAVVRKAIVDLKLQAEDNFVLKVVQLEELLAVRHSVFVVG 2149
Cdd:pfam12774  241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320

                   ....*..
gi 568973729  2150 GAGTGKS 2156
Cdd:pfam12774  321 PTGSGKT 327
DHC_N1 pfam08385
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ...
212-787 0e+00

Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.


Pssm-ID: 462457  Cd Length: 560  Bit Score: 631.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   212 LYAVESAVIKWSHQVQVVLKRESsqaliQGQNPTPKVELEFWKSRCEDLEHIYNQLMTIKVKGMAELLDKLQSSYLPAFK 291
Cdd:pfam08385    1 LHALESVVIKWTKQIQDVLKEDS-----QGRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   292 AMFRDVEAALTEAQDIHVHLLPLQQHLDILENV-EFPKVKGRLRPLLHVVCLIWATCKWYRSPGRLTVLLQEICNLLIQQ 370
Cdd:pfam08385   76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEELtDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   371 ASNYLSPEDLLRSEVEESQKKLQVVSDTLSFFKQAFQDRREHLHTYFKEdsevRVWDFQASLVFVRLDGFLGRVHMVEDL 450
Cdd:pfam08385  156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEESPRE----RPWDFSERYIFGRFDAFLERLEKILEL 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   451 LKTALDLNNLEKLefSGLRGNSLSQKVQRMHEEFEEMYKVFLDCSYDCLDPKGTEFENDVCEFNKRVEDLDRRLGTILIQ 530
Cdd:pfam08385  232 FETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQ 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   531 AFDDAPDVEHAFKLLDITGTLIKRPLVAQDVSQKYLALIRMFSTELDAVRVIYSQHIQKEaehgfSPVHKNMPTMAGGIC 610
Cdd:pfam08385  310 AFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYNP-----SPIAKNMPPVAGAII 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   611 WAQELRQRVKGPFGNFKNIPHLyLQSAEGKRMIQKYEDLLSLLEEYERRLYEDWCQTVSEKSQYNLSLPLLHRDP-NTKQ 689
Cdd:pfam08385  385 WARQLFRRIQEPMKRFKEELGL-LKHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLLVRHPeTGKL 463
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729   690 LSVNFNPQLISVLKEMNYLQPSEVKtIPETAAAMFSSREFYRQLVANLELMANWYNKVIKILLEVEFPLVEEELQNIDLR 769
Cdd:pfam08385  464 LSVNFDPQLLALLREVKYLQKLGFE-IPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEK 542
                          570
                   ....*....|....*...
gi 568973729   770 LRAAEETLSWKTEGIWDY 787
Cdd:pfam08385  543 LEPGLTTLTWNSLGIDEY 560
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
1290-1696 2.42e-152

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 479.83  E-value: 2.42e-152
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1290 LRQCRKEACQLKELWDTIGMVTSSIRAWEATSWRNISVEAMDSECKQFARHIRNLDKEFRSWDAFTGLESTVLNTLTSLR 1369
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1370 AVAELQNPAIRDRHWRQLMQATGVNFTMNQDT-TLAHLLQLQLHHFEDEVRGIVDRAVKEMSMEKTLKELQTTWASMEFQ 1448
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFDPLSEFfTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1449 YESHARTRVPLLQSDEDLIEVLEDNQVQLQNLMMSKYVAFFLEEVSSWQKKLSTADSVISIWFEVQRTWSHLESIFIgSE 1528
Cdd:pfam08393  161 LVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS-SE 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1529 DIRAQLPQDSKRFEGIDSDFRELAYDAQKTPNVVEATNKSGLYEKLEDIQSRLCLCEKALAEYLDTKRLSFPRFYFLSSS 1608
Cdd:pfam08393  240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  1609 DLLDILSNGTAPQQVQRHLSKLFDNMAKMQFqldasqNPTKTSLGMYSKEEEYVAFSE-ACDCSGQVEIWLNRVLRHMKA 1687
Cdd:pfam08393  320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEF------DENKEITGMISKEGEVVPFSKpPVEAKGNVEEWLNELEEEMRE 393

