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Conserved domains on  [gi|392895020|ref|NP_498181|]
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Dendrite extension defective protein 1 [Caenorhabditis elegans]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 11272510)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
146-287 1.25e-50

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 175.31  E-value: 1.25e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895020    146 PFWNRNDLRNGGKVYYREVTKGRVLERGQSEIRYQYDKNV--KVKSALIITWDKMQPLNTAALPeeNTNTFQAAIFITAN 223
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGgfRAKSVVIVTWENVAAYGSQSSD--GTNTFQAVLATDGS 78

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392895020    224 GTFANFIYSNIGWT----------QGAEAGFNAGDATNHFKLPTSGTPNIMYLEEYGNTGIPGEWMFELSELRV 287
Cdd:smart00539   79 RTYAIFLYPSLGWTsdttaggddgVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
502-644 4.79e-34

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


:

Pssm-ID: 214712  Cd Length: 152  Bit Score: 127.93  E-value: 4.79e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895020    502 PFFGPIDLSRNGAVSVEEVDDVEVLRRVTRTIGENY-NDPTFVAKSALVVTFSNVTD---GRQTKGNTFQALLIDgsnsk 577
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFtDMGGFRAKSVVIVTWENVAAygsQSSDGTNTFQAVLAT----- 75

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392895020    578 NEKMTFVELMYRDLPWASG----------AEAGILSSDASSSILLPASGTEAISQLSKNSNIKQPGTWLYRIDKAQL 644
Cdd:smart00539   76 DGSRTYAIFLYPSLGWTSDttaggddgvrARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 396-428 2.61e-12

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 61.85  E-value: 2.61e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392895020   396 CKTNSTICHKNAICTNTPGRYFCMCKEGFSGDG 428
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDG 33
 
Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
146-287 1.25e-50

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 175.31  E-value: 1.25e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895020    146 PFWNRNDLRNGGKVYYREVTKGRVLERGQSEIRYQYDKNV--KVKSALIITWDKMQPLNTAALPeeNTNTFQAAIFITAN 223
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGgfRAKSVVIVTWENVAAYGSQSSD--GTNTFQAVLATDGS 78

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392895020    224 GTFANFIYSNIGWT----------QGAEAGFNAGDATNHFKLPTSGTPNIMYLEEYGNTGIPGEWMFELSELRV 287
Cdd:smart00539   79 RTYAIFLYPSLGWTsdttaggddgVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
502-644 4.79e-34

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 127.93  E-value: 4.79e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895020    502 PFFGPIDLSRNGAVSVEEVDDVEVLRRVTRTIGENY-NDPTFVAKSALVVTFSNVTD---GRQTKGNTFQALLIDgsnsk 577
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFtDMGGFRAKSVVIVTWENVAAygsQSSDGTNTFQAVLAT----- 75

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392895020    578 NEKMTFVELMYRDLPWASG----------AEAGILSSDASSSILLPASGTEAISQLSKNSNIKQPGTWLYRIDKAQL 644
Cdd:smart00539   76 DGSRTYAIFLYPSLGWTSDttaggddgvrARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 211-282 1.20e-18

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 81.57  E-value: 1.20e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895020   211 TNTFQAAIFITANGTFANFIYSNIG--WTQG-------------AEAGFNAGDA-TNHFKLPTSGTPNIMYLEEYGNTGI 274
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDGGiqWTTGkasggtnglggtpAQAGFSAGDGdGRYYELPGSGTDSIRNLTETSNVGV 80


                   ....*...
gi 392895020   275 PGEWMFEL 282
Cdd:pfam06119   81 PGRWVFRI 88
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 396-428 2.61e-12

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 61.85  E-value: 2.61e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392895020   396 CKTNSTICHKNAICTNTPGRYFCMCKEGFSGDG 428
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDG 33
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 564-640 1.68e-10

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 58.46  E-value: 1.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895020   564 NTFQALLIDgsnskNEKMTFVELMY--RDLPWASG-------------AEAGILSSDASSSIL-LPASGTEAISQLSKNS 627
Cdd:pfam06119    2 NTFQAVLAT-----DGSGSFAIFNYpdGGIQWTTGkasggtnglggtpAQAGFSAGDGDGRYYeLPGSGTDSIRNLTETS 76

                           90
                   ....*....|...
gi 392895020   628 NIKQPGTWLYRID 640
Cdd:pfam06119   77 NVGVPGRWVFRID 89
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 392-427 2.52e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.41  E-value: 2.52e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 392895020  392 DVDECKTNStICHKNAICTNTPGRYFCMCKEGFSGD 427
Cdd:cd00054     1 DIDECASGN-PCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
392-430 1.42e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 51.48  E-value: 1.42e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 392895020    392 DVDECKTNStICHKNAICTNTPGRYFCMCKEGFSgDGQN 430
Cdd:smart00179    1 DIDECASGN-PCQNGGTCVNTVGSYRCECPPGYT-DGRN 37
 
