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    dex-1 Dendrite extension defective protein 1 [ Caenorhabditis elegans ]

    Gene ID: 175761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dex-1
    Official Full Name
    Dendrite extension defective protein 1
    Primary source
    WormBase:WBGene00017028
    Locus tag
    CELE_D1044.2
    See related
    AllianceGenome:WB:WBGene00017028
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Involved in amphid sensory organ dendrite retrograde extension. Located in dendrite membrane. Is expressed in anterior deirid sensillum; epithelial cell; excretory system; pharynx; and rectum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dex-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    15
    Sequence:
    Chromosome: III; NC_003281.10 (5526104..5535507)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene putative kinase-like protein D1044.1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epidermal Remodeling in Caenorhabditis elegans Dauers Requires the Nidogen Domain Protein DEX-1. Flatt KM, et al. Genetics, 2019 Jan. PMID 30409788, Free PMC Article
    2. DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration. Heiman MG, et al. Cell, 2009 Apr 17. PMID 19344940, Free PMC Article
    3. Epithelial Shaping by Diverse Apical Extracellular Matrices Requires the Nidogen Domain Protein DEX-1 in Caenorhabditis elegans. Cohen JD, et al. Genetics, 2019 Jan. PMID 30409789, Free PMC Article
    4. The glia of Caenorhabditis elegans. Oikonomou G, et al. Glia, 2011 Sep. PMID 21732423, Free PMC Article
    5. Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126). Schmitz C, et al. Proc Natl Acad Sci U S A, 2007 Jan 16. PMID 17213328, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DEX-1 is a component of embryonic ECMs that shapes developing epithelia.
      Title: Epithelial Shaping by Diverse Apical Extracellular Matrices Requires the Nidogen Domain Protein DEX-1 in Caenorhabditis elegans.
    2. DEX-1 is an extracellular matrix component that plays a central role in C. elegans epidermal remodeling during dauer.
      Title: Epidermal Remodeling in Caenorhabditis elegans Dauers Requires the Nidogen Domain Protein DEX-1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in amphid sensory organ dendrite retrograde extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in amphid sensory organ dendrite retrograde extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dendrite extension defective protein 1
    NP_001379843.1
    • Confirmed by transcript evidence
    NP_498181.3
    • Partially confirmed by transcript evidence
    NP_498182.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5526104..5535507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065781.6 → NP_498182.2  Dendrite extension defective protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498182.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D7SFI8, P41950, Q8TA75, Q95QP5, Q95QP6
      Conserved Domains (2) summary
      smart00539
      Location:163 → 304
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      pfam12947
      Location:413 → 445
      EGF_3; EGF domain

    2. NM_001392098.1 → NP_001379843.1  Dendrite extension defective protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      smart00539
      Location:146 → 287
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      pfam12947
      Location:396 → 428
      EGF_3; EGF domain

    3. NM_065780.6 → NP_498181.3  Dendrite extension defective protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498181.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41950
      Conserved Domains (2) summary
      smart00539
      Location:146 → 287
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      pfam12947
      Location:396 → 428
      EGF_3; EGF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41950.3

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