                   ....*....
gi 568973729  1688 TVRHEMTEG 1696
Cdd:pfam08393  394 TLRDLLKEA 402
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4109-4404 2.88e-125

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 397.38  E-value: 2.88e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  4109 TQTSEKLFRTVLEMQPRDSQAGDGAGITREEKVKTFLEEILDRMTDEFNIAELMAK--VEERTPYIVVALQECERMNILT 4186
Cdd:pfam18199    1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKypVGYEDPLNTVLLQEIERFNKLL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  4187 REIQRSLRELHLGLQGELTMTSEMENLQNALYLDVVPESWARRAYPSTAGLAAWFLDLLNRIKELESWTGDFLMPSTVWL 4266
Cdd:pfam18199   81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  4267 TGFFNPQSFLTAIMQSMARKNEWPLDQMALQCDVTKKNR-EEFRSPPREGAYIYGLFMEGACWDTQTGIIAEAKLKDLTP 4345
Cdd:pfam18199  161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKVSpEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568973729  4346 PMPVMFLKAIPADKQDCR-SVYACPVYKTCQRG-PTYVWTFNLKTKENPSKWVLAGVALLL 4404
Cdd:pfam18199  241 PLPVIHLKPVESDKKKLDeNTYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3356-3574 2.18e-108

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 345.58  E-value: 2.18e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3356 AAWQNEGLPADRMSMENATILINCERWPLMVDPQLQGIKWIKNKYGEE-LRVTQIGQKGCLQTIERALEAGDVVLIENLE 3434
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNgLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3435 ESIDPVLGPLLGREVIKKGR--FIKIGDKECEFNPKFRLILHTKLANPHYQPELQAQATLINFTVTRDGLEDQLLAAVVS 3512
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGGrkVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568973729  3513 MERPDLEQLKSDLTKQQNGFKITLKTLEDNLLSRLSSASGNFLGETALVENLEVTKQTAADV 3574
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1517-4070 1.37e-102