Name Accession Description Interval E-value
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
146-287 1.25e-50

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 175.31  E-value: 1.25e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895020    146 PFWNRNDLRNGGKVYYREVTKGRVLERGQSEIRYQYDKNV--KVKSALIITWDKMQPLNTAALPeeNTNTFQAAIFITAN 223
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFTDMGgfRAKSVVIVTWENVAAYGSQSSD--GTNTFQAVLATDGS 78

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392895020    224 GTFANFIYSNIGWT----------QGAEAGFNAGDATNHFKLPTSGTPNIMYLEEYGNTGIPGEWMFELSELRV 287
Cdd:smart00539   79 RTYAIFLYPSLGWTsdttaggddgVRARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
NIDO smart00539
Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;
502-644 4.79e-34

Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins;


Pssm-ID: 214712  Cd Length: 152  Bit Score: 127.93  E-value: 4.79e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895020    502 PFFGPIDLSRNGAVSVEEVDDVEVLRRVTRTIGENY-NDPTFVAKSALVVTFSNVTD---GRQTKGNTFQALLIDgsnsk 577
Cdd:smart00539    1 PFWADADTEGTGKVYYRETTDHAILDRATESVREGFtDMGGFRAKSVVIVTWENVAAygsQSSDGTNTFQAVLAT----- 75

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392895020    578 NEKMTFVELMYRDLPWASG----------AEAGILSSDASSSILLPASGTEAISQLSKNSNIKQPGTWLYRIDKAQL 644
Cdd:smart00539   76 DGSRTYAIFLYPSLGWTSDttaggddgvrARAGFNGGDGTFSYTLPASGEENIKNLAEGSNVGIPGRWMFRVDGAEI 152
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 211-282 1.20e-18

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 81.57  E-value: 1.20e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895020   211 TNTFQAAIFITANGTFANFIYSNIG--WTQG-------------AEAGFNAGDA-TNHFKLPTSGTPNIMYLEEYGNTGI 274
Cdd:pfam06119    1 TNTFQAVLATDGSGSFAIFNYPDGGiqWTTGkasggtnglggtpAQAGFSAGDGdGRYYELPGSGTDSIRNLTETSNVGV 80


                   ....*...
gi 392895020   275 PGEWMFEL 282
Cdd:pfam06119   81 PGRWVFRI 88
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 396-428 2.61e-12

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 61.85  E-value: 2.61e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 392895020   396 CKTNSTICHKNAICTNTPGRYFCMCKEGFSGDG 428
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDG 33
NIDO pfam06119
Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found ...
 564-640 1.68e-10

Nidogen-like; This is a nidogen-like domain (NIDO) domain and is an extracellular domain found in nidogen and hypothetical proteins of unknown function.


Pssm-ID: 461833  Cd Length: 90  Bit Score: 58.46  E-value: 1.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392895020   564 NTFQALLIDgsnskNEKMTFVELMY--RDLPWASG-------------AEAGILSSDASSSIL-LPASGTEAISQLSKNS 627
Cdd:pfam06119    2 NTFQAVLAT-----DGSGSFAIFNYpdGGIQWTTGkasggtnglggtpAQAGFSAGDGDGRYYeLPGSGTDSIRNLTETS 76

                           90
                   ....*....|...
gi 392895020   628 NIKQPGTWLYRID 640
Cdd:pfam06119   77 NVGVPGRWVFRID 89
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 392-427 2.52e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.41  E-value: 2.52e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 392895020  392 DVDECKTNStICHKNAICTNTPGRYFCMCKEGFSGD 427
Cdd:cd00054     1 DIDECASGN-PCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
392-430 1.42e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 51.48  E-value: 1.42e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 392895020    392 DVDECKTNStICHKNAICTNTPGRYFCMCKEGFSgDGQN 430
Cdd:smart00179    1 DIDECASGN-PCQNGGTCVNTVGSYRCECPPGYT-DGRN 37
EGF_CA pfam07645
Calcium-binding EGF domain;
392-423 4.03e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 47.23  E-value: 4.03e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 392895020   392 DVDECKTNSTICHKNAICTNTPGRYFCMCKEG 423
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 395-428 3.24e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 44.77  E-value: 3.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 392895020  395 ECKTNSTiCHKNAICTNTPGRYFCMCKEGFSGDG 428
Cdd:cd00053     1 ECAASNP-CSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF smart00181
Epidermal growth factor-like domain;
395-427 1.10e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 40.19  E-value: 1.10e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 392895020    395 ECKTNStICHkNAICTNTPGRYFCMCKEGFSGD 427
Cdd:smart00181    1 ECASGG-PCS-NGTCINTPGSYTCSCPPGYTGD 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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