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    Rint1 RAD50 interactor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38807, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rint1provided by FlyBase
    Official Full Name
    RAD50 interactor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035762
    Locus tag
    Dmel_CG8605
    See related
    AllianceGenome:FB:FBgn0035762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8605; Dmel\CG8605; Rint-1; rint1; Tip20
    Summary
    Involved in Golgi organization; cleavage furrow ingression; and male meiosis cytokinesis. Predicted to be located in endoplasmic reticulum. Predicted to be part of Dsl1/NZR complex. Is expressed in several structures, including adult head; embryonic/larval salivary gland; gut section; hindgut proper primordium; and posterior midgut primordium. Human ortholog(s) of this gene implicated in infantile liver failure syndrome. Orthologous to human RINT1 (RAD50 interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Rint1 in Genome Data Viewer
    Location:
    65F4-65F4; 3-20 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7323619..7326255)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7316719..7319355)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene unc-13-4A Neighboring gene uncharacterized protein Neighboring gene Rho guanine nucleotide exchange factor 4 Neighboring gene minerva Neighboring gene uncharacterized protein Neighboring gene mutagen-sensitive 312

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    part_of Dsl1/NZR complex  
    part_of Dsl1/NZR complex  
    part_of Dsl1/NZR complex  
    located_in endoplasmic reticulum  

    General protein information

    Preferred Names
    RAD50 interactor 1
    Names
    CG8605-PA
    RINT1 ortholog
    Rint1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7323619..7326255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139845.3 → NP_648102.2  RAD50 interactor 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648102.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q961W7, Q9VS46
      UniProtKB/TrEMBL
      B6IDL7
      Related
      FBpp0076549
      Conserved Domains (1) summary
      pfam04437
      Location:259 → 718
      RINT1_TIP1; RINT-1 / TIP-1 family
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