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 372.40  E-value: 1.37e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1517 WSHLESIFIGSEDIRAQLPQDSKRFEGIDSDFREL---AYDAQKTPNVVEATNKSGL---YEKLEDIQSrlclcekALAE 1590
Cdd:COG5245   627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIykrVVSGCEAINTILEDVGDDLdlfYKEMDQVFM-------SIEK 699
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1591 YLDTKRLSFPRFyfLSSSDLLDILSNGTAPQQVQRHLSKLFDNMAKMQFQLDASQNPTKTSLgmysKEEEYVAFSEACDc 1670
Cdd:COG5245   700 VLGLRWREVERA--SEVEELMDRVRELENRVYSYRFFVKKIAKEEMKTVFSSRIQKKEPFSL----DSEAYVGFFRLYE- 772
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1671 SGQVEIWLNRVLRHMKATVRHEMTEgvtAYEEKPRDQWLFDYPAQVALTCTQIWwtTEVgiafarLEEGYESAMKDYYKk 1750
Cdd:COG5245   773 KSIVIRGINRSMGRVLSQYLESVQE---ALEIEDGSFFVSRHRVRDGGLEKGRG--CDA------WENCFDPPLSEYFR- 840
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1751 qvaQLKTLITMLIGPLSKGDRQKIMTICTIDVHARDVVaKMIAQKVDNAQAFLWLSQLRHRWDDEAKHCFANICDAQFLY 1830
Cdd:COG5245   841 ---ILEKIFPSEEGYFFDEVLKRLDPGHEIKSRIEEII-RMVTVKYDFCLEVLGSVSISELPQGLYKRFIKVRSSYRSAE 916
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1831 SYEYLGNTPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGIMVyvfncsEQMDYKScgNIYKGL 1910
Cdd:COG5245   917 MFAKNTIPFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGP 984
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1911 AQTGAWGcFDEFNRISvEVLSVVAVQVKSIQDAIRDKKQRFSFLGEEISLDPSVGIFITMNPgyagRTELPENLKALFRP 1990
Cdd:COG5245   985 ICEEERG-TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDM 1058
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 1991 CAMVVPdFELISEIMlvaegfieaRLLARKFITLYRLCKELLSKQDHYDWglRAIKsvlvvaGSLKRGDPDRPE-DQVLM 2069
Cdd:COG5245  1059 FLSNIP-FGAIKSRR---------ESLDREIGAFNNEVDGIAREEDELMF--YPMF------KSLKAKHRMLEEkTEYLN 1120
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2070 RSLRDFNIPkivtddmpvfmgLIGDLFpaldVPRKRDLDFE--AVVRKAIVDLKLQAEDNFVLKVVQLEELLAVRHS--- 2144
Cdd:COG5245  1121 KILSITGLP------------LISDTL----RERIDTLDAEwdSFCRISESLKKYESQQVSGLDVAQFVSFLRSVDTgaf 1184
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2145 VFVVGGAGTGKSqvlrslhKTYQIMrrrpVWTDLNPKAV-TNDELFgiinPATREWKdGLFSSIMRE-LAIISHDGPKWI 2222
Cdd:COG5245  1185 HAEYFRVFLCKI-------KHYTDA----CDYLWHVKSPyVKKKYF----DADMELR-QFFLMFNREdMEARLADSKMEY 1248
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2223 LLDGdidpmWIESLNTVMDDNKVLTLASNERiplnptmRLLFEisHLRTaTPATVSRAGILYINPADLGwnppVSSWIDQ 2302
Cdd:COG5245  1249 EVER-----YVEKTKAEVSSLKLELSSVGEG-------QVVVS--NLGS-IGDKVGRCLVEYDSISRLS----TKGVFLD 1309
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2303 REVQTERanltilfdkYLPTCLDTLRT-RFKKIIpvpeqSMIQMLCYLLECLLTKEDIPADCPKEIYE--LYFVFAAIWA 2379
Cdd:COG5245  1310 ELGDTKR---------YLDECLDFFSCfEEVQKE-----IDELSMVFCADALRFSADLYHIVKERRFSgvLAGSDASESL 1375
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2380 FGS-----AVIQDQ-LVDY---------------------RAEFSKWWLTEF----KTVKFPSQGTVFDYYIDPETKKFE 2428
Cdd:COG5245  1376 GGKsielaAILEHKdLIVEmkrgindvlklrifgdkcresTPRFYLISDGDLikdlNERSDYEEMLIMMFNISAVITNNG 1455
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2429 PwaklIPQFEFDPE--MPLQACLVHTSETIRVCYFMERLMQWRRPVMLVGPAGSGKSVLVGAKLssLNPEEYMVKNVPFN 2506
Cdd:COG5245  1456 S----IAGFELRGErvMLRKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSL--RSELITEVKYFNFS 1529
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2507 YYTTSAMLQAVLEKPLEK----KAGRNYGPPGNRKLIYFIDDMNMPEVDAYGtvqPHTVI---RQHLDYGHWYDRNKLSL 2579
