U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nos-3 Nanos-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174535, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nos-3
    Official Full Name
    Nanos-type domain-containing protein
    Primary source
    WormBase:WBGene00003785
    Locus tag
    CELE_Y53C12B.3
    See related
    AllianceGenome:WB:WBGene00003785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Involved in positive regulation of meiotic nuclear division. Located in cytoplasm. Is expressed in several structures, including Psub1; Psub2; Psub3; Psub4; and germ line. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nos-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (9746316..9750462)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RNA-binding protein pno-1 Neighboring gene U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein Neighboring gene Secreted protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An improved in vivo tethering assay with single molecule FISH reveals that a nematode Nanos enhances reporter expression and mRNA stability. Doenier J, et al. RNA, 2021 Jun. PMID 33727224, Free PMC Article
    2. Repressive translational control in germ cells. Lai F, et al. Mol Reprod Dev, 2013 Aug. PMID 23408501
    3. GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans. Eckmann CR, et al. Genetics, 2004 Sep. PMID 15454534, Free PMC Article
    4. C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival. Kapelle WS, et al. Genesis, 2011 May. PMID 21305687
    5. NANOS-3 and FBF proteins physically interact to control the sperm-oocyte switch in Caenorhabditis elegans. Kraemer B, et al. Curr Biol, 1999 Sep 23. PMID 10508609

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An improved in vivo tethering assay with single molecule FISH reveals that a nematode Nanos enhances reporter expression and mRNA stability.
      Title: An improved in vivo tethering assay with single molecule FISH reveals that a nematode Nanos enhances reporter expression and mRNA stability.
    2. Data indicate that meg-1 and meg-2 differentially interact with the nanos family nos-1, nos-2 and nos-3 for germ cell proliferaiton.
      Title: C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival.
    3. nos-3 loss of function mutant suppresses the lethality of par-2 mutants by regulating PAR-6 protein levels.
      Title: PAR-6 levels are regulated by NOS-3 in a CUL-2 dependent manner in Caenorhabditiselegans.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of meiotic nuclear division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Nanos-type domain-containing protein
    NP_001379360.1
    • Confirmed by transcript evidence
    NP_001379361.1
    • Confirmed by transcript evidence
    NP_001382696.1
    • Confirmed by transcript evidence
    NP_496101.1
    • Partially confirmed by transcript evidence
    NP_496102.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9746316..9750462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393165.1 → NP_001379360.1  Nanos-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9XMZ3
      Conserved Domains (2) summary
      TIGR01628
      Location:129 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam05741
      Location:718 → 770
      zf-nanos; Nanos RNA binding domain

    2. NM_001393164.1 → NP_001379361.1  Nanos-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9XLP7
      Conserved Domains (2) summary
      TIGR01628
      Location:129 → 347
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam05741
      Location:715 → 767
      zf-nanos; Nanos RNA binding domain

    3. NM_063701.5 → NP_496102.1  Nanos-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496102.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18217, O18218
      Conserved Domains (2) summary
      TIGR01628
      Location:111 → 329
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam05741
      Location:697 → 749
      zf-nanos; Nanos RNA binding domain

    4. NM_063700.4 → NP_496101.1  Nanos-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496101.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62486
      Conserved Domains (2) summary
      TIGR01628
      Location:111 → 329
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam05741
      Location:700 → 752
      zf-nanos; Nanos RNA binding domain

    5. NM_001395805.1 → NP_001382696.1  Nanos-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7R9XN27
      Conserved Domains (1) summary
      pfam05741
      Location:584 → 636
      zf-nanos; Nanos RNA binding domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools