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Conserved domains on  [gi|1972253774|ref|NP_001379361|]
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Nanos-type domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-nanos pfam05741
Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains ...
 715-768 1.53e-22

Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.


:

Pssm-ID: 461728  Cd Length: 54  Bit Score: 91.10  E-value: 1.53e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1972253774 715 CYRCEHYQLPAEEVSSHNIRKDNGDLWCEHMKKIKCGHCEATGEQGHHPLICPK 768
Cdd:pfam05741   1 CVFCKNNGESREVYSSHTLKDPDGRVTCPVLRKYVCPICGATGDNAHTIKYCPK 54
PABP-1234 super family cl31127
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 129-347 2.96e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


The actual alignment was detected with superfamily member TIGR01628:

Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 44.41  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972253774 129 QQQFSQMRPQPPHTGPPNGMtyyGGTVGAPGYqqqqpppqegydqqqqfgggsdggqYQRGPPGGYRQYQQMESGGPPSG 208
Cdd:TIGR01628 372 QDQFMQLQPRMRQLPMGSPM---GGAMGQPPY-------------------------YGQGPQQQFNGQPLGWPRMSMMP 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972253774 209 YADDNNGGNnnfvihGPNdnfdGRPQYNPQaGPPPQNQQQMMnsgnyeidqyrgqGPPPgntyqQQGHSGQAQYYAGPVI 288
Cdd:TIGR01628 424 TPMGPGGPL------RPN----GLAPMNAV-RAPSRNAQNAA-------------QKPP-----MQPVMYPPNYQSLPLS 474

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972253774 289 QQRPPPPHNAqsygqyrGPQGPQGQIIQMMPHNPQNQQQQQQHPMLYPMVYV--PVPAPRV 347
Cdd:TIGR01628 475 QDLPQPQSTA-------SQGGQNKKLAQVLASATPQMQKQVLGERLFPLVEAiePALAAKI 528
 
Name Accession Description Interval E-value
zf-nanos pfam05741
Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains ...
 715-768 1.53e-22

Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.


Pssm-ID: 461728  Cd Length: 54  Bit Score: 91.10  E-value: 1.53e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1972253774 715 CYRCEHYQLPAEEVSSHNIRKDNGDLWCEHMKKIKCGHCEATGEQGHHPLICPK 768
Cdd:pfam05741   1 CVFCKNNGESREVYSSHTLKDPDGRVTCPVLRKYVCPICGATGDNAHTIKYCPK 54
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 129-347 2.96e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 44.41  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972253774 129 QQQFSQMRPQPPHTGPPNGMtyyGGTVGAPGYqqqqpppqegydqqqqfgggsdggqYQRGPPGGYRQYQQMESGGPPSG 208
Cdd:TIGR01628 372 QDQFMQLQPRMRQLPMGSPM---GGAMGQPPY-------------------------YGQGPQQQFNGQPLGWPRMSMMP 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972253774 209 YADDNNGGNnnfvihGPNdnfdGRPQYNPQaGPPPQNQQQMMnsgnyeidqyrgqGPPPgntyqQQGHSGQAQYYAGPVI 288
Cdd:TIGR01628 424 TPMGPGGPL------RPN----GLAPMNAV-RAPSRNAQNAA-------------QKPP-----MQPVMYPPNYQSLPLS 474

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972253774 289 QQRPPPPHNAqsygqyrGPQGPQGQIIQMMPHNPQNQQQQQQHPMLYPMVYV--PVPAPRV 347
Cdd:TIGR01628 475 QDLPQPQSTA-------SQGGQNKKLAQVLASATPQMQKQVLGERLFPLVEAiePALAAKI 528
 
Name Accession Description Interval E-value
zf-nanos pfam05741
Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains ...
 715-768 1.53e-22

Nanos RNA binding domain; This family consists of several conserved novel zinc finger domains found in the eukaryotic proteins Nanos and Xcat-2. In Drosophila melanogaster, Nanos functions as a localized determinant of posterior pattern. Nanos RNA is localized to the posterior pole of the maturing egg cell and encodes a protein that emanates from this localized source. Nanos acts as a translational repressor and thereby establishes a gradient of the morphogen Hunchback. Xcat-2 is found in the vegetal cortical region and is inherited by the vegetal blasomeres during development, and is degraded very early in development. The localized and maternally restricted expression of Xcat-2 RNA suggests a role for its protein in setting up regional differences in gene expression that occur early in development.


Pssm-ID: 461728  Cd Length: 54  Bit Score: 91.10  E-value: 1.53e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1972253774 715 CYRCEHYQLPAEEVSSHNIRKDNGDLWCEHMKKIKCGHCEATGEQGHHPLICPK 768
Cdd:pfam05741   1 CVFCKNNGESREVYSSHTLKDPDGRVTCPVLRKYVCPICGATGDNAHTIKYCPK 54
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 129-347 2.96e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 44.41  E-value: 2.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972253774 129 QQQFSQMRPQPPHTGPPNGMtyyGGTVGAPGYqqqqpppqegydqqqqfgggsdggqYQRGPPGGYRQYQQMESGGPPSG 208
Cdd:TIGR01628 372 QDQFMQLQPRMRQLPMGSPM---GGAMGQPPY-------------------------YGQGPQQQFNGQPLGWPRMSMMP 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972253774 209 YADDNNGGNnnfvihGPNdnfdGRPQYNPQaGPPPQNQQQMMnsgnyeidqyrgqGPPPgntyqQQGHSGQAQYYAGPVI 288
Cdd:TIGR01628 424 TPMGPGGPL------RPN----GLAPMNAV-RAPSRNAQNAA-------------QKPP-----MQPVMYPPNYQSLPLS 474

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972253774 289 QQRPPPPHNAqsygqyrGPQGPQGQIIQMMPHNPQNQQQQQQHPMLYPMVYV--PVPAPRV 347
Cdd:TIGR01628 475 QDLPQPQSTA-------SQGGQNKKLAQVLASATPQMQKQVLGERLFPLVEAiePALAAKI 528
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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