Cdd:COG5245  1530 TCTMTPSKLSVLERETEYypntGVVRLYPKPVVKDLVLFCDEINLPYGFEYY---PPTVIvflRPLVERQGFWSSIAVSW 1606
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2580 KEIMNVQYISCMNP--TAGSFTINPRLQRHFSVFALCFPGADALSSIYSTILTH-HLKFGNFPTTlqksIPPLINLAVTF 2656
Cdd:COG5245  1607 VTICGIILYGACNPgtDEGRVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMGsYLCFDEFNRL----SEETMSASVEL 1682
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2657 HQKIATTFlPTAIKFHYIFNLRDFANIFQGIlFSSVECVKSTQD--LVKLYLHESSRVYRDKMVEEKDFNLFDKIQTEFL 2734
Cdd:COG5245  1683 YLSSKDKT-KFFLQMNYGYKPRELTRSLRAI-FGYAETRIDTPDvsLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFG 1760
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2735 KKNFDDSEEVLKQTQNLNMYCHFANGIGEpkympvqswdLLNQTLVEALE--------SHNEVnavmDLVLFEDAIRHIC 2806
Cdd:COG5245  1761 LRAIREMIAGHIGEAEITFSMILFFGMAC----------LLKKDLAVFVEevrkifgsSHLDV----EAVAYKDALLHIL 1826
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2807 HINRILESPRGNALLVGVGGSGKQSLTKLAAFISSMDVFQITLRKGYQIPDFKVDLASLCLKAGVKNLSTVFLMTDAHVA 2886
Cdd:COG5245  1827 RSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPV 1906
                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2887 DERFLVLINDLLASGEIPDLYSDEEEENIINNVRNEVKSQGL-MDSRENCWKFFIERVQRQLKV--TLCfSPVGNKLRIR 2963
Cdd:COG5245  1907 ESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVvfSAC-CSQDTSVLAG 1985
                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 2964 SRkFPAIVNCTAINWFHEWPQEALESVSLRFLQ-------------NTKNIE---------------------------- 3002
Cdd:COG5245  1986 IR-SPALKNRCFIDFKKLWDTEEMSQYANSVETlsrdggrvffingELGVGKgalisevfgddavviegrgfeismiegs 2064
                        1610      1620      1630      1640      1650      1660      1670      1680
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3003 ----------------------------------------------VDDLKAKLATQEVELRHKNEDTDKLIQVVGVETS 3036
Cdd:COG5245  2065 lgeskikfigglkvydarcviyieeldctnvnlvegvrkyneygrgMGELKEQLSNTVVILGVKEKNADDALSGTPGERL 2144
                        1690      1700      1710      1720      1730      1740      1750      1760
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3037 KVSREKAIADEEEQKVALIMLEVQQKQKDCEEDLAKAEPALTAAQAALNTLNKTNLTELKSFGSPPLAVSNVSAAVMVLM 3116
Cdd:COG5245  2145 EREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL 2224
                        1770      1780      1790      1800      1810      1820      1830      1840
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3117 APGGKVpkdrsWKAAKITMaKVDSFLDSLIHFDKE-NIHENCLKAIRP-YLQDPAFNPEFVATKSYAAAGLCSWVINIVR 3194
Cdd:COG5245  2225 GFEAKI-----WFGEQQSL-RRDDFIRIIGKYPDEiEFDLEARRFREArECSDPSFTGSILNRASKACGPLKRWLVRECN 2298
                        1850      1860      1870      1880      1890      1900      1910      1920
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3195 FYEVFCDVEPKRQALNKATSDLTTAQEKLAAIKAKITHLNENLAKLTTKFE---------KATAEKLKCQQEAELTAGTI 3265
Cdd:COG5245  2299 RSKVLEVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYSldilrvhgkIADMDTVHKDVLRSIFVSEI 2378
                        1930      1940      1950      1960      1970      1980      1990      2000
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3266 slanrlvggLASENIRWAEAVQNFRQQERTLCGDILLTTAFISYLGFfTKKYRKSLMDGTWRPYLSQlKVPIPTTPTLDP 3345
Cdd:COG5245  2379 ---------LINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGT-LGFLCRAIEFGMSFIRISK-EFRDKEIRRRQF 2447
                        2010      2020      2030      2040      2050      2060      2070      2080
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3346 L-RMLTDDAEVAAWQNeglpADRMSMENATILINCER-WPLMVDPQLQGIKWIKNKYGEELRV-TQIGQKGCLQTIERAL 3422
Cdd:COG5245  2448 ItEGVQKIEDFKEEAC----STDYGLENSRIRKDLQDlTAVLNDPSSKIVTSQRQMYDEKKAIlGSFREMEFAFGLSQAR 2523
                        2090      2100      2110      2120      2130      2140      2150      2160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3423 EAGDVVLIENlEESIDPVLGPLLGREVIKKGRFIK--IGDKECEFNPKFRLILHTKLANPHYQPELQAQATLINFTVTRD 3500
Cdd:COG5245  2524 REGSDKIIGD-AEALDEEIGRLIKEEFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVL 2602
                        2170      2180      2190      2200      2210      2220      2230      2240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3501 GLEDQLLAAVVSMERPDLEQLKSDLTKQQNGFKITLKTLEDNLLSRLSSASGNFLGETALVENLEVTKQTAADVEEKVQE 3580
Cdd:COG5245  2603 GCETEIPDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESE 2682
                        2250      2260      2270      2280      2290      2300      2310      2320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3581 AKLTEVKINEAREHYRPAAARASLLYFIMNDLSKIHPMYQFSLKAFSIVFQKAVEKAApseSVTERVTNLIDSITFSVYQ 3660
Cdd:COG5245  2683 SMEIEDRIDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSSEFEKWRRMKS---KYLCAIRYMLMSSEWILDH 2759
                        2330      2340      2350      2360      2370      2380      2390      2400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3661 YTTRG-LFECDKLTYL--AQLTFQILLVN---QEVNAAELDFLlrapvqtgtpspmEFLSHQAWGG-------IKALSSM 3727
Cdd:COG5245  2760 EDRSGfIHRLDVSFLLrtKRFVSTLLEDKnyrQVLSSCSLYGN-------------DVISHSCDRFdrdvyraLKHQMDN 2826
                        2410      2420      2430      2440      2450      2460      2470      2480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3728 EEFCNLDRDIegSAKSWKKfvesecpeKEKFPQEWKNKtalqrlcmmramrpdrmtyamrdFVEEKLGSKYVMGRALDfv 3807
Cdd:COG5245  2827 RTHSTILTSN--SKTNPYK--------EYTYNDSWAEA-----------------------FEVEDSGDLYKFEEGLL-- 2871
                        2490      2500      2510      2520      2530      2540      2550      2560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3808 tsfEESGPATPMFFILSPGVDPLKDVENQGKKlgytfnnrnfhnvslgqGQEVVAEAALDLAAKKGHWVILQNIHLVAKW 3887
Cdd:COG5245  2872 ---ELIVGHAPLIYAHKKSLENERNVDRLGSK-----------------ENEVYAVLNSLFSRKEKSWFEVYNISLSFGW 2931
                        2570      2580      2590      2600      2610      2620      2630      2640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3888 LST--LEKKLEELSEESHPDFRVFISAepapSPEGHIIPQGILENSIKITNEPPTGMHANLHK--ALDNFTQDTLEMCSR 3963
Cdd:COG5245  2932 FKRyvEDVVYPIKASRVCGKVKNMWTS----MVDADMLPIQLLIAIDSFVSSTYPETGCGYADlvEIDRYPFDYTLVIAC 3007
                        2650      2660      2670      2680      2690      2700      2710      2720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729 3964 EtefktILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFLEANT--KVPYDDLRYLFGEIMYGGHITDD 4041
Cdd:COG5245  3008 D-----DAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLM 3082
                        2730      2740      2750
                  ....*....|....*....|....*....|...
gi 568973729 4042 WD----RRLCRTYLEEFIRPEMLEGELSLAPGF 4070
Cdd:COG5245  3083 EDskvvDKYCRGYGAHETSSQILASVPGGDPEL 3115
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
2439-2616 1.52e-91

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 295.46  E-value: 1.52e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2439 FDPEMPLQACLVHTSETIRVCYFMERLMQWRRPVMLVGPAGSGKSVLVGAKLSSLNPEEYMVKNVPFNYYTTSAMLQAVL 2518
Cdd:pfam12775    1 IPPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDKEKYLPLFINFSAQTTSNQTQDII 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2519 EKPLEKKAGRNYGPPGNRKLIYFIDDMNMPEVDAYGTVQPHTVIRQHLDYGHWYDRNKLSLKEIMNVQYISCMNPTAGS- 2597
Cdd:pfam12775   81 ESKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGGGr 160
                          170
                   ....*....|....*....
gi 568973729  2598 FTINPRLQRHFSVFALCFP 2616
Cdd:pfam12775  161 NDITPRLLRHFNVFNITFP 179
AAA_8 pfam12780
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2793-3017 2.65e-90

P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.


Pssm-ID: 463701 [Multi-domain]  Cd Length: 259  Bit Score: 295.29  E-value: 2.65e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2793 MDLVLFEDAIRHICHINRILESPRGNALLVGVGGSGKQSLTKLAAFISSMDVFQITLRKGYQIPDFKVDLASLCLKAGVK 2872
Cdd:pfam12780    1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2873 NLSTVFLMTDAHVADERFLVLINDLLASGEIPDLYSDEEEENIINNVRNEVKSQGLMDSRENCWKFFIERVQRQLKVTLC 2952
Cdd:pfam12780   81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568973729  2953 FSPVGNKLRIRSRKFPAIVNCTAINWFHEWPQEALESVSLRFLQNTKNIEvdDLKAKLATQEVEL 3017
Cdd:pfam12780  161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPE--ELKSNVVKVFVYV 223
AAA_lid_11 pfam18198
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ...
3967-4103 2.68e-72

Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.


Pssm-ID: 465676  Cd Length: 139  Bit Score: 238.51  E-value: 2.68e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3967 FKTILFALCYFHAVVAERRKFGPQGWNRSYPFNTGDLTISVNVLYNFL-EANTKVPYDDLRYLFGEIMYGGHITDDWDRR 4045
Cdd:pfam18198    1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLdEYDEKIPWDALRYLIGEINYGGRVTDDWDRR 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  4046 LCRTYLEEFIRPEMLEGELSLAPG-FPLPGNMDYSGYHQYIDaELP-PESPYLYGLHPNA 4103
Cdd:pfam18198   81 LLNTYLEEFFNPEVLEEDFKFSPSlYYIPPDGDLEDYLEYIE-SLPlVDSPEVFGLHPNA 139
AAA_lid_1 pfam17857
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
2649-2748 5.40e-51

AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.


Pssm-ID: 465535 [Multi-domain]  Cd Length: 100  Bit Score: 176.28  E-value: 5.40e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2649 LINLAVTFHQKIATTFLPTAIKFHYIFNLRDFANIFQGILFSSVECVKSTQDLVKLYLHESSRVYRDKMVEEKDFNLFDK 2728
Cdd:pfam17857    1 LIAAALAFHQKIAATFLPTAIKFHYIFNLRDFANIFQGILFSSAECLKSPLDLIRLWLHESERVYGDKMVDEKDFDLFDK 80
                           90       100
                   ....*....|....*....|
gi 568973729  2729 IQTEFLKKNFDDSEEVLKQT 2748
Cdd:pfam17857   81 IQMASLKKFFDDIEDELEFA 100
Dynein_heavy pfam03028
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ...
3815-3935 5.17e-46

Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.


Pssm-ID: 460782  Cd Length: 115  Bit Score: 162.61  E-value: 5.17e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  3815 PATPMFFILSPGVDPLKDVENQGKKLGYtfnNRNFHNVSLGQGQEVVAEAALDLAAKKGHWVILQNIHLVAKWLST-LEK 3893
Cdd:pfam03028    2 PTTPLIFILSPGSDPTADLEKLAKKLGF---GGKLHSISLGQGQGPIAEKLIEEAAKEGGWVLLQNCHLALSWMPElEKI 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 568973729  3894 KLEELSEESHPDFRVFISAEPAPSpeghiIPQGILENSIKIT 3935
Cdd:pfam03028   79 LEELPEETLHPDFRLWLTSEPSPK-----FPISILQNSIKIT 115
Dynein_AAA_lid pfam17852
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ...
2315-2430 2.09e-30

Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.


Pssm-ID: 465532 [Multi-domain]  Cd Length: 126  Bit Score: 118.54  E-value: 2.09e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2315 LFDKYLPTCLDTLRTRFKKIIPVPEQSMIQMLCYLLECLLTK-------EDIPADCPKEIYELYFVFAAIWAFGSAVIQD 2387
Cdd:pfam17852    4 LFEWLVPPALEFVRKNCKEIVPTSDLNLVQSLCRLLESLLDEvleyngvHPLSPDKLKEYLEKLFLFALVWSIGGTLDED 83
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 568973729  2388 QlvdyRAEFSKWWLTEFKTVKFP--SQGTVFDYYIDPETKKFEPW 2430
Cdd:pfam17852   84 S----RKKFDEFLRELFSGLDLPppEKGTVYDYFVDLEKGEWVPW 124
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
2144-2279 1.32e-14

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 73.48  E-value: 1.32e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2144 SVFVVGGAGTGKSQVLRSLHKtyqIMRRRPVWTDLNPKAVTNDELFGIINPATR--EWKDGLFSSIMRElaiishdgpKW 2221
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAA---ALSNRPVFYVQLTRDTTEEDLFGRRNIDPGgaSWVDGPLVRAARE---------GE 68
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568973729  2222 ILLDGDID---PMWIESLNTVMDDNKVLTLASNERIPL-----------NPTMRLLFEIShlrtatPATVSR 2279
Cdd:pfam07728   69 IAVLDEINranPDVLNSLLSLLDERRLLLPDGGELVKAapdgfrliatmNPLDRGLNELS------PALRSR 134
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
2471-2608 8.79e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 45.36  E-value: 8.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973729  2471 PVMLVGPAGSGKSVLVGAKLSSLNPEEYMVknVPFNYYTTSA-MLQAVLEKPLEKKagRNYGP---PGNRKLIYFIDDMN 2546
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAALSNRPVFY--VQLTRDTTEEdLFGRRNIDPGGAS--WVDGPlvrAAREGEIAVLDEIN 76
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568973729  2547 MPEVDAYGTVqpHTVI---RQHLDYGHWYDRNKLSlkeimNVQYISCMNPT-AGSFTINPRLQRHF 2608
Cdd:pfam07728   77 RANPDVLNSL--LSLLderRLLLPDGGELVKAAPD-----GFRLIATMNPLdRGLNELSPALRSRF 135
DEXSc_Pif1_like cd18037
DEAD-box helicase domain of Pif1; Pif1 and other members of this family are RecD-like ...
2142-2172 2.72e-03

DEAD-box helicase domain of Pif1; Pif1 and other members of this family are RecD-like helicases involved in maintaining genome stability through unwinding double-stranded DNAs (dsDNAs), DNA/RNA hybrids, and G quadruplex (G4) structures. The members of Pif1 helicase subfamily studied so far all appear to contribute to telomere maintenance. Pif1 is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350795 [Multi-domain]  Cd Length: 183  Bit Score: 41.85  E-value: 2.72e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568973729 2142 RHSVFVVGGAGTGKSQVLRSLHKTYQIMRRR 2172
Cdd:cd18037    12 GKNVFFTGSAGTGKSYLLRRIIRALPSRPKR 42
Surf_Exclu_PgrA TIGR04320
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ...
3201-3269 2.94e-03

SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.


Pssm-ID: 275124 [Multi-domain]  Cd Length: 356  Bit Score: 43.18  E-value: 2.94e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568973729  3201 DVEPKRQALNKATSDLTTAQEKLAAIKAKITHLNENLAKLTTKFEK------ATAEKLKCQQEAELTAGTISLAN 3269
Cdd:TIGR04320  269 DLAAAQTALNTAQAALTSAQTAYAAAQAALATAQKELANAQAQALQtaqnnlATAQAALANAEARLAKAKEALAN 343